Published in Trends Cell Biol on September 18, 2008
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22
p53 and E2f: partners in life and death. Nat Rev Cancer (2009) 3.06
Lung squamous cell carcinoma mRNA expression subtypes are reproducible, clinically important, and correspond to normal cell types. Clin Cancer Res (2010) 2.15
The RB-E2F1 pathway regulates autophagy. Cancer Res (2010) 1.90
Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Am J Pathol (2010) 1.73
Circulating MiR-125b as a marker predicting chemoresistance in breast cancer. PLoS One (2012) 1.67
A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host Microbe (2014) 1.61
Arginine methylation controls growth regulation by E2F-1. EMBO J (2012) 1.44
Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation. Br J Pharmacol (2013) 1.42
A common biological mechanism in cancer and Alzheimer's disease? Curr Alzheimer Res (2009) 1.36
A pathophysiological view of the long non-coding RNA world. Oncotarget (2014) 1.36
p73 in Cancer. Genes Cancer (2011) 1.33
Regulation of the Wip1 phosphatase and its effects on the stress response. Front Biosci (Landmark Ed) (2012) 1.24
Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc. Mol Cell Biol (2009) 1.16
Dysregulation of RNA polymerase I transcription during disease. Biochim Biophys Acta (2012) 1.16
ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst (2011) 1.15
Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell (2013) 1.12
Reorganization of the host epigenome by a viral oncogene. Genome Res (2012) 1.10
Overexpression of PRMT5 promotes tumor cell growth and is associated with poor disease prognosis in epithelial ovarian cancer. J Histochem Cytochem (2013) 1.04
An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS Pathog (2011) 1.04
Regulation of the retinoblastoma proteins by the human herpesviruses. Cell Div (2009) 1.02
The antitumor activity of the fungicide ciclopirox. Int J Cancer (2010) 1.02
Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila) (2010) 1.01
Regulation of senescence by microRNA biogenesis factors. Ageing Res Rev (2012) 0.99
The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment. Mol Cancer Res (2012) 0.98
PI3-kinase/p38 kinase-dependent E2F1 activation is critical for Pin1 induction in tamoxifen-resistant breast cancer cells. Mol Cells (2011) 0.98
Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet (2014) 0.97
MiR-351 transiently increases during muscle regeneration and promotes progenitor cell proliferation and survival upon differentiation. Physiol Genomics (2012) 0.94
The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage. Mol Cancer (2013) 0.93
Dephosphorylation of nucleophosmin by PP1β facilitates pRB binding and consequent E2F1-dependent DNA repair. Mol Biol Cell (2010) 0.93
p53 inactivation upregulates p73 expression through E2F-1 mediated transcription. PLoS One (2012) 0.91
Interrogating tumor metabolism and tumor microenvironments using molecular positron emission tomography imaging. Theranostic approaches to improve therapeutics. Pharmacol Rev (2013) 0.89
E2F-1 is overexpressed and pro-apoptotic in human hepatocellular carcinoma. Virchows Arch (2012) 0.89
Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. J Virol (2011) 0.89
The RIP140 gene is a transcriptional target of E2F1. PLoS One (2012) 0.89
Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron (2013) 0.89
E2F1 and KIAA0191 expression predicts breast cancer patient survival. BMC Res Notes (2011) 0.88
pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737. Cell Death Differ (2013) 0.88
Contributions of Rad9 to tumorigenesis. J Cell Biochem (2012) 0.88
COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation. Cell Death Differ (2010) 0.88
Maternal gene expression profiling during pregnancy and preeclampsia in human peripheral blood mononuclear cells. Placenta (2010) 0.88
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis. J Cancer Res Clin Oncol (2010) 0.88
Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes. PLoS One (2014) 0.87
E2F1-mediated upregulation of p19INK4d determines its periodic expression during cell cycle and regulates cellular proliferation. PLoS One (2011) 0.87
The ancient function of RB-E2F pathway: insights from its evolutionary history. Biol Direct (2010) 0.86
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription. J Biol Chem (2011) 0.86
Genetic and functional analysis of the NKX2-5 gene promoter in patients with ventricular septal defects. Pediatr Cardiol (2012) 0.86
Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet (2010) 0.85
Ectopic expression of E2F1 stimulates beta-cell proliferation and function. Diabetes (2010) 0.85
Transcription addiction: can we garner the Yin and Yang functions of E2F1 for cancer therapy? Cell Death Dis (2014) 0.84
Combined effects of E2F1 and E2F2 polymorphisms on risk and early onset of squamous cell carcinoma of the head and neck. Mol Carcinog (2012) 0.84
Lamina-associated polypeptide (LAP)2α and other LEM proteins in cancer biology. Adv Exp Med Biol (2014) 0.83
A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel. Oncotarget (2015) 0.82
Protect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival. Cell Cycle (2013) 0.82
Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation. BMC Genomics (2010) 0.81
Mechanoregulation of proliferation. Mol Cell Biol (2009) 0.81
Dynamical behaviors of Rb-E2F pathway including negative feedback loops involving miR449. PLoS One (2012) 0.81
Decreased MicroRNA-26a expression causes cisplatin resistance in human non-small cell lung cancer. Cancer Biol Ther (2015) 0.80
CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection. J Virol (2013) 0.80
MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies. ISRN Hematol (2013) 0.80
Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. PLoS One (2010) 0.79
E2F1: a potential negative regulator of hTERT transcription in normal cells upon activation of oncogenic c-Myc. Med Sci Monit (2012) 0.79
G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients. Mol Neurobiol (2014) 0.79
