Published in J Transl Med on November 28, 2014
The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research. J Transl Med (2014) 0.95
Computational modeling of the obstructive lung diseases asthma and COPD. J Transl Med (2014) 0.87
Systems Medicine: from molecular features and models to the clinic in COPD. J Transl Med (2014) 0.84
Biomedical research in a Digital Health Framework. J Transl Med (2014) 0.83
Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management. J Transl Med (2014) 0.81
Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project. J Transl Med (2014) 0.80
Implementing systems medicine within healthcare. Genome Med (2015) 0.75
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis (1987) 174.79
Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J Physiol (1952) 137.36
Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet (1997) 29.18
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (2006) 25.99
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2012) 22.96
STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res (2012) 18.26
Systems biology: a brief overview. Science (2002) 14.69
Network medicine: a network-based approach to human disease. Nat Rev Genet (2011) 14.07
COPASI--a COmplex PAthway SImulator. Bioinformatics (2006) 10.57
Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 7.67
Regional patterns of disability-free life expectancy and disability-adjusted life expectancy: global Burden of Disease Study. Lancet (1997) 7.29
Interactome networks and human disease. Cell (2011) 7.16
Systemic manifestations and comorbidities of COPD. Eur Respir J (2009) 5.90
Measuring the global burden of disease. N Engl J Med (2013) 5.84
BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol (2010) 5.75
Improving the quality of health care for chronic conditions. Qual Saf Health Care (2004) 4.93
Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol (2011) 4.02
Systems medicine: the future of medical genomics and healthcare. Genome Med (2009) 3.85
Network medicine--from obesity to the "diseasome". N Engl J Med (2007) 3.83
Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 3.54
Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes. Thorax (2010) 3.06
Preventing chronic diseases: taking stepwise action. Lancet (2005) 3.04
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
The impact of cellular networks on disease comorbidity. Mol Syst Biol (2009) 2.23
Chaste: an open source C++ library for computational physiology and biology. PLoS Comput Biol (2013) 2.22
Dynamic modelling and analysis of biochemical networks: mechanism-based models and model-based experiments. Brief Bioinform (2006) 1.96
Systemic inflammation and comorbidity in COPD: a result of 'overspill' of inflammatory mediators from the lungs? Review of the evidence. Thorax (2010) 1.82
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Multi-dimensional phenotyping: towards a new taxonomy for airway disease. Clin Exp Allergy (2005) 1.77
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.73
Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance. Am J Physiol Heart Circ Physiol (2011) 1.70
CellML metadata standards, associated tools and repositories. Philos Trans A Math Phys Eng Sci (2009) 1.59
Epidemiologic uses of Medicare data. Epidemiol Rev (1993) 1.48
COPD and the solar system: introducing the chronic obstructive pulmonary disease comorbidome. Am J Respir Crit Care Med (2012) 1.44
Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort. Respir Med (2013) 1.41
Nitroso-redox balance in the cardiovascular system. N Engl J Med (2004) 1.30
Algebraic analysis of the determinants of VO2,max. Respir Physiol (1993) 1.29
A theoretical analysis of factors determining VO2 MAX at sea level and altitude. Respir Physiol (1996) 1.23
Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team. Am J Respir Crit Care Med (2014) 1.20
SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools. BMC Syst Biol (2013) 1.20
Systems biology: the elements and principles of life. FEBS Lett (2009) 1.17
The Elixhauser comorbidity method outperforms the Charlson index in predicting inpatient death after orthopaedic surgery. Clin Orthop Relat Res (2014) 1.16
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. PLoS Comput Biol (2011) 1.13
Predictive, preventive, personalized and participatory medicine: back to the future. Genome Med (2010) 1.12
Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS Comput Biol (2009) 1.10
Participatory medicine: a driving force for revolutionizing healthcare. Genome Med (2013) 1.10
Knowledge management for systems biology a general and visually driven framework applied to translational medicine. BMC Syst Biol (2011) 1.01
Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies. BMC Bioinformatics (2010) 0.98
Clinical Decision Support Systems (CDSS) for preventive management of COPD patients. J Transl Med (2014) 0.96
Importance of mitochondrial P(O2) in maximal O2 transport and utilization: a theoretical analysis. Respir Physiol Neurobiol (2013) 0.96
The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research. J Transl Med (2014) 0.95
Muscle and blood redox status after exercise training in severe COPD patients. Free Radic Biol Med (2011) 0.92
Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM). Interface Focus (2013) 0.88
Identifying comorbidity patterns of health conditions via cluster analysis of pairwise concordance statistics. Stat Med (2012) 0.88
Computational modeling of the obstructive lung diseases asthma and COPD. J Transl Med (2014) 0.87
