Published in Science on July 01, 2005
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". Proc Natl Acad Sci U S A (2005) 14.59
Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria. Microbiol Mol Biol Rev (2006) 4.88
A pneumococcal pilus influences virulence and host inflammatory responses. Proc Natl Acad Sci U S A (2006) 4.40
Identification of a universal Group B streptococcus vaccine by multiple genome screen. Science (2005) 3.83
Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens. Proc Natl Acad Sci U S A (2005) 3.59
Endocarditis and biofilm-associated pili of Enterococcus faecalis. J Clin Invest (2006) 3.33
Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development. Trends Microbiol (2008) 2.83
Streptococcus adherence and colonization. Microbiol Mol Biol Rev (2009) 2.83
Reverse vaccinology: developing vaccines in the era of genomics. Immunity (2010) 2.25
Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS One (2007) 2.22
Genome of the opportunistic pathogen Streptococcus sanguinis. J Bacteriol (2007) 2.21
RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet. Infect Immun (2006) 2.18
Group B Streptococcus: global incidence and vaccine development. Nat Rev Microbiol (2006) 2.16
Dual role for pilus in adherence to epithelial cells and biofilm formation in Streptococcus agalactiae. PLoS Pathog (2009) 2.15
Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae. Mol Microbiol (2009) 2.03
Assembly of distinct pilus structures on the surface of Corynebacterium diphtheriae. J Bacteriol (2006) 1.98
Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. PLoS Pathog (2009) 1.87
Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells. Mol Microbiol (2007) 1.86
The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Proc Natl Acad Sci U S A (2009) 1.79
The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria. Proc Natl Acad Sci U S A (2008) 1.75
Importance of the ebp (endocarditis- and biofilm-associated pilus) locus in the pathogenesis of Enterococcus faecalis ascending urinary tract infection. J Infect Dis (2007) 1.74
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J Bacteriol (2008) 1.72
Type III pilus of corynebacteria: Pilus length is determined by the level of its major pilin subunit. J Bacteriol (2006) 1.63
Protein secretion and surface display in Gram-positive bacteria. Philos Trans R Soc Lond B Biol Sci (2012) 1.61
Maize (Zea mays L.) genome diversity as revealed by RNA-sequencing. PLoS One (2012) 1.57
Amide bonds assemble pili on the surface of bacilli. Proc Natl Acad Sci U S A (2008) 1.53
Recent advances in understanding the molecular basis of group B Streptococcus virulence. Expert Rev Mol Med (2008) 1.52
Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence. J Clin Microbiol (2007) 1.51
Sortase A utilizes an ancillary protein anchor for efficient cell wall anchoring of pili in Streptococcus agalactiae. Infect Immun (2008) 1.51
Mycobacterium tuberculosis produces pili during human infection. Proc Natl Acad Sci U S A (2007) 1.50
A tale of two pili: assembly and function of pili in bacteria. Trends Microbiol (2010) 1.47
Putative surface proteins encoded within a novel transferable locus confer a high-biofilm phenotype to Enterococcus faecalis. J Bacteriol (2006) 1.47
Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A. PLoS Pathog (2008) 1.45
Characterization of the SpaCBA pilus fibers in the probiotic Lactobacillus rhamnosus GG. Appl Environ Microbiol (2012) 1.39
Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes. J Biol Chem (2010) 1.38
The presence of the pilus locus is a clonal property among pneumococcal invasive isolates. BMC Microbiol (2008) 1.36
Emergence and global dissemination of host-specific Streptococcus agalactiae clones. MBio (2010) 1.35
Vaccinology in the genome era. J Clin Invest (2009) 1.31
A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence. FASEB J (2008) 1.31
Molecular architecture of Streptococcus pneumoniae TIGR4 pili. EMBO J (2009) 1.29
Mode of expression and functional characterization of FCT-3 pilus region-encoded proteins in Streptococcus pyogenes serotype M49. Infect Immun (2008) 1.28
