Published in Aging (Albany NY) on May 01, 2013
Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring. Aging (Albany NY) (2015) 1.15
The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell Stress Chaperones (2014) 1.00
An integrative review of factors associated with telomere length and implications for biobehavioral research. Nurs Res (2013) 0.97
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Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. PLoS Genet (2015) 0.90
The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms. Biomed Res Int (2014) 0.84
Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative. Biogerontology (2015) 0.77
Investigation of the 5q33.3 longevity locus and age-related phenotypes. Aging (Albany NY) (2017) 0.75
Differential burden of rare protein truncating variants in Alzheimer's disease patients compared to centenarians. Hum Mol Genet (2016) 0.75
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Transcriptome analysis in blood cells from children reveals potential early biomarkers of metabolic alterations. Int J Obes (Lond) (2017) 0.75
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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
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A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet (2008) 13.95
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol (2000) 9.85
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A map of open chromatin in human pancreatic islets. Nat Genet (2010) 6.75
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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
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A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet (2010) 3.25
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet (2010) 3.24
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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81
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Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34
Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J Am Geriatr Soc (2009) 2.30
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab (2010) 2.21
Clinical phenotype of families with longevity. J Am Geriatr Soc (2004) 2.03
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet (2009) 2.02
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The role of epigenetics in the pathology of diabetic complications. Am J Physiol Renal Physiol (2010) 1.83
Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes (2008) 1.80
Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care (2003) 1.72
Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. Hum Mol Genet (2008) 1.65
Centenarians as a model for healthy aging. Biochem Soc Trans (2003) 1.63
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2. Am J Hum Genet (2003) 1.62
Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort. Diabetologia (2006) 1.53
Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol Metab (2009) 1.46
An algorithm for modularity analysis of directed and weighted biological networks based on edge-betweenness centrality. Bioinformatics (2006) 1.37
Association testing of previously reported variants in a large case-control meta-analysis of diabetic nephropathy. Diabetes (2012) 1.36
Familial longevity is marked by enhanced insulin sensitivity. Aging Cell (2010) 1.32
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Gene finding in genetically isolated populations. Hum Mol Genet (2002) 1.29
Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease. Eur Heart J (2009) 1.14
MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr) (2012) 1.13
Glucose tolerance and insulin action in healty centenarians. Am J Physiol (1996) 1.13
Characterization of protein-interaction networks in tumors. BMC Bioinformatics (2007) 1.13
TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden. Eur J Hum Genet (2007) 1.11
Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction. Atherosclerosis (2009) 1.09
Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo. Diabetologia (2010) 1.07
Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole. PLoS One (2011) 1.04
Topology of mammalian transcription networks. Genome Inform (2005) 1.04
Leukocyte telomere length is associated with complications of type 2 diabetes mellitus. Diabet Med (2011) 1.03
Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetologia (2011) 1.03
Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. PLoS One (2010) 1.01
Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians' offspring. Aging (Albany NY) (2012) 1.01
Effect of type 2 diabetes predisposing genetic variants on colorectal cancer risk. J Clin Endocrinol Metab (2012) 0.98
Discovery of functional gene variants associated with human longevity: opportunities and challenges. J Gerontol A Biol Sci Med Sci (2011) 0.96
The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur J Neurosci (2012) 0.95
Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis. PLoS One (2011) 0.95
TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy. Acta Diabetol (2012) 0.94
Simple method for haplotyping the poly(TG) repeat in individuals carrying the IVS8 5T allele in the CFTR gene. Clin Chem (2007) 0.93
The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective. Cell Biosci (2012) 0.93
Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children. Int J Obes (Lond) (2012) 0.90
Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes. Am J Clin Nutr (2012) 0.89
Why diabetes patients are more prone to the development of colon cancer? Med Hypotheses (2008) 0.88
Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes. Neurology (2011) 0.88
Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis. Rev Diabet Stud (2011) 0.87
The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity gene FTO. Obes Rev (2012) 0.86
Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients. Diabetes Res Clin Pract (2005) 0.86
Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes. Exp Gerontol (2001) 0.85
Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes. Age (Dordr) (2011) 0.85
Insulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cells. Biochim Biophys Acta (2010) 0.84
Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs. Diabetes Res Clin Pract (2012) 0.83
Risk profiles in type 2 diabetes (metabolic syndrome): integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications. Curr Pharm Des (2010) 0.82
Isolated populations as treasure troves in genetic epidemiology: the case of the Basques. Eur J Hum Genet (2009) 0.82
The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: a cross-sectional study. Acta Diabetol (2012) 0.80
Association of polymorphic markers of the catalase and superoxide dismutase genes with type 2 diabetes mellitus. DNA Cell Biol (2012) 0.80