Simulation environment and graphical visualization environment: a COPD use-case. J Transl Med (2014) 0.87
Revision history aware repositories of computational models of biological systems. BMC Bioinformatics (2011) 0.86
Structural alterations of skeletal muscle in copd. Front Physiol (2014) 0.85
CDMS (Clinical Data Mining Software): a cytokinome data mining system for a predictive medicine of chronic inflammatory diseases. Protein Eng Des Sel (2010) 0.85
Systems Medicine: from molecular features and models to the clinic in COPD. J Transl Med (2014) 0.84
Biomedical research in a Digital Health Framework. J Transl Med (2014) 0.83
Diabetes mellitus among outpatients with COPD attending a university hospital. Acta Diabetol (2014) 0.83
Workforce preparation: the Biohealth computing model for Master and PhD students. J Transl Med (2014) 0.82
The role of theory and modeling in medical research. Front Physiol (2013) 0.82
Interpreting networks in systems biology. Clin Pharmacol Ther (2013) 0.81
Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management. J Transl Med (2014) 0.81
Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol (2014) 0.80
A diVIsive Shuffling Approach (VIStA) for gene expression analysis to identify subtypes in Chronic Obstructive Pulmonary Disease. BMC Syst Biol (2014) 0.80
Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD project. J Transl Med (2014) 0.80
Epigenetics and muscle dysfunction in chronic obstructive pulmonary disease. Transl Res (2014) 0.79
Predictive diagnostics and personalized medicine for the prevention of chronic degenerative diseases. Immun Ageing (2010) 0.78
Retracted Protein-protein interaction network analysis in chronic obstructive pulmonary disease. Lung (2013) 0.77
Brief introduction to Synergy-COPD. J Transl Med (2014) 0.76
Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes. 1987. Biotechnol Bioeng (2009) 0.76
Knowledge sharing in the health scenario. J Transl Med (2014) 0.76
[Research on SOA for hospital information system]. Zhongguo Yi Liao Qi Xie Za Zhi (2010) 0.76
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
Reverse engineering gene networks using singular value decomposition and robust regression. Proc Natl Acad Sci U S A (2002) 5.29
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics (2012) 4.95
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes. Thorax (2010) 3.06
Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol (2010) 2.88
Hemodynamic and gas exchange effects of sildenafil in patients with chronic obstructive pulmonary disease and pulmonary hypertension. Am J Respir Crit Care Med (2009) 2.70
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform. Epigenetics (2013) 2.28
Telemedicine experience for chronic care in COPD. IEEE Trans Inf Technol Biomed (2006) 1.89
Data integration in the era of omics: current and future challenges. BMC Syst Biol (2014) 1.82
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discov Today (2002) 1.74
K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts. Cancer Res (2005) 1.73
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.73
Effects of nebulized N(G)-nitro-L-arginine methyl ester in patients with hepatopulmonary syndrome. Hepatology (2006) 1.66
Mechanism for top-down control of working memory capacity. Proc Natl Acad Sci U S A (2009) 1.63
Sildenafil to improve respiratory rehabilitation outcomes in COPD: a controlled trial. Eur Respir J (2013) 1.57
Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum Mutat (2006) 1.53
[Daily living activity in chronic obstructive pulmonary disease: validation of the Spanish version and comparative analysis of 2 questionnaires]. Med Clin (Barc) (2007) 1.48
Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. J Biol Chem (2002) 1.47
Training depletes muscle glutathione in patients with chronic obstructive pulmonary disease and low body mass index. Respiration (2006) 1.47
Assessment of acute pulmonary vascular reactivity in portopulmonary hypertension. Liver Transpl (2007) 1.44
Enhanced expression of vascular endothelial growth factor in pulmonary arteries of smokers and patients with moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 1.41
Gas exchange response to short-acting beta2-agonists in chronic obstructive pulmonary disease severe exacerbations. Am J Respir Crit Care Med (2007) 1.40
Brain activity related to working memory and distraction in children and adults. Cereb Cortex (2006) 1.40
[Usefulness of a lung cancer rapid diagnosis specialist clinic. Contribution of ultrasound bronchoscopy]. Arch Bronconeumol (2010) 1.39
Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity. J Appl Physiol (1985) (2009) 1.38
Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia. Proc Natl Acad Sci U S A (2007) 1.37
Physical activity and clinical and functional status in COPD. Chest (2009) 1.34
Effects of an integrated care intervention on risk factors of COPD readmission. Respir Med (2007) 1.33
Targeting cell cycle regulation in cancer therapy. Pharmacol Ther (2013) 1.32
Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood. J Cogn Neurosci (2007) 1.28
Defective RNA ribose synthesis in fibroblasts from patients with thiamine-responsive megaloblastic anemia (TRMA). Blood (2003) 1.26
Identification of vascular progenitor cells in pulmonary arteries of patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2005) 1.25
Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet (2008) 1.25
