Published in Transgenic Res on March 15, 2013
Pancreatic β cell identity requires continual repression of non-β cell programs. J Clin Invest (2016) 0.88
Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn (2014) 0.86
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development (2014) 0.85
βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function. Genes Dev (2016) 0.80
The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2. Development (2016) 0.75
Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife (2017) 0.75
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination. Neuroscience (2015) 0.75
Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic β Cell Differentiation and Function. Endocrinology (2016) 0.75
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 11.80
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development (1998) 4.08
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature (1999) 3.40
Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A (2004) 2.91
An illustrated review of early pancreas development in the mouse. Endocr Rev (2007) 2.68
Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development (2001) 2.43
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol (2007) 1.27
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab (2011) 1.18
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol (2011) 1.10
Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol (2009) 1.02
Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet (2013) 0.96
Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis (2012) 0.93
The cDNA sequence of murine Nkx-2.2. Gene (1996) 0.81
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell (2012) 4.88
The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat Med (2011) 3.20
Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A (2004) 2.91
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science (2011) 2.17
Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab (2010) 1.88
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (2006) 1.79
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev (2006) 1.66
Erythropoietin receptor signalling is required for normal brain development. Development (2002) 1.65
The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol (2004) 1.59
Gata6 is an important regulator of mouse pancreas development. Dev Biol (2006) 1.58
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis. Proc Natl Acad Sci U S A (2003) 1.55
Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest (2012) 1.55
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
The parental non-equivalence of imprinting control regions during mammalian development and evolution. PLoS Genet (2010) 1.41
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem (2002) 1.33
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol (2007) 1.27
Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q). Invest Ophthalmol Vis Sci (2008) 1.22
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol (2012) 1.21
Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development (2007) 1.18
α-Intercalated cells defend the urinary system from bacterial infection. J Clin Invest (2014) 1.18
Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation (2010) 1.17
Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness. Hum Mutat (2007) 1.15
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development (2009) 1.11
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol (2011) 1.10
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem (2009) 1.09
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development (2010) 1.07
Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol (2007) 1.06
Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain. Mol Cell Neurosci (2010) 1.04
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development (2011) 1.03
shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa. J Cell Mol Med (2011) 1.02
Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa. Exp Biol Med (Maywood) (2011) 1.02
Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol (2009) 1.02
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol (2010) 0.99
Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One (2012) 0.97
Nkx2.2 regulates beta-cell function in the mature islet. Diabetes (2007) 0.96
Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet (2013) 0.96
Phenotype-genotype correlations in autosomal dominant retinitis pigmentosa caused by RHO, D190N. Curr Eye Res (2008) 0.96
The endocrine pancreas: insights into development, differentiation, and diabetes. Wiley Interdiscip Rev Dev Biol (2012) 0.94
Halting progressive neurodegeneration in advanced retinitis pigmentosa. J Clin Invest (2015) 0.93
Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis (2012) 0.93
GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2. Cereb Cortex (2009) 0.92
AFP(+), ESC-derived cells engraft and differentiate into hepatocytes in vivo. Stem Cells (2002) 0.90
The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development (2011) 0.90
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab (2014) 0.90
Pancreatic β cell identity requires continual repression of non-β cell programs. J Clin Invest (2016) 0.88
Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept (2009) 0.88
Ets transcription factors control epithelial maturation and transit and crypt-villus morphogenesis in the mammalian intestine. Am J Pathol (2009) 0.88
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest (2016) 0.87
ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol (2012) 0.87
Therapeutic margins in a novel preclinical model of retinitis pigmentosa. J Neurosci (2013) 0.87
Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol Endocrinol (2009) 0.87
Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. BMC Bioinformatics (2011) 0.86
Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn (2014) 0.86
Faithful tissue-specific expression of the human chromosome 21-linked COL6A1 gene in BAC-transgenic mice. Mamm Genome (2007) 0.86
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development (2014) 0.85
A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet (2013) 0.85
Cellular and molecular origin of circumpapillary dysgenesis of the pigment epithelium. Ophthalmology (2009) 0.85
Mice with a D190N mutation in the gene encoding rhodopsin: a model for human autosomal-dominant retinitis pigmentosa. Mol Med (2012) 0.84
Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One (2013) 0.84
Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. PLoS One (2012) 0.83
Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun (2009) 0.82
Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases. PLoS One (2012) 0.81
Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis (2013) 0.80
Pancreatic islet cell development and regeneration. Curr Opin Endocrinol Diabetes Obes (2015) 0.79
Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling. Cell Signal (2011) 0.79
Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Mamm Genome (2012) 0.79
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest (2016) 0.78
The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.78
Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo. Cell Signal (2011) 0.76
Noncoding RNAs in β cell biology. Curr Opin Endocrinol Diabetes Obes (2015) 0.75
Engineering islets: lessons from stem cells and embryonic development. Endocrinol Metab Clin North Am (2004) 0.75
Phenotypic assays for β-amyloid in mouse embryonic stem cell-derived neurons. Chem Biol (2013) 0.75
Advances in pancreas development: generation informs regeneration. Semin Cell Dev Biol (2012) 0.75
Time to look back and to look forward. Diabetes (2014) 0.75