Published in Curr Biol on April 01, 2010
The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54
Hippo signaling: growth control and beyond. Development (2011) 5.25
The Hippo pathway and human cancer. Nat Rev Cancer (2013) 5.17
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol (2011) 4.63
The Hippo pathway: regulators and regulations. Genes Dev (2013) 4.55
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell (2010) 4.47
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev (2011) 3.15
Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol (2012) 3.07
Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer (2011) 3.06
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov (2013) 3.03
Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci U S A (2011) 2.61
Population-based resequencing of experimentally evolved populations reveals the genetic basis of body size variation in Drosophila melanogaster. PLoS Genet (2011) 2.41
Hippo signaling in Drosophila: recent advances and insights. Dev Dyn (2011) 2.01
The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development (2010) 1.93
Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol (2010) 1.92
Ajuba family proteins link JNK to Hippo signaling. Sci Signal (2013) 1.90
Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol (2013) 1.86
The Hippo signaling pathway and stem cell biology. Trends Cell Biol (2012) 1.84
The Hippo signaling pathway in stem cell biology and cancer. EMBO Rep (2014) 1.73
Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1. Proc Natl Acad Sci U S A (2013) 1.59
KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases. J Biol Chem (2011) 1.50
Organ size control by Hippo and TOR pathways. Curr Biol (2012) 1.45
Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie. PLoS Biol (2015) 1.45
A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol (2013) 1.41
Mechanisms of cell competition: themes and variations. J Cell Biol (2013) 1.35
An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene (2013) 1.35
Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics. Nat Rev Cancer (2013) 1.30
The Hippo-YAP signaling pathway and contact inhibition of growth. J Cell Sci (2014) 1.29
The role of apoptosis-induced proliferation for regeneration and cancer. Cold Spring Harb Perspect Biol (2012) 1.28
Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev Cell (2012) 1.26
Tumor suppression by cell competition through regulation of the Hippo pathway. Proc Natl Acad Sci U S A (2011) 1.26
Integrating body and organ size in Drosophila: recent advances and outstanding problems. Front Endocrinol (Lausanne) (2012) 1.23
Protein complexes that control renal epithelial polarity. Am J Physiol Renal Physiol (2011) 1.22
New frontiers in cell competition. Dev Dyn (2012) 1.21
Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. Development (2011) 1.19
Cell competition: how to eliminate your neighbours. Development (2014) 1.17
The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol (2010) 1.17
The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell (2012) 1.16
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol (2011) 1.15
Integration of intercellular signaling through the Hippo pathway. Semin Cell Dev Biol (2012) 1.14
Hippo signaling at a glance. J Cell Sci (2010) 1.14
Defining the protein-protein interaction network of the human hippo pathway. Mol Cell Proteomics (2013) 1.14
Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J (2015) 1.11
Drosophila cancer models. Dev Dyn (2011) 1.10
The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells. J Cell Biol (2013) 1.10
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. Mol Syst Biol (2013) 1.10
Sticking together the Crumbs - an unexpected function for an old friend. Nat Rev Mol Cell Biol (2013) 1.07
Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics (2011) 1.06
Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol (2013) 1.01
Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech (2011) 1.00
The role of the Hippo pathway in human disease and tumorigenesis. Clin Transl Med (2014) 0.99
Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2. Dev Cell (2015) 0.96
The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth. Mol Cell Biol (2013) 0.96
Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate. Dev Cell (2011) 0.95
Organ Size Control: Lessons from Drosophila. Dev Cell (2015) 0.95
Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol (2012) 0.94
A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie. Dev Cell (2011) 0.94
Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. Development (2012) 0.94
Cell competition and its implications for development and cancer. J Genet Genomics (2011) 0.94
Signaling pathways in cell polarity. Cold Spring Harb Perspect Biol (2012) 0.92
Control of organ growth by patterning and hippo signaling in Drosophila. Cold Spring Harb Perspect Biol (2015) 0.92
Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS Biol (2013) 0.92
Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway. Fly (Austin) (2010) 0.92
Dissecting social cell biology and tumors using Drosophila genetics. Annu Rev Genet (2013) 0.92
Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous. Nat Cell Biol (2013) 0.91
Differential regulation of the Hippo pathway by adherens junctions and apical-basal cell polarity modules. Proc Natl Acad Sci U S A (2015) 0.89
The transcriptional response to tumorigenic polarity loss in Drosophila. Elife (2015) 0.89
Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. PLoS One (2012) 0.89
The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells. Nat Commun (2016) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network. Trends Cell Biol (2016) 0.88
Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors. J Biomed Biotechnol (2011) 0.87
Regulation and function of the TAZ transcription co-activator. Int J Biochem Mol Biol (2011) 0.87
The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein Cell (2012) 0.86
YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation. PLoS One (2012) 0.85
Dual function of Yap in the regulation of lens progenitor cells and cellular polarity. Dev Biol (2013) 0.85
Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling. Development (2011) 0.84
MST kinases in development and disease. J Cell Biol (2015) 0.84
Establishment of epithelial polarity--GEF who's minding the GAP? J Cell Sci (2014) 0.84
Hippo and rassf1a Pathways: A Growing Affair. Mol Biol Int (2012) 0.83
Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. Cell Cycle (2011) 0.83
SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila. Cell Res (2014) 0.82
Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus. Nat Commun (2016) 0.81
The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary. PLoS Genet (2015) 0.81
Localization of Hippo signalling complexes and Warts activation in vivo. Nat Commun (2015) 0.81
Arhgef7 promotes activation of the Hippo pathway core kinase Lats. EMBO J (2014) 0.81
Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase. Proc Natl Acad Sci U S A (2014) 0.81
Hippo signalling controls Dronc activity to regulate organ size in Drosophila. Cell Death Differ (2012) 0.81
Epithelial neoplasia in Drosophila entails switch to primitive cell states. Proc Natl Acad Sci U S A (2013) 0.80
Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster. Dev Biol (2013) 0.80
Histone acetylation-mediated regulation of the Hippo pathway. PLoS One (2013) 0.80
Snapshots of a hybrid transcription factor in the Hippo pathway. Protein Cell (2010) 0.80
PML Surfs into HIPPO Tumor Suppressor Pathway. Front Oncol (2013) 0.80
Redemystifying MST1/hippo signaling. Protein Cell (2010) 0.79
Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Mol Biol Cell (2015) 0.79
The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers (2014) 0.79
aPKC phosphorylates p27Xic1, providing a mechanistic link between apicobasal polarity and cell-cycle control. Dev Cell (2014) 0.79
Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines. PLoS One (2012) 0.78
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell (2002) 7.15
Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol (2006) 3.72
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J (2003) 3.60
Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling. J Infect Dis (2004) 2.95
Concentration-dependent Mycobacterium tuberculosis killing and prevention of resistance by rifampin. Antimicrob Agents Chemother (2007) 2.58
Upstream regulation of the hippo size control pathway. Curr Biol (2010) 2.09
Genetic analysis of the beta-lactamases of Mycobacterium tuberculosis and Mycobacterium smegmatis and susceptibility to beta-lactam antibiotics. Microbiology (2005) 2.04
Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer (2005) 2.03
A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet (2009) 1.82
Unconventional conjugal DNA transfer in mycobacteria. Nat Genet (2003) 1.75
Modularity in the Hippo signaling pathway. Trends Biochem Sci (2010) 1.52
The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev Biol (2010) 1.50
The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell (2011) 1.46
APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Development (2008) 1.35
Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye. Dev Biol (2007) 1.33
Use of molecular methods to identify the Mycobacterium tuberculosis complex (MTBC) and other mycobacterial species and to detect rifampin resistance in MTBC isolates following growth detection with the BACTEC MGIT 960 system. J Clin Microbiol (2003) 1.26
Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines. Cancer Res (2009) 1.25
The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol (2006) 1.22
Characterization of novel Mycobacterium tuberculosis and Mycobacterium smegmatis mutants hypersusceptible to beta-lactam antibiotics. J Bacteriol (2005) 1.19
The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol (2010) 1.17
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol (2011) 1.15
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene (2003) 1.15
A quality management systems approach for CD4 testing in resource-poor settings. Am J Clin Pathol (2010) 1.12
Mycobacterium africanum genotyping using novel spacer oligonucleotides in the direct repeat locus. J Clin Microbiol (2004) 1.10
Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs. BMC Biol (2009) 1.09
The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man. Essays Biochem (2012) 1.09
Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics (2011) 1.06
Laboratory diagnosis of nontuberculous mycobacteria. Clin Chest Med (2002) 1.05
Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. Development (2010) 1.04
An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery. Dis Model Mech (2012) 1.01
Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth. Curr Biol (2012) 1.00
The Hippo pathway--from top to bottom and everything in between. Semin Cell Dev Biol (2012) 0.97
Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner. Development (2010) 0.95
Mutation of the gene encoding the ubiquitin activating enzyme ubal causes tissue overgrowth in Drosophila. Fly (Austin) (2009) 0.95
Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition! Cell Cycle (2010) 0.92
Control of tissue growth and cell transformation by the Salvador/Warts/Hippo pathway. PLoS One (2012) 0.92
Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway. Fly (Austin) (2010) 0.92
Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous. Nat Cell Biol (2013) 0.91
The Hippo size control pathway--ever expanding. Sci Signal (2013) 0.91
The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages. Elife (2014) 0.90
Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis. J Invest Dermatol (2012) 0.88
Does the MGIT 960 system improve the turnaround times for growth detection and susceptibility testing of the Mycobacterium tuberculosis complex? J Clin Microbiol (2006) 0.88
In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling. Dis Model Mech (2013) 0.85
When cell cycle meets development. Development (2011) 0.83
The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state. PLoS Genet (2013) 0.83
Viral load in 1-day-old and 6-week-old chickens infected with chicken anaemia virus by the intraocular route. Avian Pathol (2006) 0.82
New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models. Curr Opin Cell Biol (2004) 0.81
Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila. Dev Biol (2010) 0.81
Line probe and automated real-time PCR TB assays warrant adherence to strict quality assurance measures. Int J Tuberc Lung Dis (2012) 0.80
Death takes a holiday--non-apoptotic role for caspases in cell migration and invasion. EMBO Rep (2013) 0.79
Pulmonary tuberculosis due to Mycobacterium bovis subsp. caprae in captive Siberian tiger. Emerg Infect Dis (2003) 0.79
Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells. Mech Dev (2008) 0.77
Making brundlefly, one gene at a time. Cell Res (2009) 0.75
Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor. Cell Cycle (2015) 0.75