PubRank

Michael Detmar

Author PubWeight™ 180.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A promoter-level mammalian expression atlas. Nature 2014 6.25
2 An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. EMBO J 2002 5.07
3 Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol 2002 4.52
4 Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 2008 4.08
5 VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 2005 3.98
6 T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J 2003 3.82
7 Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol 2003 3.35
8 TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques 2009 3.35
9 Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005 3.21
10 Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev Dyn 2002 3.10
11 The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature. Genes Dev 2002 2.99
12 Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol 2004 2.81
13 Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 2003 2.81
14 VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 2006 2.66
15 Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet 2004 2.47
16 Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia. Blood 2004 2.37
17 VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J 2004 2.27
18 Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell 2010 2.26
19 Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol 2005 2.12
20 Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis. Blood 2003 2.03
21 Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed Microdevices 2004 1.97
22 Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science 2015 1.91
23 Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J 2005 1.89
24 Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. J Clin Invest 2011 1.88
25 VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood 2007 1.78
26 The lymphatic system in health and disease. Lymphat Res Biol 2008 1.78
27 Tumor progression: the effects of thrombospondin-1 and -2. Int J Biochem Cell Biol 2004 1.77
28 New insights into the molecular control of the lymphatic vascular system and its role in disease. J Invest Dermatol 2006 1.76
29 The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. Am J Pathol 2002 1.75
30 Tumor and lymph node lymphangiogenesis--impact on cancer metastasis. J Leukoc Biol 2006 1.72
31 Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation. J Exp Med 2010 1.69
32 Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin. Blood 2010 1.67
33 Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. J Biol Chem 2003 1.66
34 Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell 2005 1.62
35 An important role of lymphatic vessel activation in limiting acute inflammation. Blood 2011 1.62
36 Pathways targeting tumor lymphangiogenesis. Clin Cancer Res 2006 1.56
37 Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene 2003 1.48
38 Lymphangiogenesis and cancer metastasis. J Cell Mol Med 2009 1.47
39 Mechanisms of lymphatic metastasis. J Clin Invest 2014 1.46
40 Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer Res 2010 1.43
41 A critical role of placental growth factor in the induction of inflammation and edema formation. Blood 2002 1.38
42 Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol 2002 1.35
43 Tumor lymphangiogenesis and melanoma metastasis. J Cell Physiol 2008 1.32
44 Vascular endothelial growth factor-A mediates ultraviolet B-induced impairment of lymphatic vessel function. Am J Pathol 2006 1.31
45 Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest 2002 1.30
46 Prox1, master regulator of the lymphatic vasculature phenotype. Cell Tissue Res 2003 1.28
47 Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis. Blood 2008 1.28
48 Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice. Oncogene 2002 1.27
49 Lymphatic endothelium in health and disease. Cell Tissue Res 2008 1.25
50 Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials 2013 1.22
51 An important role of lymphatic vessels in the control of UVB-induced edema formation and inflammation. J Invest Dermatol 2006 1.20
52 Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci U S A 2009 1.19
53 SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann Rheum Dis 2011 1.19
54 Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis. J Cutan Pathol 2008 1.18
55 Lymphangiogenesis and cancer. Genes Cancer 2011 1.16
56 Vascular endothelial growth factor promotes sensitivity to ultraviolet B-induced cutaneous photodamage. Blood 2004 1.15
57 miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol 2010 1.15
58 An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation. Circ Res 2012 1.15
59 Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. Cancer Res 2012 1.14
60 Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice. Blood 2002 1.14
61 An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood 2010 1.14
62 Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol 2010 1.13
63 Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum 2011 1.13
64 Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J Invest Dermatol 2008 1.12
65 Infantile hemangiomas are arrested in an early developmental vascular differentiation state. Mod Pathol 2004 1.10
66 In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res 2010 1.10
67 Chapter 1. Inflammation, angiogenesis, and lymphangiogenesis. Methods Enzymol 2008 1.09
68 Soluble neuropilin targeted to the skin inhibits vascular permeability. Angiogenesis 2005 1.08
69 VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis. Cancer Res 2013 1.07
70 The cutaneous vascular system in chronic skin inflammation. J Investig Dermatol Symp Proc 2011 1.06
