Published in Nat Cell Biol on March 01, 2013
microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis. Adv Exp Med Biol (2015) 0.89
Overexpression and knockout of miR-126 both promote leukemogenesis. Blood (2015) 0.88
MicroRNAs as pharmacological targets in diabetes. Pharmacol Res (2013) 0.88
Prometastatic GPCR CD97 is a direct target of tumor suppressor microRNA-126. ACS Chem Biol (2013) 0.86
Role of Exosomal Noncoding RNAs in Lung Carcinogenesis. Biomed Res Int (2015) 0.77
The regulation of tumor-suppressive microRNA, miR-126, in chronic lymphocytic leukemia. Cancer Med (2017) 0.75
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20
Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell (2008) 6.59
Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07
MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer (2009) 5.47
Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res (2007) 3.76
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature (2011) 3.60
The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature (2004) 2.95
CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell (2012) 1.97
Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem (2009) 1.81
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol (2013) 1.79
Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun (2008) 1.74
miR-126 and miR-126*: new players in cancer. ScientificWorldJournal (2010) 1.56
Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer. Int J Cancer (2011) 1.11
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem (2008) 10.08
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82
Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res (2007) 3.63
Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest (2012) 3.45
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell (2011) 3.32
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell (2011) 3.23
Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res (2010) 2.88
Tumor metastasis: moving new biological insights into the clinic. Nat Med (2013) 2.71
Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev (2009) 2.59
The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol (2009) 2.56
Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol (2012) 2.46
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39
Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat Med (2009) 2.10
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05
The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res (2009) 1.89
Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Mol Cell Biol (2002) 1.86
Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem (2009) 1.81
Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. Cancer Cell (2013) 1.62
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem (2012) 1.58
Cell fusion as a hidden force in tumor progression. Cancer Res (2009) 1.51
Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia (2007) 1.49
Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis. Mol Cancer (2010) 1.45
Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci U S A (2009) 1.45
The metastasis-promoting roles of tumor-associated immune cells. J Mol Med (Berl) (2013) 1.40
Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Stem Cells (2012) 1.37
Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. J Biol Chem (2010) 1.36
Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J Biol Chem (2011) 1.33
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res (2010) 1.31
Targeting the transforming growth factor-beta signalling pathway in metastatic cancer. Eur J Cancer (2010) 1.27
MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. J Transl Med (2011) 1.22
EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J Biol Chem (2007) 1.22
Global secretome analysis identifies novel mediators of bone metastasis. Cell Res (2012) 1.22
Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy (2014) 1.14
From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer. Cell Res (2011) 1.12
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun (2013) 1.08
SnapShot: Bone Metastasis. Cell (2012) 1.07
A quantitative atlas of histone modification signatures from human cancer cells. Epigenetics Chromatin (2013) 1.06
Optimization of duplex stability and terminal asymmetry for shRNA design. PLoS One (2010) 1.05
Role of RANK, RANKL, OPG, and CXCR4 tissue markers in predicting bone metastases in breast cancer patients. Clin Breast Cancer (2011) 1.03
Dysregulation of developmental pathways in bone metastasis. Bone (2010) 0.99
Rabconnectin-3 is a functional regulator of mammalian Notch signaling. J Biol Chem (2010) 0.98
Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. J Bone Miner Res (2011) 0.97
MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett (2013) 0.97
Metadherin as a link between metastasis and chemoresistance. Cell Cycle (2009) 0.95
Bone metastases detection by circulating biomarkers: OPG and RANK-L. Int J Oncol (2011) 0.95
The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. Proc Natl Acad Sci U S A (2002) 0.94
Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int J Cancer (2013) 0.94
The endoplasmic reticulum acts as a platform for ubiquitylated components of nuclear factor κB signaling. Sci Signal (2013) 0.94
A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy. PLoS One (2009) 0.93
Signaling pathways in breast cancer metastasis - novel insights from functional genomics. Breast Cancer Res (2011) 0.92
Transcriptional control of cancer metastasis. Trends Cell Biol (2013) 0.92
Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer. Adv Cancer Res (2013) 0.91
Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. Proc Natl Acad Sci U S A (2013) 0.90
Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement. Cell Res (2010) 0.89
DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest (2014) 0.89
Current preclinical models for the advancement of translational bladder cancer research. Mol Cancer Ther (2012) 0.87
The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells. EMBO Rep (2012) 0.87
Cell fusion hypothesis of the cancer stem cell. Adv Exp Med Biol (2011) 0.85
Detection of a common chimeric transcript between human chromosomes 7 and 16. Biol Direct (2012) 0.83
Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab (2016) 0.82
MicroRNAs as regulators of tumor-associated stromal cells. Oncotarget (2013) 0.80
From breast to the brain: unraveling the puzzle of metastasis organotropism. J Mol Cell Biol (2009) 0.80
Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Rep (2012) 0.80
Comparative functional characterization of the feline foamy virus transactivator reveals its species specificity. Virology (2004) 0.78
Acute infection induces a metastatic niche: a double menace for cancer patients. Clin Cancer Res (2013) 0.78
Transplantable mouse tumor models of breast cancer metastasis. Methods Mol Biol (2015) 0.77
Metalloproteinases and osteoblast EGFR signaling in osteolytic bone metastasis of breast cancer. Cell Cycle (2009) 0.76
Increased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization. Sci Rep (2015) 0.75
Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2016) 0.75