Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats.

PubWeight™: 0.93‹?›

🔗 View Article (PMC 3602871)

Published in J Biomed Res on December 21, 2012

Authors

Pengpeng Jin1, Xiaoli Wang, Fei Chang, Yinyang Bai, Yingchun Li, Rong Zhou, Ling Chen

Author Affiliations

1: State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 210029, China; ; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 210029, China; ; Department of Physiology, Wenzhou Medical College, Wenzhou, Zhejiang 325000, China.

Articles citing this

Bisphenol a and reproductive health: update of experimental and human evidence, 2007-2013. Environ Health Perspect (2014) 1.61

Gestational Exposure to Bisphenol A Affects the Function and Proteome Profile of F1 Spermatozoa in Adult Mice. Environ Health Perspect (2016) 0.79

A mechanism of male germ cell apoptosis induced by bisphenol-A and nonylphenol involving ADAM17 and p38 MAPK activation. PLoS One (2014) 0.78

Inhibitory effects of preimplantation exposure to bisphenol-A on blastocyst development and implantation. Int J Clin Exp Med (2015) 0.76

High-Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells. Toxicol Sci (2016) 0.76

Detection of Bisphenol A and Nonylphenol in Rat's Blood Serum, Tissue and Impact on Reproductive System. Electron Physician (2016) 0.75

Histopathology and Histomorphometric Investigation of Bisphenol A and Nonylphenol on the Male Rat Reproductive System. N Am J Med Sci (2016) 0.75

The Methylcytosine Dioxygenase Ten-Eleven Translocase-2 (tet2) Enables Elevated GnRH Gene Expression and Maintenance of Male Reproductive Function. Endocrinology (2016) 0.75

The Association between Exposure to Environmental Bisphenol A and Gonadotropic Hormone Levels among Men. PLoS One (2017) 0.75

Evaluation of subacute bisphenol - A toxicity on male reproductive system. Vet World (2015) 0.75

Neuroendocrine disruption in animal models due to exposure to bisphenol A analogues. Front Neuroendocrinol (2017) 0.75

Articles cited by this

Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet (1993) 12.83

Parent bisphenol A accumulation in the human maternal-fetal-placental unit. Environ Health Perspect (2002) 5.24

Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect (1996) 4.93

Definition of the stages of the cycle of the seminiferous epithelium in the rat. Ann N Y Acad Sci (1952) 4.34

Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect (1995) 4.34

Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev (2008) 4.03

Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology (2004) 3.34

Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect (2001) 3.00

Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A (1998) 2.50

Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology (2003) 1.81

Induction of spermatogenesis by androgens in gonadotropin-deficient (hpg) mice. Endocrinology (1995) 1.47

Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology (2003) 1.42

Induction of oxidative stress by bisphenol A in the epididymal sperm of rats. Toxicology (2003) 1.37

Are environmental levels of bisphenol a associated with reproductive function in fertile men? Environ Health Perspect (2010) 1.25

Exposure with the environmental estrogen bisphenol A disrupts the male reproductive tract in young mice. Life Sci (1999) 1.18

Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells. Biochem Biophys Res Commun (2002) 1.16

Effects of bisphenol A on adult male mouse fertility. Eur J Oral Sci (2002) 1.16

Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol. Toxicol Lett (2010) 1.08

Adverse effects of bisphenol A to spermiogenesis in mice and rats. Arch Histol Cytol (2004) 1.07

Bisphenol A inhibits testicular functions and increases luteinizing hormone secretion in adult male rats. Exp Biol Med (Maywood) (2001) 1.06

Role of caspases in male infertility. Hum Reprod Update (2004) 1.05

Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Endocrinology (2003) 1.04

Spermatogenesis without gonadotropins: maintenance has a lower testosterone threshold than initiation. Endocrinology (1999) 1.03

Effect of high intratesticular estrogen on the seminiferous epithelium in adult male rats. Mol Cell Endocrinol (2005) 0.96

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction (2010) 0.95

Bisphenol A exposure induces apoptosis and upregulation of Fas/FasL and caspase-3 expression in the testes of mice. Toxicol Sci (2009) 0.94

Bisphenol A-induced aromatase activation is mediated by cyclooxygenase-2 up-regulation in rat testicular Leydig cells. Toxicol Lett (2010) 0.92

Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology (2010) 0.90

Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-kappaB. J Neurosci Res (2008) 0.89

cDNA microarray analysis reveals chop-10 plays a key role in Sertoli cell injury induced by bisphenol A. Biochem Biophys Res Commun (2003) 0.88

Bisphenol A-induced apoptosis of cultured rat Sertoli cells. Reprod Toxicol (2003) 0.87

Increase of anteroventral periventricular kisspeptin neurons and generation of E2-induced LH-surge system in male rats exposed perinatally to environmental dose of bisphenol-A. Endocrinology (2011) 0.86

