Published in Postgrad Med J on February 12, 2013
Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med (2009) 39.97
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med (2011) 28.99
Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med (2011) 23.50
Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA (2001) 16.98
A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med (2002) 16.31
Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med (2009) 11.49
Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med (2007) 10.87
A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest (2010) 10.29
Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study. Lancet (1989) 10.18
Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation. Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators. N Engl J Med (1992) 9.71
A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation. N Engl J Med (2002) 8.37
Canadian Atrial Fibrillation Anticoagulation (CAFA) Study. J Am Coll Cardiol (1991) 6.55
Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study. Eur Heart J (2006) 6.31
Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace (2010) 6.31
Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials. Arch Intern Med (2012) 5.56
A population-based study of the long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study. Am J Med (2002) 5.55
Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study. Lancet (1994) 5.37
The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation. The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators. N Engl J Med (1990) 4.77
The net clinical benefit of warfarin anticoagulation in atrial fibrillation. Ann Intern Med (2009) 4.71
Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation (1991) 4.52
Anticoagulation therapy for stroke prevention in atrial fibrillation: how well do randomized trials translate into clinical practice? JAMA (2003) 4.13
Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study. Eur Heart J (2012) 3.66
Oral anticoagulants vs aspirin in nonvalvular atrial fibrillation: an individual patient meta-analysis. JAMA (2002) 2.94
Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls. Arch Intern Med (1999) 2.07
Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: A net clinical benefit analysis using a 'real world' nationwide cohort study. Thromb Haemost (2011) 2.01
Management of atrial fibrillation: review of the evidence for the role of pharmacologic therapy, electrical cardioversion, and echocardiography. Ann Intern Med (2003) 1.65
Mixed comparison of stroke prevention treatments in individuals with nonrheumatic atrial fibrillation. Arch Intern Med (2006) 1.42
Current trial-associated outcomes with warfarin in prevention of stroke in patients with nonvalvular atrial fibrillation: a meta-analysis. Arch Intern Med (2012) 1.21
Atrial fibrillation: the most common arrhythmia. Tex Heart Inst J (2000) 1.11
Stroke prevention in elderly patients with atrial fibrillation. Lancet (2007) 0.95
Ischaemic stroke and bleeding rates in 'real-world' atrial fibrillation patients. Thromb Haemost (2011) 0.90
New oral anticoagulants for atrial fibrillation. Circulation (2012) 0.87
Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A (2002) 3.59
Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J Neurochem (2003) 2.20
Cardiac Na+ current regulation by pyridine nucleotides. Circ Res (2009) 1.87
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation (2005) 1.74
Delayed paced ventricular activation in the long QT syndrome is associated with ventricular fibrillation. Heart Rhythm (2006) 1.53
Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. J Cardiovasc Electrophysiol (2012) 1.53
Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. Cardiovasc Res (2011) 1.46
Paced ventricular electrogram fractionation predicts sudden cardiac death in hypertrophic cardiomyopathy. Eur Heart J (2008) 1.44
Temperature dependence of human ether-a-go-go-related gene K+ currents. Am J Physiol Cell Physiol (2006) 1.29
Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. J Physiol (2005) 1.27
Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. J Physiol (2003) 1.21
A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells. J Physiol (2004) 1.21
Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome. J Physiol (2007) 1.19
TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging. Circ Arrhythm Electrophysiol (2011) 1.17
The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. Pflugers Arch (2007) 1.10
Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. J Cardiovasc Electrophysiol (2005) 1.10
Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation. Circulation (2003) 1.09
Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions. J Physiol (2003) 1.08
SCN5A and sinoatrial node pacemaker function. Cardiovasc Res (2007) 1.06
Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6. J Physiol (2003) 1.06
Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model. Am J Physiol Heart Circ Physiol (2011) 1.06
Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3. J Physiol (2006) 1.05
Recent developments in the management of patients at risk for sudden cardiac death. Postgrad Med (2011) 1.04
Physiological studies of cortical spreading depression. Biol Rev Camb Philos Soc (2006) 1.03
Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome. J Cardiovasc Electrophysiol (2010) 1.03
Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption. FASEB J (2003) 1.03
Calcium and bone disease. Biofactors (2011) 1.02
Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. Am J Physiol Heart Circ Physiol (2005) 1.02
Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts. J Physiol (2013) 1.02
Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. Prog Biophys Mol Biol (2009) 1.02
Atrial fibrillation and bisphosphonate therapy. J Bone Miner Res (2010) 1.02
Determinants of myocardial conduction velocity: implications for arrhythmogenesis. Front Physiol (2013) 1.01
The effect of intracellular acidification on the relationship between cell volume and membrane potential in amphibian skeletal muscle. J Physiol (2004) 1.00
Genetic Na+ channelopathies and sinus node dysfunction. Prog Biophys Mol Biol (2008) 1.00
Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3. J Physiol (2006) 0.98
Quantitative techniques for steady-state calculation and dynamic integrated modelling of membrane potential and intracellular ion concentrations. Prog Biophys Mol Biol (2006) 0.97
Nifedipine and diltiazem suppress ventricular arrhythmogenesis and calcium release in mouse hearts. Pflugers Arch (2004) 0.96
Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle. J Gen Physiol (2011) 0.96
Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1 modelling long QT syndrome 5. J Physiol (2006) 0.96
Sudden cardiac death and inherited channelopathy: the basic electrophysiology of the myocyte and myocardium in ion channel disease. Heart (2012) 0.95
Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart. Pflugers Arch (2008) 0.94
Translational musculoskeletal science: is sarcopenia the next clinical target after osteoporosis? Ann N Y Acad Sci (2011) 0.93
Ventricular arrhythmogenesis following slowed conduction in heptanol-treated, Langendorff-perfused mouse hearts. J Physiol Sci (2012) 0.92
Transient alterations in transmural repolarization gradients and arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts. J Physiol (2007) 0.90
The developmental basis of skeletal cell differentiation and the molecular basis of major skeletal defects. Biol Rev Camb Philos Soc (2008) 0.89
Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome. Pflugers Arch (2007) 0.89
A novel mechanism for coupling cellular intermediary metabolism to cytosolic Ca2+ signaling via CD38/ADP-ribosyl cyclase, a putative intracellular NAD+ sensor. FASEB J (2002) 0.89
Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction. Pflugers Arch (2010) 0.89
Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model. Am J Physiol Heart Circ Physiol (2010) 0.89
Ventricular arrhythmogenesis: insights from murine models. Prog Biophys Mol Biol (2008) 0.89
Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor. Am J Physiol Renal Physiol (2002) 0.88
In vivo studies of Scn5a+/- mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities. J Electrocardiol (2010) 0.88
Slow volume transients in amphibian skeletal muscle fibres studied in hypotonic solutions. J Physiol (2005) 0.88
Dispersions of repolarization and ventricular arrhythmogenesis: lessons from animal models. Prog Biophys Mol Biol (2008) 0.88
Control of cell volume in skeletal muscle. Biol Rev Camb Philos Soc (2008) 0.87
Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts. Cardiovasc Res (2010) 0.87
Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts. Pflugers Arch (2007) 0.87
Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation. Cardiovasc Res (2013) 0.86
Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome. Am J Physiol Heart Circ Physiol (2012) 0.86
Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sex. Pflugers Arch (2010) 0.86
