miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

PubWeight™: 1.79‹?› | Rank: Top 3%

🔗 View Article (PMC 3672398)

Published in Nat Cell Biol on February 10, 2013

Authors

Yun Zhang1, Pengyuan Yang, Tao Sun, Dong Li, Xin Xu, Yaocheng Rui, Chaoran Li, Mengyang Chong, Toni Ibrahim, Laura Mercatali, Dino Amadori, Xincheng Lu, Dong Xie, Qi-Jing Li, Xiao-Fan Wang

Author Affiliations

1: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Articles citing this

Control of metastatic progression by microRNA regulatory networks. Nat Cell Biol (2013) 1.73

Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity. J Am Soc Nephrol (2014) 1.57

Regulation of microRNAs in cancer metastasis. Biochim Biophys Acta (2014) 1.53

Lessons from miR-143/145: the importance of cell-type localization of miRNAs. Nucleic Acids Res (2014) 1.34

Microenvironmental regulation of cancer metastasis by miRNAs. Trends Cell Biol (2013) 1.20

MicroRNAs as mediators and communicators between cancer cells and the tumor microenvironment. Oncogene (2015) 1.16

microRNA-mediated regulation of the tumor microenvironment. Cell Cycle (2013) 1.14

miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. Clin Cancer Res (2014) 1.11

MicroRNA regulons in tumor microenvironment. Oncogene (2014) 1.08

Mechanisms of endocrine resistance in breast cancer: an overview of the proposed roles of noncoding RNA. Breast Cancer Res (2015) 1.08

CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks. Oncogene (2015) 1.07

miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells. Oncotarget (2015) 1.00

MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1. Sci Rep (2015) 1.00

Identification and validation of miRNAs as endogenous controls for RQ-PCR in blood specimens for breast cancer studies. PLoS One (2013) 0.99

Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells. Aging (Albany NY) (2014) 0.99

MicroRNAs: regulators of cancer metastasis and epithelial-mesenchymal transition (EMT). Chin J Cancer (2013) 0.95

Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis. Cell Rep (2014) 0.94

Chemokines and microRNAs in atherosclerosis. Cell Mol Life Sci (2015) 0.94

Association of microRNA-126 expression with clinicopathological features and the risk of biochemical recurrence in prostate cancer patients undergoing radical prostatectomy. Diagn Pathol (2013) 0.93

Association between mir-24 and mir-378 in formalin-fixed paraffin-embedded tissues of breast cancer. Int J Clin Exp Pathol (2014) 0.93

Tumor tissue microRNA expression in association with triple-negative breast cancer outcomes. Breast Cancer Res Treat (2015) 0.91

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway. Stem Cell Res Ther (2015) 0.90

Usefulness of circulating microRNAs for the prediction of early preeclampsia at first-trimester of pregnancy. Sci Rep (2014) 0.90

RASAL2 activates RAC1 to promote triple-negative breast cancer progression. J Clin Invest (2014) 0.90

MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer. Mol Cancer (2015) 0.89

Tumor-associated stromal cells as key contributors to the tumor microenvironment. Breast Cancer Res (2016) 0.89

The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases. J Cell Mol Med (2014) 0.89

Targeting microRNAs as key modulators of tumor immune response. J Exp Clin Cancer Res (2016) 0.89

Overexpression and knockout of miR-126 both promote leukemogenesis. Blood (2015) 0.88

MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells. J Biomed Sci (2014) 0.87

microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway. PLoS One (2013) 0.86

Prometastatic GPCR CD97 is a direct target of tumor suppressor microRNA-126. ACS Chem Biol (2013) 0.86

Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b. Oncotarget (2015) 0.86

Frequent co-expression of miRNA-5p and -3p species and cross-targeting in induced pluripotent stem cells. Int J Med Sci (2014) 0.85

Harnessing the immune system for the treatment of breast cancer. J Zhejiang Univ Sci B (2014) 0.85