Functional inactivation of Rb sensitizes cancer cells to TSC2 inactivation induced cell death. Cancer Lett (2012) 0.79
Lentivirus-mediated RNA interference targeting E2F-1 inhibits human gastric cancer MGC-803 cell growth in vivo. Exp Mol Med (2011) 0.79
ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells. BMC Cell Biol (2013) 0.78
Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures. Nucleic Acids Res (2015) 0.78
Protein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling. PLoS One (2014) 0.78
MEF2D Deficiency in Neonatal Cardiomyocytes Triggers Cell Cycle Re-entry and Programmed Cell Death in Vitro. J Biol Chem (2015) 0.78
p85α promotes nucleolin transcription and subsequently enhances EGFR mRNA stability and EGF-induced malignant cellular transformation. Oncotarget (2016) 0.78
Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation. Aging Cell (2016) 0.77
Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients. Oncotarget (2015) 0.77
Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer. Int J Mol Sci (2015) 0.77
Analysis of Pigeon (Columba) Ovary Transcriptomes to Identify Genes Involved in Blue Light Regulation. PLoS One (2015) 0.77
The Impact of Carrot Enriched in Iodine through Soil Fertilization on Iodine Concentration and Selected Biochemical Parameters in Wistar Rats. PLoS One (2016) 0.77
Dynamic transcription factor activity and networks during ErbB2 breast oncogenesis and targeted therapy. Integr Biol (Camb) (2014) 0.77
Nuclear Smad7 Overexpressed in Mesenchymal Cells Acts as a Transcriptional Corepressor by Interacting with HDAC-1 and E2F to Regulate Cell Cycle. Biol Open (2012) 0.77
Deletion of Rb1 induces both hyperproliferation and cell death in murine germinal center B cells. Exp Hematol (2015) 0.77
ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nat Commun (2016) 0.76
Characterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell death. PLoS One (2012) 0.76
Targeting CDK6 in cancer: State of the art and new insights. Cell Cycle (2015) 0.76
Inhibition of mTOR's Catalytic Site by PKI-587 Is a Promising Therapeutic Option for Gastroenteropancreatic Neuroendocrine Tumor Disease. Neuroendocrinology (2016) 0.75
The role of E2F1 in the development of hypertrophic cardiomyopathy. Int J Clin Exp Pathol (2011) 0.75
Effects of Auraptene on IGF-1 Stimulated Cell Cycle Progression in the Human Breast Cancer Cell Line, MCF-7. Int J Breast Cancer (2012) 0.75
E2F6 Impairs Glycolysis and Activates BDH1 Expression Prior to Dilated Cardiomyopathy. PLoS One (2017) 0.75
A novel lncRNA, GASL1, inhibits cell proliferation and restricts E2F1 activity. Oncotarget (2017) 0.75
Cell cycle regulated transcription: from yeast to cancer. F1000Res (2016) 0.75
hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles. Sci Rep (2016) 0.75
TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair. PLoS One (2015) 0.75
Functional variants at the miRNA binding sites of the E2F1 gene and its mRNA expression. Oncol Lett (2012) 0.75
Effect of human papillomavirus seropositivity and E2F2 promoter variants on risk of squamous cell carcinomas of oropharynx and oral cavity. Carcinogenesis (2016) 0.75
Pattern analysis uncovers a chronic ethanol-induced disruption of the switch-like dynamics of C/EBP-β and C/EBP-α genome-wide binding during liver regeneration. Physiol Genomics (2016) 0.75
T-ARG-eting E2F-1 growth control. Cell Cycle (2012) 0.75
Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures. Nat Commun (2017) 0.75
Prognostic value of E2F1 in rectal cancer. Turk J Surg (2017) 0.75
Integration of ALV into CTDSPL and CTDSPL2 genes in B-cell lymphomas promotes cell immortalization, migration and survival. Oncotarget (2017) 0.75
Roles of Long Noncoding RNAs in Recurrence and Metastasis of Radiotherapy-Resistant Cancer Stem Cells. Int J Mol Sci (2017) 0.75
p53 and E2f: partners in life and death. Nat Rev Cancer (2009) 3.06
Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis. J Biol Chem (2003) 2.41
E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis. Oncogene (2002) 2.39
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol (2008) 2.04
Transcriptional programs following genetic alterations in p53, INK4A, and H-Ras genes along defined stages of malignant transformation. Cancer Res (2005) 1.86
Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res (2003) 1.64
E2F and Ras synergize in transcriptionally activating p14ARF expression. Cell Cycle (2003) 1.54
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol Cancer Res (2011) 1.53
Transcriptional regulation of AKT activation by E2F. Mol Cell (2004) 1.49
p53-dependent down-regulation of telomerase is mediated by p21waf1. J Biol Chem (2004) 1.39
ATM is a target for positive regulation by E2F-1. Oncogene (2003) 1.34
E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1. J Biol Chem (2006) 1.02
ERK activation is regulated by E2F1 and is essential for E2F1-induced S phase entry. Cell Signal (2008) 1.02
E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress. J Biol Chem (2002) 1.00
Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations. J Cell Sci (2002) 1.00
Modulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomas. Am J Pathol (2009) 0.97
Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene. Growth Horm IGF Res (2009) 0.88
The tumor suppressor maspin mediates E2F1-induced sensitivity of cancer cells to chemotherapy. Mol Cancer Res (2010) 0.87
Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. Haematologica (2009) 0.84
RBM38 is a direct transcriptional target of E2F1 that limits E2F1-induced proliferation. Mol Cancer Res (2012) 0.84
The mitotic checkpoint gene, SIL is regulated by E2F1. Int J Cancer (2008) 0.83
JNK activation is regulated by E2F and promotes E2F1-induced apoptosis. Cell Signal (2010) 0.80
E2F and signal transduction pathways. Cell Cycle (2005) 0.77
Regulation of modular Cyclin and CDK feedback loops by an E2F transcription oscillator in the mammalian cell cycle. Math Biosci Eng (2011) 0.75