Published in Biochemistry on April 05, 2013
Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. Annu Rev Microbiol (2014) 1.55
In Situ Molecular Architecture of the Salmonella Type III Secretion Machine. Cell (2017) 1.40
Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens. Chem Biol Drug Des (2015) 1.08
Type III secretion systems: the bacterial flagellum and the injectisome. Philos Trans R Soc Lond B Biol Sci (2015) 0.98
Targeting virulence not viability in the search for future antibacterials. Br J Clin Pharmacol (2015) 0.96
Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nat Commun (2013) 0.93
The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Proc Natl Acad Sci U S A (2013) 0.90
NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system. J Mol Biol (2014) 0.90
Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines. Microbiol Mol Biol Rev (2013) 0.87
The pathogenesis, detection, and prevention of Vibrio parahaemolyticus. Front Microbiol (2015) 0.87
Comparative genomics of transport proteins in developmental bacteria: Myxococcus xanthus and Streptomyces coelicolor. BMC Microbiol (2013) 0.84
The RNA Helicase DeaD Stimulates ExsA Translation To Promote Expression of the Pseudomonas aeruginosa Type III Secretion System. J Bacteriol (2015) 0.83
The bacterial type III secretion system as a target for developing new antibiotics. Chem Biol Drug Des (2015) 0.81
Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host. Small GTPases (2014) 0.80
Characterization of the Shigella and Salmonella Type III Secretion System Tip-Translocon Protein-Protein Interaction by Paramagnetic Relaxation Enhancement. Chembiochem (2016) 0.78
Pseudomonas aeruginosa Genome Evolution in Patients and under the Hospital Environment. Pathogens (2014) 0.78
Computational and experimental analysis of the secretome of Methylococcus capsulatus (Bath). PLoS One (2014) 0.77
Microcompartments and protein machines in prokaryotes. J Mol Microbiol Biotechnol (2013) 0.77
Biological significance and topological basis of aquaporin-partnering protein-protein interactions. Plant Signal Behav (2015) 0.77
Structural basis of α-catenin recognition by EspB from enterohaemorrhagic E. coli based on hybrid strategy using low-resolution structural and protein dissection. PLoS One (2013) 0.76
Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from Shigella flexneri. Protein Sci (2016) 0.76
ExsB is required for correct assembly of the Pseudomonas aeruginosa type III secretion apparatus in the bacterial membrane and full virulence in vivo. Infect Immun (2015) 0.76
Getting across the cell membrane: an overview for small molecules, peptides, and proteins. Methods Mol Biol (2015) 0.76
Structural analysis of SepL, an enteropathogenic Escherichia coli type III secretion-system gatekeeper protein. Acta Crystallogr F Struct Biol Commun (2015) 0.76
Characterization of the Binding of Hydroxyindole, Indoleacetic acid, and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB. ChemMedChem (2016) 0.75
The LcrG Tip Chaperone Protein of the Yersinia pestis Type III Secretion System Is Partially Folded. J Mol Biol (2015) 0.75
Role of T3SS-1 SipD Protein in Protecting Mice against Non-typhoidal Salmonella Typhimurium. PLoS Negl Trop Dis (2016) 0.75
NMR identification of the binding surfaces involved in the Salmonella and Shigella Type III secretion tip-translocon protein-protein interactions. Proteins (2016) 0.75
Structural and Biochemical Characterization of Spa47 Provides Mechanistic Insight into Type III Secretion System ATPase Activation and Shigella Virulence Regulation. J Biol Chem (2016) 0.75
Comparative Genomics Identifies a Novel Conserved Protein, HpaT, in Proteobacterial Type III Secretion Systems that Do Not Possess the Putative Translocon Protein HrpF. Front Microbiol (2017) 0.75
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J Bacteriol (1993) 8.75
The type III secretion injectisome. Nat Rev Microbiol (2006) 7.62
Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science (1998) 6.55
Chaperone release and unfolding of substrates in type III secretion. Nature (2005) 4.21
Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. J Bacteriol (1995) 4.12
The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes. J Cell Biol (1999) 3.75
Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri. Cell (1994) 3.53