Bistability from double phosphorylation in signal transduction. Kinetic and structural requirements. FEBS J (2006) 1.21
Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol (2011) 1.21
Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer. Int J Cancer (2006) 1.18
Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression. J Autoimmun (2013) 1.17
Product dependence and bifunctionality compromise the ultrasensitivity of signal transduction cascades. Proc Natl Acad Sci U S A (2002) 1.17
Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes. Nucleic Acids Res (2011) 1.15
Varicose vein surgery: stripping versus the CHIVA method: a randomized controlled trial. Ann Surg (2010) 1.14
The role of external and matrix pH in mitochondrial reactive oxygen species generation. J Biol Chem (2008) 1.13
A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. PLoS Comput Biol (2011) 1.13
Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014. Am J Respir Crit Care Med (2015) 1.12
Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway. Cancer Lett (2008) 1.11
Antiproliferative effect of antioxidant polyphenols from grape in murine Hepa-1c1c7. Eur J Nutr (2003) 1.10
Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS Comput Biol (2009) 1.10
Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C2C12 cells through sustained NF-kappaB activation. Am J Pathol (2004) 1.10
Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population. BMC Med Genet (2010) 1.08
The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. J Biol Chem (2003) 1.06
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12. Carcinogenesis (2006) 1.06
Does oxidative stress modulate limb muscle atrophy in severe COPD patients? Eur Respir J (2012) 1.05
Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity. Bioorg Med Chem (2009) 1.05
Gas exchange mechanism of orthodeoxia in hepatopulmonary syndrome. Hepatology (2004) 1.04
Dynamic profiling of the glucose metabolic network in fasted rat hepatocytes using [1,2-13C2]glucose. Biochem J (2004) 1.03
Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One (2011) 1.03
An optimized algorithm for flux estimation from isotopomer distribution in glucose metabolites. Bioinformatics (2004) 1.02
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells. FEBS Lett (2006) 1.02
Knowledge management for systems biology a general and visually driven framework applied to translational medicine. BMC Syst Biol (2011) 1.01
Reconciling coherent oscillation with modulation of irregular spiking activity in selective attention: gamma-range synchronization between sensory and executive cortical areas. J Neurosci (2010) 1.00
Detection of potential enzyme targets by metabolic modelling and optimization: application to a simple enzymopathy. Bioinformatics (2007) 1.00
Telemedicine enhances quality of forced spirometry in primary care. Eur Respir J (2011) 0.99
Systems biology is taking off. Genome Res (2003) 0.99
The SERPINE2 gene and chronic obstructive pulmonary disease. Am J Hum Genet (2006) 0.99
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. Int J Cancer (2009) 0.98
Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR. Brief Bioinform (2015) 0.98
Valorization of grape (Vitis vinifera) byproducts. Antioxidant and biological properties of polyphenolic fractions differing in procyanidin composition and flavonol content. J Agric Food Chem (2002) 0.98
Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach. J Immunol (2011) 0.97
Rapid simulation and analysis of isotopomer distributions using constraints based on enzyme mechanisms: an example from HT29 cancer cells. Bioinformatics (2005) 0.97
The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism. BMC Cancer (2011) 0.96
Clinical Decision Support Systems (CDSS) for preventive management of COPD patients. J Transl Med (2014) 0.96
Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue. Stem Cells (2013) 0.95
Multicriteria optimization of biochemical systems by linear programming: application to production of ethanol by Saccharomyces cerevisiae. Biotechnol Bioeng (2003) 0.95
Reverse engineering of gene networks with LASSO and nonlinear basis functions. Ann N Y Acad Sci (2009) 0.95
The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research. J Transl Med (2014) 0.95
Frequency of antineutrophil cytoplasmic antibody in Graves' disease patients treated with methimazole. J Clin Endocrinol Metab (2003) 0.94
The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study. BMC Med Genet (2011) 0.93
Software for dynamic analysis of tracer-based metabolomic data: estimation of metabolic fluxes and their statistical analysis. Bioinformatics (2006) 0.93
Procyanidin fractions from pine (Pinus pinaster) bark: radical scavenging power in solution, antioxidant activity in emulsion, and antiproliferative effect in melanoma cells. J Agric Food Chem (2005) 0.93
Clinical assessment of peripheral muscle function in patients with chronic obstructive pulmonary disease. Am J Phys Med Rehabil (2009) 0.92
Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res (2009) 0.92
Muscle and blood redox status after exercise training in severe COPD patients. Free Radic Biol Med (2011) 0.92
Compartmentation of glycogen metabolism revealed from 13C isotopologue distributions. BMC Syst Biol (2011) 0.92
Triosephosphate isomerase deficiency. genetic, enzymatic and metabolic characterization of a new case from Spain. Haematologica (2002) 0.92
An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training. Epigenetics (2014) 0.91