Association of brain pathology with the progression of frailty in older adults.

Relationship of regional brain β-amyloid to gait speed. Neurology (2015) 1.43

Epigenomics of Alzheimer's disease. Transl Res (2014) 1.01

Age-related deficit accumulation and the risk of late-life dementia. Alzheimers Res Ther (2014) 0.99

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease. Biochem Pharmacol (2014) 0.96

Brain pathology contributes to simultaneous change in physical frailty and cognition in old age. J Gerontol A Biol Sci Med Sci (2014) 0.94

Hypoglycemia in older people - a less well recognized risk factor for frailty. Aging Dis (2015) 0.89

Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer's disease animal models. Front Aging Neurosci (2015) 0.84

Low HbA1c and Increased Mortality Risk-is Frailty a Confounding Factor? Aging Dis (2015) 0.83

Framingham cardiovascular disease risk scores and incident frailty: the English longitudinal study of ageing. Age (Dordr) (2014) 0.81

Cognitive frailty. J Nutr Health Aging (2013) 0.80

Cumulative impact of health deficits, social vulnerabilities, and protective factors on cognitive dynamics in late life: a multistate modeling approach. Alzheimers Res Ther (2015) 0.79

Frailty in childhood cancer survivors. Cancer (2014) 0.78

Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging. J Am Geriatr Soc (2016) 0.76

The Contribution of α-Synuclein Spreading to Parkinson's Disease Synaptopathy. Neural Plast (2017) 0.75

Change in motor function and adverse health outcomes in older African-Americans. Exp Gerontol (2015) 0.75

Neuropsychological Profile of "Cognitive Frailty" Subjects in MAPT Study. J Prev Alzheimers Dis (2016) 0.75

Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly. J Alzheimers Dis (2016) 0.75

Models for longitudinal data: a generalized estimating equation approach. Biometrics (1988) 27.90

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.02

The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19

A measure of primary sociobiological functions. Int J Health Serv (1976) 8.93

Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc (2006) 6.81

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (2012) 6.66

Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc (2004) 5.80

Overview and findings from the rush Memory and Aging Project. Curr Alzheimer Res (2012) 4.91

Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc (2012) 3.48

Overview and findings from the religious orders study. Curr Alzheimer Res (2012) 3.46

Relation of cerebral infarctions to dementia and cognitive function in older persons. Neurology (2003) 2.60

Nigral pathology and parkinsonian signs in elders without Parkinson disease. Ann Neurol (2012) 2.52

Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosom Med (2007) 2.27

Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc (2010) 1.78

Premotor Parkinson's disease: concepts and definitions. Mov Disord (2012) 1.70

Physical frailty in older persons is associated with Alzheimer disease pathology. Neurology (2008) 1.59

Body mass index in older persons is associated with Alzheimer disease pathology. Neurology (2006) 1.55

Change in frailty and risk of death in older persons. Exp Aging Res (2009) 1.54

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline. Neurology (2013) 1.51

Combinations of motor measures more strongly predict adverse health outcomes in old age: the rush memory and aging project, a community-based cohort study. BMC Med (2011) 1.33

Cerebrovascular disease pathology and parkinsonian signs in old age. Stroke (2011) 1.30

Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age. Arch Gen Psychiatry (2012) 1.26

The psychometric properties of three self-report screening instruments for identifying frail older people in the community. BMC Public Health (2010) 1.16

Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease. Neuron (2007) 0.92

Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.02

Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol (2003) 14.87

Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology (2007) 9.27

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol (2007) 8.10

Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA (2011) 6.92

Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging (2002) 6.18

Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA (2002) 6.18

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol (2011) 6.00

Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80

The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology (2005) 5.64

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52

Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol (2004) 5.11

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement (2012) 5.10

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol (2007) 5.02

The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol (2009) 4.96

Overview and findings from the rush Memory and Aging Project. Curr Alzheimer Res (2012) 4.91

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71

Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol (2004) 4.66

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45

Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol (2003) 4.37

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol (2002) 3.84

Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83

Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol (2011) 3.80

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol (2012) 3.77

Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol (2014) 3.75

Early and late life cognitive activity and cognitive systems in old age. J Int Neuropsychol Soc (2005) 3.68

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study. Lancet Neurol (2012) 3.66

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest (2012) 3.65

Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol (2003) 3.56

Overview and findings from the religious orders study. Curr Alzheimer Res (2012) 3.46

Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry (2007) 3.44

Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol (2004) 3.39

The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol (2006) 3.38

Design of the Chicago Health and Aging Project (CHAP). J Alzheimers Dis (2003) 3.36

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA (2002) 3.19

Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology (2006) 3.00

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91

White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study. Neurobiol Aging (2005) 2.79

Much of late life cognitive decline is not due to common neurodegenerative pathologies. Ann Neurol (2013) 2.78

Accounting for bias due to selective attrition: the example of smoking and cognitive decline. Epidemiology (2012) 2.72

Contribution of Alzheimer disease to mortality in the United States. Neurology (2014) 2.67

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66

Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons. Ann Neurol (2007) 2.66

Microinfarct pathology, dementia, and cognitive systems. Stroke (2011) 2.61

Life-span cognitive activity, neuropathologic burden, and cognitive aging. Neurology (2013) 2.59

Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. JAMA (2013) 2.58

The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis (2009) 2.54

Nigral pathology and parkinsonian signs in elders without Parkinson disease. Ann Neurol (2012) 2.52

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci (2013) 2.51

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet (2010) 2.51

Olfactory identification and incidence of mild cognitive impairment in older age. Arch Gen Psychiatry (2007) 2.41

Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol (2005) 2.38

Plasma microRNAs as potential biomarkers for non-small-cell lung cancer. Lab Invest (2010) 2.37

Cerebral microinfarcts: the invisible lesions. Lancet Neurol (2012) 2.31

Frailty is associated with incident Alzheimer's disease and cognitive decline in the elderly. Psychosom Med (2007) 2.27

Association between late-life social activity and motor decline in older adults. Arch Intern Med (2009) 2.26

Repair of Stanford type A aortic dissection with ascending aorta and hemiarch replacement combined with stent-graft elephant trunk technique by using innominate cannulation. J Thorac Cardiovasc Surg (2011) 2.21

Association of lifetime cognitive engagement and low β-amyloid deposition. Arch Neurol (2012) 2.20

GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology (2012) 2.19

Substantia nigra tangles are related to gait impairment in older persons. Ann Neurol (2006) 2.17

A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol (2015) 2.16

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron (2013) 2.13

Sex differences in the clinical manifestations of Alzheimer disease pathology. Arch Gen Psychiatry (2005) 2.08