Variations at the H-strand replication origins of mitochondrial DNA and mitochondrial DNA content in the blood of type 2 diabetes patients. Biochim Biophys Acta (2009) 0.80
Impact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy. Diabetes Care (2012) 0.78
Associations between longevity of parents and glucose regulation in their offspring: the KORA S4/F4 Study. Diabetologia (2012) 0.77
Chronic renal impairment and DDAH2-1151 A/C polymorphism determine ADMA levels in type 2 diabetic subjects. Nephrol Dial Transplant (2012) 0.76
Coronary microvascular dysfunction in patients with cardiomyopathies. Circ Heart Fail (2008) 0.76
International network of cancer genome projects. Nature (2010) 20.35
The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla. Nature (2007) 18.04
Annotating genomes with massive-scale RNA sequencing. Genome Biol (2008) 7.73
Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation (2002) 6.26
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev (2006) 5.61
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57
The role of selection in the evolution of human mitochondrial genomes. Genetics (2005) 4.56
Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes (2008) 4.05
Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature (2006) 4.00
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med (2007) 3.67
Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One (2010) 3.64
How do we define cure of diabetes? Diabetes Care (2009) 3.59
Liver enzyme alteration: a guide for clinicians. CMAJ (2005) 3.42
Diagnostic potential of circulating miR-499-5p in elderly patients with acute non ST-elevation myocardial infarction. Int J Cardiol (2012) 3.20
Microsatellite variation and evolution of human lactase persistence. Hum Genet (2005) 3.20
Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes (2003) 3.20
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics (2005) 3.19
Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial. Ann Intern Med (2009) 3.16
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol (2005) 3.06
MYO1E mutations and childhood familial focal segmental glomerulosclerosis. N Engl J Med (2011) 2.65
Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation (2008) 2.65
Platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices: results of a multicenter, prospective, validation study. Am J Gastroenterol (2006) 2.64
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab (2003) 2.51
Characterization of transcriptional complexity during berry development in Vitis vinifera using RNA-Seq. Plant Physiol (2010) 2.46
DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44
Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab (2003) 2.40
Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett (2005) 2.30
Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma. Clin Gastroenterol Hepatol (2006) 2.26
The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell (2008) 2.25
Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging. Proc Natl Acad Sci U S A (2010) 2.14
T cells and aging, January 2002 update. Front Biosci (2002) 2.14
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell (2004) 2.11
Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) (2008) 2.09
Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing (2005) 1.99
Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci (2004) 1.96
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci (2007) 1.87
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol (2007) 1.86
The effects of diet on inflammation: emphasis on the metabolic syndrome. J Am Coll Cardiol (2006) 1.83
Validity and clinical utility of the aspartate aminotransferase-alanine aminotransferase ratio in assessing disease severity and prognosis in patients with hepatitis C virus-related chronic liver disease. Arch Intern Med (2003) 1.80
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A (2008) 1.80
Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol (2006) 1.79
Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab (2003) 1.79
Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab (2002) 1.76
The grapevine expression atlas reveals a deep transcriptome shift driving the entire plant into a maturation program. Plant Cell (2012) 1.75
Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants. Mutat Res (2011) 1.75
Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects. J Immunol (2007) 1.73
A simple approach to noninvasively identifying significant fibrosis in chronic hepatitis C patients in clinical practice. J Clin Gastroenterol (2006) 1.69
Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis (2005) 1.66
Genetics of longevity and aging. Annu Rev Med (2005) 1.65
The plasticity of the grapevine berry transcriptome. Genome Biol (2013) 1.65
The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS Genet (2009) 1.64
Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab Res Rev (2006) 1.63
Accelerated epigenetic aging in Down syndrome. Aging Cell (2015) 1.61
Arabidopsis nonsymbiotic hemoglobin AHb1 modulates nitric oxide bioactivity. Plant Cell (2004) 1.61
Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene pool. Am J Hum Genet (2012) 1.60
S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration. Plant Cell (2007) 1.59
NO signals in the haze: nitric oxide signalling in plant defence. Curr Opin Plant Biol (2009) 1.58
What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment? Mech Ageing Dev (2005) 1.57
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific. Aging Cell (2013) 1.56
Direct, genome-wide assessment of DNA mutations in single cells. Nucleic Acids Res (2011) 1.56
Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell (2003) 1.55
On the origins and admixture of Malagasy: new evidence from high-resolution analyses of paternal and maternal lineages. Mol Biol Evol (2009) 1.54
Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A (2002) 1.54
Laparoscopic splenectomy: a single center experience. Unusual cases and expanded inclusion criteria for laparoscopic approach. Updates Surg (2013) 1.54
Fine characterization of the Iceman's mtDNA haplogroup. Am J Phys Anthropol (2006) 1.52
On the edge of Bantu expansions: mtDNA, Y chromosome and lactase persistence genetic variation in southwestern Angola. BMC Evol Biol (2009) 1.51
Deterioration of insulin sensitivity and glucose effectiveness with age and hypertension. Am J Hypertens (2006) 1.50
Cardiovascular health in migrants: current status and issues for prevention. A collaborative multidisciplinary task force report. J Cardiovasc Med (Hagerstown) (2014) 1.50
Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes. J Clin Endocrinol Metab (2008) 1.49
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev (2005) 1.49
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48