Published in J Immunol on October 01, 2004
Dendritic cell control of tolerogenic responses. Immunol Rev (2011) 2.13
SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest (2005) 1.75
Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care (2011) 1.65
Regeneration of the pancreatic beta cell. J Clin Invest (2005) 1.14
Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now? Clin Exp Immunol (2013) 1.09
Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells. Front Immunol (2013) 1.06
Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials. Front Immunol (2012) 1.03
A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Diabetes (2008) 1.01
Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes. Clin Exp Immunol (2009) 1.01
Redox modulation protects islets from transplant-related injury. Diabetes (2010) 0.98
Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same? Clin Dev Immunol (2011) 0.92
Current and future immunomodulation strategies to restore tolerance in autoimmune diseases. Cold Spring Harb Perspect Biol (2012) 0.91
Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks? Clin Dev Immunol (2011) 0.90
Multifunctional dendritic cell-targeting polymeric microparticles: engineering new vaccines for type 1 diabetes. Hum Vaccin (2011) 0.89
Dendritic cell subsets in type 1 diabetes: friend or foe? Front Immunol (2013) 0.88
Regulatory dendritic cell therapy: from rodents to clinical application. Immunol Lett (2013) 0.87
Antigen-specific therapeutic approaches in Type 1 diabetes. Cold Spring Harb Perspect Med (2012) 0.85
It's time to bring dendritic cell therapy to type 1 diabetes. Diabetes (2014) 0.85
Dendritic cell-based approaches for therapeutic immune regulation in solid-organ transplantation. J Transplant (2013) 0.85
The immunotherapeutic potential of dendritic cells in type 1 diabetes. Clin Exp Immunol (2010) 0.84
Interleukin-7 matures suppressive CD127(+) forkhead box P3 (FoxP3)(+) T cells into CD127(-) CD25(high) FoxP3(+) regulatory T cells. Clin Exp Immunol (2011) 0.84
The role of dendritic cells in tissue-specific autoimmunity. J Immunol Res (2014) 0.84
Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment. J Autoimmun (2009) 0.84
Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS One (2010) 0.83
The dark side of dendritic cells: development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape. Front Immunol (2013) 0.83
Retinoic acid-producing, ex-vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B lymphocytes. Clin Exp Immunol (2013) 0.83
Cell mediators of autoimmune hepatitis and their therapeutic implications. Dig Dis Sci (2014) 0.82
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. PLoS One (2014) 0.81
Targeting dendritic cell function during systemic autoimmunity to restore tolerance. Int J Mol Sci (2014) 0.80
Delivery of siRNAs to Dendritic Cells Using DEC205-Targeted Lipid Nanoparticles to Inhibit Immune Responses. Mol Ther (2015) 0.80
Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications. Immune Netw (2016) 0.80
Micro and nanoparticle drug delivery systems for preventing allotransplant rejection. Clin Immunol (2015) 0.78
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells. PLoS One (2014) 0.77
Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes. Hum Vaccin (2011) 0.77
In vivo delivery of nucleic acid-formulated microparticles as a potential tolerogenic vaccine for type 1 diabetes. Rev Diabet Stud (2012) 0.75
Characterization of Bone Marrow-Derived Dendritic Cells Developed in Serum-Free Media and their Ability to Prevent Type 1 Diabetes in Nonobese Diabetic Mice. J Blood Disord Transfus (2014) 0.75
Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens. J Immunol Res (2016) 0.75
Tolerogenic immunosuppression for organ transplantation. Lancet (2003) 4.09
Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (2002) 3.96
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am J Hum Genet (2008) 3.95
Screen and clean: a tool for identifying interactions in genome-wide association studies. Genet Epidemiol (2010) 2.70
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol (2007) 2.23
Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes (2004) 2.16
Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience. J Clin Endocrinol Metab (2015) 2.14
Clinical xenotransplantation: the next medical revolution? Lancet (2011) 1.84
Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J (2009) 1.70
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69
Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care (2011) 1.65
Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes (2005) 1.64
Monocytes are progressively activated in the circulation of pregnant women. J Leukoc Biol (2002) 1.63
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol (2006) 1.58
Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond. Pediatr Diabetes (2008) 1.50
Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Proc Natl Acad Sci U S A (2006) 1.46
Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes (2006) 1.45
Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 1.38
Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes (2005) 1.27
Clinical islet xenotransplantation: how close are we? Diabetes (2012) 1.26
Prospective and challenges of islet transplantation for the therapy of autoimmune diabetes. Pancreas (2006) 1.25
Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes (2002) 1.23