Mitochondrial signaling pathway is also involved in bisphenol A induced germ cell apoptosis in testes. Toxicol Lett (2010) 0.84

Germ cell apoptosis and its molecular trigger in mouse testes. Arch Histol Cytol (2003) 0.83

p,p'-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway. Toxicol Lett (2009) 0.83

Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A. Environ Toxicol Chem (2012) 0.79

Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells. J Transl Med (2009) 0.79

Differences of the effects of testosterone propionate on the production of LH and FSH. Acta Endocrinol (Copenh) (1976) 0.78

Dependence of testicular germ cells on hormones: a quantitative study in hypophysectomized testosterone-treated rats. J Endocrinol (1979) 0.78

Articles by these authors

(truncated to the top 100)

Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature (2002) 12.49

Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol (2003) 4.41

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood (2007) 3.60

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60

Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature (2013) 3.45

Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest (2003) 2.76

Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res (2005) 2.44

Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a phase II multicenter, single-agent study. J Clin Oncol (2008) 2.32

Trends in relative survival for ovarian cancer from 1975 to 2011. Obstet Gynecol (2015) 2.22

Randomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study. Blood (2014) 2.21

Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: results from a Multicenter Study. Cancer (2010) 2.19

A new arboreal haramiyid shows the diversity of crown mammals in the Jurassic period. Nature (2013) 2.15

Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell (2009) 2.00

FASTING VERSUS POSTPRANDIAL HYPERGLYCEMIA AS A TREATMENT TARGET TO LOWER ELEVATED HEMOGLOBIN A1C. Endocr Pract (2015) 1.99

Evidence of myocardial hibernation in the septic heart. Crit Care Med (2005) 1.94

Homeobox protein Hop functions in the adult cardiac conduction system. Circ Res (2005) 1.93

Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nat Struct Mol Biol (2007) 1.87

A new species of yunnanozoan with implications for deuterostome evolution. Science (2003) 1.82

Predicting substrates by docking high-energy intermediates to enzyme structures. J Am Chem Soc (2006) 1.81

Contributions of basal and postprandial hyperglycemia over a wide range of A1C levels before and after treatment intensification in type 2 diabetes. Diabetes Care (2011) 1.77

MRI estimation of the arterial input function in mice. Acad Radiol (2003) 1.74

The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron (2010) 1.74

A cluster randomized clinical trial comparing fit-tested and non-fit-tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers. Influenza Other Respir Viruses (2011) 1.72

MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells. J Exp Med (2008) 1.67

US-guided percutaneous microwave coagulation of small breast cancers: a clinical study. Radiology (2012) 1.66

Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase. Biochemistry (2004) 1.64

Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating. Proc Natl Acad Sci U S A (2007) 1.64

GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS One (2008) 1.63

A randomized clinical trial of three options for N95 respirators and medical masks in health workers. Am J Respir Crit Care Med (2013) 1.62

Virus subversion of the MHC class I peptide-loading complex. Immunity (2003) 1.60

Clinical study for alleviating opiate drug psychological dependence by a method of ablating the nucleus accumbens with stereotactic surgery. Stereotact Funct Neurosurg (2003) 1.59

Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice. J Physiol (2005) 1.58

Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression. Cancer Biol Ther (2010) 1.57

A preclinical 188Re tumor therapeutic investigation using MORF/cMORF pretargeting and an antiTAG-72 antibody CC49. Cancer Biol Ther (2010) 1.56

Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends. J Biol Chem (2003) 1.55

Generation and characterization of chimeric recombinant AAV vectors. Mol Ther (2003) 1.54

Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.52

von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells. PLoS Med (2007) 1.52

Disparities in ovarian cancer care quality and survival according to race and socioeconomic status. J Natl Cancer Inst (2013) 1.52

Mitochondrial ROMK channel is a molecular component of mitoK(ATP). Circ Res (2012) 1.51

Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery. Acad Radiol (2004) 1.49

Structural mechanism of ER retrieval of MHC class I by cowpox. PLoS Biol (2012) 1.49

Transcriptional programming and functional interactions within the Phytophthora sojae RXLR effector repertoire. Plant Cell (2011) 1.47

Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis. J Am Acad Dermatol (2006) 1.46

Utility of dual-modality bioluminescence and MRI in monitoring stem cell survival and impact on post myocardial infarct remodeling. Acad Radiol (2011) 1.45

HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology (2009) 1.45

Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. Gene (2002) 1.45

How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol (2011) 1.43

Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A (2009) 1.41

Analyses of 2-DEG characteristics in GaN HEMT with AlN/GaN super-lattice as barrier layer grown by MOCVD. Nanoscale Res Lett (2012) 1.41

Vaccine-induced immunity in baboons by using DNA and replication-incompetent adenovirus type 5 vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol (2003) 1.41

