Published in Nat Rev Cancer on February 07, 2013
Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer? PLoS One (2013) 1.18
Traversing the basement membrane in vivo: a diversity of strategies. J Cell Biol (2014) 1.11
Cancer across the tree of life: cooperation and cheating in multicellularity. Philos Trans R Soc Lond B Biol Sci (2015) 1.00
Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting. Dev Cell (2015) 0.97
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci (2015) 0.95
Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling. PLoS Genet (2015) 0.95
In vivo CaspaseTracker biosensor system for detecting anastasis and non-apoptotic caspase activity. Sci Rep (2015) 0.92
The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages. Elife (2014) 0.90
Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems. Nat Rev Cancer (2015) 0.89
Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila. Cell Death Dis (2013) 0.88
Moesin is a major regulator of centrosome behavior in epithelial cells with extra centrosomes. Curr Biol (2015) 0.87
Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer. Front Cell Infect Microbiol (2014) 0.87
Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis. Oncogenesis (2013) 0.87
Iro/IRX transcription factors negatively regulate Dpp/TGF-β pathway activity during intestinal tumorigenesis. EMBO Rep (2014) 0.85
Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics (2013) 0.85
Conserved mechanisms of tumorigenesis in the Drosophila adult midgut. PLoS One (2014) 0.83
Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy. Dis Model Mech (2015) 0.82
Drosophila at the intersection of infection, inflammation, and cancer. Front Cell Infect Microbiol (2013) 0.82
Asparagus cochinchinensis Extract Alleviates Metal Ion-Induced Gut Injury in Drosophila: An In Silico Analysis of Potential Active Constituents. Evid Based Complement Alternat Med (2016) 0.82
The Little Fly that Could: Wizardry and Artistry of Drosophila Genomics. Genes (Basel) (2014) 0.81
Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila. Elife (2016) 0.81
Pontin is a critical regulator for AML1-ETO-induced leukemia. Leukemia (2013) 0.80
Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing. J Cell Biol (2015) 0.80
Arl2- and Msps-dependent microtubule growth governs asymmetric division. J Cell Biol (2016) 0.79
Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva. BMC Genomics (2016) 0.79
Precision Oncology Framework for Investigation of Exercise As Treatment for Cancer. J Clin Oncol (2015) 0.79
Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila. Oncogene (2015) 0.79
The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth. EMBO Rep (2014) 0.78
Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Sci Rep (2016) 0.77
Genome engineering: Drosophila melanogaster and beyond. Wiley Interdiscip Rev Dev Biol (2015) 0.77
Drosophila as a Potential Model for Ocular Tumors. Ocul Oncol Pathol (2015) 0.77
The legacy of Drosophila imaginal discs. Chromosoma (2016) 0.76
Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. PLoS One (2015) 0.76
Tau physiology and pathomechanisms in frontotemporal lobar degeneration. J Neurochem (2016) 0.76
The transcription factor Ets21C drives tumor growth by cooperating with AP-1. Sci Rep (2016) 0.75
Drosophila Aurora A regulates mitotic timing in cancer stem cells: Possible therapeutic implications. Mol Cell Oncol (2016) 0.75
Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor. Cell Cycle (2015) 0.75
The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells. Oncotarget (2016) 0.75
Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis. Biol Open (2015) 0.75
The interplay between obesity and cancer: a fly view. Dis Model Mech (2016) 0.75
Danio rerio: Small Fish Making a Big Splash in Leukemia. Curr Pathobiol Rep (2014) 0.75
A rapid one-generation genetic screen in a Drosophila model to capture rhabdomyosarcoma effectors and therapeutic targets. G3 (Bethesda) (2014) 0.75
Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data. Cancer Res (2016) 0.75
In Vivo and In Vitro Genotoxic and Epigenetic Effects of Two Types of Cola Beverages and Caffeine: A Multiassay Approach. Biomed Res Int (2016) 0.75
Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance. Med Res Rev (2016) 0.75
Can intestinal microbiota be associated with non-intestinal cancers? Sci Rep (2017) 0.75
Transcriptome Analysis of Male Drosophila melanogaster Exposed to Ethylparaben Using Digital Gene Expression Profiling. J Insect Sci (2017) 0.75
Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species. Oncogene (2017) 0.75
Diverse mitotic functions of the cytoskeletal crosslinking protein Shortstop suggest a role in Dynein/Dynactin activity. Mol Biol Cell (2017) 0.75
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Comparative genomics of the eukaryotes. Science (2000) 26.62
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell (1991) 10.06
Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer (2005) 9.46
A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45
Genomic instability--an evolving hallmark of cancer. Nat Rev Mol Cell Biol (2010) 7.11
Lessons from 60 years of pharmaceutical innovation. Nat Rev Drug Discov (2009) 7.01
Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science (2003) 6.72
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell (2009) 6.64
The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature (2005) 6.20
Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature (2005) 5.86
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer (2007) 5.78
Minutes: mutants of drosophila autonomously affecting cell division rate. Dev Biol (1975) 5.76
Mechanisms of asymmetric stem cell division. Cell (2008) 5.59
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell (2009) 5.57
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell (1995) 5.56
DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19
Mitochondria and cancer. Nat Rev Cancer (2012) 4.81
polo, a mitotic mutant of Drosophila displaying abnormal spindle poles. J Cell Sci (1988) 4.77
Centrosome amplification can initiate tumorigenesis in flies. Cell (2008) 4.62
