Tumor metastasis: moving new biological insights into the clinic.

Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500. J Clin Oncol (2014) 3.70

MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors. Cancer Cell (2014) 1.70

Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol Med (2014) 1.62

New horizons in tumor microenvironment biology: challenges and opportunities. BMC Med (2015) 1.12

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. Cancer Cell (2014) 1.06

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness. J R Soc Interface (2014) 1.04

Bone marrow as a reservoir for disseminated tumor cells: a special source for liquid biopsy in cancer patients. Bonekey Rep (2014) 0.99

Epithelial to Mesenchymal Transition in a Clinical Perspective. J Oncol (2015) 0.99

Hypoxia-inducible factor 1α (HIF-1α) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1α/CXCR4 pathway in non-small cell lung carcinoma cells. Oncotarget (2015) 0.97

Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression. Oncotarget (2015) 0.96

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A (2014) 0.96

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat Chem Biol (2014) 0.96

Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem (2014) 0.96

Emerging Biological Principles of Metastasis. Cell (2017) 0.94

Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey. Cancer Microenviron (2014) 0.92

The isolation and characterization of CTC subsets related to breast cancer dormancy. Sci Rep (2015) 0.92

The landscape of metastatic progression patterns across major human cancers. Oncotarget (2015) 0.91

Distinctive properties of metastasis-initiating cells. Genes Dev (2016) 0.91

Surviving at a distance: organ specific metastasis. Trends Cancer (2015) 0.90

Bone metastasis and the metastatic niche. J Mol Med (Berl) (2015) 0.90

The biology of circulating tumor cells. Oncogene (2015) 0.90

Molecular targets and pathways involved in liver metastasis of colorectal cancer. Clin Exp Metastasis (2015) 0.90

Skin metastases from lung cancer: a case report. BMC Res Notes (2015) 0.89

A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis. Oncotarget (2015) 0.87

MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1. Protein Cell (2015) 0.86

The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. J Biol Chem (2015) 0.85

Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre-metastatic Niche. Cancer Res (2015) 0.85

Emergent properties of neural repair: elemental biology to therapeutic concepts. Ann Neurol (2016) 0.84

Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth. Oncotarget (2015) 0.84

MicroRNA-92b represses invasion-metastasis cascade of esophageal squamous cell carcinoma. Oncotarget (2016) 0.84

Molecular regulation of bone marrow metastasis in prostate and breast cancer. Bone Marrow Res (2014) 0.84

The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene (2016) 0.83

Prrx1 isoform switching regulates pancreatic cancer invasion and metastatic colonization. Genes Dev (2016) 0.83

The roles of microRNAs in the regulation of tumor metastasis. Cell Biosci (2015) 0.82

Diverse functions of miR-373 in cancer. J Transl Med (2015) 0.82

Negative correlation of ITCH E3 ubiquitin ligase and miRNA-106b dictates metastatic progression in pancreatic cancer. Oncotarget (2016) 0.82

CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis. Oncotarget (2016) 0.82

Fibronectin affects transient MMP2 gene expression through DNA demethylation changes in non-invasive breast cancer cell lines. PLoS One (2014) 0.81

Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma. J Cancer Res Clin Oncol (2015) 0.81

Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res (2014) 0.81

Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. Nat Commun (2015) 0.81

Chemoquiescence for ideal cancer treatment and prevention: where are we now? J Cancer Prev (2014) 0.81

The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma. Nat Commun (2017) 0.80

An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis. Clin Exp Metastasis (2015) 0.80

The emerging molecular machinery and therapeutic targets of metastasis. Trends Pharmacol Sci (2015) 0.80

Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells. World J Gastroenterol (2016) 0.80

Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages. Sci Rep (2016) 0.79

Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest (2016) 0.79

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models. Oncotarget (2015) 0.79

Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma. Bonekey Rep (2015) 0.79

Matricellular proteins: multifaceted extracellular regulators in tumor dormancy. Protein Cell (2014) 0.79

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy. Stem Cells Int (2016) 0.78

Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection. PLoS Genet (2016) 0.78

The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells. Small GTPases (2015) 0.78

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition. Front Pharmacol (2016) 0.77

Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancer. Oncotarget (2016) 0.77

Hierarchical clustering of breast cancer methylomes revealed differentially methylated and expressed breast cancer genes. PLoS One (2015) 0.77

Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy. Cancer Sci (2016) 0.77

Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics. Theranostics (2016) 0.77