Atrial arrhythmogenesis in wild-type and Scn5a+/delta murine hearts modelling LQT3 syndrome. Pflugers Arch (2009) 0.85
Refractory dispersion promotes conduction disturbance and arrhythmias in a Scn5a (+/-) mouse model. Pflugers Arch (2011) 0.85
A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts. Pflugers Arch (2007) 0.84
Simultaneous measurement of blood and myocardial velocity in the rat heart by phase contrast MRI using sparse q-space sampling. J Magn Reson Imaging (2005) 0.83
Regulation of bone turnover by calcium-regulated calcium channels. Ann N Y Acad Sci (2010) 0.83
Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification. Front Physiol (2013) 0.83
The influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle. J Physiol (2006) 0.83
Activation of purinergic receptors by ATP induces ventricular tachycardia by membrane depolarization and modifications of Ca2+ homeostasis. J Mol Cell Cardiol (2009) 0.83
Cellular and molecular consequences of calcineurin A alpha gene deletion. Ann N Y Acad Sci (2007) 0.81
Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age. J Am Heart Assoc (2014) 0.81
Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/- hearts: the effects of ageing and sex. Mech Ageing Dev (2012) 0.81
Reduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/- mice. Open Biol (2012) 0.81
Non-invasive magnetic resonance imaging assessment of myocardial changes and the effects of angiotensin-converting enzyme inhibition in diabetic rats. J Physiol (2002) 0.81
Effect of repetitive stimulation on cell volume and its relationship to membrane potential in amphibian skeletal muscle. Pflugers Arch (2006) 0.81
Pharmacological changes in cellular Ca2+ homeostasis parallel initiation of atrial arrhythmogenesis in murine Langendorff-perfused hearts. Clin Exp Pharmacol Physiol (2009) 0.80
A delayed class of BOLD waveforms associated with spreading depression in the feline cerebral cortex can be detected and characterised using independent component analysis (ICA). Magn Reson Imaging (2003) 0.80
Membrane potentials in Rana temporaria muscle fibres in strongly hypertonic solutions. J Muscle Res Cell Motil (2006) 0.79
Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models. Front Physiol (2012) 0.79
A missense mutation (G604S) in the S5/pore region of HERG causes long QT syndrome in a Chinese family with a high incidence of sudden unexpected death. Eur J Pediatr (2006) 0.79
Alternans in genetically modified langendorff-perfused murine hearts modeling catecholaminergic polymorphic ventricular tachycardia. Front Physiol (2010) 0.79
Effects of flecainide and quinidine on action potential and ventricular arrhythmogenic properties in Scn3b knockout mice. Clin Exp Pharmacol Physiol (2010) 0.79
Detubulation abolishes membrane potential stabilization in amphibian skeletal muscle. J Muscle Res Cell Motil (2004) 0.79
Nonlinearity between action potential alternans and restitution, which both predict ventricular arrhythmic properties in Scn5a+/- and wild-type murine hearts. J Appl Physiol (1985) (2012) 0.79
Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle. Pflugers Arch (2006) 0.79
The age-dependence of atrial arrhythmogenicity in Scn5a+/- murine hearts reflects alterations in action potential propagation and recovery. Clin Exp Pharmacol Physiol (2012) 0.79
Risk stratification for sudden cardiac death. Prog Biophys Mol Biol (2009) 0.78
Cortical spreading depression in the feline brain following sustained and transient stimuli studied using diffusion-weighted imaging. J Physiol (2002) 0.78
Molecular cloning, expression, and function of osteoclastic calcineurin Aalpha. Am J Physiol Renal Physiol (2002) 0.78
Arrhythmogenic substrate and its modification by nicorandil in a murine model of long QT type 3 syndrome. Prog Biophys Mol Biol (2009) 0.78
Differential effects of sarcoplasmic reticular Ca(2+)-ATPase inhibition on charge movements and calcium transients in intact amphibian skeletal muscle fibres. J Physiol (2002) 0.78
The SCN5A mutation A1180V is associated with electrocardiographic features of LQT3. Pediatr Cardiol (2013) 0.77
Osmotic processes in vacuolation and detubulation of skeletal muscle. Cell Biol Int (2002) 0.77
Atrial arrhythmogenic properties in wild-type and Scn5a+/- murine hearts. Exp Physiol (2010) 0.76
Role of the pituitary-bone axis in skeletal pathophysiology. Curr Opin Endocrinol Diabetes Obes (2009) 0.76
The role of ion channelopathies in sudden cardiac death: implications for clinical practice. Ann Med (2013) 0.76