A phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinoma.

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Published in Oral Oncol on February 04, 2013

Authors

Julie E Bauman1, Hugo Arias-Pulido, Sang-Joon Lee, M Houman Fekrazad, Hiroyuki Ozawa, Elana Fertig, Jason Howard, Justin Bishop, Hao Wang, Garth T Olson, Michael J Spafford, Dennie V Jones, Christine H Chung

Author Affiliations

1: Department of Internal Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA, USA. baumanje@upmc.edu

Associated clinical trials:

Study in Locally Advanced Squamous Cell Carcinoma of Head and Neck | NCT01133678

Combination of Cisplatin, Cetuximab and Temsirolimus in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck | NCT01015664

A Study of Carboplatin, Cetuximab and RAD001 in Advanced Head and Neck Cancer | NCT01283334

Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous Therapy (MAESTRO HN) | NCT01256385

RAD001 (Everolimus) + Docetaxel + Cisplatin as Induction Chemotherapy in Patients With Local-Regional Advanced Head and Neck Cancer | NCT00935961

Temsirolimus + Weekly Paclitaxel + Carboplatin for Recurrent or Metastatic Head and Neck Squamous Cell Cancer (HNSCC) | NCT01016769

Efficacy Study of Temsirolimus to Treat Head and Neck Cancer (TEMHEAD) | NCT01172769

A Study of RAD001 in Combination With Cetuximab and Cisplatin in Recurrent and Metastatic Squamous Cell Cancer of the Head and Neck | NCT01009346

Trial of RAD001 and Erlotinib With Recurrent Head and Neck Squamous Cell Carcinoma | NCT00942734

Temsirolimus (Torisel®) and Erlotinib (Tarceva®) in Platinum-Refractory/Ineligible, Advanced, Squamous Cell Carcinoma | NCT01009203

Radiation Therapy (IMRT) + RAD001 (Everolimus) + Cisplatin for Patients With Head and Neck Cancer | NCT00858663

Phase II Study of RAD001 Head and Neck Cancer | NCT01051791

Everolimus, Carboplatin, and Paclitaxel in Locally Advanced Head and Neck Cancer That Cannot Be Removed by Surgery (CAPRA) | NCT01333085

Everolimus Versus Placebo in Head and Neck Cancer | NCT01111058

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