Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3898967)

Published in Neuron on April 24, 2013

Authors

Da Mi1, Catherine B Carr, Petrina A Georgala, Yu-Ting Huang, Martine N Manuel, Emily Jeanes, Emi Niisato, Stephen N Sansom, Frederick J Livesey, Thomas Theil, Kerstin Hasenpusch-Theil, T Ian Simpson, John O Mason, David J Price

Author Affiliations

1: Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK.

Articles citing this

Growth and folding of the mammalian cerebral cortex: from molecules to malformations. Nat Rev Neurosci (2014) 1.44

Molecular and cellular basis of autosomal recessive primary microcephaly. Biomed Res Int (2014) 0.98

Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex. PLoS Biol (2015) 0.93

Coevolution of radial glial cells and the cerebral cortex. Glia (2015) 0.87

Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns. Neuron (2014) 0.87

Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Front Cell Neurosci (2015) 0.87

Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer. Cell Rep (2014) 0.86

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation. Cell Death Dis (2015) 0.83

Pax6 is essential for the maintenance and multi-lineage differentiation of neural stem cells, and for neuronal incorporation into the adult olfactory bulb. Stem Cells Dev (2014) 0.81

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development. Nucleic Acids Res (2015) 0.80

BAF chromatin remodeling complex: cortical size regulation and beyond. Cell Cycle (2013) 0.78

Identification of genomic regions regulating Pax6 expression in embryonic forebrain using YAC reporter transgenic mouse lines. PLoS One (2013) 0.76

PAX6 does not regulate Nfia and Nfib expression during neocortical development. Sci Rep (2015) 0.76

Coordinating progenitor cell cycle exit and differentiation in the developing vertebrate retina. Neurogenesis (Austin) (2016) 0.75

Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons. Neural Dev (2015) 0.75

Articles cited by this

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56

Empirical bayes methods and false discovery rates for microarrays. Genet Epidemiol (2002) 10.56

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell (2008) 6.88

Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature (1992) 6.32

Mammalian cyclin-dependent kinases. Trends Biochem Sci (2005) 5.54

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell (1999) 4.94

D-type cyclins. Trends Biochem Sci (1995) 4.74

Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage. Nat Neurosci (2005) 4.57

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J (1996) 4.55

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell (2004) 4.39

Cell-cycle control and cortical development. Nat Rev Neurosci (2007) 3.59

Dynamic molecular linkers of the genome: the first decade of SMC proteins. Genes Dev (2005) 3.29

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J Biol Chem (1994) 3.22

Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem (1997) 3.18

Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev (1994) 2.99

Animal transcription networks as highly connected, quantitative continua. Dev Cell (2011) 2.87

In vivo electroporation in the embryonic mouse central nervous system. Nat Protoc (2006) 2.85

Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors. Cell Stem Cell (2009) 2.81

Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One (2007) 2.77

Regulation of area identity in the mammalian neocortex by Emx2 and Pax6. Science (2000) 2.75

What is the restriction point? Curr Opin Cell Biol (1995) 2.48

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol (2000) 2.47

Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis. Dev Biol (2005) 2.41

E2F - at the crossroads of life and death. Trends Cell Biol (2008) 2.37

The dynamic roles of TGF-β in cancer. J Pathol (2010) 2.32

The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev (2009) 2.29

E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J (2003) 2.14

PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans. Nat Genet (2001) 2.05

A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev (2011) 2.04

Forebrain patterning defects in Small eye mutant mice. Development (1996) 1.95

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet (2009) 1.92

Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism. Dev Biol (2006) 1.84

Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression. Cancer Sci (2007) 1.69

A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos. EMBO J (1999) 1.67

Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development (2003) 1.64

Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cell Signal (2011) 1.50

Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex. Proc Natl Acad Sci U S A (2009) 1.47

Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. J Biol Chem (2001) 1.42

Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development (2002) 1.42

Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. Mol Cell Neurosci (2006) 1.34

Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma. Cancer Res (2005) 1.33

The role of Pax6 in forebrain development. Dev Neurobiol (2011) 1.32

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development (2007) 1.28

The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation. J Biol Chem (2000) 1.15

Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortex. J Neurosci (2009) 1.10

Role of Pax6 in forebrain regionalization. Brain Res Bull (2005) 1.08

DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. J Biol Chem (2004) 1.07

The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development (2011) 1.03

Functional interactions between Choline kinase α, epidermal growth factor receptor and c-Src in breast cancer cell proliferation. Oncogene (2011) 1.02

The Rb pathway in neurogenesis. Neuroreport (2001) 0.98

Same partners, different dance: involvement of DNA replication proteins in centrosome regulation. Cell Cycle (2010) 0.98

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse. BMC Dev Biol (2006) 0.97

The generation of superficial cortical layers is regulated by levels of the transcription factor Pax6. Cereb Cortex (2010) 0.95

Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev (2009) 0.94

Old and new functions of proneural factors revealed by the genome-wide characterization of their transcriptional targets. Cell Cycle (2011) 0.94

Er81 is a downstream target of Pax6 in cortical progenitors. BMC Dev Biol (2008) 0.89

A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T-lymphocytes reactive to tumor cells. Cancer Sci (2011) 0.89

Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. Mol Cell Biol (2004) 0.89

JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta (2006) 0.85

Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF-induced oligodendroglioma. Int J Cancer (2012) 0.85

A dual role of Cdk2 in DNA damage response. Cell Div (2009) 0.79

Articles by these authors

A role for Dicer in immune regulation. J Exp Med (2006) 5.81

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat Neurosci (2012) 3.28

Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci U S A (2003) 2.86

pho2, a phosphate overaccumulator, is caused by a nonsense mutation in a microRNA399 target gene. Plant Physiol (2006) 2.77

Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet (2003) 2.50

Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis. Dev Biol (2005) 2.41

Safety, efficacy, and quality of life following sutureless vitrectomy for symptomatic vitreous floaters. Retina (2014) 2.29

Exuberance in the development of cortical networks. Nat Rev Neurosci (2005) 2.20

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks. Nat Protoc (2012) 2.11

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A (2010) 1.97

A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Sci Transl Med (2012) 1.95

Pax6; a pleiotropic player in development. Bioessays (2002) 1.94

The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet (2009) 1.92

Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism. Dev Biol (2006) 1.84

Requirements for FGF3 and FGF10 during inner ear formation. Development (2003) 1.76

Comparative aspects of cerebral cortical development. Eur J Neurosci (2006) 1.68

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo. J Pharmacol Exp Ther (2006) 1.67

Regression analysis between heart rate variability and baroreflex-related vagus nerve activity in rats. J Cardiovasc Electrophysiol (2005) 1.63

Long-range downstream enhancers are essential for Pax6 expression. Dev Biol (2006) 1.62

Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol (2006) 1.50

Association between retinal thickness measured by spectral-domain optical coherence tomography (OCT) and rod-mediated dark adaptation in non-exudative age-related maculopathy. Br J Ophthalmol (2011) 1.48

Gradients in the brain: the control of the development of form and function in the cerebral cortex. Cold Spring Harb Perspect Biol (2009) 1.45

Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development (2002) 1.42

Disc1 point mutations in mice affect development of the cerebral cortex. J Neurosci (2011) 1.40

A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction. Cell Cycle (2004) 1.39

Traumatic lens subluxation presenting as pseudomelanoma. Ophthalmic Surg Lasers Imaging Retina (2014) 1.37

Comparative evaluation of linear and exponential amplification techniques for expression profiling at the single-cell level. Genome Biol (2006) 1.37

Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts. J Biol Chem (2003) 1.35

The motility of glioblastoma tumour cells is modulated by intracellular cofilin expression in a concentration-dependent manner. Cell Motil Cytoskeleton (2005) 1.33

Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm. J Neurosci (2006) 1.33

The role of Pax6 in forebrain development. Dev Neurobiol (2011) 1.32

Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap. Development (2005) 1.32

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development (2007) 1.28

Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF-I expression. J Orthop Res (2004) 1.23

A crucial role for primary cilia in cortical morphogenesis. J Neurosci (2008) 1.20

Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. J Cell Sci (2012) 1.20

Reversible block of mouse neural stem cell differentiation in the absence of dicer and microRNAs. PLoS One (2010) 1.19

The long non-coding RNA Paupar regulates the expression of both local and distal genes. EMBO J (2014) 1.19

Dynamic evolution of conducting nanofilament in resistive switching memories. Nano Lett (2013) 1.18

Chromatin regulation by BAF170 controls cerebral cortical size and thickness. Dev Cell (2013) 1.17

Molecular organization of the ferret visual thalamus. J Neurosci (2004) 1.13

Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury-dependent and reactivated developmental processes. J Neurochem (2006) 1.12

Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction. J Am Soc Nephrol (2009) 1.11

Role of Pax6 in forebrain regionalization. Brain Res Bull (2005) 1.08

Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol (2007) 1.08

Regulation of the Pax6 : Pax6(5a) mRNA ratio in the developing mammalian brain. BMC Dev Biol (2005) 1.08

A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev Biol (2003) 1.08

Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev (2009) 1.08

Role of neuroepithelial Sonic hedgehog in hypothalamic patterning. J Neurosci (2009) 1.08

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene (2002) 1.08

Real time observation of the formation of hollow nanostructures through solid state reactions. Anal Chem (2014) 1.07

Sustained Wnt/β-catenin signaling rescues high glucose induction of transforming growth factor-β1-mediated renal fibrosis. Am J Med Sci (2012) 1.07

The role of neurotrophin receptors in female germ-cell survival in mouse and human. Development (2003) 1.06

Mechanisms controlling the guidance of thalamocortical axons through the embryonic forebrain. Eur J Neurosci (2012) 1.04

The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. PLoS Biol (2011) 1.04

Secreted frizzled-related protein 1 modulates glucocorticoid attenuation of osteogenic activities and bone mass. Endocrinology (2005) 1.04

PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes. Breast Cancer Res (2008) 1.04

Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells. J Agric Food Chem (2004) 1.03

Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development. J Neurosci (2011) 1.03

Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3. J Neurosci (2006) 1.02

Fibrocontractive Müller cell phenotypes in proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci (2008) 1.01

Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon. Dev Dyn (2004) 1.01

MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain. Proc Natl Acad Sci U S A (2013) 1.01

The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse. Development (2004) 1.01

Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance. BMC Dev Biol (2008) 1.00

Consolidation and translation regulation. Learn Mem (2012) 0.99

CT-guided core needle biopsy of deep suprahyoid head and neck lesions. Korean J Radiol (2013) 0.98

Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development. Mech Dev (2002) 0.97

Modelling and measuring single cell RNA expression levels find considerable transcriptional differences among phenotypically identical cells. BMC Genomics (2008) 0.97

Superoxide destabilization of beta-catenin augments apoptosis of high-glucose-stressed mesangial cells. Endocrinology (2008) 0.97

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse. BMC Dev Biol (2006) 0.97

The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development. PLoS Genet (2012) 0.96

Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro. Glia (2011) 0.95

The generation of superficial cortical layers is regulated by levels of the transcription factor Pax6. Cereb Cortex (2010) 0.95

Neural stem cell biology in vertebrates and invertebrates: more alike than different? Neuron (2011) 0.95