Published in Nat Med on December 26, 2004
Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med (2005) 2.67
Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci U S A (2011) 2.61
The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance. Biochim Biophys Acta (2007) 2.34
Animal models for cartilage regeneration and repair. Tissue Eng Part B Rev (2010) 2.22
Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. PLoS Biol (2008) 2.08
Hepatic function after genetically engineered pig liver transplantation in baboons. Transplantation (2010) 1.64
Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood. Xenotransplantation (2014) 1.53
Human hepatocyte transplantation: current experience and future challenges. Nat Rev Gastroenterol Hepatol (2010) 1.52
The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation (2009) 1.47
Barriers to the successful treatment of liver disease by hepatocyte transplantation. J Hepatol (2010) 1.41
Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys. Am J Transplant (2016) 1.39
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol (2008) 1.36
Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation. Am J Transplant (2010) 1.21
Results of gal-knockout porcine thymokidney xenografts. Am J Transplant (2009) 1.19
Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transpl Immunol (2008) 1.17
Clinical lung xenotransplantation--what donor genetic modifications may be necessary? Xenotransplantation (2012) 1.16
Current status of xenotransplantation and prospects for clinical application. Xenotransplantation (2009) 1.15
Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons. Am J Transplant (2008) 1.08
Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates. Xenotransplantation (2012) 1.06
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function. Am J Transplant (2011) 1.06
Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date. Xenotransplantation (2015) 1.05
Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits. Immunology (2013) 1.04
Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature. Xenotransplantation (2014) 1.04
Accommodation of grafts: implications for health and disease. Hum Immunol (2007) 1.04
The restriction of zoonotic PERV transmission by human APOBEC3G. PLoS One (2007) 1.04
Systemic inflammation in xenograft recipients precedes activation of coagulation. Xenotransplantation (2014) 1.01
Expression and purification of soluble porcine CTLA-4 in yeast Pichia pastoris. Protein Expr Purif (2012) 1.00
Overcoming the barriers to xenotransplantation: prospects for the future. Expert Rev Clin Immunol (2010) 0.99
Xenotransplantation: immunological hurdles and progress toward tolerance. Immunol Rev (2014) 0.97
Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses. Clin Microbiol Rev (2012) 0.97
Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts. J Immunol (2013) 0.96
Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species. Xenotransplantation (2012) 0.96
Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs. Transpl Immunol (2015) 0.95
Absence of Gal epitope prolongs survival of swine lungs in an ex vivo model of hyperacute rejection. Xenotransplantation (2011) 0.95
The role of the thymus in tolerance. Transplantation (2010) 0.95
Pig liver xenotransplantation as a bridge to allotransplantation: which patients might benefit? Transplantation (2009) 0.95
Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation. Am J Transplant (2009) 0.93
Porcine cytomegalovirus infection is associated with early rejection of kidney grafts in a pig to baboon xenotransplantation model. Transplantation (2014) 0.92
Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc Natl Acad Sci U S A (2006) 0.91
A brief history of cross-species organ transplantation. Proc (Bayl Univ Med Cent) (2012) 0.91
Rituximab treatment prevents the early development of proteinuria following pig-to-baboon xeno-kidney transplantation. J Am Soc Nephrol (2014) 0.90
Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion. Biomed Eng Online (2010) 0.90
Genetic manipulation in pigs. Curr Opin Organ Transplant (2009) 0.90
Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival. Am J Transplant (2012) 0.90
Results of life-supporting galactosyltransferase knockout kidneys in cynomolgus monkeys using two different sources of galactosyltransferase knockout Swine. Transplantation (2014) 0.90
Antibody-mediated xenograft injury: mechanisms and protective strategies. Transpl Immunol (2009) 0.89
New concepts of immune modulation in xenotransplantation. Transplantation (2013) 0.89
Induction of human T-cell tolerance to pig xenoantigens via thymus transplantation in mice with an established human immune system. Am J Transplant (2009) 0.89
Pathologic characteristics of transplanted kidney xenografts. J Am Soc Nephrol (2011) 0.89
The anti-non-gal xenoantibody response to xenoantigens on gal knockout pig cells is encoded by a restricted number of germline progenitors. Am J Transplant (2008) 0.89
Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates. Curr Opin Organ Transplant (2011) 0.88
Kidney xenotransplantation. Kidney Int (2013) 0.88
Reduced binding of human antibodies to cells from GGTA1/CMAH KO pigs. Am J Transplant (2014) 0.88
Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs. PLoS One (2012) 0.88
Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons. Xenotransplantation (2012) 0.87
