Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 4190389)

Published in Respir Res on September 21, 2014

Authors

Jin Hwa Lee, Michael H Cho, Craig P Hersh, Merry-Lynn N McDonald, James D Crapo, Per S Bakke, Amund Gulsvik, Alejandro P Comellas, Christine H Wendt, David A Lomas, Victor Kim, Edwin K Silverman, COPDGene and ECLIPSE Investigators

Associated clinical trials:

Evaluation of COPD (Chronic Obstructive Pulmonary Disease) to Longitudinally Identify Predictive Surrogate Endpoints (ECLIPSE) | NCT00292552

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD) (COPDGene) | NCT00608764

Articles cited by this

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Measuring inconsistency in meta-analyses. BMJ (2003) 128.20

Genomic control for association studies. Biometrics (1999) 64.39

An integrated map of genetic variation from 1,092 human genomes. Nature (2012) 59.82

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2012) 22.96

METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21

GenABEL: an R library for genome-wide association analysis. Bioinformatics (2007) 18.10

LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics (2010) 13.54

Practical aspects of imputation-driven meta-analysis of genome-wide association studies. Hum Mol Genet (2008) 13.26

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29

Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93

Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics (2004) 4.88

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56

Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). Eur Respir J (2008) 4.53

Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev (2006) 4.39

Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature (1998) 4.24

Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70

Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44

Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies. Am J Hum Genet (2011) 3.21

The emphysematous and bronchial types of chronic airways obstruction. A clinicopathological study of patients in London and Chicago. Lancet (1966) 2.94

The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91

Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Radiology (2005) 2.37

Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care Med (2006) 2.34

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28

Transcriptional profiling of mucociliary differentiation in human airway epithelial cells. Am J Respir Cell Mol Biol (2007) 2.26

The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest (2011) 2.14

Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet (2012) 2.09

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98

Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. Chest (2008) 1.89

YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol (2008) 1.78

Chitin regulation of immune responses: an old molecule with new roles. Curr Opin Immunol (2008) 1.75

CTLA4 gene polymorphisms are associated with chronic bronchitis. Eur Respir J (2009) 1.62

Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood (2005) 1.56

Regulation of airway mucin gene expression. Annu Rev Physiol (2008) 1.53

Susceptibility to chronic mucus hypersecretion, a genome wide association study. PLoS One (2014) 1.52

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet (2012) 1.52

Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet (2002) 1.36

Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med (2010) 1.36

Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD. Chest (2013) 1.32

Interaction of Shc with adaptor protein adaptins. J Biol Chem (1996) 1.18

Coupling cystic fibrosis to endoplasmic reticulum stress: Differential role of Grp78 and ATF6. Biochim Biophys Acta (2007) 1.10

Polymorphism of human mucin genes in chest disease: possible significance of MUC2. Am J Respir Cell Mol Biol (2000) 1.06

The mechanism of cystic fibrosis transmembrane conductance regulator transcriptional repression during the unfolded protein response. J Biol Chem (2008) 1.06

Allelic association and recombination hotspots in the mucin gene (MUC) complex on chromosome 11p15.5. Ann Hum Genet (2007) 1.03

Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis. Am J Respir Cell Mol Biol (2014) 1.01

Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation. Am J Pathol (2009) 1.00

Chronic bronchitis in the general population: influence of age, gender and socio-economic conditions. Respir Med (2011) 0.95

Interaction between smoking and genetic factors in the development of chronic bronchitis. Am J Respir Crit Care Med (2007) 0.95

Calcium signaling in human airway goblet cells following purinergic activation. Am J Physiol Lung Cell Mol Physiol (2006) 0.94

Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity. J Biol Chem (2010) 0.88

The effect of chronic sputum production on respiratory symptoms in severe COPD. COPD (2011) 0.82

Genetic association between human chitinases and lung function in COPD. Hum Genet (2011) 0.82

Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5. J Biol Chem (2013) 0.78

Normalization of deranged signal transduction in lymphocytes of COPD patients by the novel calcium channel blocker H-DHPM. Biochimie (2011) 0.78

Identification of the human CYS1 gene and candidate gene analysis in Boichis disease. Pediatr Nephrol (2003) 0.76

Articles by these authors

Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med (2010) 15.07

Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet (2003) 10.97

International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet (2007) 10.12

Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55

Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67

A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93

Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner Society. Radiology (2012) 6.92

Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69

Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57

Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54

Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44

Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92

Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75

PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68

Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19

GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98

MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96

An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest (2010) 3.91

A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78

Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70

Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med (2011) 3.58

A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52

Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44

Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44

Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41

On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32

Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17

The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91

Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62

Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52

Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med (2003) 2.49

The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46

Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity. PLoS Biol (2007) 2.35

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35

The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29

Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24

Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24

The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19

Conformational pathology of the serpins: themes, variations, and therapeutic strategies. Annu Rev Biochem (2009) 2.19

Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18

Body mass index, weight gain, and other determinants of lung function decline in adult asthma. J Allergy Clin Immunol (2009) 2.16

Post-bronchodilator spirometry reference values in adults and implications for disease management. Am J Respir Crit Care Med (2006) 2.15

A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15

Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes. Am J Respir Crit Care Med (2014) 2.14

Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14

Alpha1-antitrypsin deficiency--a model for conformational diseases. N Engl J Med (2002) 2.11

Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med (2009) 2.10

Exertional desaturation as a predictor of rapid lung function decline in COPD. Respiration (2012) 2.09

Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med (2013) 2.09

Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD (2012) 2.07

Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. Am J Respir Cell Mol Biol (2013) 2.06

Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06

Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet (2002) 2.02

Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.99

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98

Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98

Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med (2007) 1.94

Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol (2002) 1.90

A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered (2003) 1.89

Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. J Allergy Clin Immunol (2007) 1.88