Mars 520-d mission simulation reveals protracted crew hypokinesis and alterations of sleep duration and timing.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 3574912)

Published in Proc Natl Acad Sci U S A on January 07, 2013

Authors

Mathias Basner1, David F Dinges, Daniel Mollicone, Adrian Ecker, Christopher W Jones, Eric C Hyder, Adrian Di Antonio, Igor Savelev, Kevin Kan, Namni Goel, Boris V Morukov, Jeffrey P Sutton

Author Affiliations

1: Division of Sleep and Chronobiology, Unit for Experimental Psychiatry, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Associated clinical trials:

Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis | NCT04856410

Articles citing this

Natural Sleep and Its Seasonal Variations in Three Pre-industrial Societies. Curr Biol (2015) 3.71

Measuring sleep: accuracy, sensitivity, and specificity of wrist actigraphy compared to polysomnography. Sleep (2013) 1.78

Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster. PLoS One (2015) 1.39

Agreement between 24-hour salt ingestion and sodium excretion in a controlled environment. Hypertension (2015) 1.12

Cognitive neuroscience in space. Life (Basel) (2014) 0.90

Disrutpted resting-state functional architecture of the brain after 45-day simulated microgravity. Front Behav Neurosci (2014) 0.87

Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to mars. PLoS One (2014) 0.87

Decreasing ventromedial prefrontal cortex deactivation in risky decision making after simulated microgravity: effects of -6° head-down tilt bed rest. Front Behav Neurosci (2014) 0.81

The effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment. J Appl Physiol (1985) (2014) 0.80

Ultra-long-term human salt balance studies reveal interrelations between sodium, potassium, and chloride intake and excretion. Am J Clin Nutr (2016) 0.80

Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts. Mil Med Res (2014) 0.77

During the long way to Mars: effects of 520 days of confinement (Mars500) on the assessment of affective stimuli and stage alteration in mood and plasma hormone levels. PLoS One (2014) 0.77

Sleepiness and Safety: Where Biology Needs Technology. Sleep Biol Rhythms (2014) 0.76

Wireless Monitoring of Changes in Crew Relations during Long-Duration Mission Simulation. PLoS One (2015) 0.75

Effects of sex and gender on adaptation to space: behavioral health. J Womens Health (Larchmt) (2014) 0.75

Increased Brain Activation for Dual Tasking with 70-Days Head-Down Bed Rest. Front Syst Neurosci (2016) 0.75

Temporal dynamics of the gut microbiota in people sharing a confined environment, a 520-day ground-based space simulation, MARS500. Microbiome (2017) 0.75

Sleeping under the Ocean: Despite Total Isolation, Nuclear Submariners Maintain Their Sleep and Wake Patterns throughout Their Under Sea Mission. PLoS One (2015) 0.75

Articles cited by this

The role of actigraphy in the study of sleep and circadian rhythms. Sleep (2003) 10.70

The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep (2003) 9.71

Stability, precision, and near-24-hour period of the human circadian pacemaker. Science (1999) 7.74

Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. Sleep (2004) 4.93

Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J Sleep Res (2003) 4.79

Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol (2000) 4.39

Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature. Physiol Rev (2003) 4.29

Sleep deprivation and vigilant attention. Ann N Y Acad Sci (2008) 3.60

Social jetlag and obesity. Curr Biol (2012) 3.37

A phase response curve to single bright light pulses in human subjects. J Physiol (2003) 3.29

American time use survey: sleep time and its relationship to waking activities. Sleep (2007) 3.18

Social jetlag: misalignment of biological and social time. Chronobiol Int (2006) 3.13

PER3 polymorphism predicts sleep structure and waking performance. Curr Biol (2007) 2.93

High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. J Clin Endocrinol Metab (2003) 2.67

The homeostatic regulation of sleep need is under genetic control. J Neurosci (2001) 2.56

Differential rescue of light- and food-entrainable circadian rhythms. Science (2008) 2.20

PERIOD3, circadian phenotypes, and sleep homeostasis. Sleep Med Rev (2009) 2.19

Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss. Sleep (2011) 2.06

DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue. Neurology (2010) 1.86

Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights. Am J Physiol Regul Integr Comp Physiol (2001) 1.76

