Published in Science on November 13, 2003
The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci (2009) 8.38
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci (2010) 8.09
Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron (2011) 8.06
The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature (2011) 6.71
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A (2004) 4.70
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell (2010) 4.30
Immune activation in brain aging and neurodegeneration: too much or too little? Neuron (2009) 3.76
Genomic analysis of reactive astrogliosis. J Neurosci (2012) 3.62
Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol (2008) 3.30
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem (2009) 3.23
IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci U S A (2008) 3.19
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science (2014) 3.11
Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys (2010) 3.05
Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A (2010) 2.70
Role of microglia in central nervous system infections. Clin Microbiol Rev (2004) 2.69
Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol Alcohol (2008) 2.52
Regulation of learning and memory by meningeal immunity: a key role for IL-4. J Exp Med (2010) 2.40
CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol (2006) 2.34
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation (2008) 2.25
Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A (2004) 2.20
The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med (2007) 2.16
The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol (2006) 2.10
Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc Natl Acad Sci U S A (2005) 2.09
Association between radiation dose to neuronal progenitor cell niches and temporal lobes and performance on neuropsychological testing in children: a prospective study. Neuro Oncol (2013) 2.05
Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging (2007) 2.03
Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. J Comp Neurol (2007) 2.02
Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci (2012) 2.01
Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. J Neurosci (2006) 1.96
Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biol Psychiatry (2008) 1.96
Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc Natl Acad Sci U S A (2006) 1.92
Radiation-induced brain injury: A review. Front Oncol (2012) 1.91
Why avoid the hippocampus? A comprehensive review. Radiother Oncol (2010) 1.90
Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev (2006) 1.88
Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci (2013) 1.86
Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J Neurochem (2009) 1.85
Interleukin-6 covaries inversely with hippocampal grey matter volume in middle-aged adults. Biol Psychiatry (2008) 1.85
Microglial activation in stroke: therapeutic targets. Neurotherapeutics (2010) 1.84
Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol (2009) 1.82
Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J Exp Med (2011) 1.80
Regulation and function of adult neurogenesis: from genes to cognition. Physiol Rev (2014) 1.79
Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J Clin Invest (2006) 1.78
Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology. Neurosci Biobehav Rev (2008) 1.77
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther (2009) 1.73
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J (2006) 1.73
Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiol Aging (2009) 1.72
New neurons in the adult brain: the role of sleep and consequences of sleep loss. Sleep Med Rev (2008) 1.72
Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system. J Biol (2008) 1.71
The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci (2005) 1.69
Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol (2013) 1.69
Persistent inflammation alters the function of the endogenous brain stem cell compartment. Brain (2008) 1.67
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res (2011) 1.67
Processing speed, attention, and working memory after treatment for medulloblastoma: an international, prospective, and longitudinal study. J Clin Oncol (2013) 1.66
The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging (Albany NY) (2011) 1.65
Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci (2011) 1.64
Hematopoietic cells maintain hematopoietic fates upon entering the brain. J Exp Med (2005) 1.63
Immune influence on adult neural stem cell regulation and function. Neuron (2009) 1.59
The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction. Crit Care (2010) 1.59
Neurogenesis, inflammation and behavior. Brain Behav Immun (2012) 1.58
Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J Psychiatry Neurosci (2009) 1.58
Astrocytes: targets for neuroprotection in stroke. Cent Nerv Syst Agents Med Chem (2011) 1.56
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery. Transl Cancer Res (2014) 1.56
Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation. Cell Stem Cell (2015) 1.55
Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat Neurosci (2012) 1.55
Cyclooxygenase-1 is involved in the inhibition of hippocampal neurogenesis after lipopolysaccharide-induced neuroinflammation. Cell Cycle (2011) 1.54
Neural precursor cells and central nervous system radiation sensitivity. Semin Radiat Oncol (2009) 1.54
Stem cells for ischemic brain injury: a critical review. J Comp Neurol (2009) 1.53
miR-132 mediates the integration of newborn neurons into the adult dentate gyrus. PLoS One (2011) 1.52
How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51
The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate. Clin Perinatol (2008) 1.50
Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.48
Neuroscience. Microglia: the enemy within? Science (2003) 1.46
Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells (2008) 1.46
Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates. PLoS One (2011) 1.45
Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. World J Gastroenterol (2010) 1.45
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells. Philos Trans R Soc Lond B Biol Sci (2006) 1.44
Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology (2011) 1.44
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. J Neuroinflammation (2008) 1.41
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol Rev (2011) 1.40
Structural plasticity and hippocampal function. Annu Rev Psychol (2010) 1.40
Glial toll-like receptor signaling in central nervous system infection and autoimmunity. Brain Behav Immun (2007) 1.40
An antagomir to microRNA Let7f promotes neuroprotection in an ischemic stroke model. PLoS One (2012) 1.40
Retracted Peripheral cytokines as a chemical mediator for postconcussion like sickness behaviour in trauma and perioperative patients: literature review. Neurol Res Int (2014) 1.39
Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease. Exp Neurol (2006) 1.39
Chronically increased transforming growth factor-beta1 strongly inhibits hippocampal neurogenesis in aged mice. Am J Pathol (2006) 1.38
The role of inflammation in perinatal brain injury. Nat Rev Neurol (2015) 1.35
Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage. Neurochem Int (2007) 1.35
Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair. Front Cell Neurosci (2013) 1.34
Neural progenitor cells regulate microglia functions and activity. Nat Neurosci (2012) 1.34
Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells (2009) 1.32
Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology (2011) 1.31
p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus. Proc Natl Acad Sci U S A (2008) 1.31
Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci (2009) 1.30
Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain. Radiat Res (2011) 1.30
Microglial activation - tuning and pruning adult neurogenesis. Front Pharmacol (2012) 1.29
Concise review: prospects of stem cell therapy for temporal lobe epilepsy. Stem Cells (2007) 1.28
Neuroprotective effects of estrogens following ischemic stroke. Front Neuroendocrinol (2009) 1.28
Molecular pathways: radiation-induced cognitive impairment. Clin Cancer Res (2013) 1.28
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci (2014) 1.27
Perivascular instruction of cell genesis and fate in the adult brain. Nat Neurosci (2011) 1.27
Functional neurogenesis in the adult hippocampus. Nature (2002) 11.17
Irradiation induces neural precursor-cell dysfunction. Nat Med (2002) 5.46
Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res (2003) 3.81
LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell (2011) 3.78
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med (2011) 3.66
FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell (2009) 3.54
Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron (2004) 3.09
VEGF is necessary for exercise-induced adult hippocampal neurogenesis. Eur J Neurosci (2003) 2.78
Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proc Natl Acad Sci U S A (2007) 2.03
Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. Mol Syst Biol (2006) 1.90
Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning. J Neurophysiol (2005) 1.72
Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Ann Neurol (2007) 1.64
Immune influence on adult neural stem cell regulation and function. Neuron (2009) 1.59
Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke (2005) 1.54
Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair. Stem Cells (2011) 1.54
