Published in Proc Natl Acad Sci U S A on April 17, 2009
Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron (2010) 2.24
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs. Circulation (2014) 2.11
Systems pharmacology of arrhythmias. Sci Signal (2010) 1.72
Vascular COX-2 modulates blood pressure and thrombosis in mice. Sci Transl Med (2012) 1.71
Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function. Hypertension (2012) 1.66
Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. J Neurosci (2011) 1.37
Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Cardiol (2010) 1.21
Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver. Dis Model Mech (2013) 1.15
Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome. J Lipid Res (2013) 1.06
Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation (2010) 1.04
PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenet Genomics (2011) 1.03
Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. J Mol Cell Cardiol (2010) 0.99
Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A (2012) 0.98
Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. Carcinogenesis (2011) 0.96
Prostaglandin E₂ promotes post-infarction cardiomyocyte replenishment by endogenous stem cells. EMBO Mol Med (2014) 0.94
Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency. J Biol Chem (2012) 0.93
Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy. Basic Res Cardiol (2013) 0.92
Long-term improvement in postinfarct left ventricular global and regional contractile function is mediated by embryonic stem cell-derived cardiomyocytes. Circ Cardiovasc Imaging (2010) 0.92
Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation (2012) 0.91
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PLoS One (2013) 0.88
Cyclooxygenase-2 in endothelial and vascular smooth muscle cells restrains atherogenesis in hyperlipidemic mice. Circulation (2014) 0.84
Akt2 knockout mitigates chronic iNOS inhibition-induced cardiomyocyte atrophy and contractile dysfunction despite persistent insulin resistance. Toxicol Lett (2011) 0.83
Cardiovascular biology of microsomal prostaglandin E synthase-1. Trends Cardiovasc Med (2010) 0.82
Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism. Circ Res (2013) 0.81
Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. Mol Cell Biol (2015) 0.81
Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta (2014) 0.80
6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. Cancer Res (2013) 0.80
Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways. Cell Chem Biol (2016) 0.79
Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis. Oncotarget (2015) 0.78
Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice. Am J Pathol (2012) 0.78
Cardiac melanocytes influence atrial reactive oxygen species involved with electrical and structural remodeling in mice. Physiol Rep (2015) 0.78
Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective. Br J Clin Pharmacol (2016) 0.77
PG F(2α) Receptor: A Promising Therapeutic Target for Cardiovascular Disease. Front Pharmacol (2010) 0.76
Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. PLoS One (2013) 0.75
Clocks and cardiovascular function. Methods Enzymol (2014) 0.75
Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor. Circ Heart Fail (2016) 0.75
Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy. Diabetes (2016) 0.75
Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol (2016) 0.75
Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med (2005) 15.46
Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med (2005) 12.46
Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med (2005) 6.32
Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res (2001) 6.15
Conditional control of gene expression in the mouse. Nat Rev Genet (2001) 5.30
Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell (1997) 4.69
Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy in relation to delayed enhancement on cardiovascular magnetic resonance. J Am Coll Cardiol (2008) 4.51
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest (2006) 4.50
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell (1995) 4.47
Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. JAMA (2006) 4.04
What causes sudden death in heart failure? Circ Res (2004) 3.44
Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery. J Thorac Cardiovasc Surg (2003) 2.91
Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab (2005) 2.82
Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits. Proc Natl Acad Sci U S A (2000) 2.28
Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat Med (1999) 2.26
Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits. J Am Coll Cardiol (2003) 2.23
Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res (2004) 2.11
Assessment of global and regional myocardial function in the mouse using cine and tagged MRI. Magn Reson Med (2003) 2.06
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest (2006) 2.03
Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J Clin Invest (2002) 1.86
Physiological regulation of prostaglandins in the kidney. Annu Rev Physiol (2008) 1.84
Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2. J Biol Chem (1999) 1.70
Cyclooxygenase knockout mice: models for elucidating isoform-specific functions. Biochem Pharmacol (1999) 1.65
Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors. Circulation (2001) 1.51
Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. Arch Intern Med (2005) 1.49
Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice. Am J Physiol Renal Physiol (2004) 1.36
Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis. J Biol Chem (1990) 1.27
Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation. Development (2008) 1.19
Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes. Prostaglandins (1997) 1.17
Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. Circulation (2008) 1.14
Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat Med (2005) 1.13
Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. J Clin Invest (2001) 1.13
Comparative analysis of pharmacologic and/or genetic disruption of cyclooxygenase-1 and cyclooxygenase-2 function in female reproduction in mice. Endocrinology (2001) 1.12
The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. J Clin Invest (2006) 1.10
COX-2 in play at the AHA and the FDA. Trends Pharmacol Sci (2007) 1.09
Inhibition of delayed rectifier potassium channels and induction of arrhythmia: a novel effect of celecoxib and the mechanism underlying it. J Biol Chem (2007) 1.09
Conditional genome alteration in mice. Bioessays (1998) 1.05
Reduced cardiac remodeling and function in cardiac-specific EP4 receptor knockout mice with myocardial infarction. Hypertension (2008) 0.98
Cyclooxygenase inhibition and baroreflex sensitivity in humans. Am J Physiol Heart Circ Physiol (2004) 0.96
Prostaglandins contribute to activation of baroreceptors in rabbits. Possible paracrine influence of endothelium. Circ Res (1990) 0.95
Augmented cardiac hypertrophy in response to pressure overload in mice lacking the prostaglandin I2 receptor. Circulation (2005) 0.95
Prostacyclin attenuates oxidative damage of myocytes by opening mitochondrial ATP-sensitive K+ channels via the EP3 receptor. Am J Physiol Heart Circ Physiol (2004) 0.92
Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism. Cardiovasc Res (2005) 0.92
New insights into the intracellular mechanisms by which PGI2 analogues elicit vascular relaxation: cyclic AMP-independent, Gs-protein mediated-activation of MaxiK channel. Curr Med Chem Cardiovasc Hematol Agents (2004) 0.88
Prostaglandin F(2alpha), cytokines and cyclic mechanical stretch augment matrix metalloproteinase-1 secretion from cultured human uterine cervical fibroblast cells. Mol Hum Reprod (2002) 0.88
Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. Int J Cancer (2008) 0.87
Prostanoids and blood pressure: which way is up? J Clin Invest (2004) 0.87
Adjusted indirect comparison of celecoxib versus rofecoxib on cardiovascular risk. Rheumatol Int (2007) 0.87
PGI2 opens potassium channels in retinal pericytes by cyclic AMP-stimulated, cross-activation of PKG. Exp Eye Res (2006) 0.85
The influence of prostacyclin on coronary occlusion induced arrhythmia in cats. Prostaglandins Med (1979) 0.85
The choreography of cyclooxygenases in the kidney. J Clin Invest (2002) 0.85
Implication of connexins 40 and 43 in functional coupling between mouse cardiac fibroblasts in primary culture. Biochim Biophys Acta (2008) 0.84
On the 7-oxo-PgI2 induced lasting protection against ouabain arrhythmias in anesthetized guinea pigs. Biomed Biochim Acta (1988) 0.80
Interaction of platelets with the vessel wall in the pathophysiology of sudden cardiac death. Circulation (1986) 0.79
Role of the prostanoid FP receptor in action potential generation and phenotypic transformation of NRK fibroblasts. Cell Signal (2008) 0.78
PGI2 attenuates baroreflex control of renal nerve activity by a vagal mechanism. Am J Physiol (1988) 0.77
The antiarrhythmic effect of PGE2 on premature ventricular beats (PVBs) in man. Prostaglandins Leukot Med (1983) 0.77
Intracoronary infusion of prostaglandin I2 attenuates arterial baroreflex control of heart rate in conscious dogs. Circ Res (1988) 0.77
Antiarrhythmic effects of prostaglandins E2 and I2 on ouabain-induced cardiac arrhythmias in cats: effect of vagotomy and adrenergic neuron blockade. Pharmacol Res (1990) 0.77
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature (2005) 8.96
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A (2006) 7.26
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature (2006) 7.22
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron (2004) 5.71
Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol (2008) 5.40
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature (2010) 5.26
Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol (2011) 4.67
Role of prostacyclin in the cardiovascular response to thromboxane A2. Science (2002) 4.59
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest (2006) 4.50
Interconversion between intestinal stem cell populations in distinct niches. Science (2011) 4.23
Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol (2003) 3.69
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med (2007) 3.61
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood (2007) 3.60
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45
Echocardiographic assessment of pulmonary hypertension in patients with advanced lung disease. Am J Respir Crit Care Med (2002) 3.32
PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell (2004) 3.24
Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol (2006) 3.03
Smooth muscle cells, but not myocytes, of host origin in transplanted human hearts. Circulation (2002) 2.93
Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development (2002) 2.88
Human C-reactive protein does not promote atherosclerosis in transgenic rabbits. Circulation (2009) 2.83
Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation (2003) 2.77
Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest (2003) 2.76
Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin. Circulation (2012) 2.76
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. J Biol Chem (2008) 2.75
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development (2005) 2.73
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell (2009) 2.72
Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation (2003) 2.69
ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol (2008) 2.67
Nf1 has an essential role in endothelial cells. Nat Genet (2002) 2.63
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
Interactions among PIN-FORMED and P-glycoprotein auxin transporters in Arabidopsis. Plant Cell (2007) 2.52
Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res (2005) 2.44
Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development (2007) 2.44
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res (2005) 2.44
Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc Natl Acad Sci U S A (2007) 2.39
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation (2003) 2.28
Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development (2004) 2.27
Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. J Clin Invest (2003) 2.27
Randomized ablation strategies for the treatment of persistent atrial fibrillation: RASTA study. Circ Arrhythm Electrophysiol (2011) 2.26
Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancer. J Clin Oncol (2007) 2.15
Genome wide association studies for milk production traits in Chinese Holstein population. PLoS One (2010) 2.13
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol (2002) 2.13
Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects. J Am Coll Cardiol (2005) 2.13
Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest (2007) 2.12
Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annu Rev Med (2010) 2.11
Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem (2007) 2.10
Assessment of global and regional myocardial function in the mouse using cine and tagged MRI. Magn Reson Med (2003) 2.06
Prostanoids in health and disease. J Lipid Res (2008) 2.06
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest (2006) 2.03
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Ig-like domains on bacteriophages: a tale of promiscuity and deceit. J Mol Biol (2006) 1.99
Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development (2004) 1.99
Selection demands versus association strength in the verb generation task. Psychon Bull Rev (2006) 1.99
FASTING VERSUS POSTPRANDIAL HYPERGLYCEMIA AS A TREATMENT TARGET TO LOWER ELEVATED HEMOGLOBIN A1C. Endocr Pract (2015) 1.99
Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study. Lancet Neurol (2008) 1.98
Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest (2004) 1.97
Safety and long-term efficacy of endovascular treatment of small posterior communicating artery aneurysms by coiling with or without stent: a single center retrospective study. Clin Neurol Neurosurg (2013) 1.97
From stem cells to viable autologous semilunar heart valve. Circulation (2005) 1.94
Evidence of myocardial hibernation in the septic heart. Crit Care Med (2005) 1.94
A molecular-imprint nanosensor for ultrasensitive detection of proteins. Nat Nanotechnol (2010) 1.93
Homeobox protein Hop functions in the adult cardiac conduction system. Circ Res (2005) 1.93
Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. J Mol Cell Cardiol (2008) 1.90
Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. Circulation (2006) 1.89
Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-phase cells. Radiat Res (2003) 1.88
Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects. Circulation (2004) 1.88
Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest (2009) 1.83
Anomalous origin of the left coronary artery from the pulmonary artery in adulthood on CT and MRI. AJR Am J Roentgenol (2005) 1.83
GATA6 regulates differentiation of distal lung epithelium. Development (2002) 1.82
Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol (2005) 1.79
Determination of interobserver variability for identifying inducible left ventricular wall motion abnormalities during dobutamine stress magnetic resonance imaging. Eur Heart J (2006) 1.79
Lower treatment blood pressure is associated with greatest reduction in hematoma growth after acute intracerebral hemorrhage. Hypertension (2010) 1.78
COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol (2007) 1.77
Contributions of basal and postprandial hyperglycemia over a wide range of A1C levels before and after treatment intensification in type 2 diabetes. Diabetes Care (2011) 1.77
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem (2003) 1.77
Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector. Blood (2004) 1.74
MRI estimation of the arterial input function in mice. Acad Radiol (2003) 1.74
ABCB19/PGP19 stabilises PIN1 in membrane microdomains in Arabidopsis. Plant J (2008) 1.74
COX-2-dependent cardiac failure in Gh/tTG transgenic mice. Circ Res (2003) 1.72
Vascular COX-2 modulates blood pressure and thrombosis in mice. Sci Transl Med (2012) 1.71