Entrainment of the human circadian pacemaker to longer-than-24-h days. Proc Natl Acad Sci U S A (2007) 1.70

Entrainment of the human circadian system by light. J Biol Rhythms (2005) 1.63

Sleep viewed as a state of adaptive inactivity. Nat Rev Neurosci (2009) 1.47

The human circadian clock's seasonal adjustment is disrupted by daylight saving time. Curr Biol (2007) 1.44

Do all animals sleep? Trends Neurosci (2008) 1.40

Heritability of performance deficit accumulation during acute sleep deprivation in twins. Sleep (2012) 1.22

Plasticity of the intrinsic period of the human circadian timing system. PLoS One (2007) 1.21

Dubious bargain: trading sleep for Leno and Letterman. Sleep (2009) 1.19

Validity and Sensitivity of a Brief Psychomotor Vigilance Test (PVT-B) to Total and Partial Sleep Deprivation. Acta Astronaut (2011) 1.12

Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers. Brain Res (1988) 1.09

Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome. Sleep Med Rev (2007) 1.03

Microgravity: the immune response and bone. Immunol Rev (2005) 1.03

Detecting deteriorated vigilance using percentage of eyelid closure time during behavioral maintenance of wakefulness tests. Int J Psychophysiol (2011) 1.02

Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase. Am J Physiol Regul Integr Comp Physiol (2003) 1.02

Impact of sleepiness and sleep deficiency on public health--utility of biomarkers. J Clin Sleep Med (2011) 1.01

Psychological effects of polar expeditions. Lancet (2008) 1.00

Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS One (2012) 1.00

Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light. Am J Physiol Regul Integr Comp Physiol (2004) 0.99

Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J Physiol (2002) 0.99

Genotype-dependent differences in sleep, vigilance, and response to stimulants. Curr Pharm Des (2008) 0.97

Predicting Risk in Space: Genetic Markers for Differential Vulnerability to Sleep Restriction. Acta Astronaut (2012) 0.96

Learning to live on a Mars day: fatigue countermeasures during the Phoenix Mars Lander mission. Sleep (2012) 0.90

Fitness for duty: a 3-minute version of the Psychomotor Vigilance Test predicts fatigue-related declines in luggage-screening performance. J Occup Environ Med (2011) 0.88

Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays. Proc Natl Acad Sci U S A (2011) 0.86

Biological rhythms during residence in polar regions. Chronobiol Int (2012) 0.83

Free-running rhythms of melatonin, cortisol, electrolytes, and sleep in humans in Antarctica. Am J Physiol (1991) 0.82

Seasonal influences on sleep and executive function in the migratory White-crowned Sparrow (Zonotrichia leucophrys gambelii). BMC Neurosci (2010) 0.81

The impact of bright artificial white and 'blue-enriched' light on sleep and circadian phase during the polar winter. J Sleep Res (2010) 0.80

Articles by these authors

The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep (2003) 9.71

Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol (2004) 6.08

Neurocognitive consequences of sleep deprivation. Semin Neurol (2005) 5.62

Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. Sleep (2004) 4.93

Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med (2007) 4.23

Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep (2007) 4.17

Sleep deprivation and vigilant attention. Ann N Y Acad Sci (2008) 3.60

The working hours of hospital staff nurses and patient safety. Health Aff (Millwood) (2004) 3.31

American time use survey: sleep time and its relationship to waking activities. Sleep (2007) 3.18

Neurocognitive consequences of sleep deprivation. Semin Neurol (2009) 2.89

Non-invasive neuroimaging using near-infrared light. Biol Psychiatry (2002) 2.67

Interfering with theories of sleep and memory: sleep, declarative memory, and associative interference. Curr Biol (2006) 2.54

Modafinil for excessive sleepiness associated with shift-work sleep disorder. N Engl J Med (2005) 2.51

The neural basis of the psychomotor vigilance task. Sleep (2005) 2.44

Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress. Proc Natl Acad Sci U S A (2005) 2.40

Individual differences in adult human sleep and wakefulness: Leitmotif for a research agenda. Sleep (2005) 2.20

