Published in EMBO Mol Med on April 01, 2009
Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature (2013) 3.69
ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta (2011) 2.17
Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem Biol (2014) 1.96
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases. Nat Rev Microbiol (2009) 1.81
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat Struct Mol Biol (2010) 1.60
Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. PLoS Pathog (2012) 1.60
The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1. PLoS One (2015) 1.55
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. Chem Biol (2010) 1.48
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J (2012) 1.31
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proc Natl Acad Sci U S A (2011) 1.22
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J Mol Biol (2010) 1.16
Biofilm-specific antibiotic tolerance and resistance. Eur J Clin Microbiol Infect Dis (2015) 1.09
Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov (2012) 1.08
Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc Natl Acad Sci U S A (2014) 1.07
Roles of adaptor proteins in regulation of bacterial proteolysis. Curr Opin Microbiol (2013) 1.06
The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo. Antimicrob Agents Chemother (2014) 1.02
Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines. Nat Rev Microbiol (2015) 1.01
Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities. PLoS One (2013) 0.98
Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. J Am Chem Soc (2014) 0.98
Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria. MBio (2015) 0.94
Regulated proteolysis in bacterial development. FEMS Microbiol Rev (2013) 0.93
β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease. Antimicrob Agents Chemother (2014) 0.90
Structural basis of mycobacterial inhibition by cyclomarin A. J Biol Chem (2013) 0.90
Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase. ACS Chem Biol (2013) 0.86
Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. J Biol Chem (2016) 0.83
A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity. Chembiochem (2014) 0.83
Life and death of proteins: a case study of glucose-starved Staphylococcus aureus. Mol Cell Proteomics (2012) 0.81
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease. Mol Microbiol (2016) 0.81
FliT selectively enhances proteolysis of FlhC subunit in FlhD4C2 complex by an ATP-dependent protease, ClpXP. J Biol Chem (2014) 0.80
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. Oxid Med Cell Longev (2016) 0.77
Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase. Chembiochem (2015) 0.76
A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. PLoS One (2016) 0.76
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P. J Nat Prod (2016) 0.75
Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle. ACS Chem Biol (2016) 0.75
Two ways to skin a cat: acyldepsipeptides antibiotics can kill bacteria through activation or inhibition of ClpP activity. Mol Microbiol (2016) 0.75
Bacterial proteases, untapped antimicrobial drug targets. J Antibiot (Tokyo) (2016) 0.75
The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone. MBio (2016) 0.75
AAA+ Machines of Protein Destruction in Mycobacteria. Front Mol Biosci (2017) 0.75
Molecular chaperones in the cytosol: from nascent chain to folded protein. Science (2002) 15.09
A common mechanism of cellular death induced by bactericidal antibiotics. Cell (2007) 12.92
Antibacterial resistance worldwide: causes, challenges and responses. Nat Med (2004) 10.46
Molecular chaperones and protein quality control. Cell (2006) 7.74
Posttranslational quality control: folding, refolding, and degrading proteins. Science (1999) 5.55
Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death. Cell (2008) 4.47
The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis. Cell (1997) 4.37
The antibiotic resistome: the nexus of chemical and genetic diversity. Nat Rev Microbiol (2007) 4.14
Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell (2004) 3.83
Proteolysis in bacterial regulatory circuits. Annu Rev Cell Dev Biol (2003) 3.45
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat Med (2005) 3.40
Molecular insights into aminoglycoside action and resistance. Chem Rev (2005) 3.17
Trigger factor and DnaK cooperate in folding of newly synthesized proteins. Nature (1999) 2.95
Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli. J Biol Chem (1990) 2.71
Biochemical characterization of a molecular switch involving the heat shock protein ClpC, which controls the activity of ComK, the competence transcription factor of Bacillus subtilis. Genes Dev (1997) 2.65
GFP vectors for controlled expression and dual labelling of protein fusions in Bacillus subtilis. Gene (1999) 2.45
ClpS, a substrate modulator of the ClpAP machine. Mol Cell (2002) 2.28
ClpP of Bacillus subtilis is required for competence development, motility, degradative enzyme synthesis, growth at high temperature and sporulation. Mol Microbiol (1998) 2.20
Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase. Nat Struct Biol (2001) 2.18
AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett (2002) 2.10
ClpS is an essential component of the N-end rule pathway in Escherichia coli. Nature (2006) 2.09
Stress induction of the Bacillus subtilis clpP gene encoding a homologue of the proteolytic component of the Clp protease and the involvement of ClpP and ClpX in stress tolerance. Mol Microbiol (1998) 2.07
Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria. Mol Microbiol (2007) 2.03
Bleach activates a redox-regulated chaperone by oxidative protein unfolding. Cell (2008) 2.00
Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proc Natl Acad Sci U S A (1986) 1.94
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol Cell (2007) 1.91
Regulation by proteolysis in bacterial cells. Curr Opin Microbiol (2003) 1.86
Communication between ClpX and ClpP during substrate processing and degradation. Nat Struct Mol Biol (2004) 1.85
Proteomic approach to understanding antibiotic action. Antimicrob Agents Chemother (2003) 1.78
Trigger Factor and DnaK possess overlapping substrate pools and binding specificities. Mol Microbiol (2003) 1.77
MecA, an adaptor protein necessary for ClpC chaperone activity. Proc Natl Acad Sci U S A (2003) 1.76
Self-compartmentalizing proteases. Trends Biochem Sci (1997) 1.71
A genetic selection for supercoiling mutants of Escherichia coli reveals proteins implicated in chromosome structure. Mol Microbiol (2005) 1.67
Chaperone rings in protein folding and degradation. Proc Natl Acad Sci U S A (1999) 1.66
Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis. Mol Microbiol (2001) 1.61
Adaptor protein controlled oligomerization activates the AAA+ protein ClpC. EMBO J (2006) 1.49
Trigger factor forms a protective shield for nascent polypeptides at the ribosome. J Biol Chem (2006) 1.38
ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease. Biochemistry (1999) 1.34
The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J Biol Chem (2005) 1.33
Dynamics of trigger factor interaction with translating ribosomes. J Biol Chem (2007) 1.28
The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexes. J Struct Biol (2005) 1.27
Localization of general and regulatory proteolysis in Bacillus subtilis cells. Mol Microbiol (2008) 1.20
MurAA, catalysing the first committed step in peptidoglycan biosynthesis, is a target of Clp-dependent proteolysis in Bacillus subtilis. Mol Microbiol (2004) 1.20
Exploring the conformational properties of the sequence space between two proteins with different folds: an experimental study. J Mol Biol (1999) 1.12
Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics. ChemMedChem (2006) 1.02
In vitro analysis of the bacterial protein export. Curr Top Microbiol Immunol (1986) 0.77
Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Cell (2004) 4.90
Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol (2010) 3.54
Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J (2009) 3.19
Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science (2003) 2.84
The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies. Trends Cell Biol (2007) 2.64
Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing. EMBO J (2010) 2.25
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett (2002) 2.10
Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes. Proc Natl Acad Sci U S A (2005) 2.01
New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat Med (2002) 1.92
ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria. Biol Chem (2005) 1.92
Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation. Mol Microbiol (2008) 1.85
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases. Nat Rev Microbiol (2009) 1.81
Chaperone-based procedure to increase yields of soluble recombinant proteins produced in E. coli. BMC Biotechnol (2007) 1.80
Trigger Factor and DnaK possess overlapping substrate pools and binding specificities. Mol Microbiol (2003) 1.77
MecA, an adaptor protein necessary for ClpC chaperone activity. Proc Natl Acad Sci U S A (2003) 1.76
M domains couple the ClpB threading motor with the DnaK chaperone activity. Mol Cell (2007) 1.72
The redox-switch domain of Hsp33 functions as dual stress sensor. Nat Struct Mol Biol (2007) 1.69
Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol (2003) 1.69
Tubules and donuts: a type VI secretion story. Mol Microbiol (2010) 1.68
Characterization of a trap mutant of the AAA+ chaperone ClpB. J Biol Chem (2003) 1.65
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat Struct Mol Biol (2010) 1.60
Structure and total synthesis of lysobactin (katanosin B). Angew Chem Int Ed Engl (2007) 1.56
Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA. EMBO J (2003) 1.55
Adaptor protein controlled oligomerization activates the AAA+ protein ClpC. EMBO J (2006) 1.49
Identification of a redox-regulated chaperone network. EMBO J (2003) 1.46
Inclusion bodies: formation and utilisation. Adv Biochem Eng Biotechnol (2004) 1.46
Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation. J Cell Biol (2012) 1.46
Hsp42 is required for sequestration of protein aggregates into deposition sites in Saccharomyces cerevisiae. J Cell Biol (2011) 1.45
Molecular mechanism and structure of Trigger Factor bound to the translating ribosome. EMBO J (2008) 1.41
Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion. J Biol Chem (2011) 1.37
Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments. Nat Struct Mol Biol (2008) 1.35
Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis. J Mol Biol (2004) 1.35
Prevention and reversion of protein aggregation by molecular chaperones in the E. coli cytosol: implications for their applicability in biotechnology. J Biotechnol (2002) 1.34
A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis. EMBO J (2005) 1.33
Dynamics of trigger factor interaction with translating ribosomes. J Biol Chem (2007) 1.28
Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces. Nat Struct Mol Biol (2012) 1.26
Dissecting structural and functional diversity of the lantibiotic mersacidin. Chem Biol (2009) 1.25
ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion. Mol Microbiol (2013) 1.25
Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization. Proc Natl Acad Sci U S A (2006) 1.24
