Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 3628318)

Published in Clin Exp Immunol on May 01, 2013

Authors

C M U Hilkens1, J D Isaacs

Author Affiliations

1: Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. catharien.hilkens@ncl.ac.uk

Articles citing this

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis. Ann Rheum Dis (2016) 1.55

Metabolic control of dendritic cell activation and function: recent advances and clinical implications. Front Immunol (2014) 0.92

Orchestration of transplantation tolerance by regulatory dendritic cell therapy or in-situ targeting of dendritic cells. Curr Opin Organ Transplant (2014) 0.91

Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man. Front Immunol (2015) 0.88

Regulatory dendritic cell therapy: from rodents to clinical application. Immunol Lett (2013) 0.87

Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort. Mediators Inflamm (2015) 0.87

Dendritic cell-based approaches for therapeutic immune regulation in solid-organ transplantation. J Transplant (2013) 0.85

It's time to bring dendritic cell therapy to type 1 diabetes. Diabetes (2014) 0.85

The dark side of dendritic cells: development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape. Front Immunol (2013) 0.83

Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications. Immune Netw (2016) 0.80

Dendritic cell maturation and survival are differentially regulated by TNFR1 and TNFR2. J Immunol (2014) 0.79

Therapeutic potential of tolerogenic dendritic cells in IBD: from animal models to clinical application. Clin Dev Immunol (2013) 0.79

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. PeerJ (2016) 0.79

Gene Expression Profiling of Human Monocyte-derived Dendritic Cells - Searching for Molecular Regulators of Tolerogenicity. Front Immunol (2015) 0.78

Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation. Exp Mol Med (2016) 0.78

1,25-Dihydroxyvitamin D3-Conditioned CD11c+ Dendritic Cells are Effective Initiators of CNS Autoimmune Disease. Front Immunol (2015) 0.77

Metabolism Is Central to Tolerogenic Dendritic Cell Function. Mediators Inflamm (2016) 0.77

Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4(+) T cells partly via transforming growth factor-β1. Clin Exp Immunol (2016) 0.77

Altered dendritic cell functions in autoimmune diseases: distinct and overlapping profiles. Nat Rev Rheumatol (2016) 0.77

DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice. J Immunol Res (2015) 0.77

Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside. Immune Netw (2016) 0.77

Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer. Mol Ther Methods Clin Dev (2014) 0.76

The Effect of Traditional Chinese Formula Danchaiheji on the Differentiation of Regulatory Dendritic Cells. Evid Based Complement Alternat Med (2016) 0.75

LPS-primed Heterotolerant Dendritic Cells suppress Experimental Autoimmune Uveoretintitis by multiple mechanisms. Immunology (2016) 0.75

The thymus and rheumatology: should we care? Curr Opin Rheumatol (2016) 0.75

Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy. EMBO Mol Med (2017) 0.75

Antigen-specific immunotherapies in rheumatic diseases. Nat Rev Rheumatol (2017) 0.75

Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype. Immunology (2017) 0.75

Emerging immunotherapies for rheumatoid arthritis. Hum Vaccin Immunother (2014) 0.75

Articles cited by this

(truncated to the top 100)

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17

Tolerogenic dendritic cells. Annu Rev Immunol (2001) 13.77

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 11.82

Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol (2012) 9.75

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 9.70

Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum (2004) 7.79

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med (2004) 6.48

Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med (2000) 6.45

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 4.96

Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project. Blood (2009) 4.74

Induction of tolerance by IL-10-treated dendritic cells. J Immunol (1997) 4.65

T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today (1999) 4.49

1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol (2000) 3.82

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med (2009) 3.38

Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med (2002) 3.17

The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med (2000) 2.80

Induced CD4+Foxp3+ regulatory T cells in immune tolerance. Annu Rev Immunol (2012) 2.71

Plasmacytoid dendritic cells mediate oral tolerance. Immunity (2008) 2.66

A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem (2002) 2.61

Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst Rev (2009) 2.61

Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance. J Immunol (2007) 2.61

Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells. J Immunol (2004) 2.56

Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol (2003) 2.54

Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. J Immunol (2006) 2.50

Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest (2011) 2.36

Dendritic cell control of tolerogenic responses. Immunol Rev (2011) 2.13

How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol (2010) 2.11

Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity (2003) 1.97

CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood (2002) 1.90

Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients. Eur J Immunol (2012) 1.87

Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses. Arthritis Rheum (2010) 1.86

Risk of tuberculosis in patients treated with tumor necrosis factor antagonists due to incomplete prevention of reactivation of latent infection. Arthritis Rheum (2007) 1.80

Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc Natl Acad Sci U S A (1989) 1.72

Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity (2003) 1.72

Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest (2001) 1.66

Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care (2011) 1.65

Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. J Immunol (2005) 1.64

Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis. Ann Rheum Dis (2009) 1.62

Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity (2003) 1.58

Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J Immunol (1994) 1.43

Dendritic cells in immunity and tolerance-do they display opposite functions? Immunity (2003) 1.41

Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells. J Leukoc Biol (2008) 1.40

Human dendritic cell deficiency: the missing ID? Nat Rev Immunol (2011) 1.32

Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease. J Exp Med (2000) 1.31

"Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. J Immunol (2006) 1.30

Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis. Ann Rheum Dis (2010) 1.29

Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. Arthritis Rheum (2010) 1.29

Identification of citrullinated vimentin peptides as T cell epitopes in HLA-DR4-positive patients with rheumatoid arthritis. Arthritis Rheum (2010) 1.28

Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J Immunol (2000) 1.27

Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv Exp Med Biol (2010) 1.27

Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J Immunol (2001) 1.27

HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets. Arthritis Rheum (2010) 1.27

Tolerogenic dendritic cells and their role in transplantation. Semin Immunol (2011) 1.26

The intrinsic migratory capacity of memory T cells contributes to their accumulation in rheumatoid synovium. Arthritis Rheum (1992) 1.25

Development of dendritic cell-based immunotherapy for autoimmunity. Int Rev Immunol (2010) 1.24

The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells. Front Immunol (2012) 1.23

LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells. J Leukoc Biol (2008) 1.23

IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction--a comparative study of human clinical-applicable DC. Clin Immunol (2011) 1.23

Infections during tumour necrosis factor-alpha blocker therapy for rheumatic diseases in daily practice: a systematic retrospective study of 709 patients. Rheumatology (Oxford) (2006) 1.22

Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J Leukoc Biol (1999) 1.20

Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition. J Immunol (2006) 1.19

Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum (2009) 1.18

Differential MHC class II-mediated presentation of rheumatoid arthritis autoantigens by human dendritic cells and macrophages. J Immunol (2002) 1.17

The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actin. Arthritis Rheum (2013) 1.17

Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol (2004) 1.16

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy. Blood (2012) 1.10

Prolongation of cardiac allograft survival using dendritic cells treated with NF-kB decoy oligodeoxyribonucleotides. Mol Ther (2000) 1.10

CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. J Clin Invest (2003) 1.10

Antigen-specific suppression of established arthritis in mice by dendritic cells deficient in NF-kappaB. Arthritis Rheum (2007) 1.10

The changing face of rheumatoid arthritis: sustained remission for all? Nat Rev Immunol (2010) 1.10

Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther (2002) 1.09

Determination of T-cell fate by dendritic cells. Immunol Cell Biol (2008) 1.07

Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3. J Leukoc Biol (1999) 1.03

Functional regulatory immune responses against human cartilage glycoprotein-39 in health vs. proinflammatory responses in rheumatoid arthritis. Proc Natl Acad Sci U S A (2004) 1.03

Activation of dendritic cells by toll-like receptors and C-type lectins. Handb Exp Pharmacol (2009) 1.00

High production of proinflammatory and Th1 cytokines by dendritic cells from patients with rheumatoid arthritis, and down regulation upon FcgammaR triggering. Ann Rheum Dis (2004) 0.99

Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells. Ann Rheum Dis (2007) 0.98

Peptides presented by HLA-DR molecules in synovia of patients with rheumatoid arthritis or antibiotic-refractory Lyme arthritis. Mol Cell Proteomics (2010) 0.98

