Published in Ann Rheum Dis on March 05, 2013
Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology. Ann Rheum Dis (2014) 2.32
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study. BMC Musculoskelet Disord (2015) 1.45
Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol (2014) 1.40
Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis. Arthritis Res Ther (2016) 1.39
Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog (2013) 1.22
The link between periodontal disease and rheumatoid arthritis: an updated review. Curr Rheumatol Rep (2014) 1.20
Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis. Arthritis Res Ther (2013) 0.99
Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis. Arthritis Res Ther (2015) 0.96
Porphyromonas gingivalis peptidylarginine deiminase, a key contributor in the pathogenesis of experimental periodontal disease and experimental arthritis. PLoS One (2014) 0.90
Toll-like receptors and chronic inflammation in rheumatic diseases: new developments. Nat Rev Rheumatol (2016) 0.89
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology. Arthritis Rheumatol (2016) 0.86
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med (2016) 0.86
Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases. J Oral Microbiol (2014) 0.86
Microbiota and chronic inflammatory arthritis: an interwoven link. J Transl Med (2016) 0.83
Citrullination in the periodontium-a possible link between periodontitis and rheumatoid arthritis. Clin Oral Investig (2015) 0.81
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis. Ann Rheum Dis (2015) 0.80
Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity. J Transl Med (2017) 0.78
The peptidylarginine deiminase gene is a conserved feature of Porphyromonas gingivalis. Sci Rep (2015) 0.78
Serum Immunoglobulin G Levels to Porphyromonas gingivalis Peptidylarginine Deiminase Affect Clinical Response to Biological Disease-Modifying Antirheumatic Drug in Rheumatoid Arthritis. PLoS One (2016) 0.77
Serum antibody levels against Porphyromonas gingivalis in patients with and without rheumatoid arthritis - a systematic review and meta-analysis. Clin Oral Investig (2016) 0.77
Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis. Sci Rep (2016) 0.76
Could early rheumatoid arthritis resolve after periodontitis treatment only?: case report and review of the literature. Medicine (Baltimore) (2014) 0.76
Rheumatic diseases and the microbiome. Int J Rheum Dis (2014) 0.75
Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice. Arthritis Res Ther (2016) 0.75
Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system. Sci Rep (2017) 0.75
Oral Health and Risk of Arthritis in the Scottish Population: Results from the Scottish Health Survey. J Oral Maxillofac Res (2017) 0.75
The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol (2017) 0.75
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum (1988) 111.05
Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med (1997) 7.42
Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum (2000) 6.88
PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays (2003) 5.04
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev (2010) 2.71
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum (2010) 2.53
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation. Arthritis Rheum (2007) 2.40
Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum (2008) 2.31
Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol (2011) 2.31
A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline. Anal Biochem (2000) 2.15
Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol (2009) 2.14
The presence of citrullinated proteins is not specific for rheumatoid synovial tissue. Arthritis Rheum (2004) 2.12
Periodontitis in RA-the citrullinated enolase connection. Nat Rev Rheumatol (2010) 1.98
Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation (2004) 1.97
Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun (1999) 1.96
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis. Arthritis Rheum (2008) 1.86
Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol (2008) 1.79
Autoantibodies in coeliac disease: tissue transglutaminase--guilt by association? Gut (1997) 1.60
Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria? J Bacteriol (2006) 1.56
Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol (2010) 1.53
Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis. Arthritis Rheum (2008) 1.48
Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J Clin Periodontol (2003) 1.48
Periodontal findings in adult twins. J Periodontol (1991) 1.44
Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation. Arthritis Rheum (2010) 1.39
Purification and characterization of gingipains. Curr Protoc Protein Sci (2007) 1.16
Serum IgG antibodies to peptidylarginine deiminase 4 in rheumatoid arthritis and associations with disease severity. Ann Rheum Dis (2007) 1.15
Serum IgG antibodies to peptidylarginine deiminase 4 predict radiographic progression in patients with rheumatoid arthritis treated with tumour necrosis factor-alpha blocking agents. Ann Rheum Dis (2008) 1.08
Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis. J Rheumatol (2008) 1.07
Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther (2010) 1.03
Expression of peptidylarginine deiminase from Porphyromonas gingivalis in Escherichia coli: enzyme purification and characterization. Arch Biochem Biophys (2009) 1.01
