Published in Nat Rev Mol Cell Biol on April 04, 2012
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet (2013) 3.19
Medulloblastomics: the end of the beginning. Nat Rev Cancer (2012) 3.01
Chromatin proteins and modifications as drug targets. Nature (2013) 2.60
Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov (2013) 2.16
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol Cell (2013) 1.70
KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res (2013) 1.65
Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res (2012) 1.60
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36. Genes Dev (2014) 1.53
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol (2012) 1.52
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia. Nature (2014) 1.47
The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. J Natl Cancer Inst (2015) 1.46
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife (2013) 1.44
Inhibition of demethylases by GSK-J1/J4. Nature (2014) 1.31
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity. Cell (2016) 1.21
Chromatin signatures of cancer. Genes Dev (2015) 1.20
Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE). J Nutr (2015) 1.20
Repression of chimeric transcripts emanating from endogenous retrotransposons by a sequence-specific transcription factor. Genome Biol (2014) 1.17
IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma. Neuro Oncol (2013) 1.15
A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response. Mol Cell (2013) 1.14
C/EBPα is required for long-term self-renewal and lineage priming of hematopoietic stem cells and for the maintenance of epigenetic configurations in multipotent progenitors. PLoS Genet (2014) 1.12
An unexpected journey: lysine methylation across the proteome. Biochim Biophys Acta (2014) 1.11
Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A. Proc Natl Acad Sci U S A (2012) 1.10
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet (2013) 1.09
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07
Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators. Psychoneuroendocrinology (2013) 1.06
Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase. J Biol Chem (2014) 1.05
The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05
Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells. Leukemia (2014) 1.03
LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition. Proc Natl Acad Sci U S A (2012) 1.02
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A (2014) 1.01
Epigenetic activation of AP1 promotes squamous cell carcinoma metastasis. Sci Signal (2013) 1.01
Targeting histone lysine demethylases - progress, challenges, and the future. Biochim Biophys Acta (2014) 1.01
Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal (2012) 1.01
Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation. PLoS One (2013) 0.99
Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics. Cell Cycle (2013) 0.98
The H3K27me3 demethylase UTX in normal development and disease. Epigenetics (2014) 0.97
An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol (2016) 0.96
Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol (2013) 0.96
A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression. MBio (2014) 0.95
Interplay between active chromatin marks and RNA-directed DNA methylation in Arabidopsis thaliana. PLoS Genet (2013) 0.94
Genetics and epigenetics of arrhythmia and heart failure. Front Genet (2013) 0.94
NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I. J Biol Chem (2013) 0.93
H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing. Nucleic Acids Res (2015) 0.92
Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis. Nat Genet (2016) 0.92
Increased expression of mdig predicts poorer survival of the breast cancer patients. Gene (2013) 0.91
Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives. Curr Pharm Des (2013) 0.91
Epigenetic regulation of inducible gene expression in the immune system. Immunology (2013) 0.90
Targeting the histone orthography of cancer: drugs for writers, erasers and readers. Br J Pharmacol (2014) 0.90
Single molecule and single cell epigenomics. Methods (2014) 0.89
Rare event of histone demethylation can initiate singular gene expression of olfactory receptors. Proc Natl Acad Sci U S A (2013) 0.89
HIF-1-dependent induction of Jumonji domain-containing protein (JMJD) 3 under hypoxic conditions. Mol Cells (2014) 0.88
KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family. Cell Cycle (2013) 0.88
Epigenetic alterations in acute kidney injury. Semin Nephrol (2013) 0.88
Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. Epigenetics (2012) 0.88
Epigenetic regulation of miR-302 by JMJD1C inhibits neural differentiation of human embryonic stem cells. J Biol Chem (2013) 0.88
The epigenome of AML stem and progenitor cells. Epigenetics (2012) 0.87
Chromatin and oxygen sensing in the context of JmjC histone demethylases. Biochem J (2014) 0.87
PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. Cell Cycle (2014) 0.86
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J Med Chem (2016) 0.86
Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase. Chem Biol (2013) 0.86
Genome-wide analysis of histone modifiers in tomato: gaining an insight into their developmental roles. BMC Genomics (2013) 0.86
JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. PLoS One (2014) 0.85
Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J Biol Chem (2013) 0.85
The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First? Front Immunol (2014) 0.85
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. Am J Cancer Res (2015) 0.85
Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis. Epigenetics (2016) 0.85
Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol (2016) 0.84
KDM1 class flavin-dependent protein lysine demethylases. Biopolymers (2015) 0.84
Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res (2014) 0.84
Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells. Proc Natl Acad Sci U S A (2014) 0.84
Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation. Antioxid Redox Signal (2013) 0.84
Hepatic TLR4 signaling is activated by LPS from digestive tract during SARA, and epigenetic mechanisms contribute to enforced TLR4 expression. Oncotarget (2015) 0.83
Cell-type-specific Jumonji histone demethylase gene expression in the healthy rat CNS: detection by a novel flow cytometry method. ASN Neuro (2014) 0.83
Emerging concepts on the epigenetic and transcriptional regulation of the Kiss1 gene. Int J Dev Neurosci (2013) 0.83
The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development. Genes Dev (2014) 0.83
Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. J Biol Chem (2013) 0.83
A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem (2014) 0.83
The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target. Am J Cancer Res (2015) 0.82
Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells. Genes Dev (2016) 0.82