Structural insights into the assembly of the type III secretion needle complex. Science (2004) 3.49
Structure and composition of the Shigella flexneri "needle complex", a part of its type III secreton. Mol Microbiol (2001) 3.46
The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell. Mol Microbiol (1997) 3.42
Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system. Proc Natl Acad Sci U S A (2000) 3.38
Yersinia type III secretion: send in the effectors. J Cell Biol (2002) 3.04
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. Science (2005) 2.90
The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague. Structure (2004) 2.53
The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells. Proc Natl Acad Sci U S A (1996) 2.37
Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells. Mol Microbiol (2005) 2.32
IpaD localizes to the tip of the type III secretion system needle of Shigella flexneri. Infect Immun (2006) 2.24
Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure. Proc Natl Acad Sci U S A (2001) 2.21
Structural characterization of the molecular platform for type III secretion system assembly. Nature (2005) 2.20
IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells. EMBO J (1999) 2.20
A sorting platform determines the order of protein secretion in bacterial type III systems. Science (2011) 2.16
Molecular model of a type III secretion system needle: Implications for host-cell sensing. Proc Natl Acad Sci U S A (2006) 2.16
Assembly of the inner rod determines needle length in the type III secretion injectisome. Nature (2006) 2.15
Helical structure of the needle of the type III secretion system of Shigella flexneri. J Biol Chem (2003) 2.15
Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: requirement for translocators YopB and YopD, but not LcrG. Mol Microbiol (1999) 2.08
Atomic model of the type III secretion system needle. Nature (2012) 2.02
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system. Nat Struct Mol Biol (2009) 2.02
Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella. EMBO J (1999) 1.96
The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus. J Biol Chem (2005) 1.92
Three-dimensional model of Salmonella's needle complex at subnanometer resolution. Science (2011) 1.88
Virulence role of V antigen of Yersinia pestis at the bacterial surface. Infect Immun (1999) 1.80
Bile salts stimulate recruitment of IpaB to the Shigella flexneri surface, where it colocalizes with IpaD at the tip of the type III secretion needle. Infect Immun (2007) 1.75
IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infect Immun (2005) 1.73
Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD. J Biol Chem (2006) 1.72
Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout. Nat Struct Mol Biol (2009) 1.70
The V antigen of Pseudomonas aeruginosa is required for assembly of the functional PopB/PopD translocation pore in host cell membranes. Infect Immun (2004) 1.70
Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells. Infect Immun (2009) 1.68
Salmonella enterica serovar typhimurium invasion is repressed in the presence of bile. Infect Immun (2000) 1.63
Structural characterization of the type-III pilot-secretin complex from Shigella flexneri. Structure (2008) 1.62
Role of SycD, the chaperone of the Yersinia Yop translocators YopB and YopD. Mol Microbiol (1999) 1.59
What's the point of the type III secretion system needle? Proc Natl Acad Sci U S A (2008) 1.58
Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei. J Mol Biol (2006) 1.55
Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH. J Mol Biol (2007) 1.53
Increased protein secretion and adherence to HeLa cells by Shigella spp. following growth in the presence of bile salts. Infect Immun (1995) 1.50
Simultaneous prediction of protein folding and docking at high resolution. Proc Natl Acad Sci U S A (2009) 1.47
Functional conservation of the effector protein translocators PopB/YopB and PopD/YopD of Pseudomonas aeruginosa and Yersinia pseudotuberculosis. Mol Microbiol (1998) 1.47
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS. Nature (2008) 1.45
Liposomes recruit IpaC to the Shigella flexneri type III secretion apparatus needle as a final step in secretion induction. Infect Immun (2009) 1.45
Function and molecular architecture of the Yersinia injectisome tip complex. Mol Microbiol (2007) 1.45
