Published in Front Physiol on June 25, 2013
Flecainide exerts paradoxical effects on sodium currents and atrial arrhythmia in murine RyR2-P2328S hearts. Acta Physiol (Oxf) (2015) 1.41
STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node. Proc Natl Acad Sci U S A (2015) 0.78
Sudden arrhythmic death: from basic science to clinical practice. Front Physiol (2013) 0.75
Murine Electrophysiological Models of Cardiac Arrhythmogenesis. Physiol Rev (2017) 0.75
Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation (2002) 5.94
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation (2001) 5.68
Mechanisms for human genomic rearrangements. Pathogenetics (2008) 4.54
Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulation. Circ Res (2001) 4.42
Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients. Circulation (1995) 4.19
A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res (2010) 3.99
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science (2004) 3.45
Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor. Circ Res (2005) 3.44
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res (2006) 3.42
A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Am J Hum Genet (2001) 3.38
Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation (2001) 3.34
Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ Arrhythm Electrophysiol (2008) 3.26
Atrial L-type Ca2+ currents and human atrial fibrillation. Circ Res (1999) 3.22
What keeps us ticking: a funny current, a calcium clock, or both? J Mol Cell Cardiol (2009) 2.99
Genesis and regulation of the heart automaticity. Physiol Rev (2008) 2.71
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation (2004) 2.69
Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves: threshold sarcoplasmic reticulum calcium content is required. Circ Res (2006) 2.57
Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. J Clin Invest (2008) 2.45
T-tubule function in mammalian cardiac myocytes. Circ Res (2003) 2.44
The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res (2001) 2.41
Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis. Circ Res (2011) 2.37
Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc Res (1999) 2.37
Sarcoplasmic reticulum Ca2+ release is not a dominating factor in sinoatrial node pacemaker activity. Circ Res (2003) 2.32
Minor contribution of cytosolic Ca2+ transients to the pacemaker rhythm in guinea pig sinoatrial node cells. Am J Physiol Heart Circ Physiol (2010) 2.20
The Ca2+-release channel/ryanodine receptor is localized in junctional and corbular sarcoplasmic reticulum in cardiac muscle. J Cell Biol (1993) 2.18
Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation (2005) 2.15
Calcium signalling--an overview. Semin Cell Dev Biol (2001) 2.06
Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes. J Physiol (2003) 2.01
Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes. Circulation (2004) 1.97
Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization. Circ Res (2004) 1.90
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A (2006) 1.85
L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases. Circulation (2004) 1.85
Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res (2012) 1.80
Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients. J Med Genet (2005) 1.78
Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features. Circulation (2007) 1.74
Catecholaminergic polymorphic ventricular tachycardia: electrocardiographic characteristics and optimal therapeutic strategies to prevent sudden death. Heart (2003) 1.69
Arrhythmic disorder mapped to chromosome 1q42-q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts. J Am Coll Cardiol (1999) 1.68
Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes. J Physiol (2001) 1.62
Intracellular calcium and Na+-Ca2+ exchange current in isolated toad pacemaker cells. J Physiol (1998) 1.60
Mechanisms of automaticity in subsidiary pacemakers from cat right atrium. Circ Res (1989) 1.57
Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies. J Mol Cell Cardiol (2006) 1.55
Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. J Cardiovasc Electrophysiol (2012) 1.53
A novel mutation in the RYR2 gene leading to catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation: dose-dependent arrhythmia-event suppression by β-blocker therapy. Can J Cardiol (2011) 1.50
The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction. J Cell Sci (2004) 1.47
Postpacing abnormal repolarization in catecholaminergic polymorphic ventricular tachycardia associated with a mutation in the cardiac ryanodine receptor gene. Heart Rhythm (2011) 1.46
Caffeine analogs: biomedical impact. Cell Mol Life Sci (2007) 1.41
Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia. Circ J (2007) 1.38
Regulation of junctional and non-junctional sarcoplasmic reticulum calcium release in excitation-contraction coupling in cat atrial myocytes. J Physiol (2003) 1.36
Sudden death in a young man with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol (2008) 1.30
Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res (2008) 1.27
Molecular and electrophysiological bases of catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Electrophysiol (2007) 1.20
Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circulation (2012) 1.19
Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem Soc Trans (2007) 1.19
Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. J Cardiovasc Pharmacol (2008) 1.15
Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies. Circ Res (2012) 1.11
Catecholaminergic polymorphic ventricular tachycardia from bedside to bench and beyond. Curr Probl Cardiol (2009) 1.08
Of circles and spirals: bridging the gap between the leading circle and spiral wave concepts of cardiac reentry. Europace (2005) 1.06
Search for cardiac calcium cycling gene mutations in familial ventricular arrhythmias resembling catecholaminergic polymorphic ventricular tachycardia. BMC Med Genet (2009) 1.06
Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. Am J Physiol Heart Circ Physiol (2005) 1.02
Mechanisms of perpetuation of atrial fibrillation in chronically dilated atria. Prog Biophys Mol Biol (2008) 1.01
The deletion of exon 3 in the cardiac ryanodine receptor is rescued by β strand switching. Structure (2011) 1.01
Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun (2004) 1.00
Atrial arrhythmia, triggering events and conduction abnormalities in isolated murine RyR2-P2328S hearts. Acta Physiol (Oxf) (2012) 0.99
Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts. Acta Physiol (Oxf) (2008) 0.98
Basic and clinical electrophysiology of pulmonary vein ectopy. Cardiovasc Res (2002) 0.98
Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia. Circulation (2011) 0.96
Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.92
Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts. Cardiovasc Res (2010) 0.87
Genetic characterization of familial CPVT after 30 years. Biol Res Nurs (2009) 0.83
Ryanodine receptor-mediated Ca2+ events in atrial myocytes of patients with atrial fibrillation. Cardiology (2008) 0.83
Pharmacological changes in cellular Ca2+ homeostasis parallel initiation of atrial arrhythmogenesis in murine Langendorff-perfused hearts. Clin Exp Pharmacol Physiol (2009) 0.80
What determines the initiation of the heartbeat? J Physiol (2000) 0.79
The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors. FEBS Lett (2003) 0.79
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature (2011) 11.59
A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature (2007) 5.78
Intrinsic motions along an enzymatic reaction trajectory. Nature (2007) 5.53
The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature (2007) 5.08
Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. Nat Cell Biol (2008) 4.68
Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a. Proc Natl Acad Sci U S A (2002) 3.59
The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. EMBO J (2003) 3.10
Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol (2006) 2.63
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science (2008) 2.30
Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J Neurochem (2003) 2.20
Transient non-native hydrogen bonds promote activation of a signaling protein. Cell (2009) 2.12
Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol (2004) 2.09
Generation of functional ion-channel tools by E3 targeting. Nat Biotechnol (2005) 2.08
Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovasc Res (2006) 2.02
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell (2002) 2.00
Cardiac Na+ current regulation by pyridine nucleotides. Circ Res (2009) 1.87
MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta. Mol Cancer (2010) 1.87
Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A (2006) 1.80
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation (2005) 1.74
Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev Cell (2010) 1.68
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem (2005) 1.64
Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation (2002) 1.63
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
Organisation of the mouse sinoatrial node: structure and expression of HCN channels. Cardiovasc Res (2006) 1.61
Delayed paced ventricular activation in the long QT syndrome is associated with ventricular fibrillation. Heart Rhythm (2006) 1.53
Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts. J Cardiovasc Electrophysiol (2012) 1.53
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. PLoS One (2010) 1.52
Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev (2009) 1.51
Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. Cardiovasc Res (2011) 1.46
Paced ventricular electrogram fractionation predicts sudden cardiac death in hypertrophic cardiomyopathy. Eur Heart J (2008) 1.44
Asymmetric optical cryptosystem based on coherent superposition and equal modulus decomposition. Opt Lett (2015) 1.39
Chinese minimally invasive percutaneous nephrolithotomy: the Guangzhou experience. J Endourol (2009) 1.34
Temperature dependence of human ether-a-go-go-related gene K+ currents. Am J Physiol Cell Physiol (2006) 1.29
A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3. Nat Struct Mol Biol (2008) 1.29
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol (2009) 1.29
Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. J Physiol (2005) 1.27
ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer. Proc Natl Acad Sci U S A (2013) 1.26
Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ Res (2007) 1.26
