Published in PLoS Genet on December 20, 2012
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med (2015) 3.29
The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol (2013) 2.56
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
A genome-wide pleiotropy scan for prostate cancer risk. Eur Urol (2014) 1.48
Genome-wide association study identifies multiple loci associated with bladder cancer risk. Hum Mol Genet (2013) 1.34
Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. Genet Epidemiol (2013) 1.27
Education influences the role of genetics in myopia. Eur J Epidemiol (2013) 1.10
Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet (2014) 1.07
A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med (2015) 1.02
Genetic determinants of depression: recent findings and future directions. Harv Rev Psychiatry (2015) 1.02
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis. Nat Commun (2015) 1.01
APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema. Eur Respir J (2013) 0.97
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet (2014) 0.97
GSTCD and INTS12 regulation and expression in the human lung. PLoS One (2013) 0.94
The DNA methylation signature of smoking: an archetype for the identification of biomarkers for behavioral illness. Nebr Symp Motiv (2014) 0.94
Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences. Hum Genet (2014) 0.91
Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women. Hum Mol Genet (2014) 0.90
A draft de novo genome assembly for the northern bobwhite (Colinus virginianus) reveals evidence for a rapid decline in effective population size beginning in the Late Pleistocene. PLoS One (2014) 0.87
Modulation of genetic associations with serum urate levels by body-mass-index in humans. PLoS One (2015) 0.83
A perspective on interaction effects in genetic association studies. Genet Epidemiol (2016) 0.82
Integrative genomics of chronic obstructive pulmonary disease. Biochem Biophys Res Commun (2014) 0.82
Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. Genet Epidemiol (2014) 0.82
Association of lung function genes with chronic obstructive pulmonary disease. Lung (2014) 0.82
Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.81
ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circ Cardiovasc Genet (2014) 0.81
Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study. Environ Health (2013) 0.81
Identification of FAM13A gene associated with the ratio of FEV1 to FVC in Korean population by genome-wide association studies including gene-environment interactions. J Hum Genet (2015) 0.80
Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study. Cancer Epidemiol Biomarkers Prev (2014) 0.80
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res (2014) 0.80
Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis. Environ Health Perspect (2014) 0.80
Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness. PLoS One (2015) 0.79
Oxidative Stress and Therapeutic Development in Lung Diseases. J Pulm Respir Med (2014) 0.79
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat Commun (2016) 0.78
Incorporating gene-environment interaction in testing for association with rare genetic variants. Hum Hered (2014) 0.78
Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases. Am J Respir Cell Mol Biol (2016) 0.78
Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up. Am J Respir Crit Care Med (2016) 0.77
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet (2017) 0.76
Increased Transcript Complexity in Genes Associated with Chronic Obstructive Pulmonary Disease. PLoS One (2015) 0.76
Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet (2015) 0.76
Secreted phosphoprotein 1 is a determinant of lung function development in mice. Am J Respir Cell Mol Biol (2014) 0.76
Functional implications of Neandertal introgression in modern humans. Genome Biol (2017) 0.75
Combining omics data to identify genes associated with allergic rhinitis. Clin Epigenetics (2017) 0.75
Robustness of meta-analyses in finding gene × environment interactions. PLoS One (2017) 0.75
Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease. BMC Pulm Med (2016) 0.75
On lung function and interactions using genome-wide data. PLoS Genet (2012) 0.75
A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease. Pharmacogenomics J (2015) 0.75
Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation. PLoS One (2017) 0.75
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75
FAM13A, A Fatty Acid Oxidation Switch in Mitochondria. Friend or Foe in Chronic Obstructive Pulmonary Disease Pathogenesis? Am J Respir Cell Mol Biol (2017) 0.75
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res (2002) 76.95
The International HapMap Project. Nature (2003) 73.65
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol (1989) 37.83
Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol (2002) 35.63
The Cardiovascular Health Study: design and rationale. Ann Epidemiol (1991) 27.24
A genome-wide association study of global gene expression. Nat Genet (2007) 22.98
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics (2008) 15.77
CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol (1988) 15.40
NCBI GEO: archive for functional genomics data sets--10 years on. Nucleic Acids Res (2010) 14.38
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol (2008) 11.28
The Framingham Offspring Study. Design and preliminary data. Prev Med (1975) 10.53
EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer (1999) 9.68
A large-scale, consortium-based genomewide association study of asthma. N Engl J Med (2010) 9.17
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42
Sox9 is required for cartilage formation. Nat Genet (1999) 7.89
The European Community Respiratory Health Survey. Eur Respir J (1994) 7.87
