Published in Sci Transl Med on May 15, 2013
Ethical alternatives to experiments with novel potential pandemic pathogens. PLoS Med (2014) 1.68
Large-scale de novo DNA synthesis: technologies and applications. Nat Methods (2014) 1.51
Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nat Rev Mol Cell Biol (2014) 1.41
Vaccines for the 21st century. EMBO Mol Med (2014) 1.17
Vaccines, new opportunities for a new society. Proc Natl Acad Sci U S A (2014) 1.06
Rapidly produced SAM(®) vaccine against H7N9 influenza is immunogenic in mice. Emerg Microbes Infect (2013) 1.04
Characterization of uncultivable bat influenza virus using a replicative synthetic virus. PLoS Pathog (2014) 0.98
Use of highly pathogenic avian influenza A(H5N1) gain-of-function studies for molecular-based surveillance and pandemic preparedness. MBio (2014) 0.97
Cross-conservation of T-cell epitopes: now even more relevant to (H7N9) influenza vaccine design. Hum Vaccin Immunother (2014) 0.95
A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. MBio (2014) 0.95
Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission. J Virol (2014) 0.93
Designing vaccines for the twenty-first century society. Front Immunol (2014) 0.92
Programming biological operating systems: genome design, assembly and activation. Nat Methods (2014) 0.89
Single-dose monomeric HA subunit vaccine generates full protection from influenza challenge. Hum Vaccin Immunother (2013) 0.87
Simultaneous non-contiguous deletions using large synthetic DNA and site-specific recombinases. Nucleic Acids Res (2014) 0.84
RNA virus reverse genetics and vaccine design. Viruses (2014) 0.82
Influenza vaccines: a moving interdisciplinary field. Viruses (2014) 0.81
Ferritin family proteins and their use in bionanotechnology. N Biotechnol (2015) 0.81
Point-of-Use Mixing of Influenza H5N1 Vaccine and MF59 Adjuvant for Pandemic Vaccination Preparedness: Antibody Responses and Safety. A Phase 1 Clinical Trial. Open Forum Infect Dis (2014) 0.79
An overview of the regulation of influenza vaccines in the United States. Influenza Other Respir Viruses (2016) 0.79
Reversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic Virus. J Virol (2016) 0.78
Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans. J Virol (2015) 0.78
Multiplex pairwise assembly of array-derived DNA oligonucleotides. Nucleic Acids Res (2015) 0.78
Vaccines for pandemics. Nat Biotechnol (2013) 0.78
Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses. J Gen Virol (2016) 0.77
Delivering vaccines to the people who need them most. Philos Trans R Soc Lond B Biol Sci (2015) 0.77
Effect of AcHERV-GmCSF as an Influenza Virus Vaccine Adjuvant. PLoS One (2015) 0.77
Protection against Influenza A Virus Challenge with M2e-Displaying Filamentous Escherichia coli Phages. PLoS One (2015) 0.76
Bringing influenza vaccines into the 21st century. Hum Vaccin Immunother (2013) 0.76
Health and economic benefits of early vaccination and nonpharmaceutical interventions for a human influenza A (H7N9) pandemic: a modeling study. Ann Intern Med (2014) 0.75
Development of an Influenza A Master Virus for Generating High-Growth Reassortants for A/Anhui/1/2013(H7N9) Vaccine Production in Qualified MDCK Cells. PLoS One (2016) 0.75
A paradigm shift in vaccine production for pandemic influenza. Ann Transl Med (2015) 0.75
Rational Design of High-Number dsDNA Fragments Based on Thermodynamics for the Construction of Full-Length Genes in a Single Reaction. PLoS One (2015) 0.75
GISAID: Global initiative on sharing all influenza data - from vision to reality. Euro Surveill (2017) 0.75
Antigenic characterization of influenza viruses produced using synthetic DNA and novel backbones. Vaccine (2016) 0.75
Genotyping and detection of common avian and human origin-influenza viruses using a portable chemiluminescence imaging microarray. Springerplus (2016) 0.75
Digital-to-biological converter for on-demand production of biologics. Nat Biotechnol (2017) 0.75
The diploid genome sequence of an individual human. PLoS Biol (2007) 44.80
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
Ranibizumab for neovascular age-related macular degeneration. N Engl J Med (2006) 30.63
Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med (2003) 27.97
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical Pacific. PLoS Biol (2007) 23.58
Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods (2009) 22.47
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
Evolution of genes and genomes on the Drosophila phylogeny. Nature (2007) 18.01
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". Proc Natl Acad Sci U S A (2005) 14.59
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
Creation of a bacterial cell controlled by a chemically synthesized genome. Science (2010) 13.45
Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome. Science (2008) 10.90
Evaluation of next generation sequencing platforms for population targeted sequencing studies. Genome Biol (2009) 9.59
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92
Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology (2012) 8.29
A Sanger/pyrosequencing hybrid approach for the generation of high-quality draft assemblies of marine microbial genomes. Proc Natl Acad Sci U S A (2006) 7.17
Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol (2002) 6.96
AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell (2003) 6.69
Genetic variation in an individual human exome. PLoS Genet (2008) 6.68
Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology (2012) 6.35
Essential genes of a minimal bacterium. Proc Natl Acad Sci U S A (2006) 6.31
Whole-genome shotgun assembly and comparison of human genome assemblies. Proc Natl Acad Sci U S A (2004) 6.08
A whole-cell computational model predicts phenotype from genotype. Cell (2012) 5.98
The microbial pan-genome. Curr Opin Genet Dev (2005) 5.93
The dog genome: survey sequencing and comparative analysis. Science (2003) 5.84
Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema. Ophthalmology (2006) 5.79
Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A (2002) 5.28
Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1. Am J Ophthalmol (2008) 5.22
De novo cardiomyocytes from within the activated adult heart after injury. Nature (2011) 5.17
Generating a synthetic genome by whole genome assembly: phiX174 bacteriophage from synthetic oligonucleotides. Proc Natl Acad Sci U S A (2003) 5.10
Functional balance between haemagglutinin and neuraminidase in influenza virus infections. Rev Med Virol (2002) 5.09
RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat Med (2004) 4.89
Microbiology in the post-genomic era. Nat Rev Microbiol (2008) 4.88
Metal chelation and inhibition of bacterial growth in tissue abscesses. Science (2008) 4.55
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
A universal vaccine for serogroup B meningococcus. Proc Natl Acad Sci U S A (2006) 4.45
Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet (2016) 4.29
Pili in gram-positive pathogens. Nat Rev Microbiol (2006) 4.21
Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses. J Virol (2009) 4.20
An agenda for personalized medicine. Nature (2009) 4.14
The dynamic genome of Hydra. Nature (2010) 4.00
Genome transplantation in bacteria: changing one species to another. Science (2007) 3.95
Genome analysis reveals pili in Group B Streptococcus. Science (2005) 3.85
Identification of a universal Group B streptococcus vaccine by multiple genome screen. Science (2005) 3.83
Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870. J Exp Med (2003) 3.83
Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations. Arch Virol (2010) 3.77
A Phase IIIb study to evaluate the safety of ranibizumab in subjects with neovascular age-related macular degeneration. Ophthalmology (2009) 3.76
Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74
Adult cardiac-resident MSC-like stem cells with a proepicardial origin. Cell Stem Cell (2011) 3.56
Cell-free cloning using phi29 DNA polymerase. Proc Natl Acad Sci U S A (2005) 3.54
West Nile virus: where are we now? Lancet Infect Dis (2004) 3.49
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. Mol Cell (2007) 3.44
Plasmodium, human and Anopheles genomics and malaria. Nature (2002) 3.42
The TLR4 gene polymorphisms and susceptibility to cancer: a systematic review and meta-analysis. Eur J Cancer (2012) 3.41
Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6. J Bacteriol (2006) 3.40
Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci U S A (2007) 3.36
NadA, a novel vaccine candidate of Neisseria meningitidis. J Exp Med (2002) 3.26
Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLoS Genet (2008) 3.23
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol (2002) 3.20
The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium. Proc Natl Acad Sci U S A (2002) 3.19
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 3.11
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes Dev (2007) 3.08
Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray. Nat Biotechnol (2009) 3.07
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
Human chromosome 7: DNA sequence and biology. Science (2003) 3.02
Mechanism of chimera formation during the Multiple Displacement Amplification reaction. BMC Biotechnol (2007) 3.01
Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol (2007) 3.00
Genomic insights to SAR86, an abundant and uncultivated marine bacterial lineage. ISME J (2011) 2.97
Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment. Lancet Infect Dis (2013) 2.95
Genomic and functional adaptation in surface ocean planktonic prokaryotes. Nature (2010) 2.93
The Sorcerer II Global Ocean Sampling Expedition: metagenomic characterization of viruses within aquatic microbial samples. PLoS One (2008) 2.91
Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome. PLoS Biol (2007) 2.90
Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature (2010) 2.85
One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome. Proc Natl Acad Sci U S A (2008) 2.82