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science (1997) 4.29
Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer (2011) 4.12
Polo-like kinases: conservation and divergence in their functions and regulation. Nat Rev Mol Cell Biol (2009) 4.09
A genetic screen in Drosophila for metastatic behavior. Science (2003) 4.09
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet (2005) 3.99
Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev (2004) 3.86
Imaging hematopoietic precursor division in real time. Cell Stem Cell (2007) 3.62
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J (2003) 3.60
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature (2003) 3.47
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell (2002) 3.41
Suppression of malignancy by cell fusion. Nature (1969) 3.41
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS One (2009) 3.36
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature (2008) 3.24
Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science (2010) 3.21
Malignant neoplasms of genetic origin in Drosophila melanogaster. Science (1978) 3.20
DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell (2005) 3.12
Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A (2009) 3.10
Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer (2011) 3.06
Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol (2010) 2.97
A long view of fashions in cancer research. Bioessays (2005) 2.95
The Drosophila lymph gland as a developmental model of hematopoiesis. Development (2005) 2.91
The Aurora kinase family in cell division and cancer. Biochim Biophys Acta (2008) 2.84
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature (2010) 2.79
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila. Cell (2011) 2.64
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest (2011) 2.60
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell (2010) 2.46
The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development (2006) 2.43
Retracted LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol (2007) 2.40
EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell (2010) 2.34
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature (2012) 2.33
Cancer chromosomal instability: therapeutic and diagnostic challenges. EMBO Rep (2012) 2.28
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev (2011) 2.25
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev (2006) 2.20
The hematopoietic stem cell and its niche: a comparative view. Genes Dev (2007) 2.15
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell (2011) 2.07
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev (2006) 2.06
Competitive interactions between cells: death, growth, and geography. Science (2009) 2.03
Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer (2005) 2.03
Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell (2011) 2.02
Hippo signaling in Drosophila: recent advances and insights. Dev Dyn (2011) 2.01
Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature (2012) 1.95
Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes Dev (2007) 1.95
The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development (2010) 1.93
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A (2011) 1.92
The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus. Mol Gen Genet (1993) 1.90
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development (2010) 1.89
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A (2009) 1.88
Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation. Development (2009) 1.85
Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature (2006) 1.85
Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature (2007) 1.83
The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc. Development (2009) 1.82
A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet (2009) 1.82
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82
Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep (2012) 1.81
Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat Rev Genet (2007) 1.78
Is cell competition relevant to cancer? Nat Rev Cancer (2008) 1.71
Roles of the Polycomb group proteins in stem cells and cancer. Cell Death Dis (2011) 1.70
The adult Drosophila malpighian tubules are maintained by multipotent stem cells. Cell Stem Cell (2007) 1.70
Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell (2011) 1.67
A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway. Proc Natl Acad Sci U S A (2010) 1.64
Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol (2008) 1.64
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature (2009) 1.63
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet (2009) 1.62
Insights into neural stem cell biology from flies. Philos Trans R Soc Lond B Biol Sci (2008) 1.61
ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res (2005) 1.60
Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. Oncogene (2011) 1.56
Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep (2012) 1.51
Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Genetics (1999) 1.48
The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell (2012) 1.47
The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell (2011) 1.46
Drosophila in cancer research: the first fifty tumor suppressor genes. J Cell Sci Suppl (1994) 1.44
Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli. Science (2008) 1.44
A drosophila model for EGFR-Ras and PI3K-dependent human glioma. PLoS Genet (2009) 1.43
Pax genes in embryogenesis and oncogenesis. J Cell Mol Med (2008) 1.37
From Plk1 to Plk5: functional evolution of polo-like kinases. Cell Cycle (2011) 1.36
Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition. Dev Cell (2010) 1.36
PI3K and mTOR inhibitors: a new generation of targeted anticancer agents. Curr Opin Cell Biol (2009) 1.34
Targeting cell cycle kinases for cancer therapy. Curr Med Chem (2007) 1.33
Intestinal stem cell function in Drosophila and mice. Curr Opin Genet Dev (2012) 1.30
A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the gene. Mech Dev (1993) 1.30