Over-expression of miR-98 in FFPE tissues might serve as a valuable source for biomarker discovery in breast cancer patients. Int J Clin Exp Pathol (2014) 0.84

SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1. Am J Cancer Res (2015) 0.83

The roles of microRNAs in the regulation of tumor metastasis. Cell Biosci (2015) 0.82

A one-two punch of miR-126/126* against metastasis. Nat Cell Biol (2013) 0.82

MiR-126 Contributes to Human Umbilical Cord Blood Cell-Induced Neurorestorative Effects After Stroke in Type-2 Diabetic Mice. Stem Cells (2016) 0.82

p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion. Int J Cancer (2014) 0.82

Intra-tumoural vessel area estimated by expression of epidermal growth factor-like domain 7 and microRNA-126 in primary tumours and metastases of patients with colorectal cancer: a descriptive study. J Transl Med (2015) 0.81

Microenvironment, oncoantigens, and antitumor vaccination: lessons learned from BALB-neuT mice. Biomed Res Int (2014) 0.81

Metastasis: an early event in cancer progression. J Cancer Res Clin Oncol (2016) 0.81

Bone and cancer: the osteoncology. Clin Cases Miner Bone Metab (2013) 0.80

Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis. Oncotarget (2016) 0.80

MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer. Oncotarget (2016) 0.80

Essential role of miRNAs in orchestrating the biology of the tumor microenvironment. Mol Cancer (2016) 0.80

MicroRNA biogenesis and their functions in regulating stem cell potency and differentiation. Biol Proced Online (2016) 0.79

Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis. Chin J Cancer (2017) 0.78

miR-16-5p Is a Stably-Expressed Housekeeping MicroRNA in Breast Cancer Tissues from Primary Tumors and from Metastatic Sites. Int J Mol Sci (2016) 0.78

MicroRNA-126 inhibits tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression. Oncotarget (2016) 0.77

MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2. Cell Death Dis (2017) 0.77

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets. Nat Rev Drug Discov (2016) 0.77

MicroRNA analysis of breast ductal fluid in breast cancer patients. Int J Oncol (2016) 0.77

Coordinated post-transcriptional regulation of the chemokine system: messages from CCL2. J Interferon Cytokine Res (2014) 0.77

Breast cancer: coordinated regulation of CCL2 secretion by intracellular glycosaminoglycans and chemokine motifs. Neoplasia (2014) 0.77

Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment. Food Chem Toxicol (2016) 0.76

Inflamma-miRs in Aging and Breast Cancer: Are They Reliable Players? Front Med (Lausanne) (2015) 0.76

AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression. Oncogene (2015) 0.76

A step-by-step microRNA guide to cancer development and metastasis. Cell Oncol (Dordr) (2017) 0.75

Using a systems biology approach to understand and study the mechanisms of metastasis. Wiley Interdiscip Rev Syst Biol Med (2013) 0.75

Identification of Biomarkers for Breast Cancer Using Databases. J Cancer Prev (2016) 0.75

microRNAs and Prostate Cancer. Adv Exp Med Biol (2015) 0.75

Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms. Int J Mol Sci (2017) 0.75

Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer. J Hum Genet (2016) 0.75

MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium. Sci Rep (2017) 0.75

The metastasis suppressor RARRES3 as an endogenous inhibitor of the immunoproteasome expression in breast cancer cells. Sci Rep (2017) 0.75

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1. Oncotarget (2017) 0.75

Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma. Stem Cell Reports (2016) 0.75

Export of microRNAs: A Bridge between Breast Carcinoma and Their Neighboring Cells. Front Oncol (2016) 0.75

SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis. Mol Cancer (2017) 0.75

Sphingosine 1-Phosphate Receptor 2 Regulates the Migration, Proliferation, and Differentiation of Mesenchymal Stem Cells. Int J Stem Cell Res Ther (2015) 0.75

Irisin Inhibits Atherosclerosis by Promoting Endothelial Proliferation Through microRNA126-5p. J Am Heart Assoc (2016) 0.75

