Published in PLoS One on March 19, 2013
Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease. Semin Respir Crit Care Med (2015) 0.77
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (2004) 125.23
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res (1998) 14.63
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell (1999) 7.33
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Pathway mapping tools for analysis of high content data. Methods Mol Biol (2007) 4.87
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell (1995) 4.53
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet (2008) 3.18
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity (2009) 2.21
MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis. J Cancer Res Clin Oncol (2010) 2.05
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet (2009) 2.04
Smoking, lung function, and alpha 1-antitrypsin deficiency. Lancet (1985) 1.99
Occupational endotoxin-exposure and possible health effects on humans. Am J Ind Med (2006) 1.87
Cotton dust and endotoxin exposure-response relationships in cotton textile workers. Am Rev Respir Dis (1987) 1.84
Framingham Heart Study genome-wide association: results for pulmonary function measures. BMC Med Genet (2007) 1.76
Inhaled endotoxin and decreased spirometric values. An exposure-response relation for cotton dust. N Engl J Med (1987) 1.73
A prospective study of chronic lung disease in cotton textile workers. Ann Intern Med (1982) 1.60
Genetic variations in the regulator of G-protein signaling genes are associated with survival in late-stage non-small cell lung cancer. PLoS One (2011) 1.51
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK. Oncogene (2010) 1.32
Genetic risk score and risk of myocardial infarction in Hispanics. Circulation (2011) 1.30
The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. J Immunol (2010) 1.21
Genetic variants associated with severe pneumonia in A/H1N1 influenza infection. Eur Respir J (2011) 1.17
Airborne endotoxin concentrations in various work areas within two cotton textile mills in the People's Republic of China. Biomed Environ Sci (1990) 1.14
Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system. PLoS Genet (2012) 1.13
Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors. J Cell Biochem (2013) 1.09
TBX2 and TBX3: the special value for anticancer drug targets. Biochim Biophys Acta (2010) 1.03
Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: novel animal models to study toxicant-induced epithelial transformation in airways. Toxicol Lett (1993) 1.02
Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet (2012) 1.02
Deletion mapping of chromosome 3p in human uterine cervical cancer. Oncogene (1993) 1.01
Bone morphogenetic protein (BMP)-4 and BMP-7 regulate differentially transforming growth factor (TGF)-beta1 in normal human lung fibroblasts (NHLF). Respir Res (2010) 1.01
Toll-like receptor signaling pathway variants and prostate cancer mortality. Cancer Epidemiol Biomarkers Prev (2009) 0.99
Follow-up study of respiratory health of newly-hired female cotton textile workers. Am J Ind Med (2002) 0.99
T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Dev Dyn (2003) 0.99
A longitudinal observation of early pulmonary responses to cotton dust. Occup Environ Med (2003) 0.98
Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect. Environ Health Perspect (2009) 0.94
Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium. J Biol Chem (2000) 0.93
Microsomal epoxide hydrolase, endotoxin, and lung function decline in cotton textile workers. Am J Respir Crit Care Med (2004) 0.92
An essential role for Stat3 in regulating IgG immune complex-induced pulmonary inflammation. FASEB J (2011) 0.88
Association between variations in cell cycle genes and idiopathic pulmonary fibrosis. PLoS One (2012) 0.86
Lung function, airway reactivity, and atopy in newly hired female cotton textile workers. Arch Environ Health (2003) 0.86
High frequency of LMAN1 abnormalities in colorectal tumors with microsatellite instability. Cancer Res (2009) 0.85
Functional polymorphism in the GPR55 gene is associated with anorexia nervosa. Synapse (2011) 0.82
Genetic effect of single-nucleotide polymorphisms in the PPARGC1B gene on airway hyperreactivity in asthmatic patients. Clin Exp Allergy (2011) 0.80
TNF polymorphisms modify endotoxin exposure-associated longitudinal lung function decline. Occup Environ Med (2007) 0.80
Genetic influences on asthma susceptibility in the developing lung. Am J Respir Cell Mol Biol (2010) 0.80
Genes differentially expressed in human lung fibroblast cells transformed by glycidyl methacrylate. Biomed Environ Sci (2004) 0.78
The chromosome 7q region association with rheumatoid arthritis in females in a British population is not replicated in a North American case-control series. Arthritis Rheum (2009) 0.77
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med (2004) 71.08
International network of cancer genome projects. Nature (2010) 20.35
ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38
A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. Nature (2009) 15.06
Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science (2009) 10.21
A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac. Nat Genet (2004) 8.55
Sequencing and analysis of Neanderthal genomic DNA. Science (2006) 8.06
Rapid whole-genome mutational profiling using next-generation sequencing technologies. Genome Res (2008) 8.01
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
Statistical analysis of real-time PCR data. BMC Bioinformatics (2006) 7.31
Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science (2011) 6.93
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science (2007) 5.69
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature (2006) 5.52
Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet (2012) 5.48
Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med (2005) 5.16
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk. Cancer Res (2008) 5.05
Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell (2008) 5.04
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94
Microbial production of recalcitrant dissolved organic matter: long-term carbon storage in the global ocean. Nat Rev Microbiol (2010) 4.58
A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China. Lancet Oncol (2008) 4.43
ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet (2010) 4.32
Patterns and implications of gene gain and loss in the evolution of Prochlorococcus. PLoS Genet (2007) 4.25
Emergency duties and deaths from heart disease among firefighters in the United States. N Engl J Med (2007) 4.20
Experimental factors affecting PCR-based estimates of microbial species richness and evenness. ISME J (2010) 4.15
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat Genet (2010) 4.01
Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A (2003) 3.85
Phthalate exposure and human semen parameters. Epidemiology (2003) 3.57
Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest (2008) 3.53
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case-control and cohort validation study. Ann Intern Med (2012) 3.45
A single-base resolution map of an archaeal transcriptome. Genome Res (2009) 3.42
Complete genome sequence of Kytococcus sedentarius type strain (541). Stand Genomic Sci (2009) 3.30
Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology (2007) 3.29
Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A (2007) 3.08
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans. DNA Res (2004) 2.95
XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy. J Clin Oncol (2004) 2.93
Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med (2012) 2.92
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet (2011) 2.85
A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cancer (2010) 2.84
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Res (2009) 2.74
AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. J Clin Invest (2006) 2.74
Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial. J Clin Oncol (2013) 2.69
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China. Lancet Oncol (2010) 2.61
Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum Mutat (2009) 2.60
DELLAs modulate jasmonate signaling via competitive binding to JAZs. Dev Cell (2010) 2.58
Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov (2008) 2.58
Regulation of floral patterning by flowering time genes. Dev Cell (2009) 2.56
Texaco and its consultants. Int J Occup Environ Health (2005) 2.55
Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small-cell lung cancer patients. J Clin Oncol (2007) 2.52
A comprehensive worksite cancer prevention intervention: behavior change results from a randomized controlled trial (United States). Cancer Causes Control (2002) 2.42
Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer. Clin Chem (2011) 2.42
Acute chemical emergencies. N Engl J Med (2004) 2.38
Qualitative and quantitative measures of various compounded formulations of 17-alpha hydroxyprogesterone caproate. Am J Obstet Gynecol (2013) 2.36
Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem (2010) 2.34
Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome. Crit Care Med (2007) 2.31
The orexin system regulates alcohol-seeking in rats. Br J Pharmacol (2006) 2.30
The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect (2003) 2.27
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
A repressor complex governs the integration of flowering signals in Arabidopsis. Dev Cell (2008) 2.24
Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. J Biol Chem (2008) 2.21
Validation of two ribosomal RNA removal methods for microbial metatranscriptomics. Nat Methods (2010) 2.21
Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats. Radiology (2005) 2.18
Disruption of tumor neovasculature by microbubble enhanced ultrasound: a potential new physical therapy of anti-angiogenesis. Ultrasound Med Biol (2011) 2.18
Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol (2012) 2.16
Body mass index and acute kidney injury in the acute respiratory distress syndrome. Crit Care Med (2012) 2.16
Using OrthoMCL to assign proteins to OrthoMCL-DB groups or to cluster proteomes into new ortholog groups. Curr Protoc Bioinformatics (2011) 2.15
Deletion of fibroblast growth factor receptor 2 from the peri-wolffian duct stroma leads to ureteric induction abnormalities and vesicoureteral reflux. PLoS One (2013) 2.15
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Arsenic methylation and skin cancer risk in southwestern Taiwan. J Occup Environ Med (2003) 2.11
Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome. Crit Care Med (2007) 2.08
Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients: a qualitative and quantitative study. BMC Health Serv Res (2009) 2.07
Epidemiology of hepatitis C virus infection among injection drug users in China: systematic review and meta-analysis. Public Health (2008) 2.05
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet (2011) 2.05
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res (2010) 2.04
Identification of ten serum microRNAs from a genome-wide serum microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis. Int J Cancer (2011) 2.01
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. Nat Genet (2012) 2.00
Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J Biol Chem (2006) 1.99
The homeotic protein AGAMOUS controls microsporogenesis by regulation of SPOROCYTELESS. Nature (2004) 1.98
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet (2011) 1.98
Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet (2010) 1.98