Population genetics and linkage analysis of loci within the FCT region of Streptococcus pyogenes. J Bacteriol (2006) 1.28
Understanding the regulation of Group B Streptococcal virulence factors. Future Microbiol (2009) 1.27
Structural vaccinology starts to deliver. Nat Rev Microbiol (2012) 1.22
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili. Mol Microbiol (2008) 1.22
Convergence of regulatory networks on the pilus locus of Streptococcus pneumoniae. Infect Immun (2008) 1.20
Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS). BMC Genomics (2011) 1.19
The key role of genomics in modern vaccine and drug design for emerging infectious diseases. PLoS Genet (2009) 1.18
Role of streptococcal T antigens in superficial skin infection. J Bacteriol (2006) 1.18
M1T1 group A streptococcal pili promote epithelial colonization but diminish systemic virulence through neutrophil extracellular entrapment. J Mol Med (Berl) (2009) 1.17
Enterococcus faecalis rnjB is required for pilin gene expression and biofilm formation. J Bacteriol (2010) 1.16
Surfome analysis as a fast track to vaccine discovery: identification of a novel protective antigen for Group B Streptococcus hypervirulent strain COH1. Mol Cell Proteomics (2009) 1.13
Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus. PLoS One (2010) 1.11
Cell wall anchor structure of BcpA pili in Bacillus anthracis. J Biol Chem (2008) 1.10
Serine-rich repeat proteins and pili promote Streptococcus agalactiae colonization of the vaginal tract. J Bacteriol (2011) 1.10
Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections. Proc Natl Acad Sci U S A (2011) 1.09
Structural biology of Gram-positive bacterial adhesins. Protein Sci (2011) 1.07
A role for glycosylated serine-rich repeat proteins in gram-positive bacterial pathogenesis. Mol Oral Microbiol (2012) 1.07
Specific involvement of pilus type 2a in biofilm formation in group B Streptococcus. PLoS One (2010) 1.06
A model for group B Streptococcus pilus type 1: the structure of a 35-kDa C-terminal fragment of the major pilin GBS80. J Mol Biol (2011) 1.06
Bacterial Pili exploit integrin machinery to promote immune activation and efficient blood-brain barrier penetration. Nat Commun (2011) 1.03
Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria. Biochim Biophys Acta (2013) 1.03
Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. J Bacteriol (2010) 1.03
CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine development. J Bacteriol (2009) 1.01
Vaccines, reverse vaccinology, and bacterial pathogenesis. Cold Spring Harb Perspect Med (2013) 1.01
Pilus biogenesis in Lactococcus lactis: molecular characterization and role in aggregation and biofilm formation. PLoS One (2012) 0.97
Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease. Front Immunol (2014) 0.95
Pilus hijacking by a bacterial coaggregation factor critical for oral biofilm development. Proc Natl Acad Sci U S A (2014) 0.94
Heterogeneity in the polarity of Nra regulatory effects on streptococcal pilus gene transcription and virulence. Infect Immun (2008) 0.94
Increase in pilus islet 2-encoded pili among Streptococcus pneumoniae isolates, Atlanta, Georgia, USA. Emerg Infect Dis (2010) 0.93
Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1. PLoS One (2012) 0.92
Adhesion determinants of the Streptococcus species. Microb Biotechnol (2009) 0.90
The two variants of the Streptococcus pneumoniae pilus 1 RrgA adhesin retain the same function and elicit cross-protection in vivo. Infect Immun (2010) 0.90
Biofilm formation by Streptococcus agalactiae: influence of environmental conditions and implicated virulence factors. Front Cell Infect Microbiol (2015) 0.89
Mitis group streptococci express variable pilus islet 2 pili. PLoS One (2011) 0.88
Structural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1. PLoS One (2011) 0.87
Transcriptional and proteomic profiles of group B Streptococcus type V reveal potential adherence proteins associated with high-level invasion. Infect Immun (2007) 0.87
Simple sequence repeats and genome plasticity in Streptococcus agalactiae. J Bacteriol (2010) 0.86
Group B Streptococcus vaccine: state of the art. Ther Adv Vaccines (2015) 0.86