The dual role of asporin in breast cancer progression. Oncotarget (2016) 0.77

Brain metastases in gastrointestinal cancers: is there a role for surgery? Int J Mol Sci (2014) 0.77

Transcriptional regulation of tenascin-W by TGF-beta signaling in the bone metastatic niche of breast cancer cells. Int J Cancer (2015) 0.77

Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration. PLoS Comput Biol (2015) 0.77

EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells. Sci Rep (2015) 0.77

MiR-200c promotes bladder cancer cell migration and invasion by directly targeting RECK. Onco Targets Ther (2016) 0.77

Detection of circulating tumor cells with CK20 RT-PCR is an independent negative prognostic marker in colon cancer patients - a prospective study. BMC Cancer (2017) 0.77

Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts. Oncotarget (2017) 0.77

Cancer cells remodel themselves and vasculature to overcome the endothelial barrier. Cancer Lett (2014) 0.76

Evidence that vitronectin is a potent migration-enhancing factor for cancer cells chaperoned by fibrinogen: a novel view of the metastasis of cancer cells to low-fibrinogen lymphatics and body cavities. Oncotarget (2016) 0.76

IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition. Sci Rep (2015) 0.76

Circulating Tumor Cells in the Adenocarcinoma of the Esophagus. Int J Mol Sci (2016) 0.76

Targeting tumor metastases: Drug delivery mechanisms and technologies. J Control Release (2015) 0.76

Circulating and disseminated tumor cells: harbingers or initiators of metastasis? Mol Oncol (2017) 0.76

PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes. JCI Insight (2017) 0.75

Unraveling the Anticancer Effect of Curcumin and Resveratrol. Nutrients (2016) 0.75

Mutational Heterogeneity in Melanoma: An Inconvenient Truth. J Invest Dermatol (2015) 0.75

Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer. Oncotarget (2016) 0.75

MicroRNA-17/20a impedes migration and invasion via TGF-β/ITGB6 pathway in esophageal squamous cell carcinoma. Am J Cancer Res (2016) 0.75

Clonal origin and spread of metastatic prostate cancer. Endocr Relat Cancer (2016) 0.75

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation. Oncotarget (2016) 0.75

Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion. Oncotarget (2016) 0.75

Primary Tumor and MEF Cell Isolation to Study Lung Metastasis. J Vis Exp (2015) 0.75

Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis. Oncotarget (2016) 0.75

Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells. BMC Cancer (2015) 0.75

Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem (2016) 0.75

Tensile Forces Originating from Cancer Spheroids Facilitate Tumor Invasion. PLoS One (2016) 0.75

Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway. PPAR Res (2017) 0.75

Breast Cancer Stem-Like Cells Are Inhibited by Diosgenin, a Steroidal Saponin, by the Attenuation of the Wnt β-Catenin Signaling via the Wnt Antagonist Secreted Frizzled Related Protein-4. Front Pharmacol (2017) 0.75

CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT. Nat Commun (2016) 0.75

RANK-RANKL signalling in cancer. Biosci Rep (2016) 0.75

Retracted FAM172A expression in circulating tumor cells for prediction of high-risk subgroups of colorectal cancer. Onco Targets Ther (2017) 0.75

A Versatile Microarray Platform for Capturing Rare Cells. Sci Rep (2015) 0.75

Means to the ends: The role of telomeres and telomere processing machinery in metastasis. Biochim Biophys Acta (2016) 0.75

The promise of liquid biopsy in cancer: a clinical perspective. Chin J Cancer Res (2015) 0.75

PRL-3 promotes cell adhesion by interacting with JAM2 in colon cancer. Oncol Lett (2016) 0.75

Targeting lemurs against cancer metastasis. Oncotarget (2014) 0.75

Properties of internalization factors contributing to the uptake of extracellular DNA into tumor-initiating stem cells of mouse Krebs-2 cell line. Stem Cell Res Ther (2016) 0.75

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer. Oncotarget (2016) 0.75

Devil's Wake: Early-stage bone colonization by breast cancer. Mol Cell Oncol (2015) 0.75

Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells. Proc Natl Acad Sci U S A (2016) 0.75

Molecular portraits of human breast tumours. Nature (2000) 94.14

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82

Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 67.34

A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med (2002) 58.15

Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med (2011) 45.46

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med (2001) 44.67

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med (2012) 44.56

Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med (2010) 36.78

Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med (2010) 29.75

Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med (2011) 26.90

Cancer genome landscapes. Science (2013) 25.33

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (2010) 23.55

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer (2003) 22.78

Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85

Genome remodelling in a basal-like breast cancer metastasis and xenograft. Nature (2010) 19.68

