Published in Am J Physiol Gastrointest Liver Physiol on January 10, 2013
Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates. Am J Physiol Gastrointest Liver Physiol (2014) 1.57
Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential. PLoS One (2014) 0.91
A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia. Sci Rep (2015) 0.88
A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. Ann Surg (2014) 0.85
A High Level of Intestinal Alkaline Phosphatase Is Protective Against Type 2 Diabetes Mellitus Irrespective of Obesity. EBioMedicine (2015) 0.84
Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase. Diabetes Obes Metab (2016) 0.80
Intestinal alkaline phosphatase: a summary of its role in clinical disease. J Surg Res (2015) 0.79
Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity. World J Gastroenterol (2014) 0.78
Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. J Pediatr Surg (2014) 0.78
Intestinal Alkaline Phosphatase: Potential Roles in Promoting Gut Health in Weanling Piglets and Its Modulation by Feed Additives - A Review. Asian-Australas J Anim Sci (2016) 0.76
Intestinal alkaline phosphatase to treat necrotizing enterocolitis. J Surg Res (2015) 0.76
Alkaline phosphatase in nasal secretion of cattle: biochemical and molecular characterisation. BMC Vet Res (2014) 0.75
Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett (2013) 0.75
Inflammatory bowel disease. N Engl J Med (2002) 21.17
Commensal host-bacterial relationships in the gut. Science (2001) 14.82
Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun (1998) 7.86
A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay. Anal Biochem (1988) 4.76
Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol (2010) 4.07
Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe (2007) 3.88
Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood (2001) 3.84
T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol (1997) 2.76
Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Mol Pharmacol (1996) 2.45
Double blind, placebo controlled trial of metronidazole in Crohn's disease. Gut (1991) 2.24
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (2005) 2.08
Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A (2008) 1.97
Role of alkaline phosphatase in colitis in man and rats. Gut (2008) 1.92
Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun (1996) 1.71
P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem (2001) 1.63
Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol Cell Biol (2003) 1.60
Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet. Nutr Rev (2010) 1.60
A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.39
Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Natl Acad Sci U S A (2010) 1.39
Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota. Gut (2010) 1.31
Dephosphorylation of endotoxin by alkaline phosphatase in vivo. Am J Pathol (1997) 1.30
Knockout mice reveal a role for P2Y6 receptor in macrophages, endothelial cells, and vascular smooth muscle cells. Mol Pharmacol (2008) 1.27
Organic pyrophosphates as substrates for human alkaline phosphatases. Biochem J (1967) 1.25
Distribution of P2Y receptor subtypes on haematopoietic cells. Br J Pharmacol (1998) 1.25
Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats. Am J Physiol Gastrointest Liver Physiol (2007) 1.24
Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum. J Physiol (2009) 1.24
Synthesis and parallel secretion of rat intestinal alkaline phosphatase and a surfactant-like particle protein. Am J Physiol (1995) 1.21
The role of the fecal stream in Crohn's disease: an historical and analytic review. Inflamm Bowel Dis (1998) 1.19
The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP. Biochem Biophys Res Commun (2005) 1.19
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis (2011) 1.18
Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol (2010) 1.17
Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. J Immunol (2008) 1.17
Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis. Am J Physiol Gastrointest Liver Physiol (2007) 1.17
Exogenous alkaline phosphatase for the treatment of patients with moderate to severe ulcerative colitis. Inflamm Bowel Dis (2010) 1.11
Concomitant activation of P2Y(2) and P2Y(6) receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion. Eur J Immunol (2009) 1.11
A novel phosphatase upregulated in Akp3 knockout mice. Am J Physiol Gastrointest Liver Physiol (2007) 1.09
Ectonucleotidases in the digestive system: focus on NTPDase3 localization. Am J Physiol Gastrointest Liver Physiol (2011) 1.07
Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J Leukoc Biol (2007) 1.05
The potato-specific apyrase is apoplastically localized and has influence on gene expression, growth, and development. Plant Physiol (2008) 1.02
A new role for intestinal alkaline phosphatase in gut barrier maintenance. Gastroenterology (2008) 1.01
Expression of the P2Y6 purinergic receptor in human T cells infiltrating inflammatory bowel disease. Lab Invest (1998) 1.01
On the role and fate of LPS-dephosphorylating activity in the rat liver. Am J Physiol Gastrointest Liver Physiol (2005) 0.99
P2Y(6) agonist uridine 5'-diphosphate promotes host defense against bacterial infection via monocyte chemoattractant protein-1-mediated monocytes/macrophages recruitment. J Immunol (2011) 0.99
Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks. Purinergic Signal (2006) 0.96
Intestinal alkaline phosphatase contributes to the reduction of severe intestinal epithelial damage. Eur J Pharmacol (2010) 0.92
NTPDase1 controls IL-8 production by human neutrophils. J Immunol (2011) 0.89
