Published in Drug Saf on January 01, 2012
Optimal therapy of type 2 diabetes: a controversial challenge. Aging (Albany NY) (2014) 0.85
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda) (2017) 0.75
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev (2006) 5.61
Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals. JAMA Intern Med (2013) 3.08
Drawing impairment predicts mortality in severe COPD. Chest (2006) 2.45
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab (2003) 2.40
Recommendations to prescribe in complex older adults: results of the CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) project. Drugs Aging (2014) 2.03
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab (2002) 1.76
Weight loss in combination with physical activity improves endothelial dysfunction in human obesity. Diabetes Care (2003) 1.72
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev (2005) 1.49
An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease. J Alzheimers Dis (2011) 1.45
Metabolic syndrome and health-related quality of life: does psychological well-being matter? Ann Epidemiol (2008) 1.40
Comorbidities of chronic obstructive pulmonary disease. Curr Opin Pulm Med (2011) 1.23
Comorbidity and social factors predicted hospitalization in frail elderly patients. J Clin Epidemiol (2004) 1.20
Moving against frailty: does physical activity matter? Biogerontology (2010) 1.19
Impact of telemonitoring at home on the management of elderly patients with congestive heart failure. J Telemed Telecare (2008) 1.17
Prevalence and risk factors for falls in an older community-dwelling population. J Gerontol A Biol Sci Med Sci (2002) 1.13
Chronic renal failure: a neglected comorbidity of COPD. Chest (2009) 1.12
Serum ionized magnesium levels in relation to metabolic syndrome in type 2 diabetic patients. J Am Coll Nutr (2006) 1.12
Potentially inappropriate drug prescriptions and risk of hospitalization among older, Italian, nursing home residents: the ULISSE project. Drugs Aging (2010) 1.11
From chronic low back pain to disability, a multifactorial mediated pathway: the InCHIANTI study. Spine (Phila Pa 1976) (2007) 1.10
Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. Mol Cell Endocrinol (2008) 1.09
Physical activity and mortality in frail, community-living elderly patients. J Gerontol A Biol Sci Med Sci (2004) 1.09
Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease. PLoS One (2010) 1.06
The economic burden of inappropriate drug prescribing, lack of adherence and compliance, adverse drug events in older people: a systematic review. Drug Saf (2012) 1.05
-174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer. Clin Cancer Res (2003) 1.05
Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) (2011) 1.05
Adverse drug events as a cause of hospitalization in older adults. Drug Saf (2012) 1.05
The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell (2004) 1.04
Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients. Clin Cancer Res (2003) 1.04
Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity. Exp Gerontol (2004) 1.03
Metformin-induced pancreatitis: A possible adverse drug effect during acute renal failure. Diabetes Care (2006) 1.03
Construct validity of the Short Form-36 Health Survey and its relationship with BMI in obese outpatients. Obesity (Silver Spring) (2006) 1.02
Underprescription of beneficial medicines in older people: causes, consequences and prevention. Drugs Aging (2012) 1.02
Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. Exp Gerontol (2004) 1.01
Clinorotation-induced weightlessness influences the cytoskeleton of glial cells in culture. Brain Res (2002) 1.01
Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest. Am J Clin Nutr (2008) 1.01
Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging (2003) 1.01
Microgravity as a model of ageing. Curr Opin Clin Nutr Metab Care (2003) 1.00
Polypharmacy in elderly patients at discharge from the acute care hospital. Ther Clin Risk Manag (2007) 0.99
Metabolic consequences of incorrect insulin administration techniques in aging subjects with diabetes. Acta Diabetol (2010) 0.99
Polypharmacy and health outcomes among older adults discharged from hospital: results from the CRIME study. Geriatr Gerontol Int (2014) 0.98
Rosiglitazone and cognitive stability in older individuals with type 2 diabetes and mild cognitive impairment. Diabetes Care (2010) 0.98
What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians. Exp Gerontol (2002) 0.97
Indwelling urethral catheter and mortality in frail elderly women living in community. Neurourol Urodyn (2004) 0.97
Potentially inappropriate medication in elderly hospitalized patients. Drugs Aging (2009) 0.97
Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study. CNS Drugs (2010) 0.97
Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects. J Nutr Biochem (2009) 0.97
Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. Mech Ageing Dev (2005) 0.96
Regimen complexity and medication nonadherence in elderly patients. Ther Clin Risk Manag (2009) 0.96
Potentially inappropriate medications and functional decline in elderly hospitalized patients. J Am Geriatr Soc (2009) 0.95
p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes. Biochem Biophys Res Commun (2002) 0.95
Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD). Curr Neuropharmacol (2008) 0.95
Predictors of hospitalization in Italian nursing home residents: the U.L.I.S.S.E. project. J Am Med Dir Assoc (2011) 0.95
Is chronic inflammation a determinant of blood pressure in the elderly? Am J Hypertens (2003) 0.94
Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes. Aging (Albany NY) (2013) 0.94
Prognostic significance of the short physical performance battery in older patients discharged from acute care hospitals. Rejuvenation Res (2011) 0.93
Screening of cognitive impairment in chronic obstructive pulmonary disease. Dement Geriatr Cogn Disord (2007) 0.92
The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing. Exp Gerontol (2004) 0.92
Prognostic stratification of elderly patients in the emergency department: a comparison between the "Identification of Seniors at Risk" and the "Silver Code". J Gerontol A Biol Sci Med Sci (2011) 0.92
The impact of long-term exposure to space environment on adult mammalian organisms: a study on mouse thyroid and testis. PLoS One (2012) 0.92
The role of IL-1 gene cluster in longevity: a study in Italian population. Mech Ageing Dev (2003) 0.92
Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians. Exp Gerontol (2002) 0.92
Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. Eur J Hum Genet (2002) 0.91
Potentially reversible risk factors and urinary incontinence in frail older people living in community. Age Ageing (2003) 0.91
Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics. Exp Gerontol (2007) 0.91
Conventional and novel diagnostic biomarkers of acute myocardial infarction: a promising role for circulating microRNAs. Biomarkers (2013) 0.90
Paraoxonase 1: genetics and activities during aging. Rejuvenation Res (2008) 0.89
Treatment of severe pulmonary hypertension secondary to scleroderma: a three-drug approach. Intern Med (2008) 0.89
A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity. J Gerontol A Biol Sci Med Sci (2006) 0.89
Targeting inflammation to slow or delay functional decline: where are we? Biogerontology (2010) 0.89
A novel, population-specific approach to define frailty. Age (Dordr) (2010) 0.89
Estimating renal function in older people: a comparison of three formulas. Age Ageing (2006) 0.88
Underrecognition and undertreatment of dementia in Italian nursing homes. J Am Med Dir Assoc (2012) 0.88
Feeding behavior in mammals including humans. Ann N Y Acad Sci (2009) 0.88
Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population. Biogerontology (2009) 0.88
Tumor necrosis factor-alpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers. Coron Artery Dis (2005) 0.88
Circulating microRNAs (miRs) for diagnosing acute myocardial infarction: an exciting challenge. Int J Cardiol (2012) 0.88
The economic burden of chronic obstructive pulmonary disease in the elderly: results from a systematic review of the literature. Curr Opin Pulm Med (2011) 0.87
Construct validity of activities of daily living scale: a clue to distinguish the disabling effects of COPD and congestive heart failure. Chest (2005) 0.86
Chronic kidney disease and 1-year survival in elderly patients discharged from acute care hospitals: a comparison of three glomerular filtration rate equations. Nephrol Dial Transplant (2010) 0.86
Consensus Document on substitution therapy with DHEA in the elderly. Aging Clin Exp Res (2006) 0.86
Risk stratification of older patients in the emergency department: comparison between the Identification of Seniors at Risk and Triage Risk Screening Tool. Rejuvenation Res (2012) 0.86
Relationship between renal function and physical performance in elderly hospitalized patients. Rejuvenation Res (2012) 0.85
An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. Gene (2002) 0.85
Relationship between renal function and functional decline: role of the estimating equation. J Am Med Dir Assoc (2011) 0.85
Predicting microRNA modulation in human prostate cancer using a simple String IDentifier (SID1.0). J Biomed Inform (2011) 0.85
Depression, hypertension, and comorbidity: disentangling their specific effect on disability and cognitive impairment in older subjects. Arch Gerontol Geriatr (2010) 0.85
Reliability of equations to estimate glomerular filtration rate in the very old. Aging Clin Exp Res (2008) 0.85
The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients. Int J Cardiol (2005) 0.85
Opioids for the treatment of chronic non-cancer pain in older people. Drugs Aging (2009) 0.85