Complex function for SicA, a Salmonella enterica serovar typhimurium type III secretion-associated chaperone. J Bacteriol (2000) 1.44
Piecing together the type III injectisome of bacterial pathogens. Curr Opin Struct Biol (2008) 1.43
Deoxycholate interacts with IpaD of Shigella flexneri in inducing the recruitment of IpaB to the type III secretion apparatus needle tip. J Biol Chem (2008) 1.40
Structural analysis of a prototypical ATPase from the type III secretion system. Nat Struct Mol Biol (2007) 1.40
Deciphering the assembly of the Yersinia type III secretion injectisome. EMBO J (2010) 1.40
IpaB-IpgC interaction defines binding motif for type III secretion translocator. Proc Natl Acad Sci U S A (2009) 1.37
LcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis. J Bacteriol (2001) 1.36
Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol (2010) 1.36
IpaB, a Shigella flexneri invasin, colocalizes with interleukin-1 beta-converting enzyme in the cytoplasm of macrophages. Infect Immun (1997) 1.36
Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bile. FEMS Immunol Med Microbiol (2004) 1.34
YscP and YscU switch the substrate specificity of the Yersinia type III secretion system by regulating export of the inner rod protein YscI. J Bacteriol (2008) 1.32
Topology and organization of the Salmonella typhimurium type III secretion needle complex components. PLoS Pathog (2010) 1.32
Structure of the heterotrimeric complex that regulates type III secretion needle formation. Proc Natl Acad Sci U S A (2007) 1.27
Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG. J Mol Biol (2008) 1.26
Architecture of the major component of the type III secretion system export apparatus. Nat Struct Mol Biol (2012) 1.24
The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate. Protein Sci (2011) 1.23
Structure and biochemical analysis of a secretin pilot protein. EMBO J (2005) 1.22
Structure and electrophysiological properties of the YscC secretin from the type III secretion system of Yersinia enterocolitica. J Bacteriol (2004) 1.22
The structures of coiled-coil domains from type III secretion system translocators reveal homology to pore-forming toxins. J Mol Biol (2012) 1.20
Structure of the Yersinia enterocolitica type III secretion translocator chaperone SycD. J Mol Biol (2007) 1.20
The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri. Cell Microbiol (1999) 1.19
Control of effector export by the Pseudomonas aeruginosa type III secretion proteins PcrG and PcrV. Mol Microbiol (2010) 1.17
Soluble invasion plasmid antigen C (IpaC) from Shigella flexneri elicits epithelial cell responses related to pathogen invasion. Infect Immun (1996) 1.17
Structure-function analysis of invasion plasmid antigen C (IpaC) from Shigella flexneri. J Biol Chem (2002) 1.15
Structural basis of chaperone recognition of type III secretion system minor translocator proteins. J Biol Chem (2010) 1.14
Structure of a type III secretion needle at 7-Å resolution provides insights into its assembly and signaling mechanisms. Proc Natl Acad Sci U S A (2012) 1.13
Organization and coordinated assembly of the type III secretion export apparatus. Proc Natl Acad Sci U S A (2010) 1.13
Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains. J Biol Chem (2002) 1.12
Ultrastructural analysis of IpaD at the tip of the nascent MxiH type III secretion apparatus of Shigella flexneri. J Mol Biol (2012) 1.12
The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology. Mol Microbiol (2003) 1.12
Crystal structure of Spa40, the specificity switch for the Shigella flexneri type III secretion system. Mol Microbiol (2008) 1.12
Identification of functional regions within invasion plasmid antigen C (IpaC) of Shigella flexneri. Mol Microbiol (2001) 1.11
Conformational changes in IpaD from Shigella flexneri upon binding bile salts provide insight into the second step of type III secretion. Biochemistry (2010) 1.11
Role of predicted transmembrane domains for type III translocation, pore formation, and signaling by the Yersinia pseudotuberculosis YopB protein. Infect Immun (2005) 1.09
Structure of the cytoplasmic domain of FlhA and implication for flagellar type III protein export. Mol Microbiol (2010) 1.09
Type III protein translocase: HrcN is a peripheral ATPase that is activated by oligomerization. J Biol Chem (2003) 1.08
