Published in Science on October 04, 2002
The COG database: an updated version includes eukaryotes. BMC Bioinformatics (2003) 60.98
The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical Pacific. PLoS Biol (2007) 23.58
Insights into social insects from the genome of the honeybee Apis mellifera. Nature (2006) 13.67
Ensembl 2002: accommodating comparative genomics. Nucleic Acids Res (2003) 12.26
The Ensembl automatic gene annotation system. Genome Res (2004) 12.24
Ensembl 2004. Nucleic Acids Res (2004) 11.88
Computational identification of Drosophila microRNA genes. Genome Biol (2003) 9.86
The Atlas genome assembly system. Genome Res (2004) 9.78
Genome sequence of Aedes aegypti, a major arbovirus vector. Science (2007) 9.19
Malaria: progress, perils, and prospects for eradication. J Clin Invest (2008) 6.54
The diploid genome sequence of Candida albicans. Proc Natl Acad Sci U S A (2004) 6.34
Whole-genome shotgun assembly and comparison of human genome assemblies. Proc Natl Acad Sci U S A (2004) 6.08
Paucity of genes on the Drosophila X chromosome showing male-biased expression. Science (2003) 6.04
A high quality draft consensus sequence of the genome of a heterozygous grapevine variety. PLoS One (2007) 5.62
MAKER2: an annotation pipeline and genome-database management tool for second-generation genome projects. BMC Bioinformatics (2011) 5.35
Heterochromatic sequences in a Drosophila whole-genome shotgun assembly. Genome Biol (2002) 5.09
Genomic islands of speciation in Anopheles gambiae. PLoS Biol (2005) 5.03
A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes. Genome Biol (2004) 4.94
Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. Genetics (2004) 4.51
Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A (2004) 3.85
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res (2004) 3.63
Late-acting dominant lethal genetic systems and mosquito control. BMC Biol (2007) 3.54
Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics. Science (2010) 3.18
A global network for investigating the genomic epidemiology of malaria. Nature (2008) 3.16
Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell (2004) 3.10
Assessing the impact of comparative genomic sequence data on the functional annotation of the Drosophila genome. Genome Biol (2002) 3.09
Molecular paleontology of transposable elements in the Drosophila melanogaster genome. Proc Natl Acad Sci U S A (2003) 3.09
An integrated gene annotation and transcriptional profiling approach towards the full gene content of the Drosophila genome. Genome Biol (2003) 3.08
Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. Genome Biol (2003) 3.03
Odorant-binding proteins OBP57d and OBP57e affect taste perception and host-plant preference in Drosophila sechellia. PLoS Biol (2007) 3.03
Gene family evolution across 12 Drosophila genomes. PLoS Genet (2007) 2.94
VectorBase: a home for invertebrate vectors of human pathogens. Nucleic Acids Res (2006) 2.94
Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proc Natl Acad Sci U S A (2005) 2.81
A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee. Insect Mol Biol (2006) 2.80
Performance and scalability of discriminative metrics for comparative gene identification in 12 Drosophila genomes. PLoS Comput Biol (2008) 2.70
Assembly of polymorphic genomes: algorithms and application to Ciona savignyi. Genome Res (2005) 2.69
Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation. PLoS Genet (2008) 2.67
Comparative genomics of transcriptional control in the human malaria parasite Plasmodium falciparum. Genome Res (2004) 2.66
Widespread divergence between incipient Anopheles gambiae species revealed by whole genome sequences. Science (2010) 2.58
The construction of an EST database for Bombyx mori and its application. Proc Natl Acad Sci U S A (2003) 2.56
Peptides encoded by short ORFs control development and define a new eukaryotic gene family. PLoS Biol (2007) 2.54
An evolutionary analysis of orphan genes in Drosophila. Genome Res (2003) 2.52
Estimating the tempo and mode of gene family evolution from comparative genomic data. Genome Res (2005) 2.50
SilkDB: a knowledgebase for silkworm biology and genomics. Nucleic Acids Res (2005) 2.50
SilkDB v2.0: a platform for silkworm (Bombyx mori ) genome biology. Nucleic Acids Res (2009) 2.45
Phylogenomic analysis reveals bees and wasps (Hymenoptera) at the base of the radiation of Holometabolous insects. Genome Res (2006) 2.42
Large-scale trends in the evolution of gene structures within 11 animal genomes. PLoS Comput Biol (2006) 2.42
