Published in Int J Cancer on October 15, 2010
DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics (2011) 2.51
Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics (2011) 2.12
Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis. PLoS One (2012) 1.43
Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS One (2010) 1.40
Epigenetics and lifestyle. Epigenomics (2011) 1.34
Physical activity and global genomic DNA methylation in a cancer-free population. Epigenetics (2011) 1.32
Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study. Cancer Causes Control (2010) 1.30
Global methylation in exposure biology and translational medical science. Environ Health Perspect (2011) 1.28
Long interspersed nuclear element-1 hypomethylation in cancer: biology and clinical applications. Clin Epigenetics (2011) 1.26
DNA methylation in peripheral blood: a potential biomarker for cancer molecular epidemiology. J Epidemiol (2012) 1.19
Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population. J Nutr (2011) 1.17
LINE-1 methylation levels in leukocyte DNA and risk of renal cell cancer. PLoS One (2011) 1.11
Global DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry. Epigenetics (2012) 1.11
Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study. Br J Cancer (2011) 1.08
White blood cell global methylation and IL-6 promoter methylation in association with diet and lifestyle risk factors in a cancer-free population. Epigenetics (2012) 1.07
Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3. PLoS One (2013) 1.05
LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis. PLoS One (2014) 1.04
Adult global DNA methylation in relation to pre-natal nutrition. Int J Epidemiol (2011) 1.02
Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. Cancer Epidemiol Biomarkers Prev (2013) 1.01
Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study. Part Fibre Toxicol (2011) 1.00
Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma. Epigenomics (2012) 0.96
Correlation of LINE-1 methylation levels in patient-matched buffy coat, serum, buccal cell, and bladder tumor tissue DNA samples. Cancer Epidemiol Biomarkers Prev (2012) 0.94
Genomic methylation changes over time in peripheral blood mononuclear cell DNA: differences by assay type and baseline values. Cancer Epidemiol Biomarkers Prev (2012) 0.93
Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes. Int J Epidemiol (2013) 0.92
Differences in DNA methylation by extent of breast cancer family history in unaffected women. Epigenetics (2013) 0.92
The prognostic significance of whole blood global and specific DNA methylation levels in gastric adenocarcinoma. PLoS One (2010) 0.91
Age-related changes in the global DNA methylation profile of leukocytes are linked to nutrition but are not associated with the MTHFR C677T genotype or to functional capacities. PLoS One (2012) 0.89
Examination of whole blood DNA methylation as a potential risk marker for gastric cancer. Cancer Prev Res (Phila) (2013) 0.88
Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer. Surg Today (2013) 0.87
Effects of age, sex, and persistent organic pollutants on DNA methylation in children. Environ Mol Mutagen (2013) 0.86
Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease: a pilot study. PLoS One (2012) 0.85
Prospective study of DNA methylation at LINE-1 and Alu in peripheral blood and the risk of prostate cancer. Prostate (2015) 0.84
Methylome analysis and epigenetic changes associated with menarcheal age. PLoS One (2013) 0.84
Global methylation levels in peripheral blood leukocyte DNA by LUMA and breast cancer: a case-control study in Japanese women. Br J Cancer (2014) 0.81
Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leukocyte DNA. Oncotarget (2016) 0.81
LINE-1 hypermethylation in peripheral blood of cutaneous melanoma patients is associated with metastasis. Melanoma Res (2015) 0.80
Genomic DNA Hypomethylation and Risk of Renal Cell Carcinoma: A Case-Control Study. Clin Cancer Res (2015) 0.80
Decreased LINE-1 methylation levels in aldosterone-producing adenoma. Int J Clin Exp Pathol (2014) 0.79
Maternal phthalate exposure during pregnancy is associated with DNA methylation of LINE-1 and Alu repetitive elements in Mexican-American children. Environ Res (2016) 0.78
Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes Nutr (2015) 0.77
Global methylation of blood leukocyte DNA and risk of melanoma. Int J Cancer (2017) 0.77
Dietary factors modulate Helicobacter-associated gastric cancer in rodent models. Toxicol Pathol (2013) 0.75
Prospective changes in global DNA methylation and cancer incidence and mortality. Br J Cancer (2016) 0.75
Higher Alu methylation levels in catch-up growth in twenty-year-old offsprings. PLoS One (2015) 0.75
Global DNA hypomethylation in leukocytes associated with glioma risk. Oncotarget (2017) 0.75
Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors. J Cancer Epidemiol (2017) 0.75
The epigenomics of cancer. Cell (2007) 30.91
The history of cancer epigenetics. Nat Rev Cancer (2004) 14.38
Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res (1998) 8.95
