PubRank

Robert C Reynolds

Author PubWeight™ 48.11‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models. Antimicrob Agents Chemother 2005 3.16
2 High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv. Tuberculosis (Edinb) 2009 2.58
3 Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives. J Med Chem 2002 2.16
4 Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb) 2009 1.94
5 EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. Antimicrob Agents Chemother 2007 1.58
6 A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. Cancer Prev Res (Phila) 2009 1.51
7 Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. PLoS One 2007 1.41
8 2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ. J Antimicrob Chemother 2002 1.39
9 The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds. Tuberculosis (Edinb) 2004 1.33
10 Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Mol Cancer Ther 2009 1.31
11 Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches. J Mol Biol 2004 1.10
12 Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery. Chem Biol 2013 1.10
13 Enhancing hit identification in Mycobacterium tuberculosis drug discovery using validated dual-event Bayesian models. PLoS One 2013 1.01
14 Combining computational methods for hit to lead optimization in Mycobacterium tuberculosis drug discovery. Pharm Res 2013 0.99
15 Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Mol Microbiol 2009 0.99
16 Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100. Vaccine 2003 0.99
17 Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydr Res 2002 0.97
18 Synthesis and preliminary in vitro evaluation of antimycobacterial activity of new pyrrolo[1,2-a] quinoxaline-carboxylic acid hydrazide derivatives. J Enzyme Inhib Med Chem 2004 0.95
19 Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors. Bioorg Med Chem 2011 0.95
20 Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis. Bioorg Med Chem Lett 2006 0.90
21 Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis. PLoS One 2012 0.89
22 Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology 2010 0.89
23 Are bigger data sets better for machine learning? Fusing single-point and dual-event dose response data for Mycobacterium tuberculosis. J Chem Inf Model 2014 0.88
24 Looking back to the future: predicting in vivo efficacy of small molecules versus Mycobacterium tuberculosis. J Chem Inf Model 2014 0.87
25 Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells. Cell Signal 2012 0.87
26 Fusing dual-event data sets for Mycobacterium tuberculosis machine learning models and their evaluation. J Chem Inf Model 2013 0.85
27 A novel quinoline derivative that inhibits mycobacterial FtsZ. Tuberculosis (Edinb) 2013 0.85
28 Antimycobacterial agents. 1. Thio analogues of purine. J Med Chem 2004 0.85
29 Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis. Protein Expr Purif 2007 0.84
30 Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis. Bioorg Med Chem 2007 0.84
31 EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. Biochem J 2008 0.84
32 Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis. Bioorg Med Chem Lett 2002 0.84
33 A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila) 2010 0.80
34 Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity. Bioorg Med Chem 2002 0.79
35 Parallel solution-phase synthesis of an adenosine antibiotic analog library. ACS Comb Sci 2013 0.79
36 Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 subunit vaccine. Int Immunopharmacol 2002 0.78
37 Binding mode analysis of 2,4-diamino-5-methyl-5-deaza-6-substituted pteridines with Mycobacterium tuberculosis and human dihydrofolate reductases. J Biomol Struct Dyn 2008 0.78
38 Synthesis of novel peptidyl adenosine antibiotic analogs. Nucleosides Nucleotides Nucleic Acids 2014 0.77
39 Parallel solution-phase synthesis and general biological activity of a uridine antibiotic analog library. ACS Comb Sci 2014 0.77
40 Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis. Carbohydr Res 2004 0.77
41 6-Oxo and 6-thio purine analogs as antimycobacterial agents. Bioorg Med Chem 2013 0.77
42 5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett 2012 0.77
43 Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis. Bioorg Med Chem Lett 2007 0.76
44 Solution-phase parallel synthesis of acyclic nucleoside libraries of purine, pyrimidine, and triazole acetamides. ACS Comb Sci 2014 0.75
45 Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis. Bioorg Med Chem 2008 0.75
46 Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors. Bioorg Med Chem Lett 2012 0.75
47 Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors. Bioorg Med Chem Lett 2012 0.75
48 Synthesis and general biological activity of a small adenosine-5'-(carboxamide and sulfanilamide) library. Nucleosides Nucleotides Nucleic Acids 2014 0.75
49 Novel substituted pyrimidines as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett 2011 0.75
50 Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors. Bioorg Med Chem Lett 2012 0.75