Tipping the lysine methylation balance in disease. Biopolymers (2013) 0.82
Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. Mol Carcinog (2015) 0.82
Epigenetic contributions to hormonally-mediated sexual differentiation of the brain. J Neuroendocrinol (2013) 0.82
Expansion and Functional Divergence of Jumonji C-Containing Histone Demethylases: Significance of Duplications in Ancestral Angiosperms and Vertebrates. Plant Physiol (2015) 0.82
Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. PLoS One (2012) 0.82
Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation. Proc Natl Acad Sci U S A (2015) 0.82
Cell cycle progression in response to oxygen levels. Cell Mol Life Sci (2014) 0.82
Cellular defense against latent colonization foiled by human cytomegalovirus UL138 protein. Sci Adv (2015) 0.81
The Interactions of microRNA and Epigenetic Modifications in Prostate Cancer. Cancers (Basel) (2013) 0.81
Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells. PLoS One (2013) 0.81
Dietary components as epigenetic-regulating agents against cancer. Biomedicine (Taipei) (2016) 0.81
Mechanism of retinoic acid-induced transcription: histone code, DNA oxidation and formation of chromatin loops. Nucleic Acids Res (2014) 0.81
Genetic and molecular alterations across medulloblastoma subgroups. J Mol Med (Berl) (2015) 0.81
Histone demethylases in chromatin biology and beyond. EMBO Rep (2015) 0.81
Histone demethylases in physiology and cancer: a tale of two enzymes, JMJD3 and UTX. Curr Opin Genet Dev (2016) 0.81
Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes. J Biol Chem (2014) 0.81
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nat Commun (2015) 0.81
Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. EMBO J (2016) 0.81
The epigenetic landscape of renal cancer. Nat Rev Nephrol (2016) 0.81
Decoding a signature-based model of transcription cofactor recruitment dictated by cardinal cis-regulatory elements in proximal promoter regions. PLoS Genet (2013) 0.81
MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators. Oncotarget (2015) 0.81
Chromatin modifications and their function. Cell (2007) 55.98
Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature (2010) 14.50
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature (2007) 8.32
Roles of histone acetyltransferases and deacetylases in gene regulation. Bioessays (1998) 7.79
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70
JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet (2006) 6.65
A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature (2005) 5.89
Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell (2005) 5.74
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet (2011) 5.73
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell (2006) 5.54
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell (2011) 5.27
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem (2007) 4.79
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol (2010) 4.66
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature (2011) 4.41
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet (2008) 4.40
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84
The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell (2007) 3.79
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat Struct Mol Biol (2007) 3.77
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell (2009) 3.75
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature (2012) 3.67
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
JMJD6 is a histone arginine demethylase. Science (2007) 3.48
Structural insights into histone demethylation by JMJD2 family members. Cell (2006) 3.37
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell (2009) 3.34
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev (2009) 3.04
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. Am J Hum Genet (2004) 2.99
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev (2009) 2.98
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature (2009) 2.98
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87
CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell (2010) 2.86
Histone modification: cause or cog? Trends Genet (2011) 2.85
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell (2010) 2.77
A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell (2009) 2.74
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J (2009) 2.72
Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell (2011) 2.68
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. Cancer Res (2009) 2.65
Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell (2007) 2.62
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence. Cancer Res (2006) 2.62
Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev (1995) 2.61
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell (2010) 2.60
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis (2009) 2.54
High throughput characterization of combinatorial histone codes. Mol Cell Proteomics (2009) 2.52
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood (2011) 2.47
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci U S A (2007) 2.45
Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers. Int J Cancer (2011) 2.42
Phosphatidylserine receptor is required for clearance of apoptotic cells. Science (2003) 2.38
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (2009) 2.37
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature (2009) 2.35
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell (2007) 2.29
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science (2011) 2.28
Jumonji, a nuclear protein that is necessary for normal heart development. Circ Res (2000) 2.26
A novel mammalian flavin-dependent histone demethylase. J Biol Chem (2009) 2.25
Histone demethylases in development and disease. Trends Cell Biol (2010) 2.25
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nat Struct Mol Biol (2007) 2.22
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature (2007) 2.21
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature (2007) 2.20
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20
Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome. Am J Hum Genet (2011) 2.14
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. Proc Natl Acad Sci U S A (2009) 2.10
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem (1999) 2.09
PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. Mol Cell (2010) 2.06
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05
A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics (2000) 2.05
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol (2007) 1.97
Crystal structure and mechanism of human lysine-specific demethylase-1. Nat Struct Mol Biol (2006) 1.94
Histone methyltransferases in cancer. Semin Cell Dev Biol (2009) 1.93
Structural basis of LSD1-CoREST selectivity in histone H3 recognition. J Biol Chem (2007) 1.92