Citrullination of autoantigens: upstream of TNFα in the pathogenesis of rheumatoid arthritis. FEBS Lett (2011) 1.00
Rheumatoid arthritis is linked to oral bacteria: etiological association. Mod Rheumatol (2009) 0.99
Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases. Cell Mol Life Sci (2010) 0.93
Identification and properties of peptidylarginine deiminase from rabbit skeletal muscle. J Biochem (1982) 0.92
Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum (2004) 4.77
Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med (2013) 3.51
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet (2009) 3.36
New method for typing Staphylococcus aureus strains: multiple-locus variable-number tandem repeat analysis of polymorphism and genetic relationships of clinical isolates. J Clin Microbiol (2003) 2.96
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum (2010) 2.53
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. Nat Genet (2009) 2.48
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother (2004) 2.34
In-depth analysis of the thylakoid membrane proteome of Arabidopsis thaliana chloroplasts: new proteins, new functions, and a plastid proteome database. Plant Cell (2004) 2.33
Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum (2008) 2.31
The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Ann Rheum Dis (2013) 2.28
The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. Arthritis Rheum (2008) 2.13
A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages. PLoS One (2008) 2.12
Consequences of membrane protein overexpression in Escherichia coli. Mol Cell Proteomics (2007) 2.11
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Sci Signal (2010) 2.05
ModifiComb, a new proteomic tool for mapping substoichiometric post-translational modifications, finding novel types of modifications, and fingerprinting complex protein mixtures. Mol Cell Proteomics (2006) 2.03
Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health Study. Am J Med (2002) 2.01
The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Mol Cell Proteomics (2005) 2.01
Periodontitis in RA-the citrullinated enolase connection. Nat Rev Rheumatol (2010) 1.98
Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice. Arthritis Rheum (2011) 1.97
De novo peptide sequencing and identification with precision mass spectrometry. J Proteome Res (2007) 1.95
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis. Arthritis Rheum (2008) 1.86
The effect of serum urate on gout flares and their associated costs: an administrative claims analysis. J Clin Rheumatol (2009) 1.82
Proteomics-grade de novo sequencing approach. J Proteome Res (2005) 1.76
Cytokine changes during rituximab therapy in HIV-associated multicentric Castleman disease. Blood (2009) 1.71
The role and regulation of the extracellular proteases of Staphylococcus aureus. Microbiology (2004) 1.70
Consequences of C4 differentiation for chloroplast membrane proteomes in maize mesophyll and bundle sheath cells. Mol Cell Proteomics (2008) 1.70
Congenital fetal heart block: a potential therapeutic role for intravenous immunoglobulin. Obstet Gynecol (2010) 1.68
Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000 (2010) 1.65
Extent of modifications in human proteome samples and their effect on dynamic range of analysis in shotgun proteomics. Mol Cell Proteomics (2006) 1.65
Validity of gout diagnoses in administrative data. Arthritis Rheum (2007) 1.62
A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA. Arthritis Rheum (2009) 1.59
Malondialdehyde-acetaldehyde adducts and anti-malondialdehyde-acetaldehyde antibodies in rheumatoid arthritis. Arthritis Rheumatol (2015) 1.58
Does the importance of the C-terminal residues in the maturation of RgpB from Porphyromonas gingivalis reveal a novel mechanism for protein export in a subgroup of Gram-Negative bacteria? J Bacteriol (2006) 1.56
A novel therapy of murine collagen-induced arthritis with soluble T1/ST2. J Immunol (2004) 1.55
Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol (2010) 1.53
Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis. Arthritis Res Ther (2011) 1.53
Improving protein identification using complementary fragmentation techniques in fourier transform mass spectrometry. Mol Cell Proteomics (2005) 1.52
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. J Clin Invest (2015) 1.51
Biphasic effect of gingipains from Porphyromonas gingivalis on the human complement system. J Immunol (2007) 1.50
New functions of the thylakoid membrane proteome of Arabidopsis thaliana revealed by a simple, fast, and versatile fractionation strategy. J Biol Chem (2004) 1.49
Electron capture dissociation of polypeptides in a three-dimensional quadrupole ion trap: Implementation and first results. J Am Soc Mass Spectrom (2005) 1.47
Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL. Blood (2011) 1.47
Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women. J Rheumatol (2002) 1.46
Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone. Arthritis Rheum (2006) 1.43
Role of rubrerythrin in the oxidative stress response of Porphyromonas gingivalis. Mol Microbiol (2002) 1.42
Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors. PLoS One (2009) 1.41
Electron capture dissociation proceeds with a low degree of intramolecular migration of peptide amide hydrogens. J Am Chem Soc (2008) 1.40
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis Rheum (2011) 1.38
