Published in Nat Genet on September 08, 2013
Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis. PLoS Negl Trop Dis (2017) 1.40
Treatment of echinococcosis: albendazole and mebendazole--what else? Parasite (2014) 0.96
A mex3 homolog is required for differentiation during planarian stem cell lineage development. Elife (2015) 0.95
Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene (2016) 0.89
Comparative genomics of flatworms (platyhelminthes) reveals shared genomic features of ecto- and endoparastic neodermata. Genome Biol Evol (2014) 0.88
An easy and efficient method for native and immunoreactive Echinococcus granulosus antigen 5 enrichment from hydatid cyst fluid. PLoS One (2014) 0.87
Validation of suitable reference genes for expression normalization in Echinococcus spp. larval stages. PLoS One (2014) 0.87
What helminth genomes have taught us about parasite evolution. Parasitology (2014) 0.87
Genome mining offers a new starting point for parasitology research. Parasitol Res (2015) 0.86
The genome of the sparganosis tapeworm Spirometra erinaceieuropaei isolated from the biopsy of a migrating brain lesion. Genome Biol (2014) 0.86
microRNA profiling in the zoonotic parasite Echinococcus canadensis using a high-throughput approach. Parasit Vectors (2015) 0.85
WormBase ParaSite - a comprehensive resource for helminth genomics. Mol Biochem Parasitol (2016) 0.85
Reinforcing the egg-timer: recruitment of novel lophotrochozoa homeobox genes to early and late development in the pacific oyster. Genome Biol Evol (2015) 0.84
HOX gene complement and expression in the planarian Schmidtea mediterranea. Evodevo (2016) 0.82
Genome-wide sequencing of small RNAs reveals a tissue-specific loss of conserved microRNA families in Echinococcus granulosus. BMC Genomics (2014) 0.81
Ion channels and drug transporters as targets for anthelmintics. Curr Clin Microbiol Rep (2014) 0.81
How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway? Trends Parasitol (2014) 0.81
Expression profile of the Schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets. PLoS Comput Biol (2014) 0.81
On the importance of targeting parasite stem cells in anti-echinococcosis drug development. Parasite (2014) 0.79
In Vitro Anti-Echinococcal and Metabolic Effects of Metformin Involve Activation of AMP-Activated Protein Kinase in Larval Stages of Echinococcus granulosus. PLoS One (2015) 0.79
Molecular insights into a tetraspanin in the hydatid tapeworm Echinococcus granulosus. Parasit Vectors (2015) 0.79
Transcriptome profiles of the protoscoleces of Echinococcus granulosus reveal that excretory-secretory products are essential to metabolic adaptation. PLoS Negl Trop Dis (2014) 0.78
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host. Nat Commun (2016) 0.77
Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis. PLoS Negl Trop Dis (2016) 0.77
Cloning and Characterization of Two Potent Kunitz Type Protease Inhibitors from Echinococcus granulosus. PLoS Negl Trop Dis (2015) 0.77
Lipid-free antigen B subunits from echinococcus granulosus: oligomerization, ligand binding, and membrane interaction properties. PLoS Negl Trop Dis (2015) 0.77
Top Down Proteomics Reveals Mature Proteoforms Expressed in Subcellular Fractions of the Echinococcus granulosus Preadult Stage. J Proteome Res (2015) 0.76
Functional characterisation of Schistosoma japonicum acetylcholinesterase. Parasit Vectors (2016) 0.76
Identification and characterization of functional Smad8 and Smad4 homologues from Echinococcus granulosus. Parasitol Res (2014) 0.76
Echinococcus granulosus Antigen B binds to monocytes and macrophages modulating cell response to inflammation. Parasit Vectors (2016) 0.76
Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions. PLoS Negl Trop Dis (2016) 0.75
Identification of Newly Synthesized Proteins by Echinococcus granulosus Protoscoleces upon Induction of Strobilation. PLoS Negl Trop Dis (2015) 0.75
Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus. Korean J Parasitol (2016) 0.75
Hydatid cyst fluid promotes peri-cystic fibrosis in cystic echinococcosis by suppressing miR-19 expression. Parasit Vectors (2016) 0.75
Echinococcus granulosus genomics: a new dawn for improved diagnosis, treatment, and control of echinococcosis. Parasite (2014) 0.75
The Echinococcus canadensis (G7) genome: a key knowledge of parasitic platyhelminth human diseases. BMC Genomics (2017) 0.75
Mechanism of protective immunity by vaccination with recombinant Echinococcus granulosus glutathione S-transferase (Chinese strain) in mice. Exp Ther Med (2015) 0.75
Gene Expression Profile in the Liver of Sheep Infected with Cystic Echinococcosis. PLoS One (2016) 0.75
Transient transgenesis of the tapeworm Taenia crassiceps. Springerplus (2015) 0.75
Characterisation of Antigen B Protein Species Present in the Hydatid Cyst Fluid of Echinococcus canadensis G7 Genotype. PLoS Negl Trop Dis (2017) 0.75
Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels. PLoS Pathog (2017) 0.75
Cloning and characterization of an Echinococcus granulosus ecdysteroid hormone nuclear receptor HR3-like gene. Parasite (2017) 0.75
Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage. PLoS One (2017) 0.75
Genome-Wide Transcriptome Analysis Reveals Extensive Alternative Splicing Events in the Protoscoleces of Echinococcus granulosus and Echinococcus multilocularis. Front Microbiol (2017) 0.75
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol (2011) 220.97
Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods (2008) 126.81
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
The KEGG resource for deciphering the genome. Nucleic Acids Res (2004) 53.05
Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res (1999) 49.21
InterProScan: protein domains identifier. Nucleic Acids Res (2005) 18.82
DEGseq: an R package for identifying differentially expressed genes from RNA-seq data. Bioinformatics (2009) 14.83
The druggable genome. Nat Rev Drug Discov (2002) 13.61
OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups. Nucleic Acids Res (2006) 11.43
Gene prediction with a hidden Markov model and a new intron submodel. Bioinformatics (2003) 8.92
De novo identification of repeat families in large genomes. Bioinformatics (2005) 7.95
Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation. Nat Methods (2005) 7.87
Blast2GO: A comprehensive suite for functional analysis in plant genomics. Int J Plant Genomics (2008) 7.12
Echinococcosis. Lancet (2003) 6.83
The genome of the blood fluke Schistosoma mansoni. Nature (2009) 5.94
Neurocysticercosis: updated concepts about an old disease. Lancet Neurol (2005) 5.37
Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev (2009) 5.11
MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res (2011) 4.90
The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature (2009) 4.19
Prevention and control of cystic echinococcosis. Lancet Infect Dis (2007) 3.64
Gene identification in novel eukaryotic genomes by self-training algorithm. Nucleic Acids Res (2005) 3.49
Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature (2004) 3.04
Concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev (2003) 2.77
Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nat Med (2006) 2.59
The genomes of four tapeworm species reveal adaptations to parasitism. Nature (2013) 2.45
Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway in Caenorhabditis elegans epidermis. Nat Immunol (2009) 1.80
Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci (2009) 1.45
Are Ca2+ channels targets of praziquantel action? Int J Parasitol (2004) 1.36
ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem (2000) 1.34
Diagnosis, treatment, and management of echinococcosis. BMJ (2012) 1.31
Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani. Mol Biol Cell (2001) 1.30
Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover. PLoS Pathog (2010) 1.26
Elucidating the transcriptome of Fasciola hepatica - a key to fundamental and biotechnological discoveries for a neglected parasite. Biotechnol Adv (2009) 1.21
Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni. Nat Commun (2011) 1.19
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan. EMBO J (2011) 1.13
Molecular discrimination of taeniid cestodes. Parasitol Int (2005) 1.11
Cestode genomics - progress and prospects for advancing basic and applied aspects of flatworm biology. Parasite Immunol (2012) 1.09
Spermatogenesis-defective (spe) mutants of the nematode Caenorhabditis elegans provide clues to solve the puzzle of male germline functions during reproduction. Dev Dyn (2010) 1.09
High polymorphism in genes encoding antigen B from human infecting strains of Echinococcus granulosus. Parasitology (2005) 1.03
TRAP: automated classification, quantification and annotation of tandemly repeated sequences. Bioinformatics (2005) 1.03
Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China. PLoS Negl Trop Dis (2011) 1.02
Molecular evidence for a functional ecdysone signaling system in Brugia malayi. PLoS Negl Trop Dis (2010) 1.00
Hydatid disease: vaccinology and development of the EG95 recombinant vaccine. Expert Rev Vaccines (2005) 0.99
Perspective: TGR5 (Gpbar-1) in liver physiology and disease. Clin Res Hepatol Gastroenterol (2012) 0.98
A novel transforming growth factor-beta receptor-interacting protein that is also a light chain of the motor protein dynein. Mol Biol Cell (2002) 0.98
Evolution and spermatogenesis. Philos Trans R Soc Lond B Biol Sci (2010) 0.96
Human hydatidosis in the central Andes of Peru: evolution of the disease over 3 years. Clin Infect Dis (1999) 0.94
The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans. Curr Biol (2005) 0.94
Compatibility in the Biomphalaria glabrata/Echinostoma caproni model: potential involvement of adhesion genes. Int J Parasitol (2005) 0.91
Latent period of 53 years in a case of hydatid cyst disease. Arch Intern Med (1974) 0.89
Ion-channels on parasite muscle: pharmacology and physiology. Invert Neurosci (2007) 0.89
Thiol-based posttranslational modifications in parasites. Antioxid Redox Signal (2012) 0.87
Finding genes in Schistosoma japonicum: annotating novel genomes with help of extrinsic evidence. Nucleic Acids Res (2009) 0.87
Praziquantel failure in the treatment of Fasciola hepatica. Can J Infect Dis (1992) 0.86
A scaffold analysis tool using mate-pair information in genome sequencing. J Biomed Biotechnol (2008) 0.86
Density-gradient separation of Taenia pisiformis oncospheres. J Parasitol (1980) 0.86
Sex steroids effects on the molting process of the helminth human parasite Trichinella spiralis. J Biomed Biotechnol (2011) 0.84
Molecular mechanisms of invasion by cancer cells, leukocytes and microorganisms. Microbes Infect (2000) 0.84
Phylogenomics reveals an anomalous distribution of USP genes in metazoans. Mol Biol Evol (2010) 0.82
Establishment of cell cultures from hydatid cysts of Echinococcus granulosus. Int J Parasitol (1988) 0.79