Nucleoside-nucleotide free diet protects rat colonic mucosa from damage induced by trinitrobenzene sulphonic acid. Gut (1996) 0.82
Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A (2013) 16.74
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
A genomic storm in critically injured humans. J Exp Med (2011) 6.67
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A (2002) 4.22
Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev (2005) 3.38
Sigmoidectomy syndrome? Patients' perspectives on the functional outcomes following surgery for diverticulitis. Dis Colon Rectum (2012) 3.28
Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med (2012) 3.27
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol (2004) 3.15
Enzyme replacement therapy for murine hypophosphatasia. J Bone Miner Res (2008) 2.64
Acute inflammatory response to endotoxin in mice and humans. Clin Diagn Lab Immunol (2005) 2.47
Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages. J Leukoc Biol (2009) 2.45
Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol Med (2003) 2.30
Chilaiditi syndrome: a rare entity with important differential diagnoses. Gastroenterol Hepatol (N Y) (2012) 2.27
MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol (2007) 2.26
Identification of surgical complications and deaths: an assessment of the traditional surgical morbidity and mortality conference compared with the American College of Surgeons-National Surgical Quality Improvement Program. J Am Coll Surg (2006) 2.07
Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures. Ann Surg (2012) 2.07
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A (2010) 2.03
Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proc Natl Acad Sci U S A (2008) 1.97
Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med (2013) 1.94
Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol (2004) 1.93
Intestinal alkaline phosphatase prevents metabolic syndrome in mice. Proc Natl Acad Sci U S A (2013) 1.89
Germ cell survival through carbohydrate-mediated interaction with Sertoli cells. Science (2002) 1.87
Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res (2003) 1.83
Prevalence and outcomes of antimicrobial treatment for Staphylococcus aureus bacteremia in outpatients with ESRD. J Am Soc Nephrol (2012) 1.77
Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization. J Bone Miner Res (2007) 1.68
The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr (2002) 1.68
Tissue-engineered small intestine improves recovery after massive small bowel resection. Ann Surg (2004) 1.64
Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol Cell Biol (2003) 1.60
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification. J Bone Miner Res (2013) 1.60
Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. J Bone Miner Res (2010) 1.40
The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells. PLoS One (2011) 1.40
Primary hyperparathyroidism after Roux-en-Y gastric bypass. Obes Surg (2015) 1.39
Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice. J Bone Miner Res (2006) 1.39
Testis-specific cytochrome c-null mice produce functional sperm but undergo early testicular atrophy. Mol Cell Biol (2002) 1.38
Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase. J Bone Miner Res (2004) 1.36
Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A (2010) 1.33
Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor. Am J Physiol Gastrointest Liver Physiol (2003) 1.29
Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles. J Bone Miner Res (2010) 1.29
Regenerative capacity in newts is not altered by repeated regeneration and ageing. Nat Commun (2011) 1.27
Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist (2011) 1.27
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27
Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. J Biol Chem (2002) 1.23
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology (2012) 1.20
Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis (2011) 1.18
Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice. PLoS One (2012) 1.18
Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome. Am J Hum Genet (2010) 1.18
Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase. Am J Physiol Gastrointest Liver Physiol (2010) 1.17
A role for intestinal alkaline phosphatase in the maintenance of local gut immunity. Dig Dis Sci (2010) 1.17
Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis. Am J Physiol Gastrointest Liver Physiol (2007) 1.17
Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide. J Infect Dis (2005) 1.15
Central role of pyrophosphate in acellular cementum formation. PLoS One (2012) 1.14
Synergistic inflammation is induced by blood degradation products with microbial Toll-like receptor agonists and is blocked by hemopexin. J Infect Dis (2010) 1.14
Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem (2009) 1.13
Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer. Endocrinology (2011) 1.13
Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action. J Biomol Screen (2009) 1.12
PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures. Bone (2011) 1.12
Severe skeletal toxicity from protracted etidronate therapy for generalized arterial calcification of infancy. J Bone Miner Res (2013) 1.11
Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). Bioorg Med Chem Lett (2008) 1.11
A novel phosphatase upregulated in Akp3 knockout mice. Am J Physiol Gastrointest Liver Physiol (2007) 1.09
Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance. World J Gastroenterol (2008) 1.08
Enzyme replacement prevents enamel defects in hypophosphatasia mice. J Bone Miner Res (2012) 1.07