Crystal structure of PrgI-SipD: insight into a secretion competent state of the type three secretion system needle tip and its interaction with host ligands. PLoS Pathog (2011) 1.07
13C spin dilution for simplified and complete solid-state NMR resonance assignment of insoluble biological assemblies. J Am Chem Soc (2011) 1.06
Synergistic pore formation by type III toxin translocators of Pseudomonas aeruginosa. Biochemistry (2006) 1.06
Characterization of Salmonella pathogenicity island 1 type III secretion-dependent hemolytic activity in Salmonella enterica serovar Typhimurium. Microb Pathog (2004) 1.05
The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar system. J Mol Biol (2010) 1.05
Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranes. FEBS Lett (1997) 1.05
The assembly of the export apparatus (YscR,S,T,U,V) of the Yersinia type III secretion apparatus occurs independently of other structural components and involves the formation of an YscV oligomer. Mol Microbiol (2011) 1.05
Identification of the bile salt binding site on IpaD from Shigella flexneri and the influence of ligand binding on IpaD structure. Proteins (2012) 1.05
PscF is a major component of the Pseudomonas aeruginosa type III secretion needle. FEMS Microbiol Lett (2005) 1.05
High resolution structure of BipD: an invasion protein associated with the type III secretion system of Burkholderia pseudomallei. J Mol Biol (2006) 1.04
Identification of the MxiH needle protein residues responsible for anchoring invasion plasmid antigen D to the type III secretion needle tip. J Biol Chem (2007) 1.04
Crystal structure of the C-terminal domain of the Salmonella type III secretion system export apparatus protein InvA. Protein Sci (2010) 1.02
NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile salts. Biochemistry (2010) 1.01
Structure of the type III secretion recognition protein YscU from Yersinia enterocolitica. J Mol Biol (2008) 1.01
The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding. Infect Immun (2010) 1.01
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc Natl Acad Sci U S A (2002) 2.97
Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J Mol Biol (2004) 1.83
Solution structure of monomeric BsaL, the type III secretion needle protein of Burkholderia pseudomallei. J Mol Biol (2006) 1.55
Differences in the electrostatic surfaces of the type III secretion needle proteins PrgI, BsaL, and MxiH. J Mol Biol (2007) 1.53
The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate. Protein Sci (2011) 1.23
Identification of the MxiH needle protein residues responsible for anchoring invasion plasmid antigen D to the type III secretion needle tip. J Biol Chem (2007) 1.04
NMR characterization of the interaction of the Salmonella type III secretion system protein SipD and bile salts. Biochemistry (2010) 1.01
The Hantavirus Glycoprotein G1 Tail Contains Dual CCHC-type Classical Zinc Fingers. J Biol Chem (2009) 0.99
Characterization of the interaction between the Salmonella type III secretion system tip protein SipD and the needle protein PrgI by paramagnetic relaxation enhancement. J Biol Chem (2010) 0.96
Structural characterization of the Crimean-Congo hemorrhagic fever virus Gn tail provides insight into virus assembly. J Biol Chem (2011) 0.95
NMR structure of the N-terminal coiled coil domain of the Andes hantavirus nucleocapsid protein. J Biol Chem (2008) 0.88
The Salmonella type III secretion system inner rod protein PrgJ is partially folded. J Biol Chem (2012) 0.88
A repulsive electrostatic mechanism for protein export through the type III secretion apparatus. Biophys J (2010) 0.87
Structural dissection of the extracellular moieties of the type III secretion apparatus. Mol Biosyst (2008) 0.86
Structure of the Yersinia pestis tip protein LcrV refined to 1.65 Å resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.85
The bacterial type III secretion system as a target for developing new antibiotics. Chem Biol Drug Des (2015) 0.81
Characterization of the Shigella and Salmonella Type III Secretion System Tip-Translocon Protein-Protein Interaction by Paramagnetic Relaxation Enhancement. Chembiochem (2016) 0.78
Thyroidal regulation of different isoforms of NaKATPase in the primary cultures of neurons derived from fetal rat brain. Life Sci (2002) 0.76
Erratum: Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation. Oncotarget (2015) 0.75