Published in Am J Respir Crit Care Med on April 01, 2013
Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome. Intensive Care Med (2015) 1.72
Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease. BMC Med (2013) 1.62
Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The "Study of Origin". Biomed Res Int (2016) 1.39
Epidemiology and clinical impact of major comorbidities in patients with COPD. Int J Chron Obstruct Pulmon Dis (2014) 1.23
Cytokine inhibition in the treatment of COPD. Int J Chron Obstruct Pulmon Dis (2014) 1.16
Analysis of comorbid factors that increase the COPD assessment test scores. Respir Res (2014) 1.06
Helping COPD patients change health behavior in order to improve their quality of life. Int J Chron Obstruct Pulmon Dis (2013) 1.03
Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease. BMC Cardiovasc Disord (2013) 1.01
Underrecognized comorbidities of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2015) 0.95
Synergy-COPD: a systems approach for understanding and managing chronic diseases. J Transl Med (2014) 0.94
Chronic obstructive pulmonary disease is just one component of the complex multimorbidities in patients with COPD. Am J Respir Crit Care Med (2013) 0.93
Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers. J Gerontol A Biol Sci Med Sci (2014) 0.93
Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey. Int J Chron Obstruct Pulmon Dis (2015) 0.91
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Identification of clinical phenotypes using cluster analyses in COPD patients with multiple comorbidities. Biomed Res Int (2014) 0.89
A simplified score to quantify comorbidity in COPD. PLoS One (2014) 0.89
Derivation and validation of clinical phenotypes for COPD: a systematic review. Respir Res (2015) 0.87
Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease. Sci Rep (2015) 0.87
Associations of Self-Reported Cigarette Smoking with Chronic Obstructive Pulmonary Disease and Co-Morbid Chronic Conditions in the United States. COPD (2014) 0.87
Comorbidities and Chronic Obstructive Pulmonary Disease: Prevalence, Influence on Outcomes, and Management. Semin Respir Crit Care Med (2015) 0.87
Finding the best thresholds of FEV1 and dyspnea to predict 5-year survival in COPD patients: the COCOMICS study. PLoS One (2014) 0.87
Subtypes of patients experiencing exacerbations of COPD and associations with outcomes. PLoS One (2014) 0.86
Ageing and the epidemiology of multimorbidity. Eur Respir J (2014) 0.85
Which patients with chronic obstructive pulmonary disease benefit from the addition of an inhaled corticosteroid to their bronchodilator? A cluster analysis. BMJ Open (2013) 0.85
Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans. Chronic Obstr Pulm Dis (2015) 0.85
Musculoskeletal disorders in chronic obstructive pulmonary disease. Biomed Res Int (2014) 0.83
Comorbid Influences on Generic Health-Related Quality of Life in COPD: A Systematic Review. PLoS One (2015) 0.83
Survival in COPD: impact of lung dysfunction and comorbidities. Medicine (Baltimore) (2014) 0.81
Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management. J Transl Med (2014) 0.81
Underdiagnosis and prognosis of chronic obstructive pulmonary disease after percutaneous coronary intervention: a prospective study. Int J Chron Obstruct Pulmon Dis (2015) 0.81
COPD: the patient perspective. Int J Chron Obstruct Pulmon Dis (2016) 0.81
Fracture prevention in COPD patients; a clinical 5-step approach. Respir Res (2015) 0.80
Aging-related systemic manifestations in COPD patients and cigarette smokers. PLoS One (2015) 0.80
Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project. J Transl Med (2014) 0.80
Risk of pneumonia with inhaled corticosteroid/long-acting β2 agonist therapy in chronic obstructive pulmonary disease: a cluster analysis. Int J Chron Obstruct Pulmon Dis (2014) 0.80
The COgnitive-Pulmonary Disease (COgnitive-PD) study: protocol of a longitudinal observational comparative study on neuropsychological functioning of patients with COPD. BMJ Open (2014) 0.80
Six-minute stepper test: a valid clinical exercise tolerance test for COPD patients. Int J Chron Obstruct Pulmon Dis (2016) 0.79
Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease. Respir Res (2014) 0.79
Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective. J Cachexia Sarcopenia Muscle (2015) 0.79
Development of an integral assessment approach of health status in patients with obstructive airway diseases: the CORONA study. Int J Chron Obstruct Pulmon Dis (2015) 0.78
The influence of comorbidities on outcomes of pulmonary rehabilitation programs in patients with COPD: a systematic review. Biomed Res Int (2013) 0.78
Dual therapy strategies for COPD: the scientific rationale for LAMA + LABA. Int J Chron Obstruct Pulmon Dis (2016) 0.78
Prognostic Value of the Six-Second Spirometry in Patients with Chronic Obstructive Pulmonary Disease: A Cohort Study. PLoS One (2015) 0.78
Differential expression of C-reactive protein and serum amyloid A in different cell types in the lung tissue of chronic obstructive pulmonary disease patients. BMC Pulm Med (2014) 0.78
Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 0.77
Czech multicenter research database of severe COPD. Int J Chron Obstruct Pulmon Dis (2014) 0.77
A randomized clinical trial to assess the influence of a three months training program (gym-based individualized vs. calisthenics-based non-invidualized) in COPD-patients. Respir Res (2014) 0.77
The mediating role of cytokine IL-6 on the relationship of FEV₁ upon 6-minute walk distance in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2014) 0.77
