Published in Science on September 12, 2003
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell (2008) 9.92
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A (2003) 4.69
Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science (2007) 4.59
The stem cell niches in bone. J Clin Invest (2006) 4.11
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Centrosome misorientation reduces stem cell division during ageing. Nature (2008) 3.66
Imaging hematopoietic precursor division in real time. Cell Stem Cell (2007) 3.62
GSK3 signalling in neural development. Nat Rev Neurosci (2010) 3.29
The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries. Nat Cell Biol (2011) 3.17
The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells. Cell (2008) 2.94
Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings. Am J Hum Genet (2005) 2.86
A localized Wnt signal orients asymmetric stem cell division in vitro. Science (2013) 2.82
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev (2009) 2.76
Catenins: keeping cells from getting their signals crossed. Dev Cell (2006) 2.70
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal. Cell Stem Cell (2008) 2.62
Integrin-dependent anchoring of a stem-cell niche. Nat Cell Biol (2007) 2.59
The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. Nat Cell Biol (2005) 2.52
Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol (2009) 2.42
A role for a novel centrosome cycle in asymmetric cell division. J Cell Biol (2007) 2.40
Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testes. Nat Cell Biol (2010) 2.29
Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature (2008) 2.27
Cellular analyses of the mitotic region in the Caenorhabditis elegans adult germ line. Mol Biol Cell (2006) 2.23
APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol Biol Cell (2005) 2.14
Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. J Cell Biol (2005) 2.08
Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Dev (2006) 2.05
beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96
GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics (2004) 1.92
A transient niche regulates the specification of Drosophila intestinal stem cells. Science (2010) 1.89
A molecular mechanism directly linking E-cadherin adhesion to initiation of epithelial cell surface polarity. J Cell Biol (2007) 1.87
The germline stem cell niche unit in mammalian testes. Physiol Rev (2012) 1.86
The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut (2006) 1.86
Drosophila male germline stem cells do not asymmetrically segregate chromosome strands. J Cell Sci (2011) 1.83
Nanotubes mediate niche-stem-cell signalling in the Drosophila testis. Nature (2015) 1.82
A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage. Genetics (2004) 1.74
Polarity and differential inheritance--universal attributes of life? Cell (2008) 1.72
From stem cell to embryo without centrioles. Curr Biol (2007) 1.71
Control of cell adhesion dynamics by Rap1 signaling. Curr Opin Cell Biol (2009) 1.68
The stem cell niche: lessons from the Drosophila testis. Development (2011) 1.67
Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Cell Res (2010) 1.64
Robust control of mitotic spindle orientation in the developing epidermis. J Cell Biol (2010) 1.63
Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis. Cell Stem Cell (2009) 1.61
Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. J Cell Biol (2010) 1.58
Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin. J Cell Biol (2007) 1.58
Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J Cell Biol (2009) 1.57
Stem cell in gastrointestinal structure and neoplastic development. Gut (2004) 1.57
APC is a component of an organizing template for cortical microtubule networks. Nat Cell Biol (2005) 1.54
Germline stem cells. Cold Spring Harb Perspect Biol (2011) 1.53
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC. Nat Rev Cancer (2006) 1.53
Stem cell dynamics in response to nutrient availability. Curr Biol (2010) 1.52
WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation. Cell (2016) 1.52
Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ (2011) 1.51
Asymmetric centrosome behavior and the mechanisms of stem cell division. J Cell Biol (2008) 1.48
GSK-3 inhibitors induce chromosome instability. BMC Cell Biol (2007) 1.48
Arabidopsis TANGLED identifies the division plane throughout mitosis and cytokinesis. Curr Biol (2007) 1.47
The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell (2012) 1.47
Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Mol Biol Cell (2009) 1.46
Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary. Development (2011) 1.46
Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. J Immunol (2010) 1.46
Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Dev Biol (2008) 1.43
E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. PLoS One (2010) 1.43
A critical role for Apc in hematopoietic stem and progenitor cell survival. J Exp Med (2008) 1.42
Chromosome-specific nonrandom sister chromatid segregation during stem-cell division. Nature (2013) 1.37
Planar spindle orientation and asymmetric cytokinesis in the mouse small intestine. J Histochem Cytochem (2007) 1.37
Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output. Development (2011) 1.36
(A)symmetric stem cell replication and cancer. PLoS Comput Biol (2007) 1.36
Molecular pathways regulating mitotic spindle orientation in animal cells. Development (2013) 1.33
Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol (2008) 1.32
Adhesion molecules in the stem cell niche--more than just staying in shape? J Cell Sci (2010) 1.31
A matter of life and death: self-renewal in stem cells. EMBO Rep (2012) 1.30
Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics. Nat Rev Cancer (2013) 1.30
Adhesion in the stem cell niche: biological roles and regulation. Development (2013) 1.30
Hypoxia-inducible factors in stem cells and cancer. J Cell Mol Med (2009) 1.27
Prostate cancer stem cells. J Pathol (2009) 1.26
HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks. Cell Cycle (2006) 1.25
Dual role of Cdc42 in spindle orientation control of adherent cells. Mol Cell Biol (2009) 1.24
Mitotic spindle (DIS)orientation and DISease: cause or consequence? J Cell Biol (2012) 1.21
Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex. Genes Dev (2004) 1.20
The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly. J Cell Biol (2004) 1.17
Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis. Cold Spring Harb Perspect Biol (2010) 1.17
The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity. Proc Natl Acad Sci U S A (2006) 1.16
Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics. Mol Biol Cell (2009) 1.16
CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. Proc Natl Acad Sci U S A (2014) 1.15
Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning. Development (2011) 1.15
Stem cell competition: finding balance in the niche. Trends Cell Biol (2013) 1.14
Biased segregation of DNA and centrosomes: moving together or drifting apart? Nat Rev Mol Cell Biol (2009) 1.11
Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells. Dev Biol (2011) 1.10
EFHC1 interacts with microtubules to regulate cell division and cortical development. Nat Neurosci (2009) 1.09
Interdependence of cell attachment and cell cycle signaling. Curr Opin Cell Biol (2006) 1.08
Asymmetric division of Drosophila male germline stem cell shows asymmetric histone distribution. Science (2012) 1.06
Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. J Cell Physiol (2010) 1.06
The development of germline stem cells in Drosophila. Methods Mol Biol (2008) 1.06
Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells (2010) 1.06
magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. Dev Biol (2011) 1.05
Akt regulates centrosome migration and spindle orientation in the early Drosophila melanogaster embryo. J Cell Biol (2008) 1.05
Oriented divisions, fate decisions. Curr Opin Cell Biol (2013) 1.05
Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis. Dev Biol (2009) 1.03
lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis. Development (2011) 1.02
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42
Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science (2007) 4.59
Centrosome misorientation reduces stem cell division during ageing. Nature (2008) 3.66
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab (2011) 3.23
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci (2003) 2.68
Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis. Cell Stem Cell (2007) 2.53
Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Development (2004) 2.35
Drosophila germ-line modulation of insulin signaling and lifespan. Proc Natl Acad Sci U S A (2008) 2.31
Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis. Nature (2008) 2.27
Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Science (2005) 2.13
Stem cells and the niche: a dynamic duo. Cell Stem Cell (2010) 2.06
Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Genes Dev (2006) 2.05
Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells. J Cell Biol (2008) 2.02
A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Curr Biol (2008) 1.75
A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineage. Genetics (2004) 1.74
Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells. Development (2002) 1.70
Signaling in stem cell niches: lessons from the Drosophila germline. J Cell Sci (2005) 1.69