The impact of obesity and adiposity on inflammatory markers in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) (2017) 1.38
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection. PLoS Pathog (2006) 1.35
Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol (2003) 1.35
Retracted The pathogen-inducible nitric oxide synthase (iNOS) in plants is a variant of the P protein of the glycine decarboxylase complex. Cell (2003) 1.33
Hydrogen rearrangement to and from radical z fragments in electron capture dissociation of peptides. J Am Soc Mass Spectrom (2006) 1.33
Defining the role of the Escherichia coli chaperone SecB using comparative proteomics. J Biol Chem (2005) 1.28
Sequential autolytic processing activates the zymogen of Arg-gingipain. J Biol Chem (2003) 1.27
Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23. Am J Hum Genet (2010) 1.27
Remission of rheumatoid arthritis in clinical practice: application of the American College of Rheumatology/European League Against Rheumatism 2011 remission criteria. Arthritis Rheum (2011) 1.27
IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4. J Immunol (2003) 1.26
On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator. J Biol Chem (2004) 1.25
Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. Proc Natl Acad Sci U S A (2008) 1.25
Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity. J Rheumatol (2010) 1.24
New data base-independent, sequence tag-based scoring of peptide MS/MS data validates Mowse scores, recovers below threshold data, singles out modified peptides, and assesses the quality of MS/MS techniques. Mol Cell Proteomics (2005) 1.23
C alpha-C backbone fragmentation dominates in electron detachment dissociation of gas-phase polypeptide polyanions. Chemistry (2005) 1.22
Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD). PLoS Pathog (2013) 1.22
Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides. Electrophoresis (2010) 1.22
Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells. Infect Immun (2005) 1.21
The biphasic virulence activities of gingipains: activation and inactivation of host proteins. Curr Protein Pept Sci (2003) 1.21
The link between periodontal disease and rheumatoid arthritis: an updated review. Curr Rheumatol Rep (2014) 1.20
Identification and characterization of sigma, a novel component of the Staphylococcus aureus stress and virulence responses. PLoS One (2008) 1.19
Vitamin D status and its associations with disease activity and severity in African Americans with recent-onset rheumatoid arthritis. J Rheumatol (2009) 1.19
Electron ionization dissociation of singly and multiply charged peptides. J Am Chem Soc (2009) 1.18
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Mol Cell Biol (2007) 1.17
Staphostatins: an expanding new group of proteinase inhibitors with a unique specificity for the regulation of staphopains, Staphylococcus spp. cysteine proteinases. Mol Microbiol (2003) 1.17
Investigations into sigmaB-modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus. J Bacteriol (2006) 1.17
Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73. Cell Cycle (2010) 1.17
Side-chain losses in electron capture dissociation to improve peptide identification. Anal Chem (2007) 1.17
Comparison of gingival crevicular fluid sampling methods in patients with severe chronic periodontitis. J Periodontol (2011) 1.17
Merging Veterans Affairs rheumatoid arthritis registry and pharmacy data to assess methotrexate adherence and disease activity in clinical practice. Arthritis Care Res (Hoboken) (2011) 1.16
Interpain A, a cysteine proteinase from Prevotella intermedia, inhibits complement by degrading complement factor C3. PLoS Pathog (2009) 1.16
Rapid and deep human proteome analysis by single-dimension shotgun proteomics. Mol Cell Proteomics (2013) 1.16
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontol 2000 (2010) 1.15
High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism. J Innate Immun (2008) 1.15
In silico instrumental response correction improves precision of label-free proteomics and accuracy of proteomics-based predictive models. Mol Cell Proteomics (2013) 1.14
Binding of complement inhibitor C4b-binding protein contributes to serum resistance of Porphyromonas gingivalis. J Immunol (2008) 1.14
NsaRS is a cell-envelope-stress-sensing two-component system of Staphylococcus aureus. Microbiology (2011) 1.13
Affinity purification of the tobacco plastid RNA polymerase and in vitro reconstitution of the holoenzyme. Plant J (2004) 1.12
Hydrolysis of epithelial junctional proteins by Porphyromonas gingivalis gingipains. Infect Immun (2002) 1.12
Gout-related health care utilization in US emergency departments, 2006 through 2008. Arthritis Care Res (Hoboken) (2013) 1.10
Rheumatoid factor as a potentiator of anti-citrullinated protein antibody-mediated inflammation in rheumatoid arthritis. Arthritis Rheumatol (2014) 1.10
Antinuclear antibodies: a contemporary nomenclature using HEp-2 cells. J Autoimmun (2010) 1.10
A new pathway of staphylococcal pathogenesis: apoptosis-like death induced by Staphopain B in human neutrophils and monocytes. J Innate Immun (2008) 1.10
Identification of citrullinated hsp90 isoforms as novel autoantigens in rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheum (2013) 1.10
Analytical utility of small neutral losses from reduced species in electron capture dissociation studied using SwedECD database. Anal Chem (2008) 1.10