mTOR, linking metabolism and immunity.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency. Nat Immunol (2013) 3.02

Human T cell aging and the impact of persistent viral infections. Front Immunol (2013) 1.39

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. J Exp Med (2014) 1.16

The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions. Front Immunol (2014) 0.99

Intersection of mTOR and STAT signaling in immunity. Trends Immunol (2014) 0.97

Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. PLoS One (2014) 0.96

Liver transplantation: immunosuppression and oncology. Curr Opin Organ Transplant (2014) 0.94

IL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells. Front Immunol (2015) 0.93

Metabolic control of dendritic cell activation and function: recent advances and clinical implications. Front Immunol (2014) 0.92

B cell-specific deficiencies in mTOR limit humoral immune responses. J Immunol (2013) 0.92

Essential role for autophagy during invariant NKT cell development. Proc Natl Acad Sci U S A (2014) 0.90

Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell (2015) 0.86

Ghrelin inhibits the differentiation of T helper 17 cells through mTOR/STAT3 signaling pathway. PLoS One (2015) 0.80

Differential Effects of Tacrolimus versus Sirolimus on the Proliferation, Activation and Differentiation of Human B Cells. PLoS One (2015) 0.79

Targeting CD8 T-Cell Metabolism in Transplantation. Front Immunol (2015) 0.77

Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine (2015) 0.77

DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture. J Immunol Res (2017) 0.75

Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses. Front Immunol (2017) 0.75

Natural killer group 2D and CD28 receptors differentially activate mammalian/mechanistic target of rapamycin to alter murine effector CD8(+) T-cell differentiation. Immunology (2016) 0.75

Optimization of immunosuppressive medication upon liver transplantation against HCC recurrence. Transl Gastroenterol Hepatol (2016) 0.75

Thymic emigration patterns in patients with type 2 diabetes treated with metformin. Immunology (2015) 0.75

Identification of Palmitoleic Acid Controlled by mTOR Signaling as a Biomarker of Polymyositis. J Immunol Res (2017) 0.75

The cell identity of cytotoxic T lymphocytes. Nat Immunol (2015) 0.75

Cord Blood Cells Responses to IL2, IL7 and IL15 Cytokines for mTOR Expression. Adv Pharm Bull (2017) 0.75

CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway. PLoS One (2017) 0.75

mTORC1 signaling is essential for germinal center reaction. Immunology (2017) 0.75

mTOR signaling in growth control and disease. Cell (2012) 29.21

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell (2006) 18.36

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol (2003) 15.51

Follicular helper CD4 T cells (TFH). Annu Rev Immunol (2011) 12.50

Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80

Autophagy in immunity and inflammation. Nature (2011) 11.16

Germinal centers. Annu Rev Immunol (1994) 10.85

mTOR regulates memory CD8 T-cell differentiation. Nature (2009) 10.07

Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol (2012) 9.75

mTOR signaling at a glance. J Cell Sci (2009) 8.66

Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09

Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61

The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity (2009) 6.86

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med (2009) 6.80

Memory CD8 T-cell differentiation during viral infection. J Virol (2004) 6.75

The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood (2005) 6.49

Germinal centers. Annu Rev Immunol (2012) 6.26

Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science (2010) 6.06

A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 6.00

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 5.99

Vaccines: correlates of vaccine-induced immunity. Clin Infect Dis (2008) 5.69

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 5.22

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol (2011) 4.78

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med (2008) 4.76

mTOR, translation initiation and cancer. Oncogene (2006) 4.68

Immunoregulatory functions of mTOR inhibition. Nat Rev Immunol (2009) 4.66

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity (2010) 4.21

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature (1992) 4.12

Immunosuppressive drugs for kidney transplantation. N Engl J Med (2004) 4.09

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity (2010) 4.06

Immunopharmacology of rapamycin. Annu Rev Immunol (1996) 3.86

Revving the engine: signal transduction fuels T cell activation. Immunity (2007) 3.57

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science (2009) 3.47

Activation of mTORC2 by association with the ribosome. Cell (2011) 3.38

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14

Regulation of immune responses by mTOR. Annu Rev Immunol (2011) 3.08

The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity (2010) 2.85

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J (2003) 2.84

Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol (2012) 2.79

mTOR signaling in disease. Curr Opin Cell Biol (2011) 2.73

Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J Exp Med (2006) 2.69

Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68

Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol (2009) 2.61

Genomic views of STAT function in CD4+ T helper cell differentiation. Nat Rev Immunol (2011) 2.09

Generation and maintenance of immunological memory. Semin Immunol (2004) 2.06

TOR complex 2: a signaling pathway of its own. Trends Biochem Sci (2009) 2.05

Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. Immunity (2012) 2.04

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proc Natl Acad Sci U S A (2011) 1.86

Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J Immunol (2006) 1.81

mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev (2012) 1.74

Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol (2010) 1.73

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol (2008) 1.70

Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol (2010) 1.60

Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology (1991) 1.48

Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cells. Eur J Immunol (2011) 1.45

TOR in the immune system. Curr Opin Cell Biol (2011) 1.44

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood (2010) 1.44

The role of mTOR in memory CD8 T-cell differentiation. Immunol Rev (2010) 1.41

Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. Mol Cell Biol (1988) 1.38

Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. J Immunol (2010) 1.38

Suppression of B cell activation by cyclosporin A, FK506 and rapamycin. Eur J Immunol (1990) 1.37

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines. Br J Cancer (2011) 1.33