Adjuvant Corticosteroid Treatment in Adults With Influenza A (H7N9) Viral Pneumonia. Crit Care Med (2016) 1.40

Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol (2011) 1.39

Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci U S A (2009) 1.38

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vertical Transmission in Neonates Born to Mothers With Coronavirus Disease 2019 (COVID-19) Pneumonia. Obstet Gynecol (2020) 1.38

How does salt retention raise blood pressure? Am J Physiol Regul Integr Comp Physiol (2006) 1.36

Hind wings in Basal birds and the evolution of leg feathers. Science (2013) 1.34

Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals. J Virol (2012) 1.32

The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension (2008) 1.32

Fast, comprehensive two-dimensional liquid chromatography. J Chromatogr A (2007) 1.31

Insight into the early evolution of the avian sternum from juvenile enantiornithines. Nat Commun (2012) 1.31

Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol (2007) 1.29

Easy methods to study the smart energetic TNT/CL-20 co-crystal. J Mol Model (2013) 1.27

Preventable maternal mortality: geographic/rural-urban differences and associated factors from the population-based Maternal Mortality Surveillance System in China. BMC Public Health (2011) 1.27

Cowpox virus exploits the endoplasmic reticulum retention pathway to inhibit MHC class I transport to the cell surface. Cell Host Microbe (2007) 1.27

A fine physical map of the rice chromosome 4. Genome Res (2002) 1.26

Determination of endogenous and supplied deuterated abscisic acid in plant tissues by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry with multiple reaction monitoring. Anal Biochem (2004) 1.23

Exploring genetic variation in the tomato (Solanum section Lycopersicon) clade by whole-genome sequencing. Plant J (2014) 1.22

Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. J Physiol (2006) 1.22

Embryonic stem cell grafting in normal and infarcted myocardium: serial assessment with MR imaging and PET dual detection. Radiology (2009) 1.21

The glycoprotein hGC-1 binds to cadherin and lectins. Exp Cell Res (2006) 1.21

The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells. Exp Cell Res (2002) 1.21

Visualizing influenza virus infection in living mice. Nat Commun (2013) 1.20

The hydroxyurea-induced small GTP-binding protein SAR modulates gamma-globin gene expression in human erythroid cells. Blood (2005) 1.19

Preservation of ovarian follicles reveals early evolution of avian reproductive behaviour. Nature (2013) 1.19

Outcome of revision anterior cruciate ligament reconstruction: a systematic review. J Bone Joint Surg Am (2012) 1.17

Breastfeeding rates in central and western China in 2010: implications for child and population health. Bull World Health Organ (2013) 1.17

Epidemiology and clinical presentation of the four human parainfluenza virus types. BMC Infect Dis (2013) 1.16

Nanoparticle-mediated delivery of nuclear factor kappaB decoy into lungs ameliorates monocrotaline-induced pulmonary arterial hypertension. Hypertension (2009) 1.16

Production and characterization of a bioflocculant by Proteus mirabilis TJ-1. Bioresour Technol (2007) 1.15

Invasive micropapillary carcinoma of the breast: association of pathologic features with lymph node metastasis. Am J Clin Pathol (2006) 1.15

Mycoplasma hyorhinis infection in gastric carcinoma and its effects on the malignant phenotypes of gastric cancer cells. BMC Gastroenterol (2010) 1.14

Proteomic analysis of proteins involved in spermiogenesis in mouse. J Proteome Res (2010) 1.13

The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population. Hum Mol Genet (2008) 1.13

Emerging variability in HIV-1 genetics among recently infected individuals in Yunnan, China. PLoS One (2013) 1.12

Interferon-alpha targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway. Exp Hematol (2010) 1.12

Silica nanorattle-doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy. ACS Nano (2011) 1.12

Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Adv Exp Med Biol (2007) 1.12

Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression. J Clin Invest (2014) 1.11

Source apportionment of polycyclic aromatic hydrocarbons (PAHs) in surface sediments of the Huangpu River, Shanghai, China. Sci Total Environ (2009) 1.11

Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China. J Gen Virol (2006) 1.11

Comparison of the practical resolving power of one- and two-dimensional high-performance liquid chromatography analysis of metabolomic samples. Anal Chem (2007) 1.11

Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor. Hypertension (2008) 1.11

Severe, critical and fatal cases of 2009 H1N1 influenza in China. J Infect (2010) 1.11

Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family. Biochemistry (2007) 1.10

Quantitative imaging of myocardial infarct in rats with high resolution pinhole SPECT. Int J Cardiovasc Imaging (2006) 1.10

Generation of replication-competent recombinant influenza A viruses carrying a reporter gene harbored in the neuraminidase segment. J Virol (2010) 1.10

The changes in maternal mortality in 1000 counties in mid-Western China by a government-initiated intervention. PLoS One (2012) 1.09

Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents. Neoplasia (2006) 1.09