Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 3809704)

Published in Immunology on September 01, 2013

Authors

Hidetaka Hara1, William Witt, Tanner Crossley, Cassandra Long, Kumiko Isse, Liming Fan, Carol J Phelps, David Ayares, David K C Cooper, Yifan Dai, Thomas E Starzl

Author Affiliations

1: Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA. harah@upmc.edu

Articles cited by this

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection. J Exp Med (1990) 3.73

Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med (2004) 3.58

Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A (1984) 3.14

The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol (2001) 3.14

Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A (1999) 2.83

Regulation of MHC class II gene expression by the class II transactivator. Nat Rev Immunol (2005) 2.44

Clinical xenotransplantation: the next medical revolution? Lancet (2011) 1.84

T-cell responses during pig-to-primate xenotransplantation. Xenotransplantation (2006) 1.65

Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Immunity (1997) 1.52

Induction of MHC class I expression by the MHC class II transactivator CIITA. Immunity (1997) 1.51

The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation (2009) 1.47

In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transpl Int (2008) 1.44

Phenotypic classification of porcine lymphocyte subpopulations in blood and lymphoid tissues. Immunology (1996) 1.33

Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol (1995) 1.26

Mice lacking the transcription factor CIITA--a second look. Int Immunol (1998) 1.21

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig. Xenotransplantation (2009) 1.14

Interferon-gamma inhibits transgene expression driven by SV40 or CMV promoters but augments expression driven by the mammalian MHC I promoter. Hum Gene Ther (1995) 1.11

Xenotransplantation of solid organs in the pig-to-primate model. Transpl Immunol (2008) 1.11

High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation (2000) 1.10

CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant. J Immunol (1997) 1.09

Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity. Transplantation (1997) 1.07

Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity (1994) 1.03

Direct recognition of SLA- and HLA-like class II antigens on porcine endothelium by human T cells results in T cell activation and release of interleukin-2. Transplantation (1995) 1.02

Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs. Invest Ophthalmol Vis Sci (2011) 1.01

Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7. J Immunol (2000) 1.00

Surgical and nonsurgical complications of a pig to baboon heterotopic heart transplantation model. Transplant Proc (2010) 0.99

Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses. Transplantation (2008) 0.95

Biology of porcine T lymphocytes. Anim Health Res Rev (2007) 0.93

Relative efficiency of porcine and human cytotoxic T-lymphocyte antigen 4 immunoglobulin in inhibiting human CD4+ T-cell responses co-stimulated by porcine and human B7 molecules. Immunology (2011) 0.92

Cross-species costimulation: relative contributions of CD80, CD86, and CD40. Transplantation (2003) 0.91

Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol (1996) 0.89

Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood. Vet Immunol Immunopathol (2006) 0.89

Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates. Curr Opin Organ Transplant (2011) 0.88

Constitutive expression of major histocompatibility complex class II antigens in pulmonary epithelium and endothelium varies among different species. Transplantation (2004) 0.85

Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol (2008) 0.84

Suppression of human anti-porcine T-cell immune responses by major histocompatibility complex class II transactivator constructs lacking the amino terminal domain. Transplantation (1998) 0.84

T cell response in xenorecognition and xenografts: a review. Hum Immunol (1999) 0.83

T cell-mediated xenograft rejection: specific tolerance is probably required for long term xenograft survival. Xenotransplantation (1998) 0.83

Intact pancreatic islet function despite humoral xenorecognition in the pig-to-monkey combination. Transplantation (1998) 0.81

Stimulatory and inhibitory receptor interactions in xenotransplantation. Curr Opin Organ Transplant (2010) 0.78

Articles by these authors

Targeted disruption of the alpha1,3-galactosyltransferase gene in cloned pigs. Nat Biotechnol (2002) 4.82

Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (2002) 3.96

Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here? Transplantation (2007) 3.65

Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med (2004) 3.63

Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med (2004) 3.58

Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat Biotechnol (2006) 3.07

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med (2005) 2.67

VENO-VENOUS BYPASS WITHOUT SYSTEMIC ANTICOAGULATION IN CANINE AND HUMAN LIVER TRANSPLANTATION. Surg Forum (1983) 2.30

THE USE OF COMBINED PRESERVATION TECHNIQUES FOR EXTENDED STORAGE OF ORTHOTOPIC LIVER HOMOGRAFTS. Surg Gynecol Obstet (1968) 2.20

Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath. J Am Coll Surg (2005) 1.93

Clinical xenotransplantation: the next medical revolution? Lancet (2011) 1.84

Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation (2006) 1.81

The hepatoadrenal syndrome: a common yet unrecognized clinical condition. Crit Care Med (2005) 1.75

Complications of right lobe living donor liver transplantation. J Hepatol (2009) 1.73

IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival. J Immunol (2011) 1.72

Polyanalgesic Consensus Conference 2012: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation (2012) 1.70

Hepatic function after genetically engineered pig liver transplantation in baboons. Transplantation (2010) 1.64

Alemtuzumab preconditioning with tacrolimus monotherapy-the impact of serial monitoring for donor-specific antibody. Transplantation (2008) 1.62

Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principles. Liver Transpl (2005) 1.61

EFFECT OF CYCLOSPORIN ON HEPATIC REGENERATION. Surg Forum (1986) 1.59

alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation (2005) 1.56

Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood. Xenotransplantation (2014) 1.53

Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaning. Ann Surg (2003) 1.52

Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia. Liver Int (2008) 1.51

Investigation of red blood cells from alpha1,3-galactosyltransferase-knockout pigs for human blood transfusion. Transfusion (2004) 1.48

The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation (2009) 1.47

Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation (2003) 1.47

Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Proc Natl Acad Sci U S A (2006) 1.46

In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transpl Int (2008) 1.44

Low-dose intrathecal naloxone to enhance intrathecal morphine analgesia: a case report. J Opioid Manag (2008) 1.44

Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitis C virus. Transplantation (2004) 1.43

Transplantation of en bloc pediatric kidneys when the proximal vascular cuff is too short. Transplantation (2007) 1.42

Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun (2012) 1.42

SUCCESSFUL ORTHOTOPIC TRANSPLANTATION OF LIVER HOMOGRAFTS AFTER EIGHT TO TWENTY-FIVE HOURS PRESERVATION. Surg Forum (1967) 1.37

Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol (2008) 1.36

Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation. J Pediatr (2006) 1.36

Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia. J Autoimmun (2008) 1.35

Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma. Am J Pathol (2006) 1.31

Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. Mol Cancer Ther (2009) 1.31

Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. Ann Surg (2013) 1.30

Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model. J Mol Med (Berl) (2006) 1.28

Clinical islet xenotransplantation: how close are we? Diabetes (2012) 1.26

Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation (2004) 1.26

Lipopolysaccharide activates nuclear factor-kappaB through toll-like receptors and related molecules in cultured biliary epithelial cells. Lab Invest (2003) 1.25

Origin of lymph node-derived lymphocytes in human hepatic allografts. Clin Transpl (1989) 1.24

Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes (2009) 1.22

Effect of liver transplantation on inflammatory bowel disease in patients with primary sclerosing cholangitis. Hepatology (2002) 1.21

Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies. Xenotransplantation (2007) 1.20

Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M. Liver Int (2006) 1.19

Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates. J Biol Chem (2001) 1.18

Pregnancy after liver transplantation with tacrolimus immunosuppression: a single center's experience update at 13 years. Transplantation (2003) 1.18

Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transpl Immunol (2008) 1.17

Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen. Am J Transplant (2004) 1.17

Hormonal therapy of the brain-dead organ donor: experimental and clinical studies. Transplantation (2006) 1.17

The choice of anatomical site for islet transplantation. Cell Transplant (2008) 1.17

Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. Cancer Res (2008) 1.16

Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation (2012) 1.16

Current status of xenotransplantation and prospects for clinical application. Xenotransplantation (2009) 1.15

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig. Xenotransplantation (2009) 1.14

Analogs of the marine alkaloid makaluvamines: synthesis, topoisomerase II inhibition, and anticancer activity. Bioorg Med Chem Lett (2007) 1.13

Histologic graft assessment after clinical islet transplantation. Transplantation (2009) 1.12

Phlebosclerotic colitis: imaging-pathologic correlation. AJR Am J Roentgenol (2005) 1.12

OKT3 and viral disease in pediatric liver transplant recipients. Clin Transplant (1991) 1.11

Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree. Hepatology (2004) 1.11

Xenotransplantation of solid organs in the pig-to-primate model. Transpl Immunol (2008) 1.11

Xenotransplantation--the future of corneal transplantation? Cornea (2011) 1.10

Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. Tissue Eng Part A (2009) 1.10

Early outcomes in human lung transplantation with Thymoglobulin or Campath-1H for recipient pretreatment followed by posttransplant tacrolimus near-monotherapy. J Thorac Cardiovasc Surg (2005) 1.10

Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines. Bioorg Med Chem (2007) 1.10

Carbohydrates in xenotransplantation. Immunol Cell Biol (2005) 1.10

Genetically modified pigs for medicine and agriculture. Biotechnol Genet Eng Rev (2008) 1.09

Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists. Transplantation (2006) 1.09

Research on compensation of suction deformation error of potassium dihydrogen phosphate crystal. Appl Opt (2013) 1.08

Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity. Transplantation (2004) 1.07

Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory. Gastroenterology (2006) 1.07

Production of cloned transgenic cow expressing omega-3 fatty acids. Transgenic Res (2011) 1.07

Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates. Xenotransplantation (2012) 1.06

Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation. Mol Cancer Ther (2008) 1.05

Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia. Hepatology (2007) 1.05

Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes. J Hepatol (2008) 1.04

Thyroid hormone therapy in the management of 63,593 brain-dead organ donors: a retrospective analysis. Transplantation (2014) 1.04

Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity. Hepatology (2007) 1.03

Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. J Pathol (2009) 1.03

Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation (2007) 1.03

Activation of cytomegalovirus in pig-to-primate organ xenotransplantation. J Virol (2002) 1.03