Cancer metastasis: building a framework. Cell (2006) 19.67

Tumour evolution inferred by single-cell sequencing. Nature (2011) 19.13

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature (2009) 18.08

Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer (2002) 17.49

Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature (2010) 17.38

A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature (2005) 15.57

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20

Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40

Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17

Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med (2009) 13.74

Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med (2008) 13.54

A perspective on cancer cell metastasis. Science (2011) 13.31

Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med (2013) 13.22

Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer (2003) 13.01

Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90

The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature (2010) 12.43

Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88

Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 10.87

Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) 10.68

Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51

Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34

Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med (2009) 10.01

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med (2001) 9.53

EMT and dissemination precede pancreatic tumor formation. Cell (2012) 9.27

Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell (2012) 8.71

CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell (2009) 8.54

Microenvironmental regulation of tumor progression and metastasis. Nat Med (2013) 8.37

Lysyl oxidase is essential for hypoxia-induced metastasis. Nature (2006) 8.28

Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23

Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer (2008) 7.99

Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A (2001) 7.99

Systemic spread is an early step in breast cancer. Cancer Cell (2008) 7.91

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60

A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res (2004) 7.56

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature (2013) 7.42

Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol (2006) 7.20

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05

Interactions between cancer stem cells and their niche govern metastatic colonization. Nature (2011) 6.94

A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med (2005) 6.86

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell (2009) 6.66

Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nat Med (2009) 6.61

Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer (2007) 6.58

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 6.50

Dissecting the metastatic cascade. Nat Rev Cancer (2004) 6.32

Heritability of mammographic density, a risk factor for breast cancer. N Engl J Med (2002) 6.19

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15

Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13

The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 6.07

Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res (2006) 5.90

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol (2006) 5.82

Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov (2011) 5.59

Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17. J Natl Cancer Inst (2005) 5.55

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell (2012) 5.53

Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50

The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28

Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24

Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res (2006) 5.21

Collagen density promotes mammary tumor initiation and progression. BMC Med (2008) 5.13

Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med (2011) 4.91

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature (2013) 4.90

A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell (2012) 4.89

Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg (2005) 4.86

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A (2003) 4.79

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science (2008) 4.71

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell (2010) 4.66

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature (2011) 4.57

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature (2004) 4.53

Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51

Circulating tumor cells in patients with breast cancer dormancy. Clin Cancer Res (2004) 4.48

MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest (2011) 4.43

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. Nat Cell Biol (2009) 4.39

Subtypes of breast cancer show preferential site of relapse. Cancer Res (2008) 4.38

Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell (2012) 4.29

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med (2011) 4.25

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol (2013) 4.11

Genetic heterogeneity and clonal evolution underlying development of asynchronous metastasis in human breast cancer. Cancer Res (1997) 4.02

Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem (2008) 10.08

Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer (2011) 7.69

A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med (2005) 6.86

Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin Cancer Res (2007) 6.59

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10

MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell (2009) 4.47

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat Biotechnol (2013) 4.11

Circulating tumor cells: liquid biopsy of cancer. Clin Chem (2012) 3.87

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82

Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res (2007) 3.63

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest (2012) 3.45

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell (2011) 3.32

VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell (2011) 3.23

Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res (2010) 2.98

Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res (2010) 2.88

The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence. Cancer (2005) 2.74

Review: Biological relevance of disseminated tumor cells in cancer patients. Int J Cancer (2008) 2.72

Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Clin Cancer Res (2010) 2.66

Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64

ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev (2009) 2.59

The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis. RNA Biol (2009) 2.56

Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res (2013) 2.50

Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol (2012) 2.46

Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39

Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clin Cancer Res (2005) 2.31

Circulating tumor cells and circulating tumor DNA. Annu Rev Med (2011) 2.16

HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial. Breast Cancer Res Treat (2010) 2.12

Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res (2005) 2.10

Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat Med (2009) 2.10

Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell (2013) 2.08

Circulating tumor cells and bone marrow micrometastasis. Clin Cancer Res (2008) 2.06

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05

Considerations in the development of circulating tumor cell technology for clinical use. J Transl Med (2012) 2.00

The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res (2009) 1.89

Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. Mol Cell Biol (2002) 1.86

A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer (2006) 1.82

Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem (2009) 1.81

Meta-analysis of the prognostic value of circulating tumor cells in breast cancer. Clin Cancer Res (2012) 1.79