Structural insight into poly(A) binding and catalytic mechanism of human PARN. EMBO J (2005) 1.24
Chaperone networks in protein disaggregation and prion propagation. J Struct Biol (2012) 1.23
Activation of the redox-regulated chaperone Hsp33 by domain unfolding. J Biol Chem (2004) 1.23
Small cationic antimicrobial peptides delocalize peripheral membrane proteins. Proc Natl Acad Sci U S A (2014) 1.22
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proc Natl Acad Sci U S A (2011) 1.22
Deadly syringes: type VI secretion system activities in pathogenicity and interbacterial competition. Curr Opin Microbiol (2013) 1.20
Localization of general and regulatory proteolysis in Bacillus subtilis cells. Mol Microbiol (2008) 1.20
Ganglioside-dependent cell attachment and endocytosis of murine polyomavirus-like particles. FEBS Lett (2003) 1.20
Human serum albumin-polyethylenimine nanoparticles for gene delivery. J Control Release (2003) 1.20
Interaction of trigger factor with the ribosome. J Mol Biol (2003) 1.19
Unscrambling an egg: protein disaggregation by AAA+ proteins. Microb Cell Fact (2004) 1.19
Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation. Biochem Cell Biol (2010) 1.18
Novel whole-cell antibiotic biosensors for compound discovery. Appl Environ Microbiol (2007) 1.17
YcdB from Escherichia coli reveals a novel class of Tat-dependently translocated hemoproteins. J Biol Chem (2006) 1.15
Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia (2010) 1.13
A tightly regulated molecular toggle controls AAA+ disaggregase. Nat Struct Mol Biol (2012) 1.13
Novel insights into the mechanism of chaperone-assisted protein disaggregation. Biol Chem (2005) 1.12
Solubilization of aggregated proteins by ClpB/DnaK relies on the continuous extraction of unfolded polypeptides. FEBS Lett (2004) 1.12
Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease pim1. Mol Cell Biol (2006) 1.12
The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. EMBO J (2007) 1.11
The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins. Mol Cell Biol (2009) 1.10
The C-terminal domain of Escherichia coli trigger factor represents the central module of its chaperone activity. J Biol Chem (2006) 1.09
Catalytic activity and chaperone function of human protein-disulfide isomerase are required for the efficient refolding of proinsulin. J Biol Chem (2001) 1.08
Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages. Virology (2006) 1.07
The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. J Biol Chem (2009) 1.05
Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins. Biol Chem (2011) 1.04
Direct kinetic evidence for half-of-the-sites reactivity in the E1 component of the human pyruvate dehydrogenase multienzyme complex through alternating sites cofactor activation. Biochemistry (2006) 1.03
Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293. Antimicrob Agents Chemother (2002) 1.02
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis. J Nat Prod (2013) 1.02
Biological characterization of novel inhibitors of the gram-positive DNA polymerase IIIC enzyme. Antimicrob Agents Chemother (2005) 1.02
Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics. ChemMedChem (2006) 1.02
ClpS is the recognition component for Escherichia coli substrates of the N-end rule degradation pathway. Mol Microbiol (2009) 1.00
Structure and function of a novel type of ATP-dependent Clp protease. J Biol Chem (2009) 1.00
New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity. Antimicrob Agents Chemother (2004) 0.99
Microglia express GABA(B) receptors to modulate interleukin release. Mol Cell Neurosci (2004) 0.99
Killing of target cells by redirected granzyme B in the absence of perforin. FEBS Lett (2004) 0.99
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing. J Neurochem (2005) 0.98
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A (2012) 0.98
Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity. J Biol Chem (2005) 0.97
L-Arginine increases the solubility of unfolded species of hen egg white lysozyme. Protein Sci (2005) 0.97
The lantibiotic mersacidin is an autoinducing peptide. Appl Environ Microbiol (2006) 0.97
Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding. FEBS J (2008) 0.93
Renaturation of human proinsulin--a study on refolding and conversion to insulin. Anal Biochem (2002) 0.93
A PDZ switch for a cellular stress response. Cell (2004) 0.93
Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs. J Mol Biol (2006) 0.93
Bacterial cell division as a target for new antibiotics. Curr Opin Microbiol (2013) 0.93
In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106. EJNMMI Res (2013) 0.92
Chaperone-protease systems in regulation and protein quality control in Bacillus subtilis. Res Microbiol (2009) 0.90
Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein. Proc Natl Acad Sci U S A (2008) 0.89
Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells. J Physiol (2003) 0.89
ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc. Glia (2004) 0.89
The impact of transcriptome and proteome analyses on antibiotic drug discovery. Curr Opin Microbiol (2004) 0.88
Evaluation of patient satisfaction after therapy of unilateral clefts of lip, alveolus and palate. J Craniomaxillofac Surg (2006) 0.88
An old target revisited: two new privileged skeletons and an unexpected binding mode for HIV-protease inhibitors. Angew Chem Int Ed Engl (2005) 0.88
Disulfide linkage and structure of highly stable yeast-derived virus-like particles of murine polyomavirus. J Biol Chem (2014) 0.88
The role of thiol oxidative stress response in heat-induced protein aggregate formation during thermotolerance in Bacillus subtilis. Mol Microbiol (2014) 0.88