Self-efficacy in sleep apnea: instrument development and patient perceptions of obstructive sleep apnea risk, treatment benefit, and volition to use continuous positive airway pressure. Sleep (2003) 2.18

Circadian eating and sleeping patterns in the night eating syndrome. Obes Res (2004) 2.15

A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychol Bull (2010) 2.12

Maximizing sensitivity of the psychomotor vigilance test (PVT) to sleep loss. Sleep (2011) 2.06

Lapsing during sleep deprivation is associated with distributed changes in brain activation. J Neurosci (2008) 1.92

The neural basis of interindividual variability in inhibitory efficiency after sleep deprivation. J Neurosci (2006) 1.90

DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue. Neurology (2010) 1.86

Effects of Experimental Sleep Restriction on Weight Gain, Caloric Intake, and Meal Timing in Healthy Adults. Sleep (2013) 1.85

Trait interindividual differences in the sleep physiology of healthy young adults. J Sleep Res (2007) 1.84

The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine. Sleep (2005) 1.81

Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect. Neuroimage (2009) 1.78

Assessment of sleep in women with night eating syndrome. Sleep (2006) 1.56

Impaired performance in commercial drivers: role of sleep apnea and short sleep duration. Am J Respir Crit Care Med (2006) 1.56

Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: importance and techniques. Aviat Space Environ Med (2004) 1.55

PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS One (2009) 1.54

Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. Neuroimage (2006) 1.51

Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery. Sleep (2010) 1.51

Adsorbent materials for carbon dioxide capture from large anthropogenic point sources. ChemSusChem (2009) 1.47

Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis. J Cell Biol (2006) 1.46

Symposium resident work-hour guidelines. A sentence or an opportunity for orthopaedic education? J Bone Joint Surg Am (2005) 1.43

The growth of sleep science and the role of SLEEP. Sleep (2014) 1.40

Sleep restriction is associated with increased morning plasma leptin concentrations, especially in women. Biol Res Nurs (2010) 1.40

Summary of the key features of seven biomathematical models of human fatigue and performance. Aviat Space Environ Med (2004) 1.39

A new mathematical model for the homeostatic effects of sleep loss on neurobehavioral performance. J Theor Biol (2008) 1.37

Sleep, circadian rhythms, and psychomotor vigilance. Clin Sports Med (2005) 1.36

Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the mir space station. J Bone Miner Res (2004) 1.34

Sleep and inflammation. Nutr Rev (2007) 1.32

Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance. J Sleep Res (2003) 1.28

Optimization of biomathematical model predictions for cognitive performance impairment in individuals: accounting for unknown traits and uncertain states in homeostatic and circadian processes. Sleep (2007) 1.25

Mixed-model regression analysis and dealing with interindividual differences. Methods Enzymol (2004) 1.25

Sleep disordered breathing with excessive daytime sleepiness is a risk factor for mortality in older adults. Sleep (2011) 1.24

Consequences of comorbid insomnia symptoms and sleep-related breathing disorder in elderly subjects. Arch Intern Med (2006) 1.22

Circadian rhythm profiles in women with night eating syndrome. J Biol Rhythms (2009) 1.19

Hydrodeoxygenation and coupling of aqueous phenolics over bifunctional zeolite-supported metal catalysts. Chem Commun (Camb) (2009) 1.19

Dubious bargain: trading sleep for Leno and Letterman. Sleep (2009) 1.19

Claustrophobia and adherence to CPAP treatment. West J Nurs Res (2005) 1.17

The relationship between nurse work schedules, sleep duration, and drowsy driving. Sleep (2007) 1.15

Sleep deprivation and stressors: evidence for elevated negative affect in response to mild stressors when sleep deprived. Emotion (2012) 1.14

Sleep-disordered breathing and psychomotor vigilance in a community-based sample. Sleep (2007) 1.13

Validity and Sensitivity of a Brief Psychomotor Vigilance Test (PVT-B) to Total and Partial Sleep Deprivation. Acta Astronaut (2011) 1.12

Neuroendocrine profiles associated with energy intake, sleep, and stress in the night eating syndrome. J Clin Endocrinol Metab (2005) 1.12