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res (2004) 7.92
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res (2007) 4.89
SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res (2006) 4.63
Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2007) 4.01
Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect (2008) 3.85
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol (2008) 3.60
An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma. Cancer Res (1998) 3.22
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol (2002) 3.00
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One (2007) 2.99
Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem (2000) 2.60
Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis (2009) 2.58
Imprinting and the epigenetic asymmetry between parental genomes. Science (2001) 2.56
Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environ Health Perspect (2008) 2.29
Progress in understanding the biology of the human mutagen LINE-1. Hum Mutat (2007) 2.17
DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage. Int J Cancer (2007) 1.97
Causes and consequences of DNA hypomethylation in human cancer. Biochem Cell Biol (2005) 1.94
Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int J Cancer (2009) 1.94
LINE drive. retrotransposition and genome instability. Cell (2002) 1.92
Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. Am J Clin Nutr (2006) 1.89
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. Br J Cancer (2006) 1.84
Differential stress induction of individual Alu loci: implications for transcription and retrotransposition. Gene (2001) 1.62
Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr Top Microbiol Immunol (2006) 1.59
Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors). Mod Pathol (2007) 1.56
Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. J Nutr (2004) 1.52
Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy. Clin Cancer Res (2005) 1.46
CYP2D6 multiallelism. Methods Enzymol (1996) 1.45
Risk of stomach cancer in relation to consumption of cigarettes, alcohol, tea and coffee in Warsaw, Poland. Int J Cancer (1999) 1.42
DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker. Methods Mol Biol (2009) 1.42
p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients. J Cell Physiol (2006) 1.32
Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma. Cancer (2007) 1.30
Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection. J Pathol (2009) 1.23
Detection of p16 hypermethylation in circulating plasma DNA of non-small cell lung cancer patients. Cancer Lett (2002) 1.11
Diet and stomach cancer risk in Warsaw, Poland. Nutr Cancer (2004) 1.09
Promoter hypermethylation of GSTP1, AR, and 14-3-3sigma in serum of prostate cancer patients and its clinical relevance. Prostate (2007) 1.06
DNA-based detection of prostate cancer in blood, urine, and ejaculates. Ann N Y Acad Sci (2001) 1.05
Transcriptional regulation of the human LINE-1 retrotransposon L1.2B. Mol Genet Genomics (2003) 1.04
Genetic polymorphisms in folate metabolism and the risk of stomach cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.00
Glutathione S-transferase genotypes and stomach cancer in a population-based case-control study in Warsaw, Poland. Pharmacogenetics (2001) 0.99
DNA alterations in body fluids as molecular tumor markers for urological malignancies. Eur Urol (2002) 0.98
CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. Helicobacter (2008) 0.95
DNA methylation in circulating tumour DNA as a biomarker for cancer. Biomark Insights (2008) 0.95
Serum DNA as a tool for cancer patient management. Rocz Akad Med Bialymst (2003) 0.89
Upregulation and CpG island hypomethylation of the TRF2 gene in human gastric cancer. Dig Dis Sci (2009) 0.85
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
The B73 maize genome: complexity, diversity, and dynamics. Science (2009) 18.73
The accessible chromatin landscape of the human genome. Nature (2012) 16.86
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med (2015) 13.08
AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. N Engl J Med (2014) 12.29
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet (2007) 7.35
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Dietary and supplemental calcium intake and cardiovascular disease mortality: the National Institutes of Health-AARP diet and health study. JAMA Intern Med (2013) 7.30
An expansive human regulatory lexicon encoded in transcription factor footprints. Nature (2012) 7.27
Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet (2012) 6.49
The Shanghai Women's Health Study: rationale, study design, and baseline characteristics. Am J Epidemiol (2005) 6.44
Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst (2003) 6.28
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst (2008) 6.00
Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99
The genome of woodland strawberry (Fragaria vesca). Nat Genet (2010) 5.86
Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79