Do self-management interventions in COPD patients work and which patients benefit most? An individual patient data meta-analysis. Int J Chron Obstruct Pulmon Dis (2016) 0.77
Determination of Pain Phenotypes in Knee Osteoarthritis: A Latent Class Analysis Using Data From the Osteoarthritis Initiative. Arthritis Care Res (Hoboken) (2016) 0.77
Objectively identified comorbidities in COPD: impact on pulmonary rehabilitation outcomes. Eur Respir J (2015) 0.76
Assessing health-related quality of life in COPD: comparing generic and disease-specific instruments with focus on comorbidities. BMC Pulm Med (2016) 0.76
Domain-specific cognitive impairment in patients with COPD and control subjects. Int J Chron Obstruct Pulmon Dis (2016) 0.76
The Role of Mitochondria and Oxidative/Antioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease. Oxid Med Cell Longev (2016) 0.76
Molecular mechanism of sarcopenia and cachexia: recent research advances. Pflugers Arch (2017) 0.76
Effect of thyroid function on COPD exacerbation frequency: a preliminary study. Multidiscip Respir Med (2013) 0.75
Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation. Respir Res (2017) 0.75
Reflux esophagitis is one of highly prevalent comorbidities among patients with chronic obstructive pulmonary disease. Korean J Intern Med (2014) 0.75
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease. Respir Res (2016) 0.75
Depression, body mass index, and chronic obstructive pulmonary disease - a holistic approach. Int J Chron Obstruct Pulmon Dis (2016) 0.75
COPD and exercise: does it make a difference? Breathe (Sheff) (2016) 0.75
Statins and morbidity and mortality in COPD in the COMIC study: a prospective COPD cohort study. BMJ Open Respir Res (2016) 0.75
B-type natriuretic peptides in chronic obstructive pulmonary disease: a systematic review. BMC Pulm Med (2017) 0.75
Prevalence of comorbidities according to predominant phenotype and severity of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2016) 0.75
Pulmonary rehabilitation and severe exacerbations of COPD: solution or white elephant? ERJ Open Res (2015) 0.75
From comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration. BMC Bioinformatics (2016) 0.75
Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis. BMJ Open (2015) 0.75
Integrating 3-omics data analyze rat lung tissue of COPD states and medical intervention by delineation of molecular and pathway alterations. Biosci Rep (2017) 0.75
Living With Chronic Lower Pulmonary Disease: Disruptions of the Embodied Phenomenological Self. Glob Qual Nurs Res (2014) 0.75
Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD. Int J Chron Obstruct Pulmon Dis (2016) 0.75
The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study. Front Aging Neurosci (2017) 0.75
Chronic obstructive pulmonary disease and the risk of stroke: a systematic review protocol. BMJ Open (2016) 0.75
Vitamin D deficiency and airflow limitation in the Baltimore Longitudinal Study of Ageing. Eur J Clin Invest (2015) 0.75
Preliminary study on the assessment of visceral adipose tissue using dual-energy x-ray absorptiometry in chronic obstructive pulmonary disease. Multidiscip Respir Med (2016) 0.75
Improving communication between the physician and the COPD patient: an evaluation of the utility of the COPD Assessment Test in primary care. Patient Relat Outcome Meas (2014) 0.75
Impaired training-induced adaptation of blood pressure in COPD patients: implication of the muscle capillary bed. Int J Chron Obstruct Pulmon Dis (2016) 0.75
A study of chronic obstructive pulmonary disease-specific causes of osteoporosis with emphasis on the emphysema phenotype. Ann Thorac Med (2017) 0.75
Chronic Obstructive Pulmonary Disease Subtypes. Transitions over Time. PLoS One (2016) 0.75
Impact of comorbid conditions in COPD patients on health care resource utilization and costs in a predominantly Medicare population. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins. Sci Rep (2017) 0.75
Short-term Evaluation of a Comprehensive Education Program Including Inhaler Training and Disease Management on Chronic Obstructive Pulmonary Disease. Tuberc Respir Dis (Seoul) (2017) 0.75
Pulmonary function and CT biomarkers as risk factors for cardiovascular events in male lung cancer screening participants: the NELSON study. Eur Radiol (2014) 0.75
Differences in systemic inflammation between cigarette and biomass smoke-induced COPD. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Chronic obstructive pulmonary disease with mild airflow limitation: current knowledge and proposal for future research - a consensus document from six scientific societies. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med (2010) 15.07
Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med (2014) 6.29
An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med (2013) 4.49
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Systemic effects of smoking. Chest (2007) 3.63
Characteristics of physical activities in daily life in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 3.58
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD. Chest (2003) 2.90
Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Respir Crit Care Med (2010) 2.80
Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A (2006) 2.51
Disturbed intestinal integrity in patients with COPD: effects of activities of daily living. Chest (2014) 2.27
Physical activity and hospitalization for exacerbation of COPD. Chest (2006) 2.24
Differences in content and organisational aspects of pulmonary rehabilitation programmes. Eur Respir J (2013) 2.20
Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc Natl Acad Sci U S A (2004) 2.19
Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD. Chest (2004) 2.08
Exercise capacity before and after an 8-week multidisciplinary inpatient rehabilitation program in lung cancer patients: a pilot study. Lung Cancer (2006) 2.07
Arterial stiffness in patients with COPD: the role of systemic inflammation and the effects of pulmonary rehabilitation. Eur Respir J (2013) 2.05
Inaccuracy of estimating peak work rate from six-minute walk distance in patients with COPD. COPD (2012) 1.98
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.79
Increased granzyme A expression in type II pneumocytes of patients with severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.76
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.73
Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis. Ann Am Thorac Soc (2015) 1.72
Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology. Am J Respir Cell Mol Biol (2002) 1.71
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.61
Efficacy of nutritional supplementation therapy in depleted patients with chronic obstructive pulmonary disease. Nutrition (2003) 1.60
Risk factors for osteoporosis in Caucasian patients with moderate chronic obstructive pulmonary disease: a case control study. Bone (2012) 1.56
Proposal for a multidimensional staging system for chronic obstructive pulmonary disease. Respir Med (2005) 1.54
Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases. Pulm Pharmacol Ther (2013) 1.54
Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J (2004) 1.53
Critical view on diagnosing muscle wasting by single-frequency bio-electrical impedance in COPD. Respir Med (2009) 1.49
The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med (2014) 1.49
Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease. Ann Am Thorac Soc (2014) 1.49
The last wish of a patient with end stage chronic obstructive pulmonary disease. BMJ (2008) 1.41
The protective effect of sunscreens, vitamin E 6% cream, and betamethasone 0.1% cream on solar-simulating radiation-induced erythema and neutrophil influx. J Am Acad Dermatol (2013) 1.39
Activity monitoring for assessment of physical activities in daily life in patients with chronic obstructive pulmonary disease. Arch Phys Med Rehabil (2005) 1.39
Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis. Thorax (2007) 1.32
Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort. Respir Med (2010) 1.30
Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease. J Am Med Dir Assoc (2011) 1.28
In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization. Biochim Biophys Acta (2006) 1.27
Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease. Am J Respir Cell Mol Biol (2006) 1.25
Physical activity monitoring in COPD: compliance and associations with clinical characteristics in a multicenter study. Respir Med (2011) 1.23
Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team. Am J Respir Crit Care Med (2014) 1.20
Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms? Thorax (2013) 1.20
Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways. Am J Physiol Cell Physiol (2002) 1.19
Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study. Respir Med (2003) 1.17
Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation. Am J Physiol Cell Physiol (2005) 1.17
Rehabilitation decreases exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.16
Body mass index modulates aromatic DNA adduct levels and their persistence in smokers. Cancer Epidemiol Biomarkers Prev (2002) 1.16
Systemic inflammation in COPD: is genetic susceptibility a key factor? COPD (2006) 1.15
Increased systemic inflammation is a risk factor for COPD exacerbations. Chest (2008) 1.12
Striking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPD. Chest (2003) 1.12
Integration of pulmonary rehabilitation in COPD. Lancet (2008) 1.11
Nordic walking improves daily physical activities in COPD: a randomised controlled trial. Respir Res (2010) 1.11
Physical activity measured with implanted devices predicts patient outcome in chronic heart failure. Circ Heart Fail (2014) 1.10
Vitamin D status is associated with bone mineral density and functional exercise capacity in patients with chronic obstructive pulmonary disease. Ann Med (2012) 1.09
Symptoms of anxiety and depression in COPD patients entering pulmonary rehabilitation. Chron Respir Dis (2010) 1.08
The metabolic response during resistance training and neuromuscular electrical stimulation (NMES) in patients with COPD, a pilot study. Respir Med (2008) 1.06
IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study. BMC Med Genet (2009) 1.06
Symptoms, comorbidities, and health care in advanced chronic obstructive pulmonary disease or chronic heart failure. J Palliat Med (2011) 1.05
Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production. J Immunol (2009) 1.04
Differences in walking pattern during 6-min walk test between patients with COPD and healthy subjects. PLoS One (2012) 1.04
Effect of 'activity monitor-based' counseling on physical activity and health-related outcomes in patients with chronic diseases: A systematic review and meta-analysis. Ann Med (2013) 1.04
Short term and long term effects of pulmonary rehabilitation on physical activity in COPD. Respir Med (2012) 1.03
Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): a pivotal role of leptin. Respir Med (2011) 1.03
Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice. J Immunol (2010) 1.03
A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest (2003) 1.03
Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease. Am J Clin Nutr (2002) 1.02