Insertion polymorphisms of SINE200 retrotransposons within speciation islands of Anopheles gambiae molecular forms. Malar J (2008) 2.38
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc Natl Acad Sci U S A (2003) 2.38
The complexities of malaria disease manifestations with a focus on asymptomatic malaria. Malar J (2012) 2.37
Identification of putative noncoding polyadenylated transcripts in Drosophila melanogaster. Proc Natl Acad Sci U S A (2005) 2.30
Emerging infectious diseases: a 10-year perspective from the National Institute of Allergy and Infectious Diseases. Emerg Infect Dis (2005) 2.30
Olfactory regulation of mosquito-host interactions. Insect Biochem Mol Biol (2004) 2.30
Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation. Nucleic Acids Res (2015) 2.28
A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae. Proc Natl Acad Sci U S A (2004) 2.27
The analysis of large-scale gene expression correlated to the phase changes of the migratory locust. Proc Natl Acad Sci U S A (2004) 2.26
Extreme genomic variation in a natural population. Proc Natl Acad Sci U S A (2007) 2.24
Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. Science (2014) 2.21
Wolbachia infections are virulent and inhibit the human malaria parasite Plasmodium falciparum in Anopheles gambiae. PLoS Pathog (2011) 2.18
A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13
Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals. BMC Bioinformatics (2003) 2.10
Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Genetics (2008) 2.09
Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing. Genome Res (2005) 2.02
Mitotic-chromosome-based physical mapping of the Culex quinquefasciatus genome. PLoS One (2015) 2.01
Biologically meaningful expression profiling across species using heterologous hybridization to a cDNA microarray. BMC Genomics (2004) 1.98
Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies). BMC Genomics (2009) 1.98
Comparative genomics. PLoS Biol (2003) 1.97
Reversal of an ancient sex chromosome to an autosome in Drosophila. Nature (2013) 1.97
De novo transcriptome sequencing in Anopheles funestus using Illumina RNA-seq technology. PLoS One (2010) 1.95
Mosquito genomics. Extensive introgression in a malaria vector species complex revealed by phylogenomics. Science (2014) 1.94
A research agenda for malaria eradication: basic science and enabling technologies. PLoS Med (2011) 1.89
Complex early genes. Proc Natl Acad Sci U S A (2005) 1.88
Numerous transitions of sex chromosomes in Diptera. PLoS Biol (2015) 1.85
A haplome alignment and reference sequence of the highly polymorphic Ciona savignyi genome. Genome Biol (2007) 1.82
Malaria research in the post-genomic era. Nature (2008) 1.78
The C-value enigma in plants and animals: a review of parallels and an appeal for partnership. Ann Bot (2005) 1.76
Molecular characterization of the Aedes aegypti odorant receptor gene family. Insect Mol Biol (2007) 1.76
The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes. RNA (2004) 1.76
Molecular evolutionary analysis of the widespread piggyBac transposon family and related "domesticated" sequences. Mol Genet Genomics (2003) 1.76
Breakpoint structure reveals the unique origin of an interspecific chromosomal inversion (2La) in the Anopheles gambiae complex. Proc Natl Acad Sci U S A (2006) 1.75
Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth. Philos Trans R Soc Lond B Biol Sci (2013) 1.74
Gene expression patterns associated with blood-feeding in the malaria mosquito Anopheles gambiae. BMC Genomics (2005) 1.73
piggyBac-based insertional mutagenesis and enhancer detection as a tool for functional insect genomics. Genetics (2003) 1.73
Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission. Future Microbiol (2011) 1.72
Proteogenomics to discover the full coding content of genomes: a computational perspective. J Proteomics (2010) 1.71
Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei. EMBO Rep (2005) 1.70
FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. BMC Genomics (2005) 1.70
Comparative molecular modeling of Anopheles gambiae CYP6Z1, a mosquito P450 capable of metabolizing DDT. Proc Natl Acad Sci U S A (2008) 1.69
The Anopheles gambiae glutathione transferase supergene family: annotation, phylogeny and expression profiles. BMC Genomics (2003) 1.69
Novel peptide marker corresponding to salivary protein gSG6 potentially identifies exposure to Anopheles bites. PLoS One (2008) 1.61