A germline-specific gap junction protein required for survival of differentiating early germ cells. Development (2002) 1.66
The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche. Nature (2012) 1.54
Germline stem cells. Cold Spring Harb Perspect Biol (2011) 1.53
Stem cell dynamics in response to nutrient availability. Curr Biol (2010) 1.52
Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell (2004) 1.49
Asymmetric centrosome behavior and the mechanisms of stem cell division. J Cell Biol (2008) 1.48
The Drosophila Cog5 homologue is required for cytokinesis, cell elongation, and assembly of specialized Golgi architecture during spermatogenesis. Mol Biol Cell (2003) 1.46
Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Dev Biol (2005) 1.45
E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells. PLoS One (2010) 1.43
Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn. Mech Dev (2002) 1.36
The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity. J Cell Sci (2007) 1.36
Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment. Curr Biol (2007) 1.33
Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage. Proc Natl Acad Sci U S A (2009) 1.31
Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes Dev (2007) 1.23
Germ line stem cell differentiation in Drosophila requires gap junctions and proceeds via an intermediate state. Development (2003) 1.16
The class I PITP giotto is required for Drosophila cytokinesis. Curr Biol (2006) 1.14
Regulation of transcription of meiotic cell cycle and terminal differentiation genes by the testis-specific Zn-finger protein matotopetli. Development (2004) 1.14
Metabolic regulation of stem cell behavior and implications for aging. Cell Metab (2010) 1.10
Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog. Development (2007) 1.08
TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. J Cell Sci (2009) 1.06
Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development (2011) 1.05
Dietary restriction enhances germline stem cell maintenance. Aging Cell (2010) 1.05
A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage. Cell Stem Cell (2012) 1.02
Somatic cell lineage is required for differentiation and not maintenance of germline stem cells in Drosophila testes. Proc Natl Acad Sci U S A (2012) 1.00
Dual fluorescence detection of protein and RNA in Drosophila tissues. Nat Protoc (2012) 0.98
The effects of aging on stem cell behavior in Drosophila. Exp Gerontol (2010) 0.97
Asymmetric stem cell division and function of the niche in the Drosophila male germ line. Int J Hematol (2005) 0.96
Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila. Mol Biol Cell (2010) 0.96
Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing. Dev Biol (2002) 0.95
The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. J Cell Sci (2010) 0.93
A novel human polycomb binding site acts as a functional polycomb response element in Drosophila. PLoS One (2012) 0.93
The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells. Development (2014) 0.92
The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche. Development (2012) 0.90
Regulation of adult stem cell behavior by nutrient signaling. Cell Cycle (2011) 0.89
Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis. J Cell Sci (2012) 0.89
Three levels of regulation lead to protamine and Mst77F expression in Drosophila. Dev Biol (2013) 0.88
Role of Survivin in cytokinesis revealed by a separation-of-function allele. Mol Biol Cell (2011) 0.88
Local signaling within stem cell niches: insights from Drosophila. Curr Opin Cell Biol (2012) 0.86
Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells. Aging (Albany NY) (2013) 0.85
Efficiency of spermatogonial dedifferentiation during aging. PLoS One (2012) 0.84
The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila. Development (2013) 0.83
Molecular evolution of the testis TAFs of Drosophila. Mol Biol Evol (2009) 0.83
Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila. PLoS One (2012) 0.82
Headcase promotes cell survival and niche maintenance in the Drosophila testis. PLoS One (2013) 0.82
Germ-line specific variants of components of the mitochondrial outer membrane import machinery in Drosophila. FEBS Lett (2004) 0.82
What Drosophila spermatocytes tell us about the mechanisms underlying cytokinesis. Cytoskeleton (Hoboken) (2012) 0.80
The histone variant His2Av is required for adult stem cell maintenance in the Drosophila testis. PLoS Genet (2013) 0.79
The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis. Dev Biol (2012) 0.78
Smurf-mediated differential proteolysis generates dynamic BMP signaling in germline stem cells during Drosophila testis development. Dev Biol (2013) 0.78
Seminal discoveries in regenerative medicine: contributions of the male germ line to understanding pluripotency. Hum Mol Genet (2008) 0.76