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature (1994) 7.30
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Am J Epidemiol (2007) 7.06
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study. BMJ (1996) 6.25
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Exploiting gene-environment interaction to detect genetic associations. Hum Hered (2007) 5.63
Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet (2012) 5.11
Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet (2009) 4.79
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res (2001) 4.50
Cohort profile: the study of health in Pomerania. Int J Epidemiol (2010) 4.38
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization. Proc Natl Acad Sci U S A (2001) 4.13
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Recruitment in the Coronary Artery Disease Risk Development in Young Adults (Cardia) Study. Control Clin Trials (1987) 4.05
Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study. Chest (2000) 3.96
Gene-environment interaction in genome-wide association studies. Am J Epidemiol (2008) 3.96
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol (2011) 3.26
Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood. Int J Epidemiol (2007) 3.15
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Groups at risk in low birth weight infants and perinatal mortality. Acta Paediatr Scand (1969) 2.95
Increasing the power of identifying gene x gene interactions in genome-wide association studies. Genet Epidemiol (2008) 2.84
Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet (2012) 2.70
The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. Am J Respir Crit Care Med (2009) 2.60
The campomelic syndrome: review, report of 17 cases, and follow-up on the currently 17-year-old boy first reported by Maroteaux et al in 1971. Am J Med Genet (1983) 2.53
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. Nat Genet (2009) 2.48
The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: a cross-sectional study. Ann Intern Med (2010) 2.34
Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development (2009) 2.33
Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee. PLoS Genet (2011) 2.28
Modification of gene expression of the small airway epithelium in response to cigarette smoking. J Mol Med (Berl) (2006) 2.20
Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study. Eur J Epidemiol (2007) 2.18
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (2009) 2.10
Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects. Thorax (2005) 2.08
SAPALDIA: methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in Adults. Soz Praventivmed (1997) 1.88
Sample size requirements to detect gene-environment interactions in genome-wide association studies. Genet Epidemiol (2011) 1.78
The Framingham study. An epidemiological approach to coronary heart disease. Circulation (1966) 1.72
Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients. Genet Epidemiol (2011) 1.71
Long-range regulation at the SOX9 locus in development and disease. J Med Genet (2009) 1.62
KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes. Am J Hum Genet (2002) 1.60
Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.57
Gene-environment interactions in genome-wide association studies: a comparative study of tests applied to empirical studies of type 2 diabetes. Am J Epidemiol (2011) 1.55
Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate. Genet Epidemiol (2011) 1.47
Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases. PLoS Genet (2011) 1.46
Genetic and environmental influences on pulmonary function in adult twins. Am Rev Respir Dis (1982) 1.41
Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns (2002) 1.37
Gene-environment interaction for childhood asthma and exposure to farming in Central Europe. J Allergy Clin Immunol (2011) 1.30
Genome-wide meta-analysis of joint tests for genetic and gene-environment interaction effects. Hum Hered (2011) 1.22
Efficient genome-wide association testing of gene-environment interaction in case-parent trios. Am J Epidemiol (2010) 1.22
Labour induction policy in hospitals of different levels of specialisation. Br J Obstet Gynaecol (1993) 1.20
Assessment of genetic and nongenetic influences on pulmonary function. A twin study. Am Rev Respir Dis (1987) 1.15
Glucocorticoids increase repair potential in a novel in vitro human airway epithelial wounding model. J Clin Immunol (2006) 1.13
Respiratory function and self-reported functional health: EPIC-Norfolk population study. Eur Respir J (2005) 1.04
The distribution of MHC class I and II antigens on bronchial epithelium. Am Rev Respir Dis (1989) 1.01
The effect of beta2-adrenoceptor agonists on phospholipase C (beta1) signalling in human airway smooth muscle cells. Eur J Pharmacol (2006) 0.97
Impaired cerebellar functions in mutant mice lacking DNER. Mol Cell Neurosci (2005) 0.97
A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea. Dev Biol (2011) 0.92
Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis. Mol Cell Biol (2008) 0.87
Inward rectifier K(+) current in human bronchial smooth muscle cells: inhibition with antisense oligonucleotides targeted to Kir2.1 mRNA. Am J Respir Cell Mol Biol (2002) 0.86
Regulation of major histocompatibility complex class II antigens on human alveolar macrophages by granulocyte-macrophage colony-stimulating factor in the presence of glucocorticoids. Immunology (1999) 0.81
DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation. Cell Prolif (2010) 0.80
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 41.47
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (2006) 27.49
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 26.95
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet (2007) 19.08
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27