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes (2009) 1.22
Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol (2011) 1.21
Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness. J Immunol (2007) 1.19
Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates. J Biol Chem (2001) 1.18
Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes (2002) 1.17
Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells. Atherosclerosis (2008) 1.17
Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection. Clin Immunol (2002) 1.17
Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes (2003) 1.15
The role of external and matrix pH in mitochondrial reactive oxygen species generation. J Biol Chem (2008) 1.13
Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem (2003) 1.12
Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies. Stat Med (2010) 1.11
Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS One (2010) 1.10
Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS Comput Biol (2009) 1.10
Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes (2006) 1.10
Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements. Genome Res (2005) 1.09
Immunosuppressive effects of glucosamine. J Biol Chem (2002) 1.08
Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes (2003) 1.08
Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem Cells (2003) 1.07
Suppression of autoimmune diabetes by soluble galectin-1. J Immunol (2009) 1.06
Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinoma. Cancer Lett (2007) 1.05
FoxO6 integrates insulin signaling with gluconeogenesis in the liver. Diabetes (2011) 1.03
Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies. Xenotransplantation (2007) 1.02
Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein. Biotechniques (2003) 1.02
A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes. Diabetes (2008) 1.01
Harmful delayed effects of exogenous isolation enzymes on isolated human islets: relevance to clinical transplantation. Am J Transplant (2005) 1.01
Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation (2007) 0.99
Redox modulation protects islets from transplant-related injury. Diabetes (2010) 0.98
Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. J Immunol (2006) 0.98
Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes (2010) 0.97
Retaining antibodies in tumors with a self-assembling injectable system. Mol Pharm (2013) 0.96
Induction of diabetes in cynomolgus monkeys with high-dose streptozotocin: adverse effects and early responses. Pancreas (2006) 0.95
Lessons of organ-induced tolerance learned from historical clinical experience. Transplantation (2004) 0.94
The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation. J Biomed Res (2013) 0.93
AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther (2008) 0.93
Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes. Endocrinology (2010) 0.92
Facilitating physiologic self-regeneration: a step beyond islet cell replacement. Pharm Res (2006) 0.92
Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same? Clin Dev Immunol (2011) 0.92
Recovery of endogenous beta-cell function in nonhuman primates after chemical diabetes induction and islet transplantation. Diabetes (2008) 0.92
Early islet damage after direct exposure of pig islets to blood: has humoral immunity been underestimated? Cell Transplant (2012) 0.91
Multifaceted therapeutic approaches for a multigenic disease. Diabetes (2005) 0.91
Proteomic analysis of fructose-induced fatty liver in hamsters. Metabolism (2008) 0.89
Four-color flow cytometric analysis of peripheral blood donor cell chimerism. Hum Immunol (2003) 0.89
Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans. Exp Diabesity Res (2004) 0.89
FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival. Mol Endocrinol (2012) 0.88
Increased Expression of Monocyte CD11b (Mac-1) in Overweight Recent-Onset Type 1 Diabetic Children. Rev Diabet Stud (2007) 0.88
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity. Ann N Y Acad Sci (2007) 0.87
Antidiabetic sulfonylurea stimulates insulin secretion independently of plasma membrane KATP channels. Am J Physiol Endocrinol Metab (2007) 0.87
Pyrosequencing-based strategies for improved allele typing of human leukocyte antigen loci. Methods Mol Biol (2007) 0.87
Multistationary and oscillatory modes of free radicals generation by the mitochondrial respiratory chain revealed by a bifurcation analysis. PLoS Comput Biol (2012) 0.87
Cytokine and chemokine production by human pancreatic islets upon enterovirus infection. Diabetes (2012) 0.87
Rehabilitation of adaptive immunity and regeneration of beta cells. Trends Biotechnol (2006) 0.86
Pig-to-nonhuman primates pancreatic islet xenotransplantation: an overview. Curr Diab Rep (2011) 0.86
Toward clinical islet xenotransplantation - are revisions to the IXA guidelines warranted? Xenotransplantation (2013) 0.86
Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival. Am J Physiol Heart Circ Physiol (2007) 0.86
Dendritic cell mediated therapy for immunoregulation of type 1 diabetes mellitus. Pediatr Endocrinol Rev (2008) 0.86
Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice. PLoS One (2010) 0.85
Induction of immune tolerance to facilitate beta cell regeneration in type 1 diabetes. Adv Drug Deliv Rev (2007) 0.85
It's time to bring dendritic cell therapy to type 1 diabetes. Diabetes (2014) 0.85