Early treatment with artemether and praziquantel in rabbits repeatedly infected with Schistosoma japonicum cercariae. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (1994) 0.77
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
The diploid genome sequence of an Asian individual. Nature (2008) 46.29
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science (2002) 42.78
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
The sequence and de novo assembly of the giant panda genome. Nature (2009) 15.76
A human genome diversity cell line panel. Science (2002) 14.11
WEGO: a web tool for plotting GO annotations. Nucleic Acids Res (2006) 13.06
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell (2006) 10.10
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. Genome Res (2005) 8.38
The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science (2012) 7.94
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
MMDB: annotating protein sequences with Entrez's 3D-structure database. Nucleic Acids Res (2006) 7.57
Schistosomiasis. N Engl J Med (2002) 7.48
Mapping human genetic diversity in Asia. Science (2009) 7.40
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
Effects of physician experience on costs and outcomes on an academic general medicine service: results of a trial of hospitalists. Ann Intern Med (2002) 7.09
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
Risk factors for suicide in China: a national case-control psychological autopsy study. Lancet (2002) 7.00
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet (2011) 6.98
Echinococcosis. Lancet (2003) 6.83
Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet (2009) 6.79
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med (2013) 6.70
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
KCNQ1 gain-of-function mutation in familial atrial fibrillation. Science (2003) 6.60
Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A (2008) 6.42
Altered histone acetylation is associated with age-dependent memory impairment in mice. Science (2010) 6.38
Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet (2013) 6.10
Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer (2005) 6.05
Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project. Nat Biotechnol (2006) 5.92
Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol (2007) 5.53
Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med (2013) 5.38
Acute promyelocytic leukemia: from highly fatal to highly curable. Blood (2008) 5.35
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Resequencing of 31 wild and cultivated soybean genomes identifies patterns of genetic diversity and selection. Nat Genet (2010) 5.20
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell (2011) 4.90
An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (2011) 4.84
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science (2008) 4.74
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML. Science (2010) 4.52
MMDB: Entrez's 3D-structure database. Nucleic Acids Res (2002) 4.42
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science (2006) 4.38
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature (2012) 4.37
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood (2010) 4.33
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell (2012) 4.29
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat Immunol (2008) 4.28
Validation of verbal autopsy procedures for adult deaths in China. Int J Epidemiol (2005) 4.20
Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19
KaKs_Calculator: calculating Ka and Ks through model selection and model averaging. Genomics Proteomics Bioinformatics (2006) 4.15
[Human natural infection of Plasmodium knowlesi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2006) 3.99
Protein production and purification. Nat Methods (2008) 3.97
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2005) 3.97
Probing cellular protein complexes using single-molecule pull-down. Nature (2011) 3.92
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature (2007) 3.91
Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer (2009) 3.90
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol (2012) 3.89
A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle. Mol Cell (2003) 3.88
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev (2005) 3.88
mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nat Methods (2008) 3.88
Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228). Mol Microbiol (2003) 3.86
Systems medicine: the future of medical genomics and healthcare. Genome Med (2009) 3.85
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages. Proc Natl Acad Sci U S A (2005) 3.84
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81
Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res (2005) 3.79
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling. Proc Natl Acad Sci U S A (2005) 3.72
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A (2008) 3.71
Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68
Prevention and control of cystic echinococcosis. Lancet Infect Dis (2007) 3.64
Schistosomiasis elimination: lessons from the past guide the future. Lancet Infect Dis (2010) 3.63
A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature (2009) 3.63
Atomic structure of human adenovirus by cryo-EM reveals interactions among protein networks. Science (2010) 3.62
3.88 A structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy. Nature (2008) 3.57