Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 3951265)

Published in Sci Signal on April 30, 2013

Authors

Xiangming Ding1, Hongya Pan, Jiong Li, Qi Zhong, Xiaohong Chen, Sarah M Dry, Cun-Yu Wang

Author Affiliations

1: Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Articles citing this

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas. J Clin Invest (2014) 1.10

The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05

Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. Am J Transl Res (2013) 1.01

Transcriptional control of cancer metastasis. Trends Cell Biol (2013) 0.92

High-resolution interrogation of functional elements in the noncoding genome. Science (2016) 0.90

ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. Elife (2015) 0.86

FRA-1 as a driver of tumour heterogeneity: a nexus between oncogenes and embryonic signalling pathways in cancer. Oncogene (2014) 0.82

FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. Oncotarget (2016) 0.82

Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma. Am J Cancer Res (2013) 0.81

Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. Oncogene (2016) 0.80

The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1. Oncotarget (2015) 0.79

Investigating the mechanism of hepatocellular carcinoma progression by constructing genetic and epigenetic networks using NGS data identification and big database mining method. Oncotarget (2016) 0.78

Targeting BMI1(+) Cancer Stem Cells Overcomes Chemoresistance and Inhibits Metastases in Squamous Cell Carcinoma. Cell Stem Cell (2017) 0.77

KDM4A, KDM4B and KDM4C in non-small cell lung cancer. Int J Clin Exp Pathol (2015) 0.76

Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis. Oncotarget (2016) 0.76

An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter. Cell Rep (2016) 0.75

Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells. J Cell Mol Med (2016) 0.75

A novel read-through transcript JMJD7-PLA2G4B regulates head and neck squamous cell carcinoma cell proliferation and survival. Oncotarget (2016) 0.75

Stress-triggered atavistic reprogramming (STAR) addiction: driving force behind head and neck cancer? Am J Cancer Res (2016) 0.75

JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma. J Exp Clin Cancer Res (2016) 0.75

The Role of p16(INK4a) Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer. Int J Mol Sci (2017) 0.75

Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation. Oral Dis (2016) 0.75

Articles cited by this

AP-1 as a regulator of cell life and death. Nat Cell Biol (2002) 10.10

The molecular biology of head and neck cancer. Nat Rev Cancer (2010) 9.84

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell (1988) 7.76

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08

Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol (2007) 6.13

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51

Dynamic regulation of histone lysine methylation by demethylases. Mol Cell (2007) 5.14

Recent advances in head and neck cancer. N Engl J Med (2008) 5.05

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci U S A (1987) 3.99

NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med (2006) 3.40

Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol (2012) 3.40

Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell (2005) 2.47

Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene (2000) 2.27

TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nat Cell Biol (2008) 2.12

An orthotopic nude mouse model of oral tongue squamous cell carcinoma. Clin Cancer Res (2002) 2.11

Transcriptomic dissection of tongue squamous cell carcinoma. BMC Genomics (2008) 2.09

The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res (2009) 2.01

Invasive growth: from development to metastasis. J Clin Invest (2002) 1.91

Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res (2001) 1.83

Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog (1999) 1.81

Targeting the hepatocyte growth factor-cMET axis in cancer therapy. J Clin Oncol (2012) 1.77

Emerging roles of ATF2 and the dynamic AP1 network in cancer. Nat Rev Cancer (2010) 1.76

The mutationally activated Met receptor mediates motility and metastasis. Proc Natl Acad Sci U S A (1998) 1.76

Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs. Cell Stem Cell (2012) 1.58

Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genet Cytogenet (2004) 1.45

Met protein expression level correlates with survival in patients with late-stage nasopharyngeal carcinoma. Cancer Res (2002) 1.32

Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme. Eur J Cancer (2000) 1.32

Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B. J Biol Chem (2002) 1.21

Characterization of the rearranged tpr-met oncogene breakpoint. Mol Cell Biol (1987) 1.15

CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex. Int J Oral Sci (2009) 1.05

Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. Oncogene (2005) 1.01

Overexpression of scatter factor and its receptor (c-met) in oral squamous cell carcinoma. Laryngoscope (1998) 0.97

Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. J Biol Chem (2002) 0.94

Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastases. Int J Cancer (2000) 0.91

Overexpression of Fos-related antigen-1 in head and neck squamous cell carcinoma. Int J Exp Pathol (2005) 0.85

Fos-related activator-1 is overexpressed in oral squamous cell carcinoma and associated with tumor lymph node metastasis. J Oral Pathol Med (2010) 0.83

Articles by these authors

TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88

Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet (2004) 7.84

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell (2006) 7.49

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes Dev (2010) 5.38

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med (2013) 4.32

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17

Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS One (2006) 3.91

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev (2012) 3.48

FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell (2007) 3.46

NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med (2006) 3.40

Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Biol (2004) 3.29

IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol (2003) 2.77

Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. Nat Biotechnol (2002) 2.61

Diagnosis and management of synovial sarcoma. J Surg Oncol (2008) 2.53

Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat Med (2009) 2.51

Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell (2005) 2.47

Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol (2005) 2.30

Association of serum gamma-glutamyltransferase with arterial stiffness in established coronary artery disease. Angiology (2012) 2.26

TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis. Nat Cell Biol (2008) 2.12

A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem (2003) 2.12

PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A (2009) 2.07

Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology (2010) 2.06

BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nat Cell Biol (2009) 2.04

C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila. EMBO J (2006) 2.01

Maternal bereavement during pregnancy and the risk of stillbirth: a nationwide cohort study in Sweden. Am J Epidemiol (2013) 1.99

Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem (2007) 1.89

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A (2011) 1.87

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Diabetes (2012) 1.82

Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem (2006) 1.78

Characterization of the vitreous proteome in diabetes without diabetic retinopathy and diabetes with proliferative diabetic retinopathy. J Proteome Res (2008) 1.76

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol (2002) 1.75

Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J Biol Chem (2007) 1.70

High hepatitis C incidence in new injecting drug users: a policy failure? Aust N Z J Public Health (2007) 1.67

Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. PLoS Biol (2004) 1.62

Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. PLoS One (2008) 1.60

Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs. Cell Stem Cell (2012) 1.58

The natural history of aberrant crypt foci. Gastrointest Endosc (2008) 1.58

Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign. Cancer (2010) 1.56

MAVS self-association mediates antiviral innate immune signaling. J Virol (2009) 1.55

FDG-PET/CT imaging predicts histopathologic treatment responses after the initial cycle of neoadjuvant chemotherapy in high-grade soft-tissue sarcomas. Clin Cancer Res (2009) 1.47

A novel transdermal plasmid-dimethylsulfoxide delivery technique for treatment of psoriasis. Dermatology (2010) 1.45

Antimicrobial activity of an endophytic Xylaria sp.YX-28 and identification of its antimicrobial compound 7-amino-4-methylcoumarin. Appl Microbiol Biotechnol (2007) 1.44

Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol (2008) 1.43

A glycolytic mechanism regulating an angiogenic switch in prostate cancer. Cancer Res (2007) 1.43

Validation of the postoperative nomogram for 12-year sarcoma-specific mortality. Cancer (2004) 1.42

Wingless signaling induces widespread chromatin remodeling of target loci. Mol Cell Biol (2007) 1.42

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation (2012) 1.40

New understanding of hardening mechanism of TiN/SiNx-based nanocomposite films. Nanoscale Res Lett (2013) 1.39

Viewing chemokines as a third major system of communication in the brain. AAPS J (2006) 1.39

HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling. J Cereb Blood Flow Metab (2010) 1.39

Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies. Eur J Cancer (2009) 1.36

The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor. Mol Cell Biol (2002) 1.36

Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway. J Cell Biol (2007) 1.36

NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation. Proc Natl Acad Sci U S A (2013) 1.35

Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One (2010) 1.33

Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines. Cancer Res (2005) 1.32