Distribution of pilus islands in Streptococcus agalactiae that cause human infections: insights into evolution and implication for vaccine development. Clin Vaccine Immunol (2012) 0.86
Functional characterization of a newly identified group B Streptococcus pullulanase eliciting antibodies able to prevent alpha-glucans degradation. PLoS One (2008) 0.86
Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Paraná, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants. BMC Microbiol (2013) 0.86
Pilus distribution among lineages of group b streptococcus: an evolutionary and clinical perspective. BMC Microbiol (2014) 0.85
Intramolecular isopeptide but not internal thioester bonds confer proteolytic and significant thermal stability to the S. pyogenes pilus adhesin Spy0125. Proteins (2013) 0.85
Structural and functional characterization of the Streptococcus pneumoniae RrgB pilus backbone D1 domain. J Biol Chem (2011) 0.85
The Seventh International Conference on the Genetics of Streptococci, Lactococci, and Enterococci. J Bacteriol (2006) 0.85
Genomic analysis reveals the molecular basis for capsule loss in the group B Streptococcus population. PLoS One (2015) 0.85
Regulation and function of pilus island 1 in group B streptococcus. J Bacteriol (2012) 0.84
A maternal vaccine against group B Streptococcus: past, present, and future. Vaccine (2013) 0.84
Functional identification of conserved residues involved in Lactobacillus rhamnosus strain GG sortase specificity and pilus biogenesis. J Biol Chem (2014) 0.84
Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE. PLoS One (2012) 0.84
Pili prove pertinent to enterococcal endocarditis. J Clin Invest (2006) 0.84
A novel conjugative plasmid from Enterococcus faecalis E99 enhances resistance to ultraviolet radiation. Plasmid (2010) 0.84
Sortase A substrate specificity in GBS pilus 2a cell wall anchoring. PLoS One (2011) 0.83
Vaccines for the future: learning from human immunology. Microb Biotechnol (2011) 0.83
Purification, crystallization and halide phasing of a Streptococcus agalactiae backbone pilin GBS80 fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.82
Host-pathogen interactions in bacterial meningitis. Acta Neuropathol (2016) 0.82
Expression, purification, crystallization and preliminary crystallographic analysis of SpaA, a major pilin from Corynebacterium diphtheriae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.82
Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus. Mol Microbiol (2012) 0.82
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". Proc Natl Acad Sci U S A (2005) 14.59
The microbial pan-genome. Curr Opin Genet Dev (2005) 5.93
Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A (2002) 5.28
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat Med (2004) 4.89
Microbiology in the post-genomic era. Nat Rev Microbiol (2008) 4.88
A universal vaccine for serogroup B meningococcus. Proc Natl Acad Sci U S A (2006) 4.45
Pili in gram-positive pathogens. Nat Rev Microbiol (2006) 4.21
Identification of a universal Group B streptococcus vaccine by multiple genome screen. Science (2005) 3.83
Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870. J Exp Med (2003) 3.83
Group A Streptococcus produce pilus-like structures containing protective antigens and Lancefield T antigens. Proc Natl Acad Sci U S A (2005) 3.59
NadA, a novel vaccine candidate of Neisseria meningitidis. J Exp Med (2002) 3.26
c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol (2002) 3.20
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 3.11
Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome. Nat Biotechnol (2006) 3.03
Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment. Lancet Infect Dis (2013) 2.95
MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. Sci Transl Med (2011) 2.75
Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. Genome Biol (2010) 2.60
Nonviral delivery of self-amplifying RNA vaccines. Proc Natl Acad Sci U S A (2012) 2.59
Rational design of a meningococcal antigen inducing broad protective immunity. Sci Transl Med (2011) 2.59
Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels. Proc Natl Acad Sci U S A (2009) 2.41
A novel glyco-conjugate vaccine against fungal pathogens. J Exp Med (2005) 2.35
Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children. Pediatr Infect Dis J (2011) 2.33
Identification of novel genomic islands coding for antigenic pilus-like structures in Streptococcus agalactiae. Mol Microbiol (2006) 2.31
Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines. Proc Natl Acad Sci U S A (2010) 2.30
SARS--beginning to understand a new virus. Nat Rev Microbiol (2003) 2.30
Reverse vaccinology: developing vaccines in the era of genomics. Immunity (2010) 2.25
Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. Sci Transl Med (2010) 2.21
Invariant NKT cells sustain specific B cell responses and memory. Proc Natl Acad Sci U S A (2007) 2.20
Identification of iron-activated and -repressed Fur-dependent genes by transcriptome analysis of Neisseria meningitidis group B. Proc Natl Acad Sci U S A (2003) 2.17
Group B Streptococcus: global incidence and vaccine development. Nat Rev Microbiol (2006) 2.16
Fur functions as an activator and as a repressor of putative virulence genes in Neisseria meningitidis. Mol Microbiol (2004) 2.08
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers. Proc Natl Acad Sci U S A (2011) 2.08
Neisseria meningitidis NadA is a new invasin which promotes bacterial adhesion to and penetration into human epithelial cells. Mol Microbiol (2005) 2.06
Influenza vaccine immunology. Immunol Rev (2011) 2.02
Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation. Mol Microbiol (2007) 2.01
New adjuvants for human vaccines. Curr Opin Immunol (2010) 1.98
Genomic approach for analysis of surface proteins in Chlamydia pneumoniae. Infect Immun (2002) 1.94
The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med (2003) 1.87
Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination. Proc Natl Acad Sci U S A (2011) 1.84
Previously unrecognized vaccine candidates against group B meningococcus identified by DNA microarrays. Nat Biotechnol (2002) 1.83
Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One (2009) 1.82
Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli. Proc Natl Acad Sci U S A (2010) 1.75
Comparative genomics of Neisseria meningitidis: core genome, islands of horizontal transfer and pathogen-specific genes. Microbiology (2006) 1.75
Streptococcus pneumoniae pilus subunits protect mice against lethal challenge. Infect Immun (2006) 1.74
Vaccine manufacturing: challenges and solutions. Nat Biotechnol (2006) 1.73
Antibody to genome-derived neisserial antigen 2132, a Neisseria meningitidis candidate vaccine, confers protection against bacteremia in the absence of complement-mediated bactericidal activity. J Infect Dis (2003) 1.73
A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells. J Bacteriol (2008) 1.72
The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens. Vaccine (2012) 1.71
The region comprising amino acids 100 to 255 of Neisseria meningitidis lipoprotein GNA 1870 elicits bactericidal antibodies. Infect Immun (2005) 1.68
Structure-based antigen design: a strategy for next generation vaccines. Trends Biotechnol (2008) 1.68
Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans. Proc Natl Acad Sci U S A (2010) 1.66
Mucosal administration of Ag85B-ESAT-6 protects against infection with Mycobacterium tuberculosis and boosts prior bacillus Calmette-Guerin immunity. J Immunol (2006) 1.66
Preventing bacterial infections with pilus-based vaccines: the group B streptococcus paradigm. J Infect Dis (2009) 1.64
Clonal success of piliated penicillin nonsusceptible pneumococci. Proc Natl Acad Sci U S A (2007) 1.64
Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus. Vaccine (2009) 1.58
Phylogeny of the SARS coronavirus. Science (2003) 1.56
The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins. J Infect Dis (2004) 1.55
A chemokine-degrading extracellular protease made by group A Streptococcus alters pathogenesis by enhancing evasion of the innate immune response. Infect Immun (2008) 1.54
Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nat Rev Microbiol (2010) 1.52
Sortase A utilizes an ancillary protein anchor for efficient cell wall anchoring of pili in Streptococcus agalactiae. Infect Immun (2008) 1.51