A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD). Am J Med Genet A (2008) 1.89
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell (2010) 1.88
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev (2006) 14.36
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature (2007) 8.32
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature (2011) 8.31
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
A model for transmission of the H3K27me3 epigenetic mark. Nat Cell Biol (2008) 5.55
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74
Polycomb group proteins: navigators of lineage pathways led astray in cancer. Nat Rev Cancer (2009) 4.40
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
E2F target genes: unraveling the biology. Trends Biochem Sci (2004) 3.49
The E2F family: specific functions and overlapping interests. EMBO J (2004) 3.33
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev (2008) 3.10
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol (2002) 3.10
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev (2009) 3.04
Loss of Geminin induces rereplication in the presence of functional p53. J Cell Biol (2004) 2.97
Transcriptional regulation by Polycomb group proteins. Nat Struct Mol Biol (2013) 2.96
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell (2005) 2.85
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell (2010) 2.77
The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms. Genes Dev (2005) 2.67
Polycomb complexes act redundantly to repress genomic repeats and genes. Genes Dev (2010) 2.63
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol (2004) 2.61
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell (2013) 2.50
The emerging functions of histone demethylases. Curr Opin Genet Dev (2008) 2.47
Polycomb group protein-mediated repression of transcription. Trends Biochem Sci (2010) 2.37
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes. Nucleic Acids Res (2010) 2.37
Histone demethylases in development and disease. Trends Cell Biol (2010) 2.25
DNA methylation: TET proteins-guardians of CpG islands? EMBO Rep (2011) 2.23
Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov (2013) 2.16
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J (2003) 2.14
Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol (2005) 2.10
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J (2007) 1.99
HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell (2006) 1.96
Polycomb group proteins in cell cycle progression and cancer. Cell Cycle (2004) 1.94
Histone methyltransferases in cancer. Semin Cell Dev Biol (2009) 1.93
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. EMBO J (2004) 1.88
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell (2013) 1.86
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell (2010) 1.84
Identification of target genes of the p16INK4A-pRB-E2F pathway. J Biol Chem (2003) 1.83
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol Cell (2013) 1.78
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res (2005) 1.61
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res (2009) 1.60
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol (2009) 1.55
E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep (2005) 1.51
Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner. J Biol Chem (2004) 1.46
Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells. Mol Cell (2012) 1.43
Epigenetic control of embryonic stem cell fate. J Exp Med (2010) 1.40
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica (2013) 1.40
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia. Cancer Cell (2013) 1.38
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol (2011) 1.34
The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res (2011) 1.26
Quantitative mass spectrometry of histones H3.2 and H3.3 in Suz12-deficient mouse embryonic stem cells reveals distinct, dynamic post-translational modifications at Lys-27 and Lys-36. Mol Cell Proteomics (2010) 1.23
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nat Cell Biol (2013) 1.16
A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med (2008) 1.16
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biol (2013) 1.13
Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry. Nat Genet (2002) 1.13
Reduced hepatic tumor incidence in cyclin G1-deficient mice. Hepatology (2003) 1.12
NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12
Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones. Proteomics (2014) 1.11
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. PLoS Genet (2013) 1.09
The role of p53 and pRB in apoptosis and cancer. Curr Opin Genet Dev (2002) 1.09
The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol (2014) 1.07
Utx is required for proper induction of ectoderm and mesoderm during differentiation of embryonic stem cells. PLoS One (2013) 1.07
Inhibitors of histone demethylases. Bioorg Med Chem (2011) 1.06
CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell (2013) 1.06
Molecular mechanisms in gliomagenesis. Adv Cancer Res (2005) 1.04
The polycomb repressive complex 2 is a potential target of SUMO modifications. PLoS One (2008) 0.99
Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. Clin Cancer Res (2013) 0.98
Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS. Anal Chem (2013) 0.96
Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS. Oncogene (2005) 0.96
shRNA screening identifies JMJD1C as being required for leukemia maintenance. Blood (2014) 0.95
A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS One (2010) 0.95
Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation. Cancer Res (2013) 0.95
Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways. J Biol Chem (2004) 0.93
MMSET is highly expressed and associated with aggressiveness in neuroblastoma. Cancer Res (2011) 0.93
Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins. J Biol Chem (2012) 0.93
NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. Cell Cycle (2010) 0.93
Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. J Biol Chem (2006) 0.89
Profiling cancer. Curr Opin Cell Biol (2003) 0.89
Geminin: a major DNA replication safeguard in higher eukaryotes. Cell Cycle (2004) 0.89
The tumor suppressor gene hypermethylated in cancer 1 is transcriptionally regulated by E2F1. Mol Cancer Res (2009) 0.88
E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells. Cell Cycle (2007) 0.88
Identification of catechols as histone-lysine demethylase inhibitors. FEBS Lett (2012) 0.85
Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase. J Biol Chem (2008) 0.85
Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A (2013) 0.83
Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2. Epigenetics (2009) 0.83
OVCA1: emerging as a bona fide tumor suppressor. Genes Dev (2004) 0.80
TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells. Stem Cells (2014) 0.80
Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells. Nucleic Acids Res (2013) 0.80