Published in Ann Neurol on January 01, 2006
Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry (2007) 3.92
Overview and findings from the religious orders study. Curr Alzheimer Res (2012) 3.46
The trajectory of gait speed preceding mild cognitive impairment. Arch Neurol (2010) 2.66
Life-span cognitive activity, neuropathologic burden, and cognitive aging. Neurology (2013) 2.59
Nigral pathology and parkinsonian signs in elders without Parkinson disease. Ann Neurol (2012) 2.52
Clinical-pathologic study of depressive symptoms and cognitive decline in old age. Neurology (2014) 2.26
Gait dysfunction in mild cognitive impairment syndromes. J Am Geriatr Soc (2008) 2.00
Physical frailty is associated with incident mild cognitive impairment in community-based older persons. J Am Geriatr Soc (2010) 1.78
Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. Arch Neurol (2009) 1.60
Physical frailty in older persons is associated with Alzheimer disease pathology. Neurology (2008) 1.59
The relationship between cerebral Alzheimer's disease pathology and odour identification in old age. J Neurol Neurosurg Psychiatry (2006) 1.55
Neural reserve, neuronal density in the locus ceruleus, and cognitive decline. Neurology (2013) 1.51
Relationship of regional brain β-amyloid to gait speed. Neurology (2015) 1.43
In-home walking speeds and variability trajectories associated with mild cognitive impairment. Neurology (2012) 1.41
TDP-43 pathology, cognitive decline, and dementia in old age. JAMA Neurol (2013) 1.37
Aging, the central nervous system, and mobility. J Gerontol A Biol Sci Med Sci (2013) 1.32
Cerebrovascular disease pathology and parkinsonian signs in old age. Stroke (2011) 1.30
Apolipoprotein E e4 allele is associated with more rapid motor decline in older persons. Alzheimer Dis Assoc Disord (2009) 1.22
Cognitive function is associated with the development of mobility impairments in community-dwelling elders. Am J Geriatr Psychiatry (2011) 1.20
Association of Parkinson disease risk loci with mild parkinsonian signs in older persons. JAMA Neurol (2014) 1.04
Evidence of angiogenic vessels in Alzheimer's disease. J Neural Transm (Vienna) (2009) 1.03
Lewy bodies and olfactory dysfunction in old age. Chem Senses (2011) 1.02
At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimers Dement (2014) 1.02
Epigenomics of Alzheimer's disease. Transl Res (2014) 1.01
Alpha-synuclein and tau: teammates in neurodegeneration? Mol Neurodegener (2014) 1.00
Quantitative brain measurements in community-dwelling elderly persons with mild parkinsonian signs. Arch Neurol (2008) 0.98
Brainstem aminergic nuclei and late-life depressive symptoms. JAMA Psychiatry (2013) 0.95
Gait and cognition in older adults: Insights from the Bronx and Kerala. Ann Indian Acad Neurol (2010) 0.93
Gait and posture impairment, parkinsonism and cognitive decline in older people. J Neural Transm (Vienna) (2007) 0.91
Loss of motor function in preclinical Alzheimer's disease. Expert Rev Neurother (2011) 0.91
Odor identification and progression of parkinsonian signs in older persons. Exp Aging Res (2008) 0.88
Harm avoidance and risk of Alzheimer's disease. Psychosom Med (2011) 0.88
Baseline disability in activities of daily living predicts dementia risk even after controlling for baseline global cognitive ability and depressive symptoms. Int J Geriatr Psychiatry (2012) 0.88
Mild cognitive impairment is associated with mild parkinsonian signs in a door-to-door study. J Alzheimers Dis (2010) 0.84
Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease. Front Aging Neurosci (2014) 0.84
Upper and lower extremity motor performance and functional impairment in Alzheimer's disease. Am J Alzheimers Dis Other Demen (2010) 0.83
Conscientiousness, dementia related pathology, and trajectories of cognitive aging. Psychol Aging (2015) 0.83
A tangled web - tau and sporadic Parkinson's disease. Front Psychiatry (2010) 0.83
Progressive nature of a higher level gait disorder: a 3-year prospective study. J Neurol (2010) 0.83
Temporal course and pathologic basis of unawareness of memory loss in dementia. Neurology (2015) 0.81
Roles of tau protein in health and disease. Acta Neuropathol (2017) 0.80
Parkinsonian signs and incident falls in older persons without Parkinson's disease. J Am Geriatr Soc (2010) 0.79
RELATIONSHIP OF GAIT AND COGNITION IN THE ELDERLY. Curr Transl Geriatr Exp Gerontol Rep (2013) 0.79
Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis. J Alzheimers Dis (2015) 0.79
Visuoperceptual repetition priming and progression of parkinsonian signs in aging. Neurobiol Aging (2007) 0.78
Gait speed and cognitive decline over 2 years in the Ibadan study of aging. Gait Posture (2015) 0.77
Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study. BMC Geriatr (2009) 0.77
Temporal course of neurodegenerative effects on cognition in old age. Neuropsychology (2016) 0.76
Late-life depression is not associated with dementia-related pathology. Neuropsychology (2016) 0.76
Ex vivo MRI transverse relaxation in community based older persons with and without Alzheimer's dementia. Behav Brain Res (2016) 0.75
The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults. PLoS One (2016) 0.75
Pathogenesis of mild parkinsonian signs in aging. J Neurol (2014) 0.75
Decreased motor function is associated with poorer cognitive function in elderly with type 2 diabetes. Dement Geriatr Cogn Dis Extra (2014) 0.75
Progression of Extrapyramidal Signs in Alzheimer's Disease: Clinical and Neuropathological Correlates. J Alzheimers Dis (2015) 0.75
How Does Psychosocial Behavior Contribute to Cognitive Health in Old Age? Brain Sci (2017) 0.75
Clinical characteristics related to worsening of motor function assessed by the Unified Parkinson's Disease Rating Scale in the elderly population. J Neurol (2014) 0.75
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.02
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
The Genome sequence of the SARS-associated coronavirus. Science (2003) 16.68
Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA (2003) 16.08
Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol (2003) 14.87
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke (2011) 10.11
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology (2007) 9.27
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature (2011) 7.90
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A (2012) 6.27
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol (2003) 6.21
Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging (2002) 6.18
Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA (2002) 6.18
Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80
Trends in survival after in-hospital cardiac arrest. N Engl J Med (2012) 5.67
Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis (2002) 5.64
The Rush Memory and Aging Project: study design and baseline characteristics of the study cohort. Neuroepidemiology (2005) 5.64
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med (2003) 5.45
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet (2007) 5.21
A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature (2013) 5.18
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol (2004) 5.11
The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol (2009) 4.96
Overview and findings from the rush Memory and Aging Project. Curr Alzheimer Res (2012) 4.91
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science (2006) 4.71
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol (2004) 4.66
Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell (2013) 4.45
Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status. Arch Neurol (2003) 4.37
Human illness from avian influenza H7N3, British Columbia. Emerg Infect Dis (2004) 4.29
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol (2011) 4.16
New world bats harbor diverse influenza A viruses. PLoS Pathog (2013) 4.10
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). J Am Coll Cardiol (2013) 3.90
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell (2005) 3.89
Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada. PLoS Med (2010) 3.85
Long-term outcomes in elderly survivors of in-hospital cardiac arrest. N Engl J Med (2013) 3.85
Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol (2010) 3.84
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann Neurol (2002) 3.84
Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
Early and late life cognitive activity and cognitive systems in old age. J Int Neuropsychol Soc (2005) 3.68
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest (2012) 3.65
Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol (2003) 3.56
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol (2007) 3.54
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol (2010) 3.49
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med (2005) 3.46
Overview and findings from the religious orders study. Curr Alzheimer Res (2012) 3.46
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (2008) 3.44
Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry (2007) 3.44
Ambulatory arterial stiffness index as a predictor of cardiovascular mortality in the Dublin Outcome Study. Hypertension (2006) 3.42
Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol (2004) 3.39
The effect of social networks on the relation between Alzheimer's disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol (2006) 3.38
Design of the Chicago Health and Aging Project (CHAP). J Alzheimers Dis (2003) 3.36
Human Bocavirus infection, Canada. Emerg Infect Dis (2006) 3.30
Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes. Mol Ther (2007) 3.26
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature (2004) 3.24
Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA (2002) 3.19
A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host Microbe (2007) 3.15
The scale of population structure in Arabidopsis thaliana. PLoS Genet (2010) 3.12
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
Triple reassortant H3N2 influenza A viruses, Canada, 2005. Emerg Infect Dis (2006) 3.05
Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis. Nat Biotechnol (2009) 3.01
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology (2006) 3.00
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99
Identification of a novel astrovirus (astrovirus VA1) associated with an outbreak of acute gastroenteritis. J Virol (2009) 2.96
Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol (2012) 2.91
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol (2010) 2.91
Novel avian influenza H7N3 strain outbreak, British Columbia. Emerg Infect Dis (2004) 2.90
Missing pieces in the Parkinson's disease puzzle. Nat Med (2010) 2.90
Masked hypertension in diabetes mellitus: treatment implications for clinical practice. Hypertension (2013) 2.89
Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol (2007) 2.84
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study. Neurobiol Aging (2005) 2.79
Much of late life cognitive decline is not due to common neurodegenerative pathologies. Ann Neurol (2013) 2.78
Anterior chamber width measurement by high-speed optical coherence tomography. Ophthalmology (2005) 2.77
Accounting for bias due to selective attrition: the example of smoking and cognitive decline. Epidemiology (2012) 2.72
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med (2013) 2.70
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet (2005) 2.68
Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci (2006) 2.68
Contribution of Alzheimer disease to mortality in the United States. Neurology (2014) 2.67
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66
Subcortical infarcts, Alzheimer's disease pathology, and memory function in older persons. Ann Neurol (2007) 2.66
Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations. Hypertension (2010) 2.64
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat Med (2010) 2.62
Microinfarct pathology, dementia, and cognitive systems. Stroke (2011) 2.61