Periodontal disease and bisphosphonates induce osteonecrosis of the jaws in the rat. J Bone Miner Res (2011) 1.32

A study of the role of nell-1 gene modified goat bone marrow stromal cells in promoting new bone formation. Mol Ther (2007) 1.31

Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol (2010) 1.29

Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis. Mod Pathol (2011) 1.29

Parathyroid hormone and parathyroid hormone-related protein exert both pro- and anti-apoptotic effects in mesenchymal cells. J Biol Chem (2002) 1.28

Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation. PLoS One (2007) 1.27

Notch signaling in the regulation of tumor angiogenesis. Trends Cell Biol (2006) 1.26

Signaling between transforming growth factor β (TGF-β) and transcription factor SNAI2 represses expression of microRNA miR-203 to promote epithelial-mesenchymal transition and tumor metastasis. J Biol Chem (2013) 1.25

Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress. Cancer Biol Ther (2006) 1.23

Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. Mol Cell Biol (2006) 1.23

Tumor necrosis factor-related apoptosis-inducing ligand: a novel mechanism for Bacillus Calmette-Guérin-induced antitumor activity. Cancer Res (2004) 1.23

Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors. Clin Cancer Res (2011) 1.22

Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. Cell Signal (2005) 1.22

Wnt signaling and skeletal development. Cell Signal (2007) 1.22

Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B. J Biol Chem (2002) 1.21

Tetra- and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-κB signal transduction cascade and immuno-inflammatory response in human gingival fibroblasts. PLoS One (2013) 1.21

Evaluating triggers and enhancers of tau fibrillization. Microsc Res Tech (2005) 1.19

Novel functions for NFκB: inhibition of bone formation. Nat Rev Rheumatol (2010) 1.19

Label-free hybridization detection of a single nucleotide mismatch by immobilization of molecular beacons on an agarose film. Nucleic Acids Res (2002) 1.18

Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18

Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res (2009) 1.17

Histone demethylase KDM6B promotes epithelial-mesenchymal transition. J Biol Chem (2012) 1.16

High-mobility group protein box-1 and its relevance to cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.16

Pathways of tau fibrillization. Biochim Biophys Acta (2005) 1.13

The clinical significance of MAGEA3 expression in pancreatic cancer. Int J Cancer (2006) 1.11

IL-37 ameliorates the inflammatory process in psoriasis by suppressing proinflammatory cytokine production. J Immunol (2014) 1.11

Role of Th1 and Th2 cytokines in BCG-induced IFN-gamma production: cytokine promotion and simulation of BCG effect. Cytokine (2003) 1.10

Modelling the hepatitis C virus epidemic in Australia. Drug Alcohol Depend (2007) 1.08

Prophylaxis against carcinogenesis in three kinds of unestablished tumor models via IL12-gene-engineered MSCs. Carcinogenesis (2006) 1.07

Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck. Clin Cancer Res (2009) 1.07

Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J Bone Miner Res (2003) 1.07

Evaluation of well-differentiated/de-differentiated liposarcomas by high-resolution oligonucleotide array-based comparative genomic hybridization. Genes Chromosomes Cancer (2011) 1.06

Early or recurrent preterm birth and maternal cardiovascular disease risk. Ann Epidemiol (2010) 1.05

Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. PLoS One (2010) 1.04

The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. J Immunol (2004) 1.04

A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer. Clin Cancer Res (2010) 1.04

c-Myc sensitizes cells to tumor necrosis factor-mediated apoptosis by inhibiting nuclear factor kappa B transactivation. J Biol Chem (2002) 1.04

Statins: multiple neuroprotective mechanisms in neurodegenerative diseases. Exp Neurol (2010) 1.04

Short-snouted toothless ichthyosaur from China suggests Late Triassic diversification of suction feeding ichthyosaurs. PLoS One (2011) 1.04

Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt. Oral Oncol (2008) 1.03

The usefulness of toluidine red unheated serum test in the diagnosis of HIV-negative neurosyphilis. Sex Transm Dis (2011) 1.02