Designing adsorbents for CO2 capture from flue gas-hyperbranched aminosilicas capable of capturing CO2 reversibly. J Am Chem Soc (2008) 1.12

Sleep, waking and neurobehavioural performance. Front Biosci (2003) 1.11

Nonlinear mixed-effects modeling: individualization and prediction. Aviat Space Environ Med (2004) 1.10

Circadian rhythms, sleep deprivation, and human performance. Prog Mol Biol Transl Sci (2013) 1.10

The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling. J Cell Sci (2010) 1.10

Effect of a protected sleep period on hours slept during extended overnight in-hospital duty hours among medical interns: a randomized trial. JAMA (2012) 1.09

Sleep deprivation and neurobehavioral dynamics. Curr Opin Neurobiol (2013) 1.08

Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision. J Pain (2010) 1.08

Risk factors for excessive sleepiness in older adults. Ann Neurol (2006) 1.07

Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling. Elife (2014) 1.03

Sleep debt and scientific evidence. Sleep (2004) 0.99

Sleep deprivation impairs object-selective attention: a view from the ventral visual cortex. PLoS One (2010) 0.99

Time of day effects on neurobehavioral performance during chronic sleep restriction. Aviat Space Environ Med (2010) 0.98

Acid-catalyzed conversion of sugars and furfurals in an ionic-liquid phase. ChemSusChem (2009) 0.98

Controlled breaks as a fatigue countermeasure on the flight deck. Aviat Space Environ Med (2002) 0.97

Predicting Risk in Space: Genetic Markers for Differential Vulnerability to Sleep Restriction. Acta Astronaut (2012) 0.96

Response Surface Mapping of Neurobehavioral Performance: Testing the Feasibility of Split Sleep Schedules for Space Operations. Acta Astronaut (2008) 0.95

Steam-stripping for regeneration of supported amine-based CO(2) adsorbents. ChemSusChem (2010) 0.94

Controlling the density of amine sites on silica surfaces using benzyl spacers. Langmuir (2006) 0.94

Effects of night work, sleep loss and time on task on simulated threat detection performance. Sleep (2008) 0.93

Androgen and Src signaling regulate centrosome activity. J Cell Sci (2010) 0.93

Application of amine-tethered solid sorbents for direct CO2 capture from the ambient air. Environ Sci Technol (2011) 0.92

Rational approach to polymer-supported catalysts: synergy between catalytic reaction mechanism and polymer design. Acc Chem Res (2008) 0.92

A high-performance gas-separation membrane containing submicrometer-sized metal-organic framework crystals. Angew Chem Int Ed Engl (2010) 0.92

Mizoroki-Heck coupling using immobilized molecular precatalysts: leaching active species from Pd pincers, entrapped Pd salts, and Pd NHC complexes. Inorg Chem (2007) 0.91

Case-control study of subjective and objective differences in sleep patterns in older adults with insomnia symptoms. J Sleep Res (2010) 0.91

Depolymerization and hydrodeoxygenation of switchgrass lignin with formic acid. ChemSusChem (2012) 0.90

Behavioral and genetic markers of sleepiness. J Clin Sleep Med (2011) 0.90

Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss. PLoS One (2011) 0.89

The challenges and opportunities of technological approaches to fatigue management. Accid Anal Prev (2011) 0.89

Sleep deprivation and sustained attention performance: integrating mathematical and cognitive modeling. Cogn Sci (2009) 0.89

Dynamic circadian modulation in a biomathematical model for the effects of sleep and sleep loss on waking neurobehavioral performance. Sleep (2013) 0.88

Modification of the Mg/DOBDC MOF with Amines to Enhance CO2 Adsorption from Ultradilute Gases. J Phys Chem Lett (2012) 0.87

Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test. PLoS One (2012) 0.87

An adaptive-duration version of the PVT accurately tracks changes in psychomotor vigilance induced by sleep restriction. Sleep (2012) 0.87

Systematic individual differences in sleep homeostatic and circadian rhythm contributions to neurobehavioral impairment during sleep deprivation. Accid Anal Prev (2011) 0.86

Effects of sleep restriction on adiponectin levels in healthy men and women. Physiol Behav (2010) 0.86