Published in Nat Rev Immunol on March 01, 2003
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 14.33
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 8.65
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 7.73
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol (2005) 6.95
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol (2008) 6.56
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature (2007) 4.94
CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med (2007) 4.66
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood (2007) 4.50
Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J Exp Med (2004) 4.34
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest (2009) 3.80
Tregs and rethinking cancer immunotherapy. J Clin Invest (2007) 3.77
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med (2005) 3.70
Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med (2005) 3.63
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol (2004) 3.58
IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol (2010) 3.43
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med (2012) 3.40
Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog (2009) 3.35
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med (2006) 3.22
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest (2005) 3.04
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
CD4+ Tregs and immune control. J Clin Invest (2004) 2.85
T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol (2005) 2.58
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proc Natl Acad Sci U S A (2005) 2.57
Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood (2005) 2.55
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family. Immunol Rev (2011) 2.54
Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes". Blood (2008) 2.50
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A (2004) 2.50
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med (2007) 2.47
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol (2011) 2.39
The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology (2009) 2.31
Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest (2004) 2.20
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A (2007) 2.18
How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol (2010) 2.11
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol (2009) 2.07
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology (2009) 2.04
The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age. Clin Exp Immunol (2005) 2.01
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunol Rev (2009) 2.00
Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut (2005) 1.95
Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Clin Microbiol Rev (2004) 1.95
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A (2007) 1.90
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2009) 1.88
The initial phase of an immune response functions to activate regulatory T cells. J Immunol (2009) 1.88
CD28 costimulation is essential for human T regulatory expansion and function. J Immunol (2008) 1.86
A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis. Clin Exp Immunol (2006) 1.86
Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity (2014) 1.85
CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2. J Immunother (2005) 1.78
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol (2010) 1.77
CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game. J Immunol (2011) 1.76
Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection. Eur J Immunol (2007) 1.75
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc Natl Acad Sci U S A (2007) 1.75
Dysfunctional T regulatory cells in multiple myeloma. Blood (2005) 1.72
Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol (2004) 1.72
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A (2004) 1.69
Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin Immunol (2007) 1.69
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity (2014) 1.66
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol (2013) 1.65
LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med (2005) 1.65
The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology (2004) 1.65
Tregs and allergic disease. J Clin Invest (2004) 1.64
Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci U S A (2004) 1.62
Expansion of effector memory regulatory T cells represents a novel prognostic factor in lower risk myelodysplastic syndrome. J Immunol (2012) 1.61
T-cell responses to survivin in cancer patients undergoing radiation therapy. Clin Cancer Res (2008) 1.61
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions. Kidney Int (2013) 1.60
Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J Virol (2005) 1.60
T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol (2008) 1.52
Immune responses to malignancies. J Allergy Clin Immunol (2010) 1.48
Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells. Gastroenterology (2011) 1.47
CD4+CD25+ regulatory T cells restrain pathogenic responses during Leishmania amazonensis infection. J Immunol (2005) 1.46
Th17 and regulatory T cells: implications for AIDS pathogenesis. Curr Opin HIV AIDS (2010) 1.45
Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels. Clin Exp Immunol (2006) 1.43
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood. J Exp Med (2009) 1.41
CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation. J Exp Med (2007) 1.40
Control of homeostatic proliferation by regulatory T cells. J Clin Invest (2005) 1.40
FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect (2009) 1.40
The role of OX40-mediated co-stimulation in T-cell activation and survival. Crit Rev Immunol (2009) 1.39
Radiation enhances regulatory T cell representation. Int J Radiat Oncol Biol Phys (2010) 1.39
Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies? Nat Rev Endocrinol (2010) 1.39
Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS One (2011) 1.39
Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics (2011) 1.38
Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL. J Immunol (2007) 1.38
The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther (2005) 1.34
Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK. J Immunol (2008) 1.34
TGF-beta and 'adaptive' Foxp3(+) regulatory T cells. J Mol Cell Biol (2009) 1.34
The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am J Transplant (2008) 1.33
Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival. J Immunol (2009) 1.32
Regulatory T cells in systemic lupus erythematosus: past, present and future. Arthritis Res Ther (2008) 1.31
Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade. Clin Cancer Res (2009) 1.31
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation. Semin Cell Dev Biol (2008) 1.31
The levels of CD4+CD25+ regulatory T cells in paediatric patients with allergic rhinitis and bronchial asthma. Clin Exp Immunol (2007) 1.29
CD4 memory T cells: what are they and what can they do? Semin Immunol (2009) 1.29
Signatures of human regulatory T cells: an encounter with old friends and new players. Genome Biol (2006) 1.27
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells. J Exp Med (2009) 1.27
Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med (2003) 5.23
Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med (2002) 3.80
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med (2005) 3.70
The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol (2002) 3.47
Response to self antigen imprints regulatory memory in tissues. Nature (2011) 2.96
T-cell costimulation--biology, therapeutic potential, and challenges. N Engl J Med (2006) 2.81
Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med (2006) 2.46
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells. J Exp Med (2007) 1.99
Memory regulatory T cells reside in human skin. J Clin Invest (2014) 1.95
Regulatory T cells in the periphery. Immunol Rev (2006) 1.94
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Interleukin-2 in the development and control of inflammatory disease. Immunol Rev (2008) 1.83
Paths to understanding the genetic basis of autoimmune disease. Nature (2005) 1.79
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells. J Immunol (2010) 1.79
A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66
Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. J Immunol (2009) 1.66
CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J Immunol (2004) 1.66
The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat Immunol (2003) 1.57
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A (2012) 1.54
Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells. J Immunol (2009) 1.52
STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J Immunol (2010) 1.33
Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues. J Immunol (2013) 1.29
Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen. J Exp Med (2004) 1.23
Role of B7 in T cell tolerance. J Immunol (2004) 1.21
IL-2 induces a competitive survival advantage in T lymphocytes. J Immunol (2004) 1.20
CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen. J Immunol (2002) 1.19
Functional and molecular comparison of anergic and regulatory T lymphocytes. J Immunol (2006) 1.17
Treating human autoimmunity: current practice and future prospects. Sci Transl Med (2012) 1.16
Control of CD4+ T-cell memory by cytokines and costimulators. Immunol Rev (2006) 1.14
The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance. J Immunol (2005) 1.12
Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol (2004) 1.08
Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells. Immunity (2011) 1.07
CD28 signals in the immature immunological synapse. J Immunol (2004) 1.06
T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens. Immunol Rev (2005) 1.06
Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A (2010) 1.05
B7-independent inhibition of T cells by CTLA-4. J Immunol (2005) 1.05
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest (2006) 1.05
Distinct roles of helper T-cell subsets in a systemic autoimmune disease. Blood (2008) 1.04
Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance. J Immunol (2008) 0.94
Targeting T cell-specific costimulators and growth factors in a model of autoimmune hemolytic anemia. J Immunol (2007) 0.94
Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues. J Immunol (2014) 0.92
Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. J Immunol (2007) 0.91
Role of T cells in a murine model of Escherichia coli sepsis. Eur J Immunol (2007) 0.91
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Opposing functions of IL-2 and IL-7 in the regulation of immune responses. Cytokine (2011) 0.82
Life and death in effector T cells. Nat Immunol (2002) 0.82
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A network of regulatory pathways in lepromatous leprosy. Clin Immunol (2011) 0.75
Functional tolerance is maintained despite proliferation of CD4 T cells after encounter with tissue-derived antigen. Dev Immunol (2002) 0.75
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