Published in Am J Pathol on March 05, 2009
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Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium. Gastroenterology (2002) 1.52
The ETS transcription factor GABPalpha is essential for early embryogenesis. Mol Cell Biol (2004) 1.46
The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol (2001) 1.45
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The role of the Ets domain transcription factor Erm in modulating differentiation of neural crest stem cells. Dev Biol (2002) 0.93
TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice. Gastroenterology (2007) 0.92
The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA Cell Biol (2003) 0.92
Twists and turns in the development and maintenance of the mammalian small intestine epithelium. Birth Defects Res C Embryo Today (2005) 0.92
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beta-Neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factors. Mol Cell Neurosci (2002) 0.89
Targeting of the ETS factor GABPalpha disrupts neuromuscular junction synaptic function. Mol Cell Biol (2007) 0.86
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell (2012) 4.88
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A (2005) 2.96
Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A (2004) 2.91
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab (2010) 1.88
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (2006) 1.79
Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition. Thyroid (2009) 1.73
The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol (2004) 1.59
Gata6 is an important regulator of mouse pancreas development. Dev Biol (2006) 1.58
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest (2012) 1.55
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem (2002) 1.33
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Dev Biol (2007) 1.27
Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development (2007) 1.18
ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene (2004) 1.11
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development (2009) 1.11
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol (2011) 1.10
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem (2009) 1.09
Molecular mechanisms of ETS transcription factor-mediated tumorigenesis. Crit Rev Biochem Mol Biol (2013) 1.08
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development (2010) 1.07
Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol (2007) 1.06
MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. J Biol Chem (2010) 1.06
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development (2011) 1.03
The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism. Mol Cell Biol (2004) 1.02
Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol (2009) 1.02
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Mol Cell Biol (2010) 0.99
Ets transcription factors in intestinal morphogenesis, homeostasis and disease. Histol Histopathol (2008) 0.98
Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. PLoS One (2012) 0.97
Nkx2.2 regulates beta-cell function in the mature islet. Diabetes (2007) 0.96
Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet (2013) 0.96
Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. J Mammary Gland Biol Neoplasia (2004) 0.95
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Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression. Mol Cancer (2011) 0.93
Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis (2012) 0.93
The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA Cell Biol (2003) 0.92
GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2. Cereb Cortex (2009) 0.92
The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development (2011) 0.90
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab (2014) 0.90
Ghrelin is dispensable for embryonic pancreatic islet development and differentiation. Regul Pept (2009) 0.88
Pancreatic β cell identity requires continual repression of non-β cell programs. J Clin Invest (2016) 0.88
LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. J Clin Invest (2016) 0.87
Nkx2.2 activates the ghrelin promoter in pancreatic islet cells. Mol Endocrinol (2009) 0.87
Generation of mice encoding a conditional allele of Nkx2.2. Transgenic Res (2013) 0.87
ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol (2012) 0.87
Control of MicroRNA-21 expression in colorectal cancer cells by oncogenic epidermal growth factor/Ras signaling and Ets transcription factors. DNA Cell Biol (2012) 0.87
Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development. Dev Dyn (2014) 0.86
Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. BMC Bioinformatics (2011) 0.86
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development (2014) 0.85
A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet (2013) 0.85
Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One (2013) 0.84
Purification and mass spectrometric identification of GA-binding protein (GABP) as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter. J Biol Chem (2003) 0.83
Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells. Mol Endocrinol (2002) 0.83
A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter. Mol Endocrinol (2009) 0.82
Ras signaling and transcriptional synergy at a flexible Ets-1/Pit-1 composite DNA element is defined by the assembly of selective activation domains. J Biol Chem (2003) 0.81
Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 binding. Proc Natl Acad Sci U S A (2002) 0.81
Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion. Genesis (2013) 0.80
Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness. Mol Endocrinol (2006) 0.80
Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis. Adv Exp Med Biol (2015) 0.80
The Ets dominant repressor En/Erm enhances intestinal epithelial tumorigenesis in ApcMin mice. BMC Cancer (2009) 0.80
Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism. Mol Cancer (2011) 0.80
Persistent ERK/MAPK activation promotes lactotrope differentiation and diminishes tumorigenic phenotype. Mol Endocrinol (2014) 0.80
Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells. BMC Cancer (2010) 0.80
Nuclear targeting of the CaMKII anchoring protein alphaKAP is regulated by alternative splicing and protein kinases. Brain Res (2006) 0.79
Pancreatic islet cell development and regeneration. Curr Opin Endocrinol Diabetes Obes (2015) 0.79
CEBPD suppresses prolactin expression and prolactinoma cell proliferation. Mol Endocrinol (2011) 0.79
The 26-amino acid beta-motif of the Pit-1beta transcription factor is a dominant and independent repressor domain. Mol Endocrinol (2009) 0.79
The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.78
PRL-releasing peptide stimulation of PRL gene transcription--enter AKT. Endocrinology (2002) 0.77
Selective repression of rat prolactin gene by stable expression of dominant-negative Ets in GH4 pituitary cells. Endocrine (2003) 0.77
Engineering islets: lessons from stem cells and embryonic development. Endocrinol Metab Clin North Am (2004) 0.75
Noncoding RNAs in β cell biology. Curr Opin Endocrinol Diabetes Obes (2015) 0.75
Structural and functional analysis of the differential effects of c-Jun and v-Jun on prolactin gene expression. Mol Endocrinol (2004) 0.75
Hydrangeas-like Bi2WO6: facile synthesis, visible-light driven photocatalysis and theoretical analysis. J Nanosci Nanotechnol (2012) 0.75
Advances in pancreas development: generation informs regeneration. Semin Cell Dev Biol (2012) 0.75
Time to look back and to look forward. Diabetes (2014) 0.75
Editorial: PRL-Releasing Peptide Stimulation of PRL Gene Transcription-Enter AKT. Endocrinology (2002) 0.75