Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance.

PubWeight™: 6.19‹?› | Rank: Top 1%

🔗 View Article (PMC 117564)

Published in Proc Natl Acad Sci U S A on January 02, 2002

Authors

Ralph Marvin Steinman1, Michel C Nussenzweig

Author Affiliations

1: Laboratories of Cellular Physiology and Immunology, and Molecular Immunology and Howard Hughes Institute, The Rockefeller University, New York, NY 10021-6399, USA. steinma@mail.rockefeller.edu

Articles citing this

(truncated to the top 100)

Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07

Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity (2006) 6.17

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med (2007) 5.65

The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med (2002) 4.78

Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med (2003) 4.41

Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med (2003) 4.39

Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol (2005) 3.75

The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med (2004) 3.59

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med (2009) 3.38

Immune tolerance after delivery of dying cells to dendritic cells in situ. J Exp Med (2002) 3.35

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med (2007) 3.24

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13

Regulation of immune responses by mTOR. Annu Rev Immunol (2011) 3.08

Mesenchymal stem cells avoid allogeneic rejection. J Inflamm (Lond) (2005) 3.00

HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep (2004) 3.00

Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J Exp Med (2002) 2.94

The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med (2002) 2.93

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J Exp Med (2002) 2.78

CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med (2009) 2.75

Exploiting dendritic cells to improve vaccine efficacy. J Clin Invest (2002) 2.55

Inducing tumor immunity through the selective engagement of activating Fcgamma receptors on dendritic cells. J Exp Med (2002) 2.54

The innate immune system in SLE: type I interferons and dendritic cells. Lupus (2008) 2.52

Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med (2006) 2.43

Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut (2004) 2.29

Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol (2010) 2.29

Combining radiotherapy and immunotherapy: a revived partnership. Int J Radiat Oncol Biol Phys (2005) 2.29

Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs. J Exp Med (2005) 2.23

Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells. Proc Natl Acad Sci U S A (2005) 2.22

Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein. J Exp Med (2003) 2.20

Dendritic cell control of tolerogenic responses. Immunol Rev (2011) 2.13

Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev (2008) 2.13

Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol (2003) 2.12

Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory. J Immunol (2009) 2.08

Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies. J Virol (2004) 1.89

The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut (2003) 1.84

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity (2009) 1.82

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol (2011) 1.77

Resident and "inflammatory" dendritic cells in human skin. J Invest Dermatol (2008) 1.72

Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection. J Exp Med (2006) 1.72

In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol (2010) 1.71

Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood (2007) 1.70

Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. J Exp Med (2004) 1.70

Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care (2011) 1.65

A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice. J Exp Med (2003) 1.62

A contribution of mouse dendritic cell-derived IL-2 for NK cell activation. J Exp Med (2004) 1.59

Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion. J Immunol (2009) 1.59

Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J Invest Dermatol (2009) 1.59

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc Natl Acad Sci U S A (2003) 1.54

Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J Exp Med (2007) 1.52

Acute ablation of Langerhans cells enhances skin immune responses. J Immunol (2010) 1.47

Up-regulated S100 calcium binding protein A8 in Plasmodium-infected patients correlates with CD4(+)CD25(+)Foxp3 regulatory T cell generation. Malar J (2015) 1.45

A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-kappaB family. Biochem Pharmacol (2008) 1.44

mTOR: taking cues from the immune microenvironment. Immunology (2009) 1.38

Dendritic cell based tumor vaccination in prostate and renal cell cancer: a systematic review and meta-analysis. PLoS One (2011) 1.38

Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors. Blood (2003) 1.37

Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J Exp Med (2004) 1.35

Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism. J Immunol (2009) 1.33

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33

Successful induction of immune tolerance to enzyme replacement therapy in canine mucopolysaccharidosis I. Proc Natl Acad Sci U S A (2004) 1.30

Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol (2006) 1.27

Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clin Exp Immunol (2007) 1.27

Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells. Gut (2005) 1.27

Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus. Clin Exp Immunol (2011) 1.26

NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development. Blood (2011) 1.25

Dendritic cells at the oral mucosal interface. J Dent Res (2006) 1.24

Phenotypic characterization of human decidual macrophages. Clin Exp Immunol (2003) 1.24