MicroRNA-126 inhibits tumor cell invasion and metastasis by downregulating ROCK1 in renal cell carcinoma. Mol Med Rep (2016) 0.75

Variant rs1801157 in the 3'UTR of SDF-1ß does not explain variability of healthy-donor G-CSF responsiveness. PLoS One (2015) 0.75

Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury. Epigenetics Chromatin (2016) 0.75

Liquid biopsy: a step forward towards precision medicine in urologic malignancies. Mol Cancer (2017) 0.75

Surprisal analysis of Glioblastoma Multiform (GBM) microRNA dynamics unveils tumor specific phenotype. PLoS One (2014) 0.75

MicroRNA miR-126-5p Enhances the Inflammatory Responses of Monocytes to Lipopolysaccharide Stimulation by Suppressing Cylindromatosis in Chronic HIV-1 Infection. J Virol (2017) 0.75

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib. Clin Transl Med (2017) 0.75

MicroRNAs in the development and neoplasia of the mammary gland. F1000Res (2017) 0.75

Articles cited by this

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Hallmarks of cancer: the next generation. Cell (2011) 140.01

Global cancer statistics, 2002. CA Cancer J Clin (2005) 119.22

A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53

Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol (2009) 19.99

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20

The microRNA.org resource: targets and expression. Nucleic Acids Res (2007) 16.26

Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20

A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell (2006) 14.70

MethPrimer: designing primers for methylation PCRs. Bioinformatics (2002) 14.48

Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37

Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature (2009) 14.07

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods (2007) 13.94

A perspective on cancer cell metastasis. Science (2011) 13.31

Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res (1992) 9.02

CLIP identifies Nova-regulated RNA networks in the brain. Science (2003) 8.88

Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell (2012) 8.71

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature (2011) 8.62

RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell (2007) 7.06

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med (2005) 7.01

The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J Exp Med (1997) 6.39

MicroRNAs--the micro steering wheel of tumour metastases. Nat Rev Cancer (2009) 5.47

Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer (2011) 5.12

CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci U S A (2007) 3.85

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A (2003) 3.72

The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells (2007) 3.68

A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature (2011) 3.60

A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protoc (2009) 3.53

Characterization of mesenchymal stem cells isolated from murine bone marrow by negative selection. J Cell Biochem (2003) 3.40

Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells (2006) 2.85

Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum (2009) 2.64

TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell (2012) 2.60

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility. Nat Cell Biol (2010) 2.53

Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br J Haematol (2003) 2.52

CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res (2005) 2.38

Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4. Cancer Res (2004) 2.31

MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun (2008) 2.15

The type III TGF-beta receptor suppresses breast cancer progression. J Clin Invest (2006) 2.06

Inhibition of microRNA function by antimiR oligonucleotides. Silence (2012) 2.02

Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev (2008) 2.00

Recent advances into the understanding of mesenchymal stem cell trafficking. Br J Haematol (2007) 1.84

Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun (2008) 1.74

Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71

Articles by these authors

The diploid genome sequence of an Asian individual. Nature (2008) 46.29

A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78

Bayesian phylogenetics with BEAUti and the BEAST 1.7. Mol Biol Evol (2012) 32.00

HDAC6 is a microtubule-associated deacetylase. Nature (2002) 12.76

Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69

Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol (2006) 6.95

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell (2002) 5.64

Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57

miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet (2009) 4.38

RePS: a sequence assembler that masks exact repeats identified from the shotgun data. Genome Res (2002) 4.35

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16

Genome-wide patterns of genetic variation among elite maize inbred lines. Nat Genet (2010) 4.06

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78

Efficacy and safety of 12-weekly versus 4-weekly zoledronic acid for prolonged treatment of patients with bone metastases from breast cancer (ZOOM): a phase 3, open-label, randomised, non-inferiority trial. Lancet Oncol (2013) 3.67

Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res (2009) 3.66

Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell (2004) 3.63

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature (2005) 3.55

A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52

Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature (2013) 3.40

Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell (2011) 3.39

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater (2009) 3.30

Switching to anastrozole versus continued tamoxifen treatment of early breast cancer: preliminary results of the Italian Tamoxifen Anastrozole Trial. J Clin Oncol (2005) 3.19

Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA (2011) 3.16

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol (2011) 3.12

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation (2007) 3.07

Notch promotes radioresistance of glioma stem cells. Stem Cells (2010) 3.07

Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog (2009) 3.05

miR-214 targets ATF4 to inhibit bone formation. Nat Med (2012) 3.01

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol (2010) 2.95

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95

DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell (2010) 2.87

Draft genome of the wheat A-genome progenitor Triticum urartu. Nature (2013) 2.86

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol (2002) 2.83

Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res (2009) 2.82

Palliative sedation in end-of-life care and survival: a systematic review. J Clin Oncol (2012) 2.77

The global breast cancer burden: variations in epidemiology and survival. Clin Breast Cancer (2005) 2.69

Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science (2009) 2.68

TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell (2012) 2.60

Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell (2005) 2.52

Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol (2005) 2.51

Cysteine cathepsins: from structure, function and regulation to new frontiers. Biochim Biophys Acta (2011) 2.50

Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol (2004) 2.49

A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet (2004) 2.47

Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol (2012) 2.46

Endothelial cell recovery between comparator polymer-based drug-eluting stents. J Am Coll Cardiol (2008) 2.45

Gold nanocages as contrast agents for spectroscopic optical coherence tomography. Opt Lett (2005) 2.44

CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers. Cancer Lett (2007) 2.43

MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. Biochem Biophys Res Commun (2009) 2.39

Gemcitabine plus cisplatin versus gemcitabine plus carboplatin as first-line chemotherapy in advanced transitional cell carcinoma of the urothelium: results of a randomized phase 2 trial. Eur Urol (2006) 2.38

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol (2009) 2.38

Relevance of urine telomerase in the diagnosis of bladder cancer. JAMA (2005) 2.31

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science (2003) 2.31

Managing chronic pain: results from an open-label study using MC5-A Calmare® device. Support Care Cancer (2011) 2.29

Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol (2002) 2.26

Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol (2004) 2.25

Antimicrobial nanomaterials for water disinfection and microbial control: potential applications and implications. Water Res (2008) 2.23

Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension (2007) 2.20

Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. Kidney Int (2010) 2.18

IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol (2008) 2.17

The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Res (2008) 2.17

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell (2006) 2.15

Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev (2006) 2.15

Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol (2010) 2.12

Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles. Arterioscler Thromb Vasc Biol (2006) 2.12

Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma. Neuro Oncol (2006) 2.11

Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity (2007) 2.11

Duration of chemotherapy for metastatic breast cancer: a systematic review and meta-analysis of randomized clinical trials. J Clin Oncol (2011) 2.10

Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers. Mol Cell Biol (2005) 2.06

Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A (2010) 2.05

Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A (2006) 2.04

Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03

Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Genes Dev (2008) 2.00

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci U S A (2010) 1.99

An MRI-based atlas and database of the developing mouse brain. Neuroimage (2010) 1.99

Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells (2009) 1.97

miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA. EMBO Rep (2008) 1.96

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 1.94

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling. Genes Dev (2008) 1.93

Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat (2009) 1.90

Estimating the basic reproductive number from viral sequence data. Mol Biol Evol (2011) 1.86

Disposition of caspofungin: role of distribution in determining pharmacokinetics in plasma. Antimicrob Agents Chemother (2004) 1.86

Concern WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.84

Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system. Dev Dyn (2009) 1.83

Local accumulation of FOXP3+ regulatory T cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. J Immunol (2008) 1.83

Peroxisome proliferator-activated receptor alpha agonists increase nitric oxide synthase expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol (2004) 1.83

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol (2002) 1.81

Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood (2011) 1.80

Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritis. Arthritis Rheum (2005) 1.79

Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer. PLoS One (2007) 1.79