Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 23679895)

Published in Biochem J on July 15, 2013

Authors

Brooke M Swalm1, Kenneth K Hallenbeck, Christina R Majer, Lei Jin, Margaret Porter Scott, Mikel P Moyer, Robert A Copeland, Tim J Wigle

Author Affiliations

1: Epizyme Inc., 400 Technology Square, Cambridge, MA 02139, USA.

Articles by these authors

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21

Effects of physician experience on costs and outcomes on an academic general medicine service: results of a trial of hospitalists. Ann Intern Med (2002) 7.09

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists. Methods Biochem Anal (2005) 5.37

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell (2011) 4.90

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A (2010) 4.52

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol (2012) 3.89

Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks. Science (2010) 3.62

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol (2011) 3.60

3.88 A structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy. Nature (2008) 3.57

3.3 A cryo-EM structure of a nonenveloped virus reveals a priming mechanism for cell entry. Cell (2010) 3.40

Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients. Gastroenterology (2007) 3.34

PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood (2007) 2.93

Improving diabetes care in midwest community health centers with the health disparities collaborative. Diabetes Care (2004) 2.83

Use of a self-report-generated Charlson Comorbidity Index for predicting mortality. Med Care (2005) 2.70

Residence time of receptor-ligand complexes and its effect on biological function. Biochemistry (2008) 2.47

Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol (2006) 2.44

Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B. Hepatology (2010) 2.44

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection. Nature (2013) 2.38

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood (2013) 2.28

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A (2013) 2.26

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res (2008) 2.15

Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem (2003) 1.93

Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase. Biochem J (2008) 1.79

Chemogenetic analysis of human protein methyltransferases. Chem Biol Drug Des (2011) 1.77

Impairment of CD4+ cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma. Hepatology (2013) 1.74

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem (2010) 1.73

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc Natl Acad Sci U S A (2010) 1.72

General internists' views on pay-for-performance and public reporting of quality scores: a national survey. Health Aff (Millwood) (2007) 1.71

CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis. Hepatology (2015) 1.70

CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection. Hepatology (2009) 1.56

Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis. Mol Carcinog (2012) 1.55

Serum progesterone level effects on the outcome of in vitro fertilization in patients with different ovarian response: an analysis of more than 10,000 cycles. Fertil Steril (2012) 1.46

Small-molecule ligands of methyl-lysine binding proteins. J Med Chem (2011) 1.45

Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates. AIDS (2004) 1.43

The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states. FEBS Lett (2011) 1.42

Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem (2008) 1.41

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nat Chem Biol (2007) 1.39

Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. Proc Natl Acad Sci U S A (2011) 1.38

The impact of patient preferences on the cost-effectiveness of intensive glucose control in older patients with new-onset diabetes. Diabetes Care (2006) 1.38

A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues. Proc Natl Acad Sci U S A (2006) 1.38

Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther (2014) 1.37

The genome of the hydatid tapeworm Echinococcus granulosus. Nat Genet (2013) 1.29

Targeting epigenetic enzymes for drug discovery. Curr Opin Chem Biol (2010) 1.27

Sensitivity of second harmonic generation from styryl dyes to transmembrane potential. Biophys J (2004) 1.26

Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients. J Gastroenterol Hepatol (2012) 1.24

Does doctor-patient communication affect patient satisfaction with hospital care? Results of an analysis with a novel instrumental variable. Health Serv Res (2008) 1.23

Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A (2013) 1.23

Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes. Antimicrob Agents Chemother (2006) 1.22

Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. PLoS Pathog (2013) 1.22

Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection. Mol Microbiol (2014) 1.22

Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure. J Hepatol (2008) 1.21

Mechanism of inhibition of human KSP by ispinesib. Biochemistry (2008) 1.21

Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity. Mol Cancer Ther (2005) 1.20

Imbalanced intrahepatic cytokine expression of interferon-gamma, tumor necrosis factor-alpha, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection. J Clin Gastroenterol (2009) 1.20

Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol (2011) 1.20

A prognostic model for 1-year mortality in older adults after hospital discharge. Am J Med (2007) 1.19

Pain and satisfaction with pain control in hospitalized medical patients: no such thing as low risk. Arch Intern Med (2004) 1.18

Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). J Biol Chem (2011) 1.17

Synthesis, spectra, delivery and potentiometric responses of new styryl dyes with extended spectral ranges. J Neurosci Methods (2005) 1.16

Providers' assessment of barriers to effective management of hypertension and hyperlipidemia in community health centers. J Health Care Poor Underserved (2006) 1.15

The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors. Immunology (2008) 1.14

Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment. Hepatology (2014) 1.14

Cardiac thin filament regulation. Pflugers Arch (2008) 1.13

Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J Pharmacol Exp Ther (2009) 1.13

A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination. Biochemistry (2006) 1.13

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients. J Clin Invest (2014) 1.12

Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem (2013) 1.12

Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes. Philos Trans R Soc Lond B Biol Sci (2009) 1.12

Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem Biol Drug Des (2012) 1.12

Genetically encoded fluorescent voltage sensors using the voltage-sensing domain of Nematostella and Danio phosphatases exhibit fast kinetics. J Neurosci Methods (2012) 1.12

Binding of TPX2 to Aurora A alters substrate and inhibitor interactions. Biochemistry (2007) 1.12

Fluorescent protein voltage probes derived from ArcLight that respond to membrane voltage changes with fast kinetics. PLoS One (2013) 1.11

Resident satisfaction on an academic hospitalist service: time to teach. Am J Med (2002) 1.10

Differential restoration of myeloid and plasmacytoid dendritic cells in HIV-1-infected children after treatment with highly active antiretroviral therapy. J Immunol (2006) 1.06

Variation in treatment preferences and care goals among older patients with diabetes and their physicians. Med Care (2008) 1.06