MicroRNA-23b promotes tolerogenic properties of dendritic cells in vitro through inhibiting Notch1/NF-κB signalling pathways. Allergy (2012) 0.97

Dendritic cells matured with TNF can be further activated in vitro and after subcutaneous injection in vivo which converts their tolerogenicity into immunogenicity. J Immunother (2006) 0.97

Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features. J Immunol (2011) 0.97

L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance. J Immunol (2002) 0.97

Dendritic cells exposed in vitro to TGF-beta1 ameliorate experimental autoimmune myasthenia gravis. Clin Exp Immunol (2002) 0.95

Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice. Eur J Immunol (2009) 0.95

Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis. J Immunol (2002) 0.95

Human myeloid dendritic cells transduced with an adenoviral interleukin-10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric mice. Gene Ther (2001) 0.93

Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients. Gene Ther (1999) 0.90

Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models? Ann Rheum Dis (2011) 0.90

Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-alpha antagonists. Expert Opin Biol Ther (2009) 0.90

Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritis. Ann Rheum Dis (2010) 0.90

Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. Blood (2005) 0.89

Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis. J Transl Med (2012) 0.88

Tolerogenic dendritic cells: applications for solid organ transplantation. Curr Opin Organ Transplant (2012) 0.88

Targeted lymphoid homing of dendritic cells is required for prolongation of allograft survival. J Immunol (2006) 0.87

Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. Adv Exp Med Biol (2009) 0.85

T cells signaled by NF-kappa B- dendritic cells are sensitized not anergic to subsequent activation. J Immunol (2004) 0.83

Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles. Rheumatol Int (2011) 0.83

Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survival. Transplantation (2003) 0.82

Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res Ther (2004) 0.82

Articles by these authors

The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography. Arthritis Rheum (2000) 3.85

Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood (2001) 3.66

Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid arthritis and an inadequate response to methotrexate (Study Evaluating Rituximab's Efficacy in MTX iNadequate rEsponders (SERENE)). Ann Rheum Dis (2010) 2.68

Fcgamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups. Arthritis Rheum (2000) 1.44

Immediate postpartum curettage: accelerated recovery from severe preeclampsia. Obstet Gynecol (1993) 1.42

Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy. Lancet (1993) 1.40

Prospective study of anti-tumour necrosis factor receptor superfamily 1B fusion protein, and case study of anti-tumour necrosis factor receptor superfamily 1A fusion protein, in tumour necrosis factor receptor associated periodic syndrome (TRAPS): clinical and laboratory findings in a series of seven patients. Rheumatology (Oxford) (2003) 1.33

Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood. Rheumatology (Oxford) (2006) 1.30

Giant amphipod from the abyssal pacific ocean. Science (1972) 1.22

Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H. Eye (Lond) (1995) 1.17

Campath-1H therapy in refractory ocular inflammatory disease. Br J Ophthalmol (2000) 1.13

Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H. Br J Ophthalmol (1995) 1.06

Determination of thymic function directly from peripheral blood: a validated modification to an established method. J Immunol Methods (2008) 1.05

Incidence of corneal melting in association with systemic disease in the Yorkshire Region, 1995-7. Br J Ophthalmol (1999) 0.98

FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study. Rheumatology (Oxford) (2003) 0.94

Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy. J Clin Invest (2001) 0.94

Internalization and degradation of thrombin and up regulation of thrombin-binding sites in corneal endothelial cells. J Biol Chem (1981) 0.92

Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium. Gene Ther (1999) 0.92

The nature of oceanic life. Sci Am (1969) 0.88

Management of rheumatoid arthritis in primary care--an educational need? Rheumatology (Oxford) (2005) 0.87

Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse. Ann Rheum Dis (2007) 0.86

Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration. Ann Rheum Dis (2005) 0.86

Thymic function in juvenile idiopathic arthritis. Ann Rheum Dis (2008) 0.85

Regaining self-control--regulation and immunotherapy. Br J Rheumatol (1998) 0.85

Endothelial cell and platelet binding sites for thrombin. Ann N Y Acad Sci (1981) 0.85

Atacicept, a novel B cell-targeting biological therapy for the treatment of rheumatoid arthritis. Expert Opin Biol Ther (2009) 0.84