IGF-I has a direct proliferative effect in adult hippocampal progenitor cells. Mol Cell Neurosci (2003) 1.50
Enriched monolayer precursor cell cultures from micro-dissected adult mouse dentate gyrus yield functional granule cell-like neurons. PLoS One (2007) 1.45
Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress. Radiat Res (2004) 1.41
SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress. PLoS One (2011) 1.37
Novel neuronal phenotypes from neural progenitor cells. J Neurosci (2004) 1.26
A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Mol Cell Neurosci (2009) 1.14
Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J Neurosci (2010) 1.12
Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo. J Neurosci (2010) 1.06
Neuroscience. Cellular interactions in the stem cell niche. Science (2004) 1.06
The CCR2/CCL2 interaction mediates the transendothelial recruitment of intravascularly delivered neural stem cells to the ischemic brain. Stroke (2011) 1.05
New roles for astrocytes: the nightlife of an 'astrocyte'. La vida loca! Trends Neurosci (2003) 1.04
Neurodegeneration and cell replacement. Philos Trans R Soc Lond B Biol Sci (2008) 1.01
Cellular repair of CNS disorders: an immunological perspective. Hum Mol Genet (2008) 1.00
Functional engraftment of the medial ganglionic eminence cells in experimental stroke model. Cell Transplant (2009) 0.98
Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis. Am J Pathol (2008) 0.95
MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts. PLoS One (2011) 0.93
Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells. J Biol Chem (2003) 0.92
Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis. Brain Behav Immun (2013) 0.92
Placental TNF-α signaling in illness-induced complications of pregnancy. Am J Pathol (2011) 0.90
PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06. Mol Imaging Biol (2013) 0.90
Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells. Proc Natl Acad Sci U S A (2013) 0.89
PPARγ activation prevents impairments in spatial memory and neurogenesis following transient illness. Brain Behav Immun (2012) 0.85
Absence of CCL2 is sufficient to restore hippocampal neurogenesis following cranial irradiation. Brain Behav Immun (2012) 0.85
Neuronal Rac1 is required for learning-evoked neurogenesis. J Neurosci (2013) 0.84
Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Neuromuscul Disord (2002) 0.83
[Remission of lymphomatosis cerebri induced by corticosteroid and high-doses intravenous methotrexate]. Rinsho Shinkeigaku (2012) 0.83
A Mobile Schwannoma of the Cervical Spinal Cord: Case Report and Review of the Literature. Neurosurgery (2016) 0.82
Intramedullary spinal cord abscess and subsequent granuloma formation: a rare complication of vertebral osteomyelitis detected by diffusion-weighted magnetic resonance imaging. Neurosurg Focus (2014) 0.82
Autologous clavicle bone graft for anterior cervical discectomy and fusion with titanium interbody cage. J Neurosurg Spine (2014) 0.81
Long-term transgene expression in mouse neural progenitor cells modified with phiC31 integrase. J Neurosci Methods (2008) 0.81
Adult neural progenitor cells reactivate superbursting in mature neural networks. Exp Neurol (2011) 0.80
Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS (2014) 0.80
Stereotypical alterations in cortical patterning are associated with maternal illness-induced placental dysfunction. J Neurosci (2013) 0.79
Pallidal deep brain stimulation for a case of hemidystonia secondary to a striatal stroke. Stereotact Funct Neurosurg (2013) 0.77
Subthalamic nucleus deep brain stimulation restores normal rapid eye movement sleep in Parkinson's disease. Mov Disord (2011) 0.77
Aging-like changes in the transcriptome of irradiated microglia. Glia (2015) 0.77
Natural killer cell-activating receptor NKG2D mediates innate immune targeting of allogeneic neural progenitor cell grafts. Stem Cells (2013) 0.77
Copernican stem cells: regulatory constellations in adult hippocampal neurogenesis. J Cell Biochem (2003) 0.76
A Perforating Artery Compressing the Nerve Rootlet and Causing Glossopharyngeal Neuralgia. Neurosurgery (2015) 0.75
[Treatment of Non-Traumatic Spinal Epidural Hematoma:A Report of Five Cases and a Systematic Review of the Literature]. No Shinkei Geka (2016) 0.75
Enhanced production of fattiviracins by bacitracin-resistant strains of Streptomyces microflavus strain No. 2445. J Antibiot (Tokyo) (2003) 0.75
Grafts of Neural Precursors Derived from the Basal Forebrain Improve Motor Function in Experimental Stroke 887. Neurosurgery (2006) 0.75
[A Single-Stage Combined Supra- and Infra-Sellar Approach for Recurrent Large Pituitary Adenomas:Report of Two Cases]. No Shinkei Geka (2015) 0.75