Use of molecular modeling and site-directed mutagenesis to define the structural basis for the immune response to carbohydrate xenoantigens. BMC Immunol (2007) 0.87
Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein. Xenotransplantation (2015) 0.87
Targeted genetic modification: xenotransplantation and beyond. Cloning Stem Cells (2007) 0.87
Transplantation of renal primordia: renal organogenesis. Pediatr Nephrol (2007) 0.87
The role of genetically engineered pigs in xenotransplantation research. J Pathol (2015) 0.87
Xenotransplantation as a model of integrated, multidisciplinary research. Organogenesis (2009) 0.86
Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization. Acta Biomater (2014) 0.85
Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation. J Virol (2008) 0.85
First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-to-primate xenotransplantation: the effect of T-cell depletion on outcome. Transplantation (2011) 0.85
Current progress of genetically engineered pig models for biomedical research. Biores Open Access (2014) 0.84
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol (2008) 0.84
T-cell-mediated immunological barriers to xenotransplantation. Xenotransplantation (2012) 0.84
Human immune reactivity against liver sinusoidal endothelial cells from GalTα(1,3)GalT-deficient pigs. Cell Transplant (2010) 0.83
CD47 in xenograft rejection and tolerance induction. Xenotransplantation (2010) 0.83
Porcine model of hemophilia A. PLoS One (2012) 0.83
Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs. Xenotransplantation (2012) 0.83
Organogenesis of kidney and endocrine pancreas: the window opens. Organogenesis (2007) 0.83
Production of cloned NIBS (Nippon Institute for Biological Science) and α-1, 3-galactosyltransferase knockout MGH miniature pigs by somatic cell nuclear transfer using the NIBS breed as surrogates. Xenotransplantation (2013) 0.83
Prolonged survival of GalT-KO swine skin on baboons. Xenotransplantation (2010) 0.82
Xenotransplantation of embryonic pig kidney or pancreas to replace the function of mature organs. J Transplant (2010) 0.82
Immunobiological barriers to xenotransplantation. Int J Surg (2015) 0.82
Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs. Xenotransplantation (2016) 0.82
Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts. Transplantation (2008) 0.81
Immune responses following mouse peripheral nerve xenotransplantation in rats. J Biomed Biotechnol (2009) 0.81
Current status of xenotransplantation. JAMA (2009) 0.81
Immunobiology of liver xenotransplantation. Expert Rev Clin Immunol (2012) 0.81
Clinical xenotransplantation of organs: why aren't we there yet? PLoS Med (2007) 0.81
Lung xenotransplantation: recent progress and current status. Xenotransplantation (2014) 0.81
Bortezomib, C1-inhibitor and plasma exchange do not prolong the survival of multi-transgenic GalT-KO pig kidney xenografts in baboons. Am J Transplant (2015) 0.81
Porcine Knock-in Fibroblasts Expressing hDAF on α-1,3-Galactosyltransferase (GGTA1) Gene Locus. Asian-Australas J Anim Sci (2012) 0.81
Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPα capable of binding to human CD47. Cell Transplant (2011) 0.81
Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation. J Immunol (2008) 0.81
High incidence of xenogenic bone marrow engraftment in pig-to-baboon intra-bone bone marrow transplantation. Am J Transplant (2015) 0.80
The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation. Am J Transplant (2016) 0.80
The case for xenotransplantation. Clin Transplant (2015) 0.80
The anti-nonGal xenoantibody response to alpha1,3-galactosyltransferase gene knockout pig xenografts. Curr Opin Organ Transplant (2010) 0.80
Composite islet-kidneys from single baboon donors cure diabetes across fully allogenic barriers. Am J Transplant (2011) 0.80
How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology? World J Gastroenterol (2012) 0.80
Double transgenic pigs with combined expression of human α1,2-fucosyltransferase and α-galactosidase designed to avoid hyperacute xenograft rejection. Arch Immunol Ther Exp (Warsz) (2014) 0.80
CD47: a new player in phagocytosis and xenograft rejection. Cell Mol Immunol (2011) 0.80
Acceleration of wound healing by α-gal nanoparticles interacting with the natural anti-Gal antibody. J Immunol Res (2015) 0.80
B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells. Blood (2006) 0.79
Development of a consensus protocol to quantify primate anti-non-Gal xenoreactive antibodies using pig aortic endothelial cells. Xenotransplantation (2014) 0.79
Current progress in xenogeneic tolerance. Curr Opin Organ Transplant (2012) 0.79
The need for xenotransplantation as a source of organs and cells for clinical transplantation. Int J Surg (2015) 0.79
HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med (2008) 7.42
Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science (2002) 5.64
Alpha1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here? Transplantation (2007) 3.65
Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med (2004) 3.58
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity (2012) 3.21
Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation. Blood (2006) 2.94
Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med (2004) 2.91