Detection of Mycobacterium tuberculosis group organisms in human and mouse joint tissue by reverse transcriptase PCR: prevalence in diseased synovial tissue suggests lack of specific association with rheumatoid arthritis. Infect Immun (2001) 0.83

The clinical utility of a rule for predicting rheumatoid arthritis in patients with early undifferentiated arthritis: comment on the article by van der Helm-van Mil et al. Arthritis Rheum (2009) 0.83

Covalent binding of thrombin to specific sites on corneal endothelial cells. Biochemistry (1981) 0.82

Overexpression of transcripts containing LINE-1 in the synovia of patients with rheumatoid arthritis. Ann Rheum Dis (2003) 0.81

Immunotherapy of rheumatoid arthritis. Ann Rheum Dis (1992) 0.81

Corticosteroids for the enhancement of fetal lung maturity: impact on the gravida with preeclampsia and the HELLP syndrome. Aust N Z J Obstet Gynaecol (1993) 0.81

Local bioactive tumour necrosis factor (TNF) in corneal allotransplantation. Clin Exp Immunol (2000) 0.80

D D Cunningham and the aetiology of cholera in British India, 1869-1897. Med Hist (1998) 0.80

Ovulation induction in the poor responder or hyperresponder. Am J Obstet Gynecol (1995) 0.80

Neurological picture. Bilateral facial nerve palsy associated with Epstein-Barr virus infection. J Neurol Neurosurg Psychiatry (2010) 0.80

Acquired factor VIII inhibitor associated with lung abscess. Br Med J (Clin Res Ed) (1987) 0.80

CAMPATH-1H in inflammatory arthritis. Clin Exp Rheumatol (1993) 0.78

Salt domes: is there more energy available from their salt than from their oil? Science (1978) 0.78

Immunomodulation of autoimmune responses with monoclonal antibodies and immunoadhesins: treatment of ocular inflammatory disease in the next millennium. Br J Ophthalmol (1999) 0.78

Proliferation and differentiation of bovine corneal endothelial cells in culture. Metab Pediatr Syst Ophthalmol (1982) 0.78

Analysis of the insertion/deletion related polymorphism within T cell antigen receptor beta variable genes in primary Sjögren's syndrome. Ann Rheum Dis (2005) 0.77

Application of differential display to immunological research. J Immunol Methods (2001) 0.77

Juvenile chronic pancreatitis--a cause of painless jaundice in a patient with multiple somatic abnormalities. J Clin Gastroenterol (1985) 0.77

A pilot study of combination anti-cytokine and anti-lymphocyte biological therapy in rheumatoid arthritis. QJM (2008) 0.76

Thymic function and immune senescence in juvenile idiopathic arthritis: comment on the article by Prelog et al. Arthritis Rheum (2009) 0.75

No strong association between alleles of tumour necrosis factor alpha and interleukin-1 receptor antagonist and corneal melting associated with systemic vasculitis. Br J Ophthalmol (2000) 0.75

Salinity gradient power: utilizing vapor pressure differences. Science (1979) 0.75

Trisomy/tetrasomy 13 in seven cases of acute leukemia. Leukemia (1990) 0.75

Atmospheric Jet Streams. Science (1963) 0.75

Night-Caught and Day-Caught Larvae of the California Sardine. Science (1964) 0.75

Satellite elongation into a true "sky-hook". Science (1966) 0.75

Does the shared epitope genotype influence either the susceptibility to or the phenotype of corneal melting? Eye (Lond) (2001) 0.75

Sky-hook. Science (1966) 0.75

Mineral salt: a source of costly energy? Science (1979) 0.75

Regulation of early gestational corpus luteum function in spontaneous and follicular stimulated conceptions. Fertil Steril (1994) 0.75

Migrant Sound Scatterers: Interaction with the Sea Floor. Science (1965) 0.75

Ocean energy: forms and prospects. Science (1980) 0.75

Immunoadhesins for immunomodulation of autoimmune and rheumatic disease. Br J Rheumatol (1997) 0.75

Transient Circulation Event near the Deep Ocean Floor. Science (1969) 0.75