Inhibition of human B lymphocyte cell cycle progression and differentiation by rapamycin. Cell Immunol (1994) 1.26

Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur J Immunol (2007) 1.23

Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. Am J Transplant (2011) 1.23

Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proc Natl Acad Sci U S A (2012) 1.20

Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells. Eur J Immunol (2011) 1.09

Mammalian target of rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells. J Immunol (2012) 1.08

Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes. J Immunol (2005) 1.08

Characterization of the metabolic phenotype of rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells. PLoS One (2011) 1.03

Involvement of a rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro. Immunol Lett (1999) 0.96

The influence of mTOR on T helper cell differentiation and dendritic cell function. Eur J Immunol (2011) 0.87

Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature (2006) 20.00

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat Immunol (2003) 15.51

Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol (2003) 15.51

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J Virol (2003) 11.48

Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity (2007) 10.83

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature (2008) 10.80

mTOR regulates memory CD8 T-cell differentiation. Nature (2009) 10.07

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27

Molecular and functional profiling of memory CD8 T cell differentiation. Cell (2002) 8.06

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol (2007) 7.60

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med (2011) 7.29

Memory CD8 T-cell differentiation during viral infection. J Virol (2004) 6.75

Redefining chronic viral infection. Cell (2009) 6.30

Systems biology of vaccination for seasonal influenza in humans. Nat Immunol (2011) 6.09

Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression. J Virol (2006) 6.00

Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature (2008) 5.94

Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol (2003) 5.90

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med (2008) 5.71

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells. J Exp Med (2002) 5.64

Cutting edge: long-term B cell memory in humans after smallpox vaccination. J Immunol (2003) 5.51

Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines. Immunity (2008) 5.22

Estimating the precursor frequency of naive antigen-specific CD8 T cells. J Exp Med (2002) 5.16

Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system. J Immunol Methods (2004) 4.57

Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc Natl Acad Sci U S A (2004) 4.56

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2010) 4.56

Cutting edge: rapid in vivo killing by memory CD8 T cells. J Immunol (2003) 4.25

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med (2006) 4.17

Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest (2003) 4.14

Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med (2010) 4.09

Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity (2010) 4.06

Translating innate immunity into immunological memory: implications for vaccine development. Cell (2006) 3.98

SAP is required for generating long-term humoral immunity. Nature (2003) 3.85

Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J Virol (2008) 3.83

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med (2003) 3.68

Immunological mechanisms of vaccination. Nat Immunol (2011) 3.35

Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population. J Immunol (2006) 3.35

From vaccines to memory and back. Immunity (2010) 3.30

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat Protoc (2009) 3.30

Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination. J Immunol (2006) 3.29

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc Natl Acad Sci U S A (2012) 3.27

A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27

Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity (2011) 3.19

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med (2008) 2.81

The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response. J Immunol (2009) 2.68

Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science (2007) 2.67

Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection. Science (2009) 2.64

Recombinant vaccinia virus-induced T-cell immunity: quantitation of the response to the virus vector and the foreign epitope. J Virol (2002) 2.64

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J Exp Med (2006) 2.55

Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells. Immunity (2011) 2.49

Memory CD8 T-cell compartment grows in size with immunological experience. Nature (2008) 2.49

The role of models in understanding CD8+ T-cell memory. Nat Rev Immunol (2005) 2.43

Features of responding T cells in cancer and chronic infection. Curr Opin Immunol (2010) 2.42

High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2009) 2.42

The role of programming in memory T-cell development. Curr Opin Immunol (2004) 2.41

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A (2007) 2.39

Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax. J Infect Dis (2004) 2.29

Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo. J Immunol (2002) 2.26

Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J Virol (2007) 2.21

Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity (2012) 2.16

Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes. J Infect Dis (2008) 2.14

Proteome-wide analysis of the serological response to vaccinia and smallpox. Proteomics (2007) 2.10

Generation and maintenance of immunological memory. Semin Immunol (2004) 2.06

Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination. J Virol (2005) 2.06

Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection. Immunity (2013) 2.05

Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation. J Immunol (2007) 2.04

Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells. J Immunol (2005) 1.95

Immunological memory in humans. Semin Immunol (2004) 1.90

Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J Immunol (2003) 1.83

NFATc1 regulates PD-1 expression upon T cell activation. J Immunol (2008) 1.81

Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought. J Virol (2006) 1.78

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J Virol (2009) 1.77

Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. J Virol (2012) 1.74

Accelerating next-generation vaccine development for global disease prevention. Science (2013) 1.73

Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology (2003) 1.69

Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. J Immunol (2011) 1.66

Defective generation but normal maintenance of memory T cells in old mice. Eur J Immunol (2002) 1.64

Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol (2008) 1.63

Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A (2011) 1.62

BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. Proc Natl Acad Sci U S A (2005) 1.61

Requirement of B cells for generating CD4+ T cell memory. J Immunol (2009) 1.60

Differentiation of memory B and T cells. Curr Opin Immunol (2006) 1.59

A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol (2003) 1.59

Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells. J Immunol (2006) 1.58

A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity (2011) 1.58

Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. J Immunol (2002) 1.55

HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. Virology (2006) 1.54

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest (2010) 1.53

Role of PD-1 in regulating T-cell immunity. Curr Top Microbiol Immunol (2011) 1.50

Immune history shapes specificity of pandemic H1N1 influenza antibody responses. J Exp Med (2013) 1.47

Dynamic regulation of T cell immunity by CD43. J Immunol (2002) 1.45

TOR in the immune system. Curr Opin Cell Biol (2011) 1.44

Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. J Immunol (2002) 1.44