Cancer micrometastasis and tumour dormancy. APMIS (2008) 1.78

ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin Cancer Res (2011) 1.75

High incidence of EMMPRIN expression in human tumors. Int J Cancer (2006) 1.74

Controversies in clinical cancer dormancy. Proc Natl Acad Sci U S A (2011) 1.71

Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer. Clin Cancer Res (2012) 1.63

Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. Cancer Cell (2013) 1.62

Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J Natl Cancer Inst (2005) 1.60

Circulating tumor cell isolation and diagnostics: toward routine clinical use. Cancer Res (2011) 1.58

Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem (2012) 1.58

Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis. Clin Cancer Res (2011) 1.56

Biologic challenges in the detection of circulating tumor cells. Cancer Res (2012) 1.55

Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer. Clin Chem (2012) 1.53

Rare expression of epithelial cell adhesion molecule on residual micrometastatic breast cancer cells after adjuvant chemotherapy. Clin Cancer Res (2003) 1.53

Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. Mol Cancer Res (2006) 1.52

Cell fusion as a hidden force in tumor progression. Cancer Res (2009) 1.51

Molecular signature associated with bone marrow micrometastasis in human breast cancer. Cancer Res (2003) 1.51

Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer. Clin Cancer Res (2009) 1.50

Tumor cell dormancy: an NCI workshop report. Cancer Biol Ther (2007) 1.50

Organotropism of breast cancer metastasis. J Mammary Gland Biol Neoplasia (2007) 1.49

Plasticity of disseminating cancer cells in patients with epithelial malignancies. Cancer Metastasis Rev (2012) 1.47

Disseminated tumor cells in bone marrow and circulating tumor cells in blood of breast cancer patients: current state of detection and characterization. Pathobiology (2008) 1.47

Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis. Mol Cancer (2010) 1.45

Efficient acquisition of dual metastasis organotropism to bone and lung through stable spontaneous fusion between MDA-MB-231 variants. Proc Natl Acad Sci U S A (2009) 1.45

The metastasis-promoting roles of tumor-associated immune cells. J Mol Med (Berl) (2013) 1.40

Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients. Clin Cancer Res (2004) 1.40

Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling. Stem Cells (2012) 1.37

Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor model. J Biol Chem (2010) 1.36

Clinical relevance and biology of circulating tumor cells. Breast Cancer Res (2011) 1.34

Identification of staphylococcal nuclease domain-containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions. J Biol Chem (2011) 1.33

Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer. Clin Cancer Res (2004) 1.33

In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer Res (2010) 1.31

Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cells. Clin Cancer Res (2004) 1.31

Changes in keratin expression during metastatic progression of breast cancer: impact on the detection of circulating tumor cells. Clin Cancer Res (2012) 1.30

Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. Cancer Res (2013) 1.29

Detection and characterization of putative metastatic precursor cells in cancer patients. Clin Chem (2007) 1.28

Targeting the transforming growth factor-beta signalling pathway in metastatic cancer. Eur J Cancer (2010) 1.27

Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer. Int J Cancer (2013) 1.27

Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ. Int J Cancer (2011) 1.27

High-resolution genomic profiling of occult micrometastatic tumor cells. Genes Chromosomes Cancer (2003) 1.25

Circulating tumors cells as biomarkers: progress toward biomarker qualification. Cancer J (2011) 1.25

Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer. Breast Cancer Res (2009) 1.25

Technologies for detection of circulating tumor cells: facts and vision. Lab Chip (2013) 1.24

Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma. Int J Cancer (2013) 1.23

Circulating tumor cells as therapy-related biomarkers in cancer patients. Cancer Immunol Immunother (2013) 1.23

MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. J Transl Med (2011) 1.22

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Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer. BJU Int (2010) 1.22

Global secretome analysis identifies novel mediators of bone metastasis. Cell Res (2012) 1.22

Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer. Mol Oncol (2011) 1.21

Prognostic impact of circulating tumor cells assessed with the CellSearch System™ and AdnaTest Breast™ in metastatic breast cancer patients: the DETECT study. Breast Cancer Res (2012) 1.21

Relevance of PTEN loss in brain metastasis formation in breast cancer patients. Breast Cancer Res (2012) 1.20

Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions. Mod Pathol (2013) 1.19

Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood (2013) 1.19

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Detection and monitoring of cell-free DNA in blood of patients with colorectal cancer. Ann N Y Acad Sci (2008) 1.17

Prognostic role and HER2 expression of circulating tumor cells in peripheral blood of patients prior to radical cystectomy: a prospective study. Eur Urol (2012) 1.16

Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients. Breast Cancer Res Treat (2012) 1.16

Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients. PLoS One (2013) 1.16