Published in Mol Cell Biol on January 01, 2000
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene (2007) 3.17
A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol (2008) 3.02
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell (2010) 2.86
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol (2001) 2.74
Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol (2003) 2.22
Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci U S A (2002) 2.15
RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ (2000) 2.13
PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol Cell Biol (2002) 2.12
A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. EMBO J (2004) 2.05
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol (2006) 1.95
IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell (2003) 1.86
DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol Cell Biol (2006) 1.80
Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol (2006) 1.75
Cyclin D1 cooperates with p21 to regulate TGFβ-mediated breast cancer cell migration and tumor local invasion. Breast Cancer Res (2013) 1.64
Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J (2004) 1.62
The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth. Cancer Res (2009) 1.58
The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition. Mol Cell Biol (2001) 1.55
Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells. Am J Pathol (2006) 1.55
ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol (2002) 1.55
Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell (2003) 1.53
The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice. Cancer Res (2008) 1.53
Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8. Proc Natl Acad Sci U S A (2008) 1.51
Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol (2002) 1.48
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Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. Mol Cell Biol (2001) 1.46
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J (2006) 1.45
The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion. Cancer Res (2010) 1.44
microRNA, cell cycle, and human breast cancer. Am J Pathol (2010) 1.32
Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol Biol Cell (2006) 1.29
Reviewing once more the c-myc and Ras collaboration: converging at the cyclin D1-CDK4 complex and challenging basic concepts of cancer biology. Cell Cycle (2011) 1.27
Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene (2010) 1.21
Treating cancer with selective CDK4/6 inhibitors. Nat Rev Clin Oncol (2016) 1.20
A novel interaction between HER2/neu and cyclin E in breast cancer. Oncogene (2010) 1.17
The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling. Cancer Res (2009) 1.14
Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism. J Clin Invest (2001) 1.14
An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry. Mol Cell Biol (2004) 1.12
The prolyl isomerase Pin1 in breast development and cancer. Breast Cancer Res (2003) 1.12
Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo. Am J Pathol (2009) 1.11
Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e. J Biol Chem (2011) 1.10
EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. Cancer Res (2013) 1.10
Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element. Nucleic Acids Res (2010) 1.06
p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion. PLoS One (2007) 1.04
Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-beta signaling in ErbB2/Neu-induced tumors from transgenic mice. Oncogene (2005) 1.04
Induction of cell proliferation and survival genes by estradiol-repressed microRNAs in breast cancer cells. BMC Cancer (2012) 1.02
DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. Cancer Discov (2012) 1.02
The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells. Carcinogenesis (2013) 1.01
LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression. Oncogene (2009) 1.00
PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. Cell Cycle (2011) 0.99
Cyclin alterations in diverse cancers: Outcome and co-amplification network. Oncotarget (2015) 0.97
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis. Oncotarget (2015) 0.96
Cyclin D1 determines estrogen signaling in the mammary gland in vivo. Mol Endocrinol (2013) 0.95
HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors. Oncogene (2013) 0.92
miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget (2014) 0.92
The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification. Cell Div (2011) 0.90
The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition. Int J Cancer (2010) 0.89
Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron (2013) 0.89
Inhibition of tumor growth and metastasis by non-small cell lung cancer cells transfected with cyclin D1-targeted siRNA. Oligonucleotides (2009) 0.88
The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer. Am J Pathol (2004) 0.88
Cytokine-induced tumor suppressors: a GRIM story. Cytokine (2010) 0.88
K63-linked ubiquitination in kinase activation and cancer. Front Oncol (2012) 0.87
Cyclin D1 integrates estrogen-mediated DNA damage repair signaling. Cancer Res (2014) 0.87
E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2. Nucleic Acids Res (2001) 0.87
PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells. Curr Cancer Drug Targets (2009) 0.86
Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer. Am J Pathol (2013) 0.86
Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific. Br J Pharmacol (2004) 0.86
Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model. PLoS One (2013) 0.86
Inflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancers. Breast Cancer Res (2003) 0.85
E2F activators signal and maintain centrosome amplification in breast cancer cells. Mol Cell Biol (2014) 0.83
Small non-coding RNAs govern mammary gland tumorigenesis. J Mammary Gland Biol Neoplasia (2012) 0.83
Absence of CCND1 gene amplification in breast tumours of BRCA1 mutation carriers. Mol Pathol (2001) 0.82
The Wilms' tumor suppressor WT1 induces estrogen-independent growth and anti-estrogen insensitivity in ER-positive breast cancer MCF7 cells. Oncol Rep (2010) 0.82
Aryl hydrocarbon receptor ligands inhibit igf-ii and adipokine stimulated breast cancer cell proliferation. ISRN Endocrinol (2013) 0.82
Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples. Mol Cancer (2011) 0.82
Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins. J Biol Chem (2014) 0.81
Periodic expression of Kv10.1 driven by pRb/E2F1 contributes to G2/M progression of cancer and non-transformed cells. Cell Cycle (2016) 0.80
Single and Multiple Gene Manipulations in Mouse Models of Human Cancer. Cancer Growth Metastasis (2015) 0.80
The elements of human cyclin D1 promoter and regulation involved. Clin Epigenetics (2011) 0.79
Targeting ErbB-2 nuclear localization and function inhibits breast cancer growth and overcomes trastuzumab resistance. Oncogene (2014) 0.79
Cyclin D1 Promotes Androgen-Dependent DNA Damage Repair in Prostate Cancer Cells. Cancer Res (2015) 0.79
Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b). Mol Carcinog (2009) 0.79
Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells. Oncol Rep (2006) 0.78
Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene. Evid Based Complement Alternat Med (2012) 0.78
When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase. Cells (2014) 0.78
Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1. Cell Cycle (2006) 0.77
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. BMC Cell Biol (2009) 0.77
Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med (Berl) (2016) 0.76
GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses. Transl Oncogenomics (2008) 0.76
Gene regulatory network underlying the immortalization of epithelial cells. BMC Syst Biol (2017) 0.75
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Chemoprevention of Rat Mammary Carcinogenesis by Apiaceae Spices. Int J Mol Sci (2017) 0.75
The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency. Sci Rep (2016) 0.75
v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1. Cancer Res (2016) 0.75
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