Multiple loss-of-function mechanisms contribute to SCN5A-related familial sick sinus syndrome. PLoS One (2010) 1.25
Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α. Cell Res (2010) 1.23
Electrogram prolongation and nifedipine-suppressible ventricular arrhythmias in mice following targeted disruption of KCNE1. J Physiol (2003) 1.21
A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells. J Physiol (2004) 1.21
Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1. Cardiovasc Res (2005) 1.19
Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome. J Physiol (2007) 1.19
Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circ Res (2010) 1.18
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation (2011) 1.18
Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice. Circulation (2009) 1.18
TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging. Circ Arrhythm Electrophysiol (2011) 1.17
Heterogeneous expression of Ca(2+) handling proteins in rabbit sinoatrial node. J Histochem Cytochem (2002) 1.16
Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res (2003) 1.16
Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife (2014) 1.16
CCT chaperonin complex is required for the biogenesis of functional Plk1. Mol Cell Biol (2005) 1.14
Voltage-gated sodium channels potentiate the invasive capacities of human non-small-cell lung cancer cell lines. Int J Biochem Cell Biol (2007) 1.13
SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep (2013) 1.13
Outcome evaluation of the National Cancer Institute career development awards program. J Cancer Educ (2013) 1.12
Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node. Prog Biophys Mol Biol (2007) 1.11
Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth. Circ Res (2009) 1.11
The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts. Pflugers Arch (2007) 1.10
Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol (2011) 1.10
Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. J Cardiovasc Electrophysiol (2005) 1.10
Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells. Inflammation (2012) 1.09
Sudden death in noncoronary heart disease is associated with delayed paced ventricular activation. Circulation (2003) 1.09
Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. J Mol Cell Cardiol (2011) 1.09
Membrane potential stabilization in amphibian skeletal muscle fibres in hypertonic solutions. J Physiol (2003) 1.08
Environmental and genetic control of arsenic accumulation and speciation in rice grain: comparing a range of common cultivars grown in contaminated sites across Bangladesh, China, and India. Environ Sci Technol (2009) 1.08
Aesthetic full-perioral reconstruction of burn scar by using a bilateral-pedicled expanded forehead flap. Ann Plast Surg (2009) 1.07
Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. Am J Physiol Heart Circ Physiol (2004) 1.06
SCN5A and sinoatrial node pacemaker function. Cardiovasc Res (2007) 1.06
Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery. Adv Drug Deliv Rev (2004) 1.06
Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro-arrhythmia in long QT syndrome type 6. J Physiol (2003) 1.06
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol (2011) 1.06
Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model. Am J Physiol Heart Circ Physiol (2011) 1.06
Effects of L-type Ca2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3. J Physiol (2006) 1.05
High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc (2012) 1.05
Recent developments in the management of patients at risk for sudden cardiac death. Postgrad Med (2011) 1.04
Modeling correlated main-chain motions in proteins for flexible molecular recognition. Proteins (2004) 1.04
Physiological studies of cortical spreading depression. Biol Rev Camb Philos Soc (2006) 1.03
Increased right ventricular repolarization gradients promote arrhythmogenesis in a murine model of Brugada syndrome. J Cardiovasc Electrophysiol (2010) 1.03
High-resolution technique for fabricating environmentally sensitive hydrogel microstructures. Langmuir (2004) 1.03
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Structure (2010) 1.03
Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption. FASEB J (2003) 1.03
Calcium and bone disease. Biofactors (2011) 1.02
Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a(+/-) hearts. J Physiol (2013) 1.02
Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression. PLoS One (2012) 1.02
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase. Nucleic Acids Res (2008) 1.02
Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. Am J Physiol Heart Circ Physiol (2005) 1.02
Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. Prog Biophys Mol Biol (2009) 1.02
Atrial fibrillation and bisphosphonate therapy. J Bone Miner Res (2010) 1.02
Determinants of myocardial conduction velocity: implications for arrhythmogenesis. Front Physiol (2013) 1.01
Occurrence and partitioning of cadmium, arsenic and lead in mine impacted paddy rice: Hunan, China. Environ Sci Technol (2009) 1.01
Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc Natl Acad Sci U S A (2011) 1.00
The effect of intracellular acidification on the relationship between cell volume and membrane potential in amphibian skeletal muscle. J Physiol (2004) 1.00
Genetic Na+ channelopathies and sinus node dysfunction. Prog Biophys Mol Biol (2008) 1.00