71 Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. Exp Cell Res 2010 1.05
72 Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflamm Bowel Dis 2013 1.05
73 Induction of lymphatic endothelial cell differentiation in embryoid bodies. Blood 2005 1.05
74 Targeted overexpression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photo-damage. J Invest Dermatol 2002 1.05
75 Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol 2008 1.05
76 Lymphatic vessels: new targets for the treatment of inflammatory diseases. Angiogenesis 2013 1.05
77 The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma. PLoS One 2012 1.04
78 An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis. Blood 2009 1.04
79 Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta. Am J Pathol 2004 1.02
80 Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression. J Invest Dermatol 2004 1.01
81 Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am J Pathol 2004 1.01
82 Dynamics of lymphatic regeneration and flow patterns after lymph node dissection. Breast Cancer Res Treat 2013 1.01
83 Prox-1 promotes invasion of kaposiform hemangioendotheliomas. J Invest Dermatol 2008 1.01
84 Development of the lymphatic vascular system: a mystery unravels. Dev Dyn 2004 1.01
85 Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions. Exp Cell Res 2009 1.00
86 Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. Proc Natl Acad Sci U S A 2012 0.99
87 Nitric oxide mediates lymphatic vessel activation via soluble guanylate cyclase alpha1beta1-impact on inflammation. FASEB J 2007 0.97
88 Systemic inhibition of tumor growth and angiogenesis by thrombospondin-2 using cell-based antiangiogenic gene therapy. Cancer Res 2002 0.95
89 An N-terminal 80 kDa recombinant fragment of human thrombospondin-2 inhibits vascular endothelial growth factor induced endothelial cell migration in vitro and tumor growth and angiogenesis in vivo. J Invest Dermatol 2003 0.95
90 An important role of blood and lymphatic vessels in inflammation and allergy. J Allergy (Cairo) 2013 0.94
91 An unexpected connection: lymph node lymphangiogenesis and dendritic cell migration. Immunity 2006 0.94
92 Reduction of lymphatic vessels in photodamaged human skin. J Dermatol Sci 2007 0.93
93 Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro. Exp Cell Res 2008 0.93
94 Identification of the surface-accessible, lineage-specific vascular proteome by two-dimensional peptide mapping. FASEB J 2008 0.92
95 Growth hormone promotes lymphangiogenesis. Am J Pathol 2008 0.92
96 Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol 2003 0.92
97 Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res 2012 0.90
98 Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease. Am J Pathol 2009 0.90
99 The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions. J Invest Dermatol 2009 0.90
100 Angiogenesis and lymphangiogenesis of skin cancers. Hematol Oncol Clin North Am 2004 0.89
101 Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo. Angiogenesis 2013 0.89
102 Thrombospondin-1 plays a critical role in the induction of hair follicle involution and vascular regression during the catagen phase. J Invest Dermatol 2003 0.89
103 The miR-290-295 cluster suppresses autophagic cell death of melanoma cells. Sci Rep 2012 0.88
104 The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem 2013 0.88
105 A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development. J Vasc Res 2010 0.88
106 Induced lymphatic sinus hyperplasia in sentinel lymph nodes by VEGF-C as the earliest premetastatic indicator. Int J Oncol 2012 0.87
107 Lymphangiogenesis in development and disease. Thromb Haemost 2007 0.87
108 New insights into the biology and pathology of the cutaneous lymphatic system. J Dermatol Sci 2004 0.87
109 Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer-based virtual screening. J Biol Chem 2012 0.86
110 Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. PLoS One 2010 0.84
111 Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin. J Dermatol Sci 2013 0.84
112 Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo. J Ethnopharmacol 2011 0.83
113 A human mAb specific to oncofetal fibronectin selectively targets chronic skin inflammation in vivo. J Invest Dermatol 2006 0.81
114 Watching lymphatic vessels grow by making them glow. Cell Res 2011 0.81
115 Expansion of the lymphatic vasculature in cancer and inflammation: new opportunities for in vivo imaging and drug delivery. J Control Release 2013 0.81
116 Inflammation-induced lymph node lymphangiogenesis is reversible. Am J Pathol 2011 0.81
117 Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor. Int J Oncol 2012 0.81
118 Lymphatic-specific expression of dipeptidyl peptidase IV and its dual role in lymphatic endothelial function. Exp Cell Res 2008 0.80
119 Differential effects of photoaging vs intrinsic aging on the vascularization of human skin. Arch Dermatol 2002 0.79
120 Steering target selectivity and potency by fragment-based de novo drug design. Angew Chem Int Ed Engl 2013 0.78
121 In vivo imaging of lymph node lymphangiogenesis by immuno-positron emission tomography. Methods Mol Biol 2013 0.77
122 Multifocal lymphangioendotheliomatosis with thrombocytopenia: a newly recognized clinicopathological entity. Arch Dermatol 2004 0.77
123 Mutation of threonine 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining antilymphangiogenic activity. J Biol Chem 2014 0.75
124 The role of neuropilin-1/semaphorin 3A signaling in lymphatic vessel development and maturation. Adv Anat Embryol Cell Biol 2014 0.75
125 High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice. Eur Surg Res 2017 0.75