A BAC-based integrated linkage map of the silkworm Bombyx mori. Genome Biol (2008) 1.60
Immune response of Anopheles gambiae to the early sporogonic stages of the human malaria parasite Plasmodium falciparum. EMBO J (2002) 1.59
Comparative genomics of small RNA regulatory pathway components in vector mosquitoes. BMC Genomics (2008) 1.58
AnoEST: toward A. gambiae functional genomics. Genome Res (2005) 1.58
Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos. Nucleic Acids Res (2007) 1.56
Leveraging skewed transcript abundance by RNA-Seq to increase the genomic depth of the tree of life. Proc Natl Acad Sci U S A (2010) 1.55
Anopheles gambiae APL1 is a family of variable LRR proteins required for Rel1-mediated protection from the malaria parasite, Plasmodium berghei. PLoS One (2008) 1.55
The use of transcriptional profiles to predict adult mosquito age under field conditions. Proc Natl Acad Sci U S A (2006) 1.55
Detection and correction of false segmental duplications caused by genome mis-assembly. Genome Biol (2010) 1.54
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Genome Res (2008) 151.16
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Fast gapped-read alignment with Bowtie 2. Nat Methods (2012) 83.79
TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13
A method and server for predicting damaging missense mutations. Nat Methods (2010) 78.53
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol (2010) 75.21
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The Bioperl toolkit: Perl modules for the life sciences. Genome Res (2002) 58.63
The Pfam protein families database. Nucleic Acids Res (2002) 51.34
Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45
Versatile and open software for comparing large genomes. Genome Biol (2004) 49.45
Identifying bacterial genes and endosymbiont DNA with Glimmer. Bioinformatics (2007) 47.63
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
De novo assembly of human genomes with massively parallel short read sequencing. Genome Res (2009) 45.91
Environmental genome shotgun sequencing of the Sargasso Sea. Science (2004) 45.23
Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19
The diploid genome sequence of an individual human. PLoS Biol (2007) 44.80
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem (2009) 40.90
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc (2012) 35.75
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol (2013) 32.42
Comparative metagenomics of microbial communities. Science (2005) 25.88
InterPro: the integrative protein signature database. Nucleic Acids Res (2008) 25.07
Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res (2002) 25.06
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
Automated generation of heuristics for biological sequence comparison. BMC Bioinformatics (2005) 24.54
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Enterotypes of the human gut microbiome. Nature (2011) 24.36
Comparative assessment of large-scale data sets of protein-protein interactions. Nature (2002) 24.25
The Sorcerer II Global Ocean Sampling expedition: northwest Atlantic through eastern tropical Pacific. PLoS Biol (2007) 23.58
Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature (2005) 23.04
Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods (2009) 22.47
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
Recent segmental duplications in the human genome. Science (2002) 21.30
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89
Proteome survey reveals modularity of the yeast cell machinery. Nature (2006) 20.77
STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res (2008) 20.62
Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science (2002) 20.59
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
International network of cancer genome projects. Nature (2010) 20.35
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37
CDD: a Conserved Domain Database for the functional annotation of proteins. Nucleic Acids Res (2010) 19.07
CDD: a Conserved Domain Database for protein classification. Nucleic Acids Res (2005) 18.85
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res (2010) 18.73
Assembling millions of short DNA sequences using SSAKE. Bioinformatics (2006) 18.71
A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39
STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res (2012) 18.26
The Sequence Ontology: a tool for the unification of genome annotations. Genome Biol (2005) 18.20