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med (2006) 2.83
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol (2009) 2.70
Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med (2005) 2.67
Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci U S A (2004) 2.54
Public stem cell banks: considerations of justice in stem cell research and therapy. Hastings Cent Rep (2004) 2.53
Clinical trial of islet xenotransplantation in Mexico. Xenotransplantation (2006) 2.51
Transcription-coupled events associating with immunoglobulin switch region chromatin. Science (2003) 2.50
CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant (2004) 2.45
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature (2011) 2.44
Organ transplantation--how much of the promise has been realized? Nat Med (2005) 2.26
Proliferative glomerulonephritis with monoclonal immunoglobulin G3κ deposits in association with parvovirus B19 infection. Hum Pathol (2012) 2.16
Prolonged survival of porcine hepatocytes in cynomolgus monkeys. Gastroenterology (2006) 2.04
A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. Int Immunol (2004) 2.02
Host alloreactive memory T cells influence tolerance to kidney allografts in nonhuman primates. Sci Transl Med (2011) 1.97
The balance between Pax5 and Id2 activities is the key to AID gene expression. J Exp Med (2003) 1.96
Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Clin Exp Nephrol (2012) 1.95
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med (2006) 1.94
Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J Immunol (2008) 1.92
Tolerance induction in clinical transplantation. Transpl Immunol (2004) 1.90
Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. J Clin Oncol (2004) 1.87
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol (2004) 1.85
Clinical xenotransplantation: the next medical revolution? Lancet (2011) 1.84
Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates. Transplantation (2004) 1.82
UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients. Int J Clin Oncol (2009) 1.82
Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation (2006) 1.81
Xenotransplantation: current status and a perspective on the future. Nat Rev Immunol (2007) 1.80
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A (2007) 1.80
Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts. J Am Soc Nephrol (2005) 1.79
Complete pulmonary venous occlusion after radiofrequency ablation for atrial fibrillation. Ann Thorac Surg (2009) 1.79
Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes. Arch Surg (2011) 1.78
Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation (2002) 1.75
Will the pig solve the transplantation backlog? Annu Rev Med (2002) 1.74
Canadian society of transplantation consensus workshop on cytomegalovirus management in solid organ transplantation final report. Am J Transplant (2005) 1.73
Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol (2002) 1.71
ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol (2010) 1.69
Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites. Blood (2003) 1.64
Hepatic function after genetically engineered pig liver transplantation in baboons. Transplantation (2010) 1.64
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood (2008) 1.60
alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months. Transplantation (2005) 1.56
Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine. J Virol (2002) 1.53
Isolation and species distribution of staphylococci from animal and human skin. J Vet Med Sci (2002) 1.52
Renoprotective effect of erythropoietin against ischaemia-reperfusion injury in a non-human primate model. Nephrol Dial Transplant (2010) 1.52
The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood (2002) 1.49
Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab (2005) 1.48
Investigation of red blood cells from alpha1,3-galactosyltransferase-knockout pigs for human blood transfusion. Transfusion (2004) 1.48
The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients. Transplantation (2009) 1.47
Carbamylated erythropoietin ameliorates cyclosporine nephropathy without stimulating erythropoiesis. Cell Transplant (2012) 1.47
Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation (2003) 1.47
An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics. J Pharm Sci (2010) 1.45
In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transpl Int (2008) 1.44
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood (2006) 1.44
Adipose tissue-derived stem cells suppress acute cellular rejection by TSG-6 and CD44 interaction in rat kidney transplantation. Transplantation (2014) 1.43
Preoperative chronic kidney disease as a strong predictor of postoperative infection and mortality after coronary artery bypass grafting. Circ J (2014) 1.43
Immunogenicity of umbilical cord tissue derived cells. Blood (2007) 1.42
A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex. The Journal of Experimental Medicine. 1973. 138: 1289-1304. J Immunol (2011) 1.39
The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood (2007) 1.37
Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation (2003) 1.36
Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons. Am J Pathol (2008) 1.36
Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature Swine. J Virol (2004) 1.35
Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant (2003) 1.35