Influence of tumors on protective anti-tumor immunity and the effects of irradiation.

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Published in Front Oncol on February 01, 2013

Authors

Gemma A Foulds1, Jürgen Radons, Mira Kreuzer, Gabriele Multhoff, Alan G Pockley

Author Affiliations

1: Department of Oncology, The Medical School, The University of Sheffield Sheffield, UK ; Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München Munich, Germany.

Associated clinical trials:

BMS-936558 (MDX-1106) In Subjects With Advanced/Metastatic Clear-Cell Renal Cell Carcinoma (RCC) | NCT01354431

Phase I Biomarker Study (BMS-936558) | NCT01358721

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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15

In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today (1990) 10.84

DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol (2006) 10.73

Paradoxical roles of the immune system during cancer development. Nat Rev Cancer (2006) 10.57

Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer (2005) 10.06

Functions of natural killer cells. Nat Immunol (2008) 9.88

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Natural versus adaptive regulatory T cells. Nat Rev Immunol (2003) 8.74

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med (1996) 8.54

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med (2006) 8.41

"Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol (1975) 7.61

Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol (1999) 7.60

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med (2001) 7.46

CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol (1998) 7.31

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Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58

Regulatory T cells in transplantation tolerance. Nat Rev Immunol (2003) 6.42

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med (2001) 6.22

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Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev (2006) 6.08

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res (1999) 5.41

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest (2005) 5.30

MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells. Nature (1992) 5.04

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. J Exp Med (1990) 4.90

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med (2006) 4.84

Induction of tolerance by IL-10-treated dendritic cells. J Immunol (1997) 4.65

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Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv Immunol (2000) 4.23

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Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature (2011) 4.07

Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci (2006) 4.04

Natural killer cell signaling pathways. Science (2004) 4.00

Tregs and rethinking cancer immunotherapy. J Clin Invest (2007) 3.77

Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 3.70

Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64

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Comparative studies of human FcRIII-positive and negative natural killer cells. J Immunol (1989) 3.28

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