Published in Tuberculosis (Edinb) on May 04, 2013
Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem (2014) 1.41
New target prediction and visualization tools incorporating open source molecular fingerprints for TB Mobile 2.0. J Cheminform (2014) 1.03
SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents. J Med Chem (2013) 0.89
Drug discovery targeting cell division proteins, microtubules and FtsZ. Bioorg Med Chem (2014) 0.86
A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis. PLoS One (2014) 0.83
Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis. PLoS One (2016) 0.76
Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov (2006) 15.21
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science (2004) 13.04
The challenge of new drug discovery for tuberculosis. Nature (2011) 4.23
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An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science (2008) 3.21
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) (2009) 2.58
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb) (2009) 1.94
Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics. J Biol Chem (2003) 1.75
Structure-activity relationships for a series of quinoline-based compounds active against replicating and nonreplicating Mycobacterium tuberculosis. J Med Chem (2009) 1.69
Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B. Org Lett (2005) 1.39
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ. J Antimicrob Chemother (2002) 1.39
Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents. ChemMedChem (2007) 1.38
Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. J Med Chem (2010) 1.29
High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) (2011) 1.23
Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents. ChemMedChem (2006) 1.23
A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ. Bioorg Med Chem Lett (2004) 1.18
Discovery of anti-TB agents that target the cell-division protein FtsZ. Future Med Chem (2010) 1.14
Discovery and validation of new antitubercular compounds as potential drug leads and probes. Tuberculosis (Edinb) (2009) 1.07
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors. Bioorg Med Chem (2011) 0.95
The development of FtsZ inhibitors as potential antibacterial agents. ChemMedChem (2012) 0.95
Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J Med Chem (2009) 0.95
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis. PLoS One (2012) 0.89
An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy. Antimicrob Agents Chemother (2012) 0.88
Synthesis of potential antimalarial agents. II. 6,8-Disubstituted pyrido(2,3-b)pyrazines. J Med Chem (1968) 0.83
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity. J Med Chem (2008) 0.82
New antifolate inhibitors for Mycobacterium avium. Med Chem (2006) 0.82
Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring. Bioorg Med Chem Lett (2010) 0.81
Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother (2005) 3.16
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) (2009) 2.58
Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives. J Med Chem (2002) 2.16
Genome evolution in the genus Sorghum (Poaceae). Ann Bot (2005) 2.13
Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb) (2009) 1.94
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. Antimicrob Agents Chemother (2007) 1.58
A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. Cancer Prev Res (Phila) (2009) 1.51
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. PLoS One (2007) 1.41
2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ. J Antimicrob Chemother (2002) 1.39
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds. Tuberculosis (Edinb) (2004) 1.33
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Mol Cancer Ther (2009) 1.31
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J Biomol Screen (2006) 1.14
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J Mol Biol (2004) 1.10
Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery. Chem Biol (2013) 1.10
Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models. PLoS One (2013) 1.01
Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery. Pharm Res (2013) 0.99
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Mol Microbiol (2009) 0.99
Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100. Vaccine (2003) 0.99
Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydr Res (2002) 0.97
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors. Bioorg Med Chem (2011) 0.95
Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives. J Enzyme Inhib Med Chem (2004) 0.95
Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis. Bioorg Med Chem Lett (2006) 0.90
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology (2010) 0.89
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis. PLoS One (2012) 0.89
Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis. J Chem Inf Model (2014) 0.88
Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits. Bioorg Med Chem (2008) 0.88
Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cell Signal (2012) 0.87
Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis. J Chem Inf Model (2014) 0.87
Fusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation. J Chem Inf Model (2013) 0.85
Antimycobacterial agents. 1. Thio analogues of purine. J Med Chem (2004) 0.85
Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis. Bioorg Med Chem (2007) 0.84
Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis. Bioorg Med Chem Lett (2002) 0.84
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis. Protein Expr Purif (2007) 0.84
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. Biochem J (2008) 0.84
A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila) (2010) 0.80
Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity. Bioorg Med Chem (2002) 0.79
Parallel solution-phase synthesis of an adenosine antibiotic analog library. ACS Comb Sci (2013) 0.79
Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine. Int Immunopharmacol (2002) 0.78
Binding mode analysis of 2,4-diamino-5-methyl-5-deaza-6-substituted pteridines with Mycobacterium tuberculosis and human dihydrofolate reductases. J Biomol Struct Dyn (2008) 0.78
Metoclopramide does not influence the frequency of propofol-induced spontaneous movements. J Clin Anesth (2007) 0.77
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett (2012) 0.77
6-Oxo and 6-thio purine analogs as antimycobacterial agents. Bioorg Med Chem (2013) 0.77
Synthesis of novel peptidyl adenosine antibiotic analogs. Nucleosides Nucleotides Nucleic Acids (2014) 0.77
Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis. Carbohydr Res (2004) 0.77
Parallel solution-phase synthesis and general biological activity of a uridine antibiotic analog library. ACS Comb Sci (2014) 0.77
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis. Bioorg Med Chem Lett (2007) 0.76
Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis. Bioorg Med Chem (2008) 0.75
Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamides. ACS Comb Sci (2014) 0.75
Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett (2012) 0.75
Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors. Bioorg Med Chem Lett (2012) 0.75
Synthesis and general biological activity of a small adenosine-5'-(carboxamide and sulfanilamide) library. Nucleosides Nucleotides Nucleic Acids (2014) 0.75
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors. Bioorg Med Chem Lett (2012) 0.75
Novel substituted pyrimidines as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett (2011) 0.75