Social inequalities in male mortality, and in male mortality from smoking: indirect estimation from national death rates in England and Wales, Poland, and North America. Lancet (2006) 5.70
Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med (2009) 5.20
Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res (2007) 4.89
Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst (2007) 4.55
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst (2010) 4.54
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51
Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol (2003) 4.44
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38
Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. Am J Respir Crit Care Med (2010) 4.35
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. JAMA (2004) 4.31
Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev (2007) 4.23
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res (2008) 4.02
Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev (2008) 3.93
LTR_FINDER: an efficient tool for the prediction of full-length LTR retrotransposons. Nucleic Acids Res (2007) 3.89
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86
Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect (2008) 3.85
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Investigation of the fine structure of European populations with applications to disease association studies. Eur J Hum Genet (2008) 3.65
Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology (2003) 3.58
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. Nat Genet (2010) 3.53
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42
Accuracy of determining nodal negativity in colorectal cancer on the basis of the number of nodes retrieved on resection. Ann Surg Oncol (2003) 3.27
Reference genome sequence of the model plant Setaria. Nat Biotechnol (2012) 3.21
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Cessation of dual antiplatelet treatment and cardiac events after percutaneous coronary intervention (PARIS): 2 year results from a prospective observational study. Lancet (2013) 3.17
Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival. J Clin Oncol (2005) 3.12
Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst (2003) 3.07
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet (2010) 2.96
De novo genome sequencing and comparative genomics of date palm (Phoenix dactylifera). Nat Biotechnol (2011) 2.94
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. J Natl Cancer Inst (2009) 2.88
Epigenetics and environmental chemicals. Curr Opin Pediatr (2009) 2.83
A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell (2012) 2.81
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res (2013) 2.81
Environmental causes of esophageal cancer. Gastroenterol Clin North Am (2009) 2.80
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Hum Mol Genet (2011) 2.72
Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. Am J Epidemiol (2007) 2.64
Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control (2006) 2.64
Identification of new genetic risk variants for type 2 diabetes. PLoS Genet (2010) 2.62
Occupational exposure to crystalline silica and risk of lung cancer: a multicenter case-control study in Europe. Epidemiology (2007) 2.60
The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res (2012) 2.55
Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environ Health Perspect (2007) 2.54
Multiple ADH genes are associated with upper aerodigestive cancers. Nat Genet (2008) 2.53
Night-shift work and breast cancer risk in a cohort of Chinese women. Am J Epidemiol (2010) 2.48
Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study. Lancet Oncol (2013) 2.48
Can we trust national smoking prevalence figures? Discrepancies between biochemically assessed and self-reported smoking rates in three countries. Cancer Epidemiol Biomarkers Prev (2007) 2.39
Obesity and cancer risk among white and black United States veterans. Cancer Causes Control (2004) 2.36
Diaqua-bis(5-carb-oxy-2-propyl-1H-imidazole-4-carboxyl-ato-κN,O)manganese(II) N,N-dimethyl-formamide disolvate. Acta Crystallogr Sect E Struct Rep Online (2009) 2.35
Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn (2009) 2.35
Association of leukocyte telomere length with breast cancer risk: nested case-control findings from the Shanghai Women's Health Study. Am J Epidemiol (2013) 2.34
Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol (2010) 2.34
Tobacco smoking, NAT2 acetylation genotype and breast cancer risk. Int J Cancer (2006) 2.31
Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J Surg (2009) 2.31
Evaluation of continuous aspiration of subglottic secretion in an in vivo study. Crit Care Med (2004) 2.30
Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit. Environ Health Perspect (2008) 2.29
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clin Cancer Res (2006) 2.24
Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer. Genes Chromosomes Cancer (2014) 2.24
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome. Hum Mol Genet (2012) 2.24