Dendritic cell regulation of immune responses: a new role for interleukin 2 at the intersection of innate and adaptive immunity. EMBO J (2003) 1.22

CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med (2004) 1.20

Trapping of misdirected dendritic cells in the granulomatous lesions of giant cell arteritis. Am J Pathol (2002) 1.19

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. J Exp Med (2012) 1.19

Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues. J Immunol (2009) 1.18

IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation. J Immunol (2012) 1.18

Qualitative and quantitative abnormalities in splenic dendritic cell populations in NOD mice. Clin Exp Immunol (2004) 1.18

Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells. Immunology (2005) 1.18

Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells. J Immunol (2011) 1.16

Activated inflammatory infiltrate in HSV-1-infected corneas without herpes stromal keratitis. Invest Ophthalmol Vis Sci (2008) 1.15

Cutting edge: Lipopolysaccharide induces IL-10-producing regulatory CD4+ T cells that suppress the CD8+ T cell response. J Immunol (2007) 1.15

CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming. J Exp Med (2008) 1.14

Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells. Immunology (2010) 1.13

Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9. J Virol (2006) 1.13

Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13

Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function. Clin Immunol (2009) 1.11

Targeting skin dendritic cells to improve intradermal vaccination. Curr Top Microbiol Immunol (2012) 1.11

Expansion of regulatory T cells in patients with Langerhans cell histiocytosis. PLoS Med (2007) 1.10

TLR-mediated induction of negative regulatory ligands on dendritic cells. J Mol Med (Berl) (2008) 1.09

Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now? Clin Exp Immunol (2013) 1.09

Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes. J Exp Med (2003) 1.08

Impact of aging on dendritic cell functions in humans. Ageing Res Rev (2010) 1.08

Regulation of dendritic cell differentiation and function by estrogen receptor ligands. Cell Immunol (2008) 1.05

The role of virus-induced regulatory T cells in immunopathology. Springer Semin Immunopathol (2006) 1.05

Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells. J Exp Med (2007) 1.05

Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease. Clin Exp Immunol (2009) 1.04

Role of mucosal dendritic cells in inflammatory bowel disease. World J Gastroenterol (2008) 1.04

CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function. J Exp Med (2010) 1.03

Increased FcgammaRII expression and aberrant tumour necrosis factor alpha production by mature dendritic cells from patients with active rheumatoid arthritis. Ann Rheum Dis (2004) 1.02

Immunoglobulin heavy chain constant regions regulate immunity and tolerance to idiotypes of antibody variable regions. Proc Natl Acad Sci U S A (2002) 1.02

Dendritic cell infiltration and prognosis of human hepatocellular carcinoma. J Cancer Res Clin Oncol (2006) 1.02

Apoptotic cell-based therapies against transplant rejection: role of recipient's dendritic cells. Apoptosis (2010) 1.01

The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses. Clin Exp Immunol (2007) 1.01

Cancer immunotherapy using RNA-loaded dendritic cells. Clin Exp Immunol (2003) 1.01

Articles cited by this

(truncated to the top 100)

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 34.97

Viral dynamics in human immunodeficiency virus type 1 infection. Nature (1995) 28.54

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15

Immunobiology of dendritic cells. Annu Rev Immunol (2000) 23.65

The dendritic cell system and its role in immunogenicity. Annu Rev Immunol (1991) 23.09

Actively acquired tolerance of foreign cells. Nature (1953) 19.82

Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 16.28

Tolerance, danger, and the extended family. Annu Rev Immunol (1994) 14.94

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell (2000) 14.43

T cell tolerance by clonal elimination in the thymus. Cell (1987) 13.83

IMMUNOGENETIC CONSEQUENCES OF VASCULAR ANASTOMOSES BETWEEN BOVINE TWINS. Science (1945) 12.87

Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol (1989) 12.08

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature (1988) 11.55

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro. J Exp Med (1985) 11.14

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol (2001) 11.07

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol (1991) 11.04

The nature of the principal type 1 interferon-producing cells in human blood. Science (1999) 10.90

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67

Dendritic cells: specialized and regulated antigen processing machines. Cell (2001) 10.44

Regulatory T cells: key controllers of immunologic self-tolerance. Cell (2000) 10.19

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature (1998) 9.77

Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 9.70

Regulatory T cells in autoimmmunity*. Annu Rev Immunol (2000) 9.36

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature (1988) 9.17

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med (2001) 8.60

Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell (2000) 8.34

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med (1999) 8.01

Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med (2001) 7.86

Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med (1974) 7.58

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med (2001) 7.46

Regulatory T cells in the control of immune pathology. Nat Immunol (2001) 6.98

B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med (2001) 6.97

Identification of a novel cell type in peripheral lymphoid organs of mice. 3. Functional properties in vivo. J Exp Med (1974) 6.60

In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell (1991) 6.49

Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med (2000) 6.45

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med (2001) 6.22

Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med (1998) 6.12

The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today (1992) 5.93

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature (1997) 5.80

The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med (2000) 5.74

Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med (1997) 5.72

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J Exp Med (1989) 5.65

Granulocyte/macrophage colony-stimulating factor is essential for the viability and function of cultured murine epidermal Langerhans cells. J Exp Med (1987) 5.64

Genes and antibodies. Science (1959) 5.63

Characterization of nonlymphoid cells derived from rat peripheral lymph. J Exp Med (1983) 5.63

Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells. Science (1992) 5.61

Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med (1998) 5.59

TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol (2001) 5.49

Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med (1993) 5.49

Receptor editing in self-reactive bone marrow B cells. J Exp Med (1993) 5.49

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J Exp Med (1990) 5.35

The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med (1997) 5.23

Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity (1999) 5.23

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J Exp Med (1986) 5.23

Developmental regulation of MHC class II transport in mouse dendritic cells. Nature (1997) 5.17

Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol (2001) 5.15

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature (1995) 5.13

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol (2000) 5.13

A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med (2000) 5.11

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol (2001) 5.11

Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J Exp Med (1981) 5.00

Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science (1998) 4.97

Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods (1996) 4.87

Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med (2001) 4.78

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med (1996) 4.70

Induction of tolerance by IL-10-treated dendritic cells. J Immunol (1997) 4.65

Peripheral selection of the T cell repertoire. Science (1991) 4.56

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol (1998) 4.51

Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med (1990) 4.48

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell (1991) 4.38

Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature (1999) 4.28

Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell (1994) 4.04

Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol (2001) 3.99

Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J Exp Med (2001) 3.90

CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha. J Exp Med (1996) 3.82

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J Immunol Methods (1996) 3.80

Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J Exp Med (1999) 3.79

Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J Exp Med (1986) 3.74

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med (1994) 3.66

Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood (2001) 3.66

The dendritic cell populations of mouse lymph nodes. J Immunol (2001) 3.57

Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat Med (1997) 3.55

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med (2001) 3.47

Certified professionals: CD4(+)CD25(+) suppressor T cells. J Exp Med (2001) 3.39

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med (1996) 3.30

CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity (2000) 3.28

CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity (2000) 3.27

Endotoxin-induced maturation of MyD88-deficient dendritic cells. J Immunol (2001) 3.26

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med (2000) 3.26

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med (1988) 3.21

Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication. J Exp Med (1983) 3.20

Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med (1995) 3.16

IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol (2001) 3.13

Bone marrow origin of Ia-positive cells in the medulla rat thymus. J Exp Med (1981) 3.11

Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med (1993) 3.09

Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. J Clin Invest (1999) 3.00

Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-tropic virus to T cells. J Virol (1998) 2.92

Articles by these authors

(truncated to the top 100)

Tolerogenic dendritic cells. Annu Rev Immunol (2001) 13.77

Predominant autoantibody production by early human B cell precursors. Science (2003) 13.14

Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science (2010) 10.69

Genomic instability in mice lacking histone H2AX. Science (2002) 10.23

Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol (2005) 9.91

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature (2009) 9.51

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science (2011) 9.00

Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42

Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13

Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med (2002) 6.56

Germinal centers. Annu Rev Immunol (2012) 6.26

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J Immunol Methods (2007) 5.97

Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity (2008) 5.03

Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science (2011) 4.30

Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med (2005) 4.16

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell (2008) 4.13

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature (2010) 3.96

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature (2006) 3.90

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature (2013) 3.90

AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89

In vivo imaging of germinal centres reveals a dynamic open structure. Nature (2007) 3.83

Autoreactivity in human IgG+ memory B cells. Immunity (2007) 3.71

Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand. Nat Immunol (2003) 3.58

53BP1 is required for class switch recombination. J Cell Biol (2004) 3.57

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. J Exp Med (2003) 3.55

53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc Natl Acad Sci U S A (2012) 3.33

The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature (2006) 3.31

Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol (2006) 3.31

A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature (2013) 3.14

Antibodies in HIV-1 vaccine development and therapy. Science (2013) 3.13

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13

Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell (2013) 3.04

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02

Origin of chromosomal translocations in lymphoid cancer. Cell (2010) 2.94

Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92

Origin and development of dendritic cells. Immunol Rev (2010) 2.90

Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol (2005) 2.89

A subset of dendritic cells induces CD4+ T cells to produce IFN-gamma by an IL-12-independent but CD70-dependent mechanism in vivo. J Exp Med (2007) 2.82

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med (2010) 2.81

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol (2010) 2.80

Chromatin dynamics and the preservation of genetic information. Nature (2007) 2.80

AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79

Mannose receptor-mediated regulation of serum glycoprotein homeostasis. Science (2002) 2.75

AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell (2009) 2.75

CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells. J Immunol (2008) 2.69

Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat Immunol (2002) 2.64

Role of BCR affinity in T cell dependent antibody responses in vivo. Nat Immunol (2002) 2.63

A checkpoint for autoreactivity in human IgM+ memory B cell development. J Exp Med (2006) 2.60

A method for identification of HIV gp140 binding memory B cells in human blood. J Immunol Methods (2008) 2.56

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med (2004) 2.55

Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. J Exp Med (2006) 2.53

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med (2012) 2.51

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell (2003) 2.50

Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell (2011) 2.46

Chromosome translocation, B cell lymphoma, and activation-induced cytidine deaminase. Annu Rev Pathol (2012) 2.45

DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature (2012) 2.44

Development and migration of plasma cells in the mouse lymph node. Immunity (2010) 2.44

Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J Exp Med (2006) 2.43

ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med (2004) 2.30

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood (2012) 2.30

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proc Natl Acad Sci U S A (2008) 2.18

Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity (2013) 2.17

Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120. Proc Natl Acad Sci U S A (2012) 2.13

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein. J Exp Med (2012) 2.12

Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies. J Exp Med (2003) 2.09

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science (2010) 2.05

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05

DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes. Proc Natl Acad Sci U S A (2007) 2.04

Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity (2004) 1.99

Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol (2007) 1.98

A backup DNA repair pathway moves to the forefront. Cell (2007) 1.97

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med (2011) 1.97

Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A (2006) 1.95

Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol (2007) 1.90

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol (2012) 1.90

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87

CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med (2007) 1.86

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci U S A (2013) 1.85

T follicular helper cell dynamics in germinal centers. Science (2013) 1.80

Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol (2010) 1.78

AID targeting in antibody diversity. Adv Immunol (2011) 1.78

T-independent type II immune responses generate memory B cells. J Exp Med (2006) 1.76

Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness. J Exp Med (2010) 1.74

A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer. Nat Immunol (2004) 1.73

CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain. J Comp Neurol (2008) 1.72

Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses. PLoS One (2011) 1.69

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc Natl Acad Sci U S A (2005) 1.69

B-cell self-tolerance in humans. Adv Immunol (2007) 1.65

The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells. J Clin Invest (2008) 1.59

Persistent expression of autoantibodies in SLE patients in remission. J Exp Med (2006) 1.56

Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies. J Exp Med (2013) 1.56

RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Rep (2013) 1.53

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med (2011) 1.43

Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J Exp Med (2003) 1.43

The role of activation-induced deaminase in antibody